Publications by authors named "Gabriela M Baerlocher"

70Publications

Risk stratification using FLT3 and NPM1 in acute myeloid leukemia patients autografted in first complete remission.

Bone Marrow Transplant 2020 May 10. Epub 2020 May 10.

Hematology and Bone Marrow Transplantation Division, Chaim Sheba Medical Center, Tel-Hashomer, Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel.

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http://dx.doi.org/10.1038/s41409-020-0936-zDOI Listing
May 2020

Imatinib dose reduction in major molecular response of chronic myeloid leukemia: results from the German Chronic Myeloid Leukemia-Study IV.

Haematologica 2019 05 4;104(5):955-962. Epub 2018 Dec 4.

Institut für Medizinische Informationsverarbeitung, Biometrie und Epidemiologie, Ludwig-Maximilians-Universität München, Munich, Germany.

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http://dx.doi.org/10.3324/haematol.2018.206797DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6518910PMC
May 2019

Peripheral blood progenitor cell collection in pediatric patients optimized by high pre-apheresis count of circulating CD34+ cells and high blood flow.

Bone Marrow Transplant 2019 06 23;54(6):885-893. Epub 2018 Oct 23.

Division of Pediatric Hematology/Oncology, Department of Pediatrics, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.

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http://www.nature.com/articles/s41409-018-0353-8
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http://dx.doi.org/10.1038/s41409-018-0353-8DOI Listing
June 2019

Consolidation with autologous stem cell transplantation in first remission is safe and effective in AML patients above 65 years.

Leuk Res 2017 02 8;53:28-34. Epub 2016 Dec 8.

Department of Medical Oncology, Inselspital, University Hospital Bern, University of Bern, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.leukres.2016.12.001DOI Listing
February 2017

Autologous stem cell transplantation in elderly patients with multiple myeloma: evaluation of its safety and efficacy.

Leuk Lymphoma 2017 05 13;58(5):1076-1083. Epub 2016 Oct 13.

a Department of Medical Oncology, Inselspital , University Hospital Bern , Bern , Switzerland.

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http://dx.doi.org/10.1080/10428194.2016.1233542DOI Listing
May 2017

Mutations in SNORD118 cause the cerebral microangiopathy leukoencephalopathy with calcifications and cysts.

Nat Genet 2016 10 29;48(10):1185-92. Epub 2016 Aug 29.

Faculty of Biology, Medicine and Health, School of Biological Sciences, Division of Evolution and Genomic Sciences, University of Manchester, Manchester, UK.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5045717PMC
http://dx.doi.org/10.1038/ng.3661DOI Listing
October 2016

A novel, bedside technique to rapidly identify umbilical cord blood units with high total nucleated cell numbers.

Transfusion 2016 06 17;56(6):1406-12. Epub 2016 May 17.

Department of Obstetrics and Gynecology, University Hospital and University of Bern, Bern.

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http://dx.doi.org/10.1111/trf.13610DOI Listing
June 2016

Shorter telomeres correlate with an increase in the number of uniparental disomies in patients with chronic lymphocytic leukemia.

Leuk Lymphoma 2016 12;57(3):590-5. Epub 2015 Oct 12.

c Experimental Haematology, Department of Clinical Research , University Bern , Switzerland , and.

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http://dx.doi.org/10.3109/10428194.2015.1076929DOI Listing
December 2016

Telomerase Inhibitor Imetelstat in Patients with Essential Thrombocythemia.

N Engl J Med 2015 Sep;373(10):920-8

From the Department of Hematology, University Hospital of Bern and University of Bern, Bern, Switzerland (G.M.B., E.O.L., M.D.); the Department of Hematology, School of Medicine, Cardiff University, Cardiff, United Kingdom (O.G.O.); Upstate Oncology Associates, Greenville, SC (G.S.); the Section of Hematology and Oncology, University of Chicago, Chicago (O.O.); the Divisions of Hematologic Malignancies and Hematology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore (M.A.M.); the Department of Hematology, University Hospital Essen, Essen, Germany (A.R.); and Geron, Menlo Park (B.B., M.S.), and the Department of Hematology and Hematopoietic Cell Transplantation, City of Hope, Gehr Family Center for Leukemia Research, Duarte (D.S.S.) - both in California.

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http://dx.doi.org/10.1056/NEJMoa1503479DOI Listing
September 2015

Tyrosine kinase inhibitor-induced CD70 expression mediates drug resistance in leukemia stem cells by activating Wnt signaling.

Sci Transl Med 2015 Jul;7(298):298ra119

Tumor Immunology, Department of Clinical Research, University of Bern, Murtenstrasse 35, 3010 Bern, Switzerland. Department of Medical Oncology, Inselspital, University Hospital and University of Bern, 3010 Bern, Switzerland.

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http://dx.doi.org/10.1126/scitranslmed.aab1740DOI Listing
July 2015

Longitudinal Telomere Erosion in Lymphocyte Subsets of Patients with Atherosclerotic Peripheral Arterial Disease (PAD).

J Clin Diagn Res 2015 Mar 1;9(3):OM01-3. Epub 2015 Mar 1.

Experimental Hematology, Department of Clinical Research, University of Bern, Bern Switzerland; Department of Hematology, University Hospital/Inselspital Bern , Bern, Switzerland .

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http://dx.doi.org/10.7860/JCDR/2015/10931.5684DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4413106PMC
March 2015

CD34+ selected versus unselected autologous stem cell transplantation in patients with advanced-stage mantle cell and diffuse large B-cell lymphoma.

Leuk Res 2015 Jun 19;39(6):561-7. Epub 2015 Mar 19.

Department of Medical Oncology, University Hospital and University of Berne, Berne, Switzerland; Department of Clinical Research, University Hospital and University of Berne, Berne, Switzerland. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01452126150007
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http://dx.doi.org/10.1016/j.leukres.2015.03.004DOI Listing
June 2015

Delayed Haematological recovery after autologous stem cell transplantation is associated with favourable outcome in acute myeloid leukaemia.

Br J Haematol 2015 Jan 12;168(2):268-73. Epub 2014 Sep 12.

Department of Medical Oncology, University Hospital and University of Berne, Berne, Switzerland.

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http://dx.doi.org/10.1111/bjh.13118DOI Listing
January 2015

Deep molecular response is reached by the majority of patients treated with imatinib, predicts survival, and is achieved more quickly by optimized high-dose imatinib: results from the randomized CML-study IV.

J Clin Oncol 2014 Feb 2;32(5):415-23. Epub 2013 Dec 2.

Rüdiger Hehlmann, Martin C. Müller, Benjamin Hanfstein, Alice Fabarius, Annette Schreiber, Ulrike Proetel, Nadine Pletsch, Susanne Saußele, Universitätsmedizin Mannheim Medizinische Fakultät Mannheim der Universität Heidelberg, Mannheim; Jolanta Dengler Universitätsklinikum Heidelberg, Heidelberg; Michael Lauseker, Markus Pfirrmann, Joerg Hasford, Institut für Medizinische Informationsverarbeitung, Biometrie und Epidemiologie (IBE), Ludwig-Maximilians-Universität; Christoph Nerl, Städtisches Klinikum Munchen Schwabing; Hans-Jochem Kolb, Klinikum rechts der Isar, Technische Universität München; Karsten Spiekermann, Universitätsklinikum, Ludwig-Maximilians Universität München; Claudia Haferlach, Susanne Schnittger, MLL Münchner Leukämielabor, Munich; Hermann Einsele, Universitätsklinikum Würzburg, Würzburg; Christiane Falge, Klinikum Nürnberg Nord, Nuremberg; Lothar Kanz, Universitätsklinikum Tübingen, Tübingen; Andreas Neubauer, Universitätsklinikum Gießen und Marburg, Marburg; Michael Kneba, Universitätsklinikum Schleswig-Holstein, Kiel; Frank Stegelmann, Hermann Heimpel, Universitätsklinikum Ulm, Ulm; Michael Pfreundschuh, Universitätsklinikum des Saarlandes, Homburg/Saar; Cornelius F. Waller, Universitätsklinikum Freiburg, Freiburg; Gerhard Ehninger, Universitätsklinikum Carl Gustav Carus, Dresden; Stefan W. Krause, Universitätsklinikum Erlangen, Erlangen; Dieter K. Hossfeld, Universitätsklinikum Eppendorf, Hamburg; Andreas Hochhaus, Universitätsklinikum Jena, Jena, Germany; Gabriela M. Baerlocher, Inselspital Bern, Bern; Dominik Heim, Universitätsspital Basel, Basel, Switzerland.

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http://dx.doi.org/10.1200/JCO.2013.49.9020DOI Listing
February 2014

Rapid and highly specific screening for NPM1 mutations in acute myeloid leukemia.

Ann Hematol 2013 Jan 17;92(2):173-7. Epub 2012 Nov 17.

Laboratory of Molecular Diagnostics, Department of Hematology, University Hospital Bern and University of Bern, Freiburgstrasse 4, Bern, Switzerland.

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http://dx.doi.org/10.1007/s00277-012-1617-9DOI Listing
January 2013

CLLU1 expression distinguishes chronic lymphocytic leukemia from other mature B-cell neoplasms.

Leuk Res 2012 Sep 25;36(9):1204-7. Epub 2012 Jun 25.

Department of Hematology, University Hospital and University of Bern, Bern, Switzerland.

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http://dx.doi.org/10.1016/j.leukres.2012.05.015DOI Listing
September 2012

Collapse of telomere homeostasis in hematopoietic cells caused by heterozygous mutations in telomerase genes.

PLoS Genet 2012 17;8(5):e1002696. Epub 2012 May 17.

Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1371/journal.pgen.1002696DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3355073PMC
September 2012

Telomere length is associated with disease severity and declines with age in dyskeratosis congenita.

Haematologica 2012 Mar 4;97(3):353-9. Epub 2011 Nov 4.

Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Rockville, MD 20852-7231, USA.

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http://dx.doi.org/10.3324/haematol.2011.055269DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3291588PMC
March 2012

Deregulated expression of Kruppel-like factors in acute myeloid leukemia.

Leuk Res 2011 Jul 5;35(7):909-13. Epub 2011 Apr 5.

Department of Clinicial Research, Experimental Oncology and Hematology, University of Bern, and Department of Hematology, Inselspital, Bern University Hospital, Bern, Switzerland.

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http://dx.doi.org/10.1016/j.leukres.2011.03.010DOI Listing
July 2011

[Molecular analyses for (early) recognition of hematologic diseases - sense and sensibility for molecular analysis: the art of intelligent decision-making].

Ther Umsch 2010 Jul;67(7):349-58

Universitätsklinik für Hämatologie und Hämatologisches Zentrallabor, Inselspital Bern.

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http://dx.doi.org/10.1024/0040-5930/a000063DOI Listing
July 2010

Imetelstat (GRN163L)--telomerase-based cancer therapy.

Recent Results Cancer Res 2010 ;184:221-34

Department of Hematology, University Hospital Essen, University of Duisburg-Essen, Hufelandstrasse 55, 45122, Essen, Germany.

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http://dx.doi.org/10.1007/978-3-642-01222-8_16DOI Listing
March 2010

NDRG1/2 expression is inhibited in primary acute myeloid leukemia.

Leuk Res 2010 Mar 22;34(3):393-8. Epub 2009 Sep 22.

Experimental Oncology/Hematology, Bern University Hospital, Bern, Switzerland.

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http://dx.doi.org/10.1016/j.leukres.2009.08.037DOI Listing
March 2010

Significantly shorter telomeres in T-cells of patients with ZAP-70+/CD38+ chronic lymphocytic leukaemia.

Br J Haematol 2008 Nov 28;143(3):383-6. Epub 2008 Aug 28.

Department of Haematology, University Hospital, Essen, Germany.

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http://dx.doi.org/10.1111/j.1365-2141.2008.07363.xDOI Listing
November 2008

Dyskeratosis congenita.

Br J Haematol 2008 May 26;141(4):412. Epub 2008 Mar 26.

Department of Hematology, University Hospital, Essen, Germany.

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http://dx.doi.org/10.1111/j.1365-2141.2008.07052.xDOI Listing
May 2008

TINF2, a component of the shelterin telomere protection complex, is mutated in dyskeratosis congenita.

Am J Hum Genet 2008 Feb 31;82(2):501-9. Epub 2008 Jan 31.

Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.ajhg.2007.10.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2427222PMC
February 2008

Telomere length in paroxysmal nocturnal hemoglobinuria correlates with clone size.

Exp Hematol 2007 Dec 13;35(12):1777-81. Epub 2007 Aug 13.

Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, BC, Canada.

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http://dx.doi.org/10.1016/j.exphem.2007.06.010DOI Listing
December 2007

Flow cytometry and FISH to measure the average length of telomeres (flow FISH).

Nat Protoc 2006 ;1(5):2365-76

Terry Fox Laboratory, British Columbia Cancer Agency, 675 West 10th Avenue, Vancouver, British Columbia, V5Z 1L3, Canada.

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http://www.nature.com/doifinder/10.1038/nprot.2006.263
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http://dx.doi.org/10.1038/nprot.2006.263DOI Listing
October 2007

Longitudinal data on telomere length in leukocytes from newborn baboons support a marked drop in stem cell turnover around 1 year of age.

Aging Cell 2007 Feb 5;6(1):121-3. Epub 2006 Dec 5.

Terry Fox Laboratory, BC Cancer Agency, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1111/j.1474-9726.2006.00254.xDOI Listing
February 2007

Mutations in TERT, the gene for telomerase reverse transcriptase, in aplastic anemia.

N Engl J Med 2005 Apr;352(14):1413-24

Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Md 20892-1202, USA.

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http://www.nejm.org/doi/abs/10.1056/NEJMoa042980
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http://dx.doi.org/10.1056/NEJMoa042980DOI Listing
April 2005

Telomere loss, senescence, and genetic instability in CD4+ T lymphocytes overexpressing hTERT.

Blood 2005 Jul 1;106(1):43-50. Epub 2005 Mar 1.

Terry Fox Laboratory, British Columbia Cancer Agency, 12th floor, 675 W 10th Ave, Vancouver, BC, V5Z 1L3, Canada.

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http://dx.doi.org/10.1182/blood-2004-10-4144DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1895130PMC
July 2005

Telomere length measurements using fluorescence in situ hybridization and flow cytometry.

Methods Cell Biol 2004 ;75:719-50

Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, British Columbia V5Z 1L3, Canada.

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http://dx.doi.org/10.1016/s0091-679x(04)75031-1DOI Listing
March 2005

Functional characterization of telomerase RNA variants found in patients with hematologic disorders.

Blood 2005 Mar 18;105(6):2332-9. Epub 2004 Nov 18.

Department of Pathology and Laboratory Medicine, Emory University, Whitehead Biomedical Research Bldg, 615 Michael St, Rm 175, Atlanta, GA 30322, USA.

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http://dx.doi.org/10.1182/blood-2004-09-3659DOI Listing
March 2005

Telomere length in subpopulations of human hematopoietic cells.

Stem Cells 2003 ;21(6):654-60

Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, BC, Canada.

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http://dx.doi.org/10.1634/stemcells.21-6-654DOI Listing
June 2004

Telomere length measurements in leukocyte subsets by automated multicolor flow-FISH.

Cytometry A 2003 Sep;55(1):1-6

Terry Fox Laboratory, BC Cancer Agency, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1002/cyto.a.10064DOI Listing
September 2003

Telomeres in hematopoietic stem cells.

Ann N Y Acad Sci 2003 May;996:44-8

Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, British Columbia, V5Z 1L3, Canada.

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http://dx.doi.org/10.1111/j.1749-6632.2003.tb03231.xDOI Listing
May 2003

Mutations of the human telomerase RNA gene (TERC) in aplastic anemia and myelodysplastic syndrome.

Blood 2003 Aug 3;102(3):916-8. Epub 2003 Apr 3.

Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, 10 Center Dr, MSC 1652, Bethesda, MD 20892-1652, USA.

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http://dx.doi.org/10.1182/blood-2003-01-0335DOI Listing
August 2003

Telomere shortening in leukocyte subpopulations from baboons.

J Leukoc Biol 2003 Feb;73(2):289-96

Terry Fox Laboratory, British Columbia Cancer Agency, 601 West 10th Avenue, Vancouver, BC, V5Z 1L3 Canada.

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http://dx.doi.org/10.1189/jlb.0702361DOI Listing
February 2003

Telomere shortening in hematopoietic stem cell transplantation: a potential mechanism for late graft failure?

Biol Blood Marrow Transplant 2002 ;8(11):597-600

Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109-1024, USA.

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http://dx.doi.org/10.1053/bbmt.2002.v8.abbmt080597DOI Listing
July 2003

Anti-Xa activity in obese patients after double standard dose of nadroparin for prophylaxis.

Thromb Res 2002 May;106(4-5):179-81

Division of Hematology, Department of Internal Medicine, Kantonsspital, CH-6000 Lucerne 16, Switzerland.

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http://dx.doi.org/10.1016/s0049-3848(02)00188-3DOI Listing
May 2002

Telomere length measurement by fluorescence in situ hybridization and flow cytometry: tips and pitfalls.

Cytometry 2002 Feb;47(2):89-99

Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1002/cyto.10053DOI Listing
February 2002