Publications by authors named "Gabriela Cobos"

19 Publications

  • Page 1 of 1

Characterizing top educational TikTok videos by dermatologists in response to "TikTok and dermatology: An opportunity for public health engagement."

J Am Acad Dermatol 2021 Feb 26. Epub 2021 Feb 26.

Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA. Electronic address:

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaad.2021.02.051DOI Listing
February 2021

Overview of TikTok's most viewed dermatologic content and assessment of its reliability.

J Am Acad Dermatol 2020 Dec 25. Epub 2020 Dec 25.

Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts. Electronic address:

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaad.2020.12.028DOI Listing
December 2020

Clinical Characteristics of Lupus Erythematosus Panniculitis/Profundus: A Retrospective Review of 61 Patients.

JAMA Dermatol 2020 Sep 2. Epub 2020 Sep 2.

The Ronald O. Perelman Department of Dermatology, New York University Langone Medical Center, New York, New York.

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1001/jamadermatol.2020.2797DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7489404PMC
September 2020

Dermatomyositis: An Update on Diagnosis and Treatment.

Am J Clin Dermatol 2020 Jun;21(3):339-353

Autoimmune Skin Disease Program, Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, 221 Longwood Avenue, Boston, MA, 02115, USA.

Dermatomyositis is a rare inflammatory disease with characteristic cutaneous findings and varying amounts of systemic involvement. Patients may present with skin disease alone, have concomitant muscle disease, or have extracutaneous manifestations such as pulmonary disease or an associated malignancy. Given such diverse presentations, dermatomyositis is both a diagnostic and therapeutic challenge. However, a prompt diagnosis is of utmost importance to institute adequate therapy and screen patients for an associated malignancy. Dermatologists should play a crucial role in the diagnosis and management of patients with dermatomyositis as cutaneous disease tends to be chronic, negatively impact quality of life, and be more recalcitrant to therapy. In this review, we discuss diagnosis, with a focus on myositis-specific antibodies and their associated phenotypes. We also review therapies available for this often refractory skin disease.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1007/s40257-020-00502-6DOI Listing
June 2020

Intravenous Immunoglobulin for Refractory Eosinophilic Fasciitis: A Retrospective Analysis from 3 Tertiary Care Centers.

J Am Acad Dermatol 2019 Dec 14. Epub 2019 Dec 14.

The Ronald O. Perelman Department of Dermatology, New York University Langone Medical Center, New York, NY. Electronic address:

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaad.2019.12.022DOI Listing
December 2019

Willingness-to-pay stated preferences in cutaneous lupus erythematosus: a pilot study.

Arch Dermatol Res 2020 Sep 26;312(7):527-531. Epub 2019 Nov 26.

Department of Dermatology, Brigham and Women's Hospital and Harvard Medical School, 221 Longwood Ave, Boston, MA, 02115, USA.

Cutaneous lupus erythematosus (CLE) is a chronic skin disease that significantly impacts quality of life (QOL). This study tested a novel method to measure QOL in CLE using willingness-to-pay (WTP) stated preferences, and aimed to determine which of nine domains of life are most affected by CLE. Twenty-one participants with CLE ranked the domains in order of impact on CLE-related QOL, and then stated how many United States dollars they would be willing to pay for a hypothetical cure for each domain. Eighty-one percent of participants were female; mean age was 42.4 years. Photosensitivity was ranked highest by 71.4% of respondents. Participants were willing to pay the most for a hypothetical cure for CLE specific to photosensitivity (median = $200,000), the least for a cure specific to self-care (median = $0). Participants were willing to pay a median of $1,000,000 for an overall cure for CLE. Limitations include a small sample size for this pilot study and that willingness-to-pay may be influenced by individual perception of money and socioeconomic factors. This study successfully pilot-tested a WTP method and ranking task for health-related QOL. Photosensitivity was the domain of life most affected by CLE, which is a domain unique to our novel tool.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00403-019-02006-8DOI Listing
September 2020

Capecitabine-Related Eruption Mimicking Dermatomyositis in 2 Patients With Metastatic Breast Cancer.

JAMA Dermatol 2020 01;156(1):103-104

Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1001/jamadermatol.2019.3162DOI Listing
January 2020

Genital ulcers in an immunocompromised man.

JAAD Case Rep 2018 Aug 14;4(7):619-621. Epub 2018 Jul 14.

The Ronald O. Perelman Department of Dermatology, New York University School of Medicine, New York, New York.

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jdcr.2017.10.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6070680PMC
August 2018

Local heat urticaria.

Dermatol Online J 2017 Dec 15;23(12). Epub 2017 Dec 15.

New York University Langone Health, New York.

We present a 38-year-old woman with local heat urticaria confirmed by heat provocation testing. Heat urticaria is a rare form of physical urticaria that istriggered by exposure to a heat source, such as hot water or sunlight. Although it is commonly localized and immediate, generalized and delayed onset forms exist. Treatment options include antihistamines and heat desensitization. A brisk, mechanical stroke elicited a linear wheal. Five minutes after exposure to hot water, she developed well-demarcated,erythematous blanching wheals that covered the distal forearm and entire hand.
View Article and Find Full Text PDF

Download full-text PDF

Source
December 2017

Epidermolysis bullosa acquisita.

Dermatol Online J 2017 Dec 15;23(12). Epub 2017 Dec 15.

New York University, New York.

Epidermolysis bullosa acquisita (EBA) is a rare, acquired subepidermal blistering disease. EBA is characterized by autoantibodies to collagen VII,which serves to link the epidermis to the dermis. The two most common presentations of EBA are classical noninflammatory EBA and bullous pemphigoid-like EBA. Diagnosis of EBA can be challenging as it sharesclinical and histopathologic features with other blistering diseases. Treatment is often recalcitrant and will often necessitate multiple therapies. We presenta case of a thirty-six-year-old Chinese man with EBA and review the literature.
View Article and Find Full Text PDF

Download full-text PDF

Source
December 2017

A systematic review and meta-analysis of the effects of topical nitrates in the treatment of primary and secondary Raynaud's phenomenon.

J Am Acad Dermatol 2018 Jun 31;78(6):1110-1118.e3. Epub 2018 Mar 31.

Skin Lupus and Autoimmune Connective Tissue Section, The Ronald O. Perelman Department of Dermatology, New York University School of Medicine, New York, New York; Division of Rheumatology, The Department of Internal Medicine, New York University School of Medicine, New York, New York. Electronic address:

Background: Multiple placebo-controlled trials have assessed locally applied topical nitrate preparations in treating Raynaud's phenomenon (RP).

Objectives: The objective of this meta-analysis was to assess the effects of local topical nitrates in primary and secondary RP with respect to a combined end point integrating parameters of digital blood flow and clinical severity.

Methods: A systematic review was performed using MEDLINE, Embase, and the Cochrane library. Only trials comparing locally applied topical nitrates with placebo comparators were included. Studies were appraised for bias by 2 independent reviewers.

Results: A total of 7 placebo-controlled trials including 346 patients were used in the meta-analysis; 4 trials used nitroglycerin ointments, 2 used the nitroglycerin gel vehicle MQX-503, and 1 used compounded nitrite. The meta-analysis results supported a moderate-to-large treatment effect in RP (standardized mean difference [SMD] = 0.70; 95% CI, 0.35-1.05; P < .0001). Subgroup analyses showed a large treatment effect in secondary RP (SMD = 0.95; 95% CI, 0.25-1.65; P = .008) and moderate effect in primary RP (SMD = 0.45; 95% CI, 0.05-0.85; P = .03).

Limitations: Limitations include the inclusion of multiple topical nitrate preparations and integration of different outcomes assessments.

Conclusion: Local topical nitrates have significant efficacy in the treatment of both primary and secondary RP.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaad.2018.01.043DOI Listing
June 2018

The Frisbee maneuver: A novel method to abort acute attacks of the Raynaud phenomenon.

J Am Acad Dermatol 2018 03 7;78(3):e61. Epub 2017 Oct 7.

Ronald O. Perelman Department of Dermatology, New York University School of Medicine, New York, New York. Electronic address:

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaad.2017.09.066DOI Listing
March 2018

A General Approach to the Evaluation and the Management of Vulvar Disorders.

Obstet Gynecol Clin North Am 2017 Sep;44(3):321-327

Ronald O. Perelman Department of Dermatology, NYU Dermatologic Associates, 240 East 38th Street, 12th Floor, New York, NY 10016, USA. Electronic address:

The evaluation of the vulva should always begin with a detailed clinical history. The clinician should be very familiar with vulvar anatomy and the changes it undergoes depending on the patient's age and hormonal status. A systematic approach should be developed when examining the vulva so as to not leave out any parts. Finally, there is a wide array of ancillary tests and diagnostics procedures that can be pursued to arrive at the correct diagnosis and begin proper management.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ogc.2017.04.001DOI Listing
September 2017

Lichen planus pigmentosus and lichen planopilaris.

Dermatol Online J 2016 Dec 15;22(12). Epub 2016 Dec 15.

Ronald O. Perelman Department of Dermatology, NYU School of Medicine, NYU Langone Medical Center.

Lichen planus is an inflammatory skin conditionwith characteristic histopathological findings thathas many clinical variants. Recently, there have been25 cases reported in the literature of lichen planuspigmentosus (LPPi) that preceded the developmentof frontal fibrosing alopecia (FFA), which is a variantof lichen planopilaris (LPP). We review the literatureregarding LPPi, LPP, and FFA and present a case of a40-year-old African American woman with LPPi andLPP.
View Article and Find Full Text PDF

Download full-text PDF

Source
December 2016

The Africa Teledermatology Project: A retrospective case review of 1229 consultations from sub-Saharan Africa.

J Am Acad Dermatol 2015 Jun;72(6):1084-5

Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address:

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaad.2015.02.1119DOI Listing
June 2015

Mucinous nevus: report of a case and review of the literature.

JAMA Dermatol 2014 Sep;150(9):1018-9

Department of Dermatology, Hospital of the University of Pennsylvania, Philadelphia.

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1001/jamadermatol.2013.9451DOI Listing
September 2014

A case of exuberant candidal onychomycosis in a child with hyper IgE syndrome.

J Allergy Clin Immunol Pract 2014 Jan-Feb;2(1):99-100

Section of Dermatology, Division of General Pediatrics, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, Pa. Electronic address:

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaip.2013.10.004DOI Listing
April 2014

A case of phrynoderma in a patient with Crohn's disease.

Pediatr Dermatol 2015 Mar-Apr;32(2):234-6. Epub 2013 Nov 26.

Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.

Phrynoderma is a type of follicular hyperkeratosis associated with nutritional deficiencies. It is rarely seen in developed countries, although cases have been reported in patients with severe malnutrition or malabsorption secondary to various causes. This report describes a 19-year-old patient with poorly controlled Crohn's disease and malnutrition who developed the characteristic hyperkeratotic papules and plaques on his trunk and extremities in the setting of low serum vitamin A levels. To our knowledge, there are no reports of phrynoderma associated with Crohn's disease. It is likely that our patient's low vitamin A level and subsequent phrynoderma was the result of increased Crohn's disease activity and malnutrition.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1111/pde.12265DOI Listing
December 2015