Gabriele Costantino

Division of Pharmacology, Department of Molecular and Translational Medicine, University of Brescia, Viale Europa 11, 25123 Brescia, Italy; Laboratory for Preventive and Personalized Medicine, Department of Molecular and Translational Medicine, University of Brescia, Viale Europa 11, 25123 Brescia, Italy. Electronic address:

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May 2020

Cycloserine enantiomers are reversible inhibitors of human alanine:glyoxylate aminotransferase: implications for Primary Hyperoxaluria type 1.

Authors:

Mirco Dindo Silvia Grottelli Giannamaria Annunziato Giorgio Giardina Marco Pieroni Gioena Pampalone Andrea Faccini Francesca Cutruzzolà Paola Laurino Gabriele Costantino Barbara Cellini

Biochem J 2019 12;476(24):3751-3768

Department of Experimental Medicine, University of Perugia, Perugia, Italy.

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December 2019

Ultrasound-based real-time neuronavigated fluorescence-guided surgery for high-grade gliomas: technical note and preliminary experience.

Authors:

Alessandro Villa Gabriele Costantino Francesco Meli Antonino Odierna Contino Alessia Imperato Natale Francaviglia

Acta Neurochir (Wien) 2019 12 28;161(12):2595-2605. Epub 2019 Oct 28.

Division of Neurosurgery, ARNAS Civico Hospital, Piazza Nicola Leotta 4, 90127, Palermo, Italy.

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December 2019

The Aryl Hydrocarbon Receptor (AhR) Mediates the Counter-Regulatory Effects of Pelargonidins in Models of Inflammation and Metabolic Dysfunctions.

Authors:

Michele Biagioli Adriana Carino Chiara Fiorucci Giannamaria Annunziato Silvia Marchianò Martina Bordoni Rosalinda Roselli Cristina Di Giorgio Federica Castiglione Patrizia Ricci Agostino Bruno Andrea Faccini Eleonora Distrutti Monia Baldoni Gabriele Costantino Stefano Fiorucci

Nutrients 2019 Aug 7;11(8). Epub 2019 Aug 7.

Dipartimento di Scienze Biomediche e Chirurgiche, Università di Perugia, 06100 Perugia, Italy.

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August 2019

Reconstruction of vertebral body in thoracolumbar AO type A post-traumatic fractures by balloon kyphoplasty. A series of 85 patients with a long follow-up and review of literature.

Authors:

Natale Francaviglia Alessandro Villa Marco Maiello Gabriele Costantino Raffaele F Alessandrello Francesco Meli Antonino Odierna Contino Rita Lipani Vito Fiorenza Benedetto Lo Duca Francesco Ascanio Domenico G Iacopino Rosario Maugeri

J Neurosurg Sci 2019 Apr 23. Epub 2019 Apr 23.

Department of Experimental Biomedicine and Clinical Neurosciences, Neurosurgical Clinic, School of Medicine, University of Palermo, Palermo, Italy.

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April 2019

Scaffold Morphing Approach To Expand the Toolbox of Broad-Spectrum Antivirals Blocking Dengue/Zika Replication.

Authors:

Paolo Vincetti Suzanne J F Kaptein Gabriele Costantino Johan Neyts Marco Radi

ACS Med Chem Lett 2019 Apr 23;10(4):558-563. Epub 2019 Jan 23.

Dipartimento di Scienze degli Alimenti e del Farmaco, Università degli Studi di Parma, Viale delle Scienze, 27/A, 43124 Parma, Italy.

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April 2019

Pharmacophore modeling and virtual screening studies to identify novel selective SIRT2 inhibitors.

Authors:

Gokcen Eren Agostino Bruno Sezen Guntekin-Ergun Rengul Cetin-Atalay Fikriye Ozgencil Yesim Ozkan Mahmut Gozelle Selen Gozde Kaya Gabriele Costantino

J Mol Graph Model 2019 06 5;89:60-73. Epub 2019 Mar 5.

PT4 Group, Dipartimento di Farmacia, Università degli Studi di Parma, Viale delle Scienze, 27/A, 43124, Parma, Italy.

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June 2019

New Hope in Brain Glioma Surgery: The Role of Intraoperative Ultrasound. A Review.

Authors:

Maria Angela Pino Alessia Imperato Irene Musca Rosario Maugeri Giuseppe Roberto Giammalva Gabriele Costantino Francesca Graziano Francesco Meli Natale Francaviglia Domenico Gerardo Iacopino Alessandro Villa

Brain Sci 2018 Nov 19;8(11). Epub 2018 Nov 19.

Division of Neurosurgery, ARNAS Civico Hospital, 90100 Palermo, Italy.

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November 2018

Refining the structure-activity relationships of 2-phenylcyclopropane carboxylic acids as inhibitors of O-acetylserine sulfhydrylase isoforms.

Authors:

Joana Magalhães Nina Franko Giannamaria Annunziato Marco Pieroni Roberto Benoni Anna Nikitjuka Andrea Mozzarelli Stefano Bettati Anna Karawajczyk Aigars Jirgensons Barbara Campanini Gabriele Costantino

J Enzyme Inhib Med Chem 2019 Dec;34(1):31-43

a P4T group, Department of Food and Drug, University of Parma, Parma, Italy.

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December 2019

Discovering a new class of antifungal agents that selectively inhibits microbial carbonic anhydrases.

Authors:

Giannamaria Annunziato Laura Giovati Andrea Angeli Marialaura Pavone Sonia Del Prete Marco Pieroni Clemente Capasso Agostino Bruno Stefania Conti Walter Magliani Claudiu T Supuran Gabriele Costantino

J Enzyme Inhib Med Chem 2018 Dec;33(1):1537-1544

a Department of Food and Drugs , University of Parma , Parma , Italy.

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December 2018

Adjuvant therapies against tuberculosis: discovery of a 2-aminothiazole targeting Mycobacterium tuberculosis energetics.

Authors:

Diana Machado Elisa Azzali Isabel Couto Gabriele Costantino Marco Pieroni Miguel Viveiros

Future Microbiol 2018 09 27;13:1383-1402. Epub 2018 Sep 27.

Global Health & Tropical Medicine, GHTM, Instituto de Higiene e Medicina Tropical, IHMT, Universidade Nova de Lisboa, UNL, Lisboa, Portugal.

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September 2018

Inhibition of O-acetylserine sulfhydrylase by fluoroalanine derivatives.

Authors:

Nina Franko Konstantinos Grammatoglou Barbara Campanini Gabriele Costantino Aigars Jirgensons Andrea Mozzarelli

J Enzyme Inhib Med Chem 2018 Dec;33(1):1343-1351

a Food and Drug Department , University of Parma , Parma , Italy.

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December 2018

Discovery of novel fragments inhibiting O-acetylserine sulphhydrylase by combining scaffold hopping and ligand-based drug design.

Authors:

Joana Magalhães Nina Franko Giannamaria Annunziato Martin Welch Stephen K Dolan Agostino Bruno Andrea Mozzarelli Stefano Armao Aigars Jirgensons Marco Pieroni Gabriele Costantino Barbara Campanini

J Enzyme Inhib Med Chem 2018 Dec;33(1):1444-1452

b Laboratory of Biochemistry and Molecular Biology, Department of Food and Drug , University of Parma , Parma , Italy.

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December 2018

Modulation of bacterial metabolism by the microenvironment controls MAIT cell stimulation.

Authors:

Mathias Schmaler Alessia Colone Julian Spagnuolo Michael Zimmermann Marco Lepore Artem Kalinichenko Sumedha Bhatia Fabien Cottier Tobias Rutishauser Norman Pavelka Adrian Egli Elisa Azzali Marco Pieroni Gabriele Costantino Petr Hruz Uwe Sauer Lucia Mori Gennaro De Libero

Mucosal Immunol 2018 07 9;11(4):1060-1070. Epub 2018 May 9.

Experimental Immunology, Department of Biomedicine, University and University Hospital Basel, 4031, Basel, Switzerland.

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July 2018

Identification of Broad-Spectrum Dengue/Zika Virus Replication Inhibitors by Functionalization of Quinoline and 2,6-Diaminopurine Scaffolds.

Authors:

Suzanne J F Kaptein Paolo Vincetti Emmanuele Crespan Jorge I Armijos Rivera Gabriele Costantino Giovanni Maga Johan Neyts Marco Radi

ChemMedChem 2018 07 1;13(14):1371-1376. Epub 2018 Jun 1.

Dipartimento di Scienze degli Alimenti e del Farmaco, Università degli Studi di Parma, Viale delle Scienze, 27/A, 43124, Parma, Italy.

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July 2018

Integration of Enhanced Sampling Methods with Saturation Transfer Difference Experiments to Identify Protein Druggable Pockets.

Authors:

Joana Magalhães Giannamaria Annunziato Nina Franko Marco Pieroni Barbara Campanini Agostino Bruno Gabriele Costantino

J Chem Inf Model 2018 03 6;58(3):710-723. Epub 2018 Mar 6.

Food and Drug Department , P4T group , Parco Area Delle Scienze 27/A - 43124 , Parma , Italy.

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March 2018

With a Little Help from My Friends: The Role of Intraoperative Fluorescent Dyes in the Surgical Management of High-Grade Gliomas.

Authors:

Rosario Maugeri Alessandro Villa Mariangela Pino Alessia Imperato Giuseppe Roberto Giammalva Gabriele Costantino Francesca Graziano Carlo Gulì Francesco Meli Natale Francaviglia Domenico Gerardo Iacopino

Brain Sci 2018 Feb 7;8(2). Epub 2018 Feb 7.

Department of Experimental Biomedicine and Clinical Neurosciences, School of Medicine, Postgraduate Residency Program in Neurological Surgery, Neurosurgical Clinic, AOUP "Paolo Giaccone", 90100 Palermo, Italy.

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February 2018

Genetic and Pharmacological Dissection of the Role of Spleen Tyrosine Kinase (Syk) in Intestinal Inflammation and Immune Dysfunction in Inflammatory Bowel Diseases.

Authors:

Michele Biagioli Andrea Mencarelli Adriana Carino Sabrina Cipriani Silvia Marchianò Chiara Fiorucci Annibale Donini Luigina Graziosi Franco Baldelli Eleonora Distrutti Gabriele Costantino Stefano Fiorucci

Inflamm Bowel Dis 2017 12;24(1):123-135

Department of Surgical and Biomedical Sciences, University of Perugia, Perugia, Italy.

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December 2017

The In Silico Drug Discovery Toolbox: Applications in Lead Discovery and Optimization.

Authors:

Agostino Bruno Gabriele Costantino Luca Sartori Marco Radi

Curr Med Chem 2019 ;26(21):3838-3873

Dipartimento di Scienze degli Alimenti e del Farmaco, Universita degli Studi di Parma, Viale delle Scienze, 27/A, 43124 Parma, Italy.

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October 2019

Preliminary Experience with a Novel System of Facet Fixation to Treat Patients with Lumbar Degenerative Disease. A New Perspective in Minimally Invasive Spine Surgery?

Authors:

Natale Francaviglia Gabriele Costantino Alessandro Villa Domenico Gerardo Iacopino Maria Pia Pappalardo Fabio Barone Cristina Gallo Antonino Odierna Contino Francesco Meli Rosario Maugeri

J Neurol Surg A Cent Eur Neurosurg 2018 Jul 17;79(4):296-301. Epub 2017 Oct 17.

Department of Neurosurgery, Università degli Studi di Palermo, Palermo, Italy.

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July 2018

Fluorescein for resection of high-grade gliomas: A safety study control in a single center and review of the literature.

Authors:

Natale Francaviglia Domenico Gerardo Iacopino Gabriele Costantino Alessandro Villa Pietro Impallaria Francesco Meli Rosario Maugeri

Surg Neurol Int 2017 11;8:145. Epub 2017 Jul 11.

Department of Experimental Biomedicine and Clinical Neurosciences, School of Medicine, Neurosurgical Clinic, AOUP "Paolo Giaccone", Palermo, Italy.

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July 2017

Substituted N-Phenyl-5-(2-(phenylamino)thiazol-4-yl)isoxazole-3-carboxamides Are Valuable Antitubercular Candidates that Evade Innate Efflux Machinery.

Authors:

Elisa Azzali Diana Machado Amit Kaushik Federica Vacondio Sara Flisi Clotilde Silvia Cabassi Gyanu Lamichhane Miguel Viveiros Gabriele Costantino Marco Pieroni

J Med Chem 2017 08 10;60(16):7108-7122. Epub 2017 Aug 10.

Global Health and Tropical Medicine, GHTM, Instituto de Higiene e Medicina Tropical, IHMT, Universidade Nova de Lisboa, UNL , Rua da Junqueira, 100, 1349-008 Lisbon, Portugal.

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August 2017