Gabriele Pradel

Gabriele Pradel

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Gabriele Pradel

Publications by authors named "Gabriele Pradel"

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A patatin-like phospholipase functions during gametocyte induction in the malaria parasite Plasmodium falciparum.

Cell Microbiol 2020 Mar 8;22(3):e13146. Epub 2019 Dec 8.

Division of Cellular and Applied Infection Biology, Institute of Zoology, RWTH Aachen University, Aachen, Germany.

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http://dx.doi.org/10.1111/cmi.13146DOI Listing
March 2020

The molecular machinery of translational control in malaria parasites.

Mol Microbiol 2019 12 30;112(6):1658-1673. Epub 2019 Sep 30.

Division of Cellular and Applied Infection Biology, Institute of Zoology, RWTH Aachen University, Worringerweg 1, 52074, Aachen, Germany.

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http://dx.doi.org/10.1111/mmi.14388DOI Listing
December 2019

The G9a Histone Methyltransferase Inhibitor BIX-01294 Modulates Gene Expression during Gametocyte Development and Transmission.

Int J Mol Sci 2019 Oct 14;20(20). Epub 2019 Oct 14.

Division of Cellular and Applied Infection Biology, Institute of Zoology, RWTH Aachen University, 52074 Aachen, Germany.

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http://dx.doi.org/10.3390/ijms20205087DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6829282PMC
October 2019

Cutting Edge: FHR-1 Binding Impairs Factor H-Mediated Complement Evasion by the Malaria Parasite .

J Immunol 2018 12 19;201(12):3497-3502. Epub 2018 Nov 19.

Division of Cellular and Applied Infection Biology, RWTH Aachen University, 52074 Aachen, Germany; and

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http://www.jimmunol.org/lookup/doi/10.4049/jimmunol.1800662
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http://dx.doi.org/10.4049/jimmunol.1800662DOI Listing
December 2018

Pathways of host cell exit by intracellular pathogens.

Microb Cell 2018 Oct 18;5(12):525-544. Epub 2018 Oct 18.

Division of Cellular and Applied Infection Biology, Institute of Biology II, RWTH Aachen University, Germany.

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http://microbialcell.com/researcharticles/pathways-of-host-c
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http://dx.doi.org/10.15698/mic2018.12.659DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282021PMC
October 2018

Phospholipases during membrane dynamics in malaria parasites.

Int J Med Microbiol 2018 Jan 23;308(1):129-141. Epub 2017 Sep 23.

Division of Cellular and Applied Infection Biology, Institute of Zoology, RWTH Aachen University, Worringerweg 1, 52074 Aachen, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.ijmm.2017.09.015DOI Listing
January 2018

The cytosolic glyoxalases of are dispensable during asexual blood-stage development.

Microb Cell 2017 Nov 20;5(1):32-41. Epub 2017 Nov 20.

Department of Parasitology, Ruprecht-Karls University, D-69120 Heidelberg, Germany.

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http://dx.doi.org/10.15698/mic2018.01.608DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5772037PMC
November 2017

Transcript and protein expression analysis of proteases in the blood stages of Plasmodium falciparum.

Exp Parasitol 2017 Sep 27;180:33-44. Epub 2017 Mar 27.

Division of Cellular and Applied Infection Biology, Institute of Zoology, RWTH Aachen University, Worringerweg 1, 52074 Aachen, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.exppara.2017.03.006DOI Listing
September 2017

Bioactivity of topologically confined gramicidin A dimers.

Bioorg Med Chem 2017 01 9;25(1):261-268. Epub 2016 Nov 9.

Friedrich Schiller University Jena, Institute of Organic Chemistry and Macromolecular Chemistry, Humboldtstr. 10, D-07743 Jena, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2016.10.033DOI Listing
January 2017

Bistacrine derivatives as new potent antimalarials.

Bioorg Med Chem 2016 08 4;24(16):3636-42. Epub 2016 Jun 4.

Institute of Pharmacy and Food Chemistry, University of Würzburg, Am Hubland, 97074 Würzburg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2016.06.003DOI Listing
August 2016

The development of malaria parasites in the mosquito midgut.

Cell Microbiol 2016 07 24;18(7):905-18. Epub 2016 May 24.

Division of Cellular and Applied Infection Biology, Institute of Zoology, RWTH Aachen University, Worringerweg 1, 52074, Aachen, Germany.

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http://dx.doi.org/10.1111/cmi.12604DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5089571PMC
July 2016

The Plasmodium falciparum blood stages acquire factor H family proteins to evade destruction by human complement.

Cell Microbiol 2016 Apr 12;18(4):573-90. Epub 2015 Nov 12.

Division of Cellular and Applied Infection Biology, RWTH Aachen University, Worringerweg 1, 52074, Aachen, Germany.

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http://dx.doi.org/10.1111/cmi.12535DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5063132PMC
April 2016

Adhesion protein complexes of malaria gametocytes assemble following parasite transmission to the mosquito.

Parasitol Int 2016 Feb 25;65(1):27-30. Epub 2015 Sep 25.

Division of Cellular and Applied Infection Biology, RWTH Aachen University, Worringerweg 1, 52074 Aachen, Germany.

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http://dx.doi.org/10.1016/j.parint.2015.09.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422033PMC
February 2016

Synthesis and evaluation of the antiplasmodial activity of tryptanthrin derivatives.

Int J Parasitol Drugs Drug Resist 2015 Aug 17;5(2):48-57. Epub 2015 Apr 17.

Institute of Molecular Biotechnology, RWTH Aachen University, 52074 Aachen, Germany ; Department of Chemistry, University of Cape Town, Rondebosch 7701, South Africa.

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http://dx.doi.org/10.1016/j.ijpddr.2015.03.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4417838PMC
August 2015

Heat-precipitation allows the efficient purification of a functional plant-derived malaria transmission-blocking vaccine candidate fusion protein.

Biotechnol Bioeng 2015 Jul 13;112(7):1297-305. Epub 2015 Mar 13.

Fraunhofer Institute for Molecular Biology and Applied Ecology (IME), Forckenbeckstrasse 6, 52074, Aachen, Germany.

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http://dx.doi.org/10.1002/bit.25548DOI Listing
July 2015

Perforin-like protein PPLP4 is crucial for mosquito midgut infection by Plasmodium falciparum.

Mol Biochem Parasitol 2015 Jun 9;201(2):90-9. Epub 2015 Jul 9.

Cellular and Applied Infection Biology Section, RWTH Aachen University, Worringerweg 1, 52074 Aachen, Germany; Fraunhofer Institute for Molecular Biology and Applied Ecology, Forckenbeckstr. 6, 52074 Aachen, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.molbiopara.2015.06.005DOI Listing
June 2015

Coming soon: probiotics-based malaria vaccines.

Trends Parasitol 2015 Jan 18;31(1):2-4. Epub 2014 Dec 18.

Cellular and Applied Infection Biology Section, RWTH Aachen University, Aachen, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.pt.2014.11.006DOI Listing
January 2015

A primaquine-chloroquine hybrid with dual activity against Plasmodium liver and blood stages.

Int J Med Microbiol 2013 Dec 5;303(8):539-47. Epub 2013 Aug 5.

Institute of Organic Chemistry, University of Wuerzburg, Am Hubland, D-97074 Wuerzburg, Germany.

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http://dx.doi.org/10.1016/j.ijmm.2013.07.005DOI Listing
December 2013

Broad-spectrum antimalarial activity of peptido sulfonyl fluorides, a new class of proteasome inhibitors.

Antimicrob Agents Chemother 2013 Aug 20;57(8):3576-84. Epub 2013 May 20.

University of Tübingen, Institute of Tropical Medicine, and German Centre for Infection Research, Tübingen, Germany.

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http://dx.doi.org/10.1128/AAC.00742-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3719782PMC
August 2013

Malaria parasites co-opt human factor H to prevent complement-mediated lysis in the mosquito midgut.

Cell Host Microbe 2013 Jan 16;13(1):29-41. Epub 2013 Jan 16.

Research Center for Infectious Diseases, University of Würzburg, Josef-Schneider-Strasse 2/D15, 97080 Würzburg, Germany.

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http://dx.doi.org/10.1016/j.chom.2012.11.013DOI Listing
January 2013

The proteasome of malaria parasites: A multi-stage drug target for chemotherapeutic intervention?

Int J Parasitol Drugs Drug Resist 2012 Dec 9;2:1-10. Epub 2012 Jan 9.

Julius-Maximilians-University Würzburg, Research Center for Infectious Diseases, Josef-Schneider-Str. 2/D15, 97080 Würzburg, Germany.

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http://dx.doi.org/10.1016/j.ijpddr.2011.12.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3862440PMC
December 2012

Molecular mechanisms of host cell egress by malaria parasites.

Int J Med Microbiol 2012 Oct 27;302(4-5):172-8. Epub 2012 Aug 27.

Institute for Molecular Biotechnology, RWTH Aachen University, Worringerweg 1, 52074 Aachen, Germany.

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http://dx.doi.org/10.1016/j.ijmm.2012.07.003DOI Listing
October 2012

Synthesis and evaluation of hybrid drugs for a potential HIV/AIDS-malaria combination therapy.

Bioorg Med Chem 2012 Sep 29;20(17):5277-89. Epub 2012 Jun 29.

University of Würzburg, Research Center for Infectious Diseases, Josef-Schneider-Str. 2/D15, 97080 Würzburg, Germany.

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http://dx.doi.org/10.1016/j.bmc.2012.06.038DOI Listing
September 2012

Quaternary ammonium salts and their antimicrobial potential: targets or nonspecific interactions?

ChemMedChem 2012 Jan 24;7(1):22-31. Epub 2011 Nov 24.

Institute of Pharmacy and Food Chemistry, University of Würzburg, Würzburg, Germany.

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http://dx.doi.org/10.1002/cmdc.201100404DOI Listing
January 2012

Malaria proteases mediate inside-out egress of gametocytes from red blood cells following parasite transmission to the mosquito.

Cell Microbiol 2011 Jun 26;13(6):897-912. Epub 2011 Apr 26.

Research Center for Infectious Diseases, University of Würzburg, Würzburg, Germany.

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http://dx.doi.org/10.1111/j.1462-5822.2011.01588.xDOI Listing
June 2011

Two nucleus-localized CDK-like kinases with crucial roles for malaria parasite erythrocytic replication are involved in phosphorylation of splicing factor.

J Cell Biochem 2011 May;112(5):1295-310

Research Center for Infectious Diseases, University of Würzburg, Josef-Schneider-Strasse 2, Building D15, 97080 Würzburg, Germany.

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http://dx.doi.org/10.1002/jcb.23034DOI Listing
May 2011

Thiostrepton and derivatives exhibit antimalarial and gametocytocidal activity by dually targeting parasite proteasome and apicoplast.

Antimicrob Agents Chemother 2011 Apr 18;55(4):1338-48. Epub 2011 Jan 18.

Research Center for Infectious Diseases, University of Würzburg, Josef-Schneider-Str. 2/D15, 97080 Würzburg, Germany.

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http://dx.doi.org/10.1128/AAC.01096-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3067198PMC
April 2011

Family members stick together: multi-protein complexes of malaria parasites.

Med Microbiol Immunol 2010 Aug 24;199(3):209-26. Epub 2010 Apr 24.

Research Center for Infectious Diseases, University of Würzburg, Josef-Schneider-Strasse 2, Building D15, Würzburg, Germany.

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http://dx.doi.org/10.1007/s00430-010-0157-yDOI Listing
August 2010

A putative kinase-related protein (PKRP) from Plasmodium berghei mediates infection in the midgut and salivary glands of the mosquito.

Int J Parasitol 2010 Jul 12;40(8):979-88. Epub 2010 Mar 12.

Institute of Parasitology and Centre for Host-Parasite Interactions, McGill University, 21,111 Lakeshore Road, Sainte-Anne-de-Bellevue, Que. H9X3V9, Canada.

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http://dx.doi.org/10.1016/j.ijpara.2010.02.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2875340PMC
July 2010

Compounds of the upper gastrointestinal tract induce rapid and efficient excystation of Entamoeba invadens.

Int J Parasitol 2010 May 14;40(6):751-60. Epub 2009 Dec 14.

Department of Medical Parasitology, New York University School of Medicine, NY 10010, USA.

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http://dx.doi.org/10.1016/j.ijpara.2009.11.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2881592PMC
May 2010

The bisnaphthalimides as new active lead compounds against Plasmodium falciparum.

Bioorg Med Chem 2010 May 29;18(9):2998-3003. Epub 2010 Mar 29.

Institute of Pharmacy and Food Chemistry, University of Wuerzburg, Am Hubland, 97074 Wuerzburg, Germany.

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http://dx.doi.org/10.1016/j.bmc.2010.03.067DOI Listing
May 2010

The coming-out of malaria gametocytes.

J Biomed Biotechnol 2010 5;2010:976827. Epub 2010 Jan 5.

Research Center for Infectious Diseases, University of Würzburg, Josef-Schneider-Strasse 2, Building D15, 97080 Würzburg, Germany.

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http://dx.doi.org/10.1155/2010/976827DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2810480PMC
April 2010

Antiplasmodial thiostrepton derivatives: proteasome inhibitors with a dual mode of action.

Angew Chem Int Ed Engl 2010 Apr;49(19):3317-21

Technische Universität Dortmund, Fakultät Chemie, Otto-Hahn-Strasse 6, 44221 Dortmund, Germany.

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http://doi.wiley.com/10.1002/anie.200906988
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http://dx.doi.org/10.1002/anie.200906988DOI Listing
April 2010

Inducible APOBEC3G-Vif double stable cell line as a high-throughput screening platform to identify antiviral compounds.

Antimicrob Agents Chemother 2010 Jan 19;54(1):78-87. Epub 2009 Oct 19.

University of Würzburg, Institute for Virology and Immunobiology, Versbacher Str. 7, Würzburg 97078, Germany.

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http://dx.doi.org/10.1128/AAC.00775-09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2798503PMC
January 2010

Sexual stage adhesion proteins form multi-protein complexes in the malaria parasite Plasmodium falciparum.

J Biol Chem 2009 May 20;284(21):14537-46. Epub 2009 Mar 20.

Research Center for Infectious Diseases, University of Würzburg, Röntgenring 11, 97070 Würzburg, Germany.

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http://dx.doi.org/10.1074/jbc.M808472200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2682902PMC
May 2009

Effect of protease inhibitors on exflagellation in Plasmodium falciparum.

Mol Biochem Parasitol 2008 Apr 14;158(2):208-12. Epub 2008 Jan 14.

Research Center for Infectious Diseases, University of Würzburg, Röntgenring 11, 97070 Würzburg, Germany.

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http://dx.doi.org/10.1016/j.molbiopara.2007.12.009DOI Listing
April 2008

Telithromycin and quinupristin-dalfopristin induce delayed death in Plasmodium falciparum.

Antimicrob Agents Chemother 2008 Feb 3;52(2):774-7. Epub 2007 Dec 3.

Research Center for Infectious Diseases, University of Würzburg, Röntgenring 11, 97070 Würzburg, Germany.

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http://aac.asm.org/content/52/2/774.full.pdf
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http://aac.asm.org/cgi/doi/10.1128/AAC.00892-07
Publisher Site
http://dx.doi.org/10.1128/AAC.00892-07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2224768PMC
February 2008

Development of peptidomimetics with a vinyl sulfone warhead as irreversible falcipain-2 inhibitors.

J Med Chem 2008 Feb 31;51(4):988-96. Epub 2008 Jan 31.

Dipartimento Farmaco-Chimico, University of Messina, Viale Annunziata, 98168 Messina, Italy.

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http://dx.doi.org/10.1021/jm701141uDOI Listing
February 2008

Potent antimalarial and transmission-blocking activities of centanamycin, a novel DNA-binding agent.

J Infect Dis 2008 Feb;197(4):527-34

Institute of Parasitology and Centre for Host-Parasite Interactions, McGill University, Ste. Anne-de-Bellevue, Quebec, Canada.

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http://dx.doi.org/10.1086/526788DOI Listing
February 2008

Plasmodium falciparum: Co-dependent expression and co-localization of the PfCCp multi-adhesion domain proteins.

Exp Parasitol 2006 Apr 4;112(4):263-8. Epub 2006 Jan 4.

Research Center for Infectious Diseases, University of Würzburg, Röntgenring 11, 97070 Würzburg, Germany.

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http://dx.doi.org/10.1016/j.exppara.2005.11.010DOI Listing
April 2006

A multidomain adhesion protein family expressed in Plasmodium falciparum is essential for transmission to the mosquito.

J Exp Med 2004 Jun;199(11):1533-44

Department of Microbiology and Immunology, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA.

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http://dx.doi.org/10.1084/jem.20031274DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2211786PMC
June 2004

Kupffer and stellate cell proteoglycans mediate malaria sporozoite targeting to the liver.

Comp Hepatol 2004 Jan 14;3 Suppl 1:S47. Epub 2004 Jan 14.

New York University School of Medicine, Department of Medical and Molecular Parasitology, New York, New York 10010, USA.

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http://dx.doi.org/10.1186/1476-5926-2-S1-S47DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2410262PMC
January 2004

Proteoglycans mediate malaria sporozoite targeting to the liver.

Mol Microbiol 2002 Aug;45(3):637-51

Department of Medical and Molecular Parasitology, New York University School of Medicine, New York 10010, USA.

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http://dx.doi.org/10.1046/j.1365-2958.2002.03057.xDOI Listing
August 2002