Gabriel Nunez

Gabriel Nunez

UNVERIFIED PROFILE

Are you Gabriel Nunez?   Register this Author

Register author
Gabriel Nunez

Gabriel Nunez

Publications by authors named "Gabriel Nunez"

Are you Gabriel Nunez?   Register this Author

99Publications

3837Reads

9Profile Views

Microbial Metabolite Signaling Is Required for Systemic Iron Homeostasis.

Cell Metab 2020 Jan 7;31(1):115-130.e6. Epub 2019 Nov 7.

Department of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA; Department of Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cmet.2019.10.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6949377PMC
January 2020

Recognition of the microbiota by Nod2 contributes to the oral adjuvant activity of cholera toxin through the induction of interleukin-1β.

Immunology 2019 11 2;158(3):219-229. Epub 2019 Sep 2.

Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, South Korea.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/imm.13105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6797898PMC
November 2019

Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition).

Authors:
Andrea Cossarizza Hyun-Dong Chang Andreas Radbruch Andreas Acs Dieter Adam Sabine Adam-Klages William W Agace Nima Aghaeepour Mübeccel Akdis Matthieu Allez Larissa Nogueira Almeida Giorgia Alvisi Graham Anderson Immanuel Andrä Francesco Annunziato Achille Anselmo Petra Bacher Cosima T Baldari Sudipto Bari Vincenzo Barnaba Joana Barros-Martins Luca Battistini Wolfgang Bauer Sabine Baumgart Nicole Baumgarth Dirk Baumjohann Bianka Baying Mary Bebawy Burkhard Becher Wolfgang Beisker Vladimir Benes Rudi Beyaert Alfonso Blanco Dominic A Boardman Christian Bogdan Jessica G Borger Giovanna Borsellino Philip E Boulais Jolene A Bradford Dirk Brenner Ryan R Brinkman Anna E S Brooks Dirk H Busch Martin Büscher Timothy P Bushnell Federica Calzetti Garth Cameron Ilenia Cammarata Xuetao Cao Susanna L Cardell Stefano Casola Marco A Cassatella Andrea Cavani Antonio Celada Lucienne Chatenoud Pratip K Chattopadhyay Sue Chow Eleni Christakou Luka Čičin-Šain Mario Clerici Federico S Colombo Laura Cook Anne Cooke Andrea M Cooper Alexandra J Corbett Antonio Cosma Lorenzo Cosmi Pierre G Coulie Ana Cumano Ljiljana Cvetkovic Van Duc Dang Chantip Dang-Heine Martin S Davey Derek Davies Sara De Biasi Genny Del Zotto Gelo Victoriano Dela Cruz Michael Delacher Silvia Della Bella Paolo Dellabona Günnur Deniz Mark Dessing James P Di Santo Andreas Diefenbach Francesco Dieli Andreas Dolf Thomas Dörner Regine J Dress Diana Dudziak Michael Dustin Charles-Antoine Dutertre Friederike Ebner Sidonia B G Eckle Matthias Edinger Pascale Eede Götz R A Ehrhardt Marcus Eich Pablo Engel Britta Engelhardt Anna Erdei Charlotte Esser Bart Everts Maximilien Evrard Christine S Falk Todd A Fehniger Mar Felipo-Benavent Helen Ferry Markus Feuerer Andrew Filby Kata Filkor Simon Fillatreau Marie Follo Irmgard Förster John Foster Gemma A Foulds Britta Frehse Paul S Frenette Stefan Frischbutter Wolfgang Fritzsche David W Galbraith Anastasia Gangaev Natalio Garbi Brice Gaudilliere Ricardo T Gazzinelli Jens Geginat Wilhelm Gerner Nicholas A Gherardin Kamran Ghoreschi Lara Gibellini Florent Ginhoux Keisuke Goda Dale I Godfrey Christoph Goettlinger Jose M González-Navajas Carl S Goodyear Andrea Gori Jane L Grogan Daryl Grummitt Andreas Grützkau Claudia Haftmann Jonas Hahn Hamida Hammad Günter Hämmerling Leo Hansmann Goran Hansson Christopher M Harpur Susanne Hartmann Andrea Hauser Anja E Hauser David L Haviland David Hedley Daniela C Hernández Guadalupe Herrera Martin Herrmann Christoph Hess Thomas Höfer Petra Hoffmann Kristin Hogquist Tristan Holland Thomas Höllt Rikard Holmdahl Pleun Hombrink Jessica P Houston Bimba F Hoyer Bo Huang Fang-Ping Huang Johanna E Huber Jochen Huehn Michael Hundemer Christopher A Hunter William Y K Hwang Anna Iannone Florian Ingelfinger Sabine M Ivison Hans-Martin Jäck Peter K Jani Beatriz Jávega Stipan Jonjic Toralf Kaiser Tomas Kalina Thomas Kamradt Stefan H E Kaufmann Baerbel Keller Steven L C Ketelaars Ahad Khalilnezhad Srijit Khan Jan Kisielow Paul Klenerman Jasmin Knopf Hui-Fern Koay Katja Kobow Jay K Kolls Wan Ting Kong Manfred Kopf Thomas Korn Katharina Kriegsmann Hendy Kristyanto Thomas Kroneis Andreas Krueger Jenny Kühne Christian Kukat Désirée Kunkel Heike Kunze-Schumacher Tomohiro Kurosaki Christian Kurts Pia Kvistborg Immanuel Kwok Jonathan Landry Olivier Lantz Paola Lanuti Francesca LaRosa Agnès Lehuen Salomé LeibundGut-Landmann Michael D Leipold Leslie Y T Leung Megan K Levings Andreia C Lino Francesco Liotta Virginia Litwin Yanling Liu Hans-Gustaf Ljunggren Michael Lohoff Giovanna Lombardi Lilly Lopez Miguel López-Botet Amy E Lovett-Racke Erik Lubberts Herve Luche Burkhard Ludewig Enrico Lugli Sebastian Lunemann Holden T Maecker Laura Maggi Orla Maguire Florian Mair Kerstin H Mair Alberto Mantovani Rudolf A Manz Aaron J Marshall Alicia Martínez-Romero Glòria Martrus Ivana Marventano Wlodzimierz Maslinski Giuseppe Matarese Anna Vittoria Mattioli Christian Maueröder Alessio Mazzoni James McCluskey Mairi McGrath Helen M McGuire Iain B McInnes Henrik E Mei Fritz Melchers Susanne Melzer Dirk Mielenz Stephen D Miller Kingston H G Mills Hans Minderman Jenny Mjösberg Jonni Moore Barry Moran Lorenzo Moretta Tim R Mosmann Susann Müller Gabriele Multhoff Luis Enrique Muñoz Christian Münz Toshinori Nakayama Milena Nasi Katrin Neumann Lai Guan Ng Antonia Niedobitek Sussan Nourshargh Gabriel Núñez José-Enrique O'Connor Aaron Ochel Anna Oja Diana Ordonez Alberto Orfao Eva Orlowski-Oliver Wenjun Ouyang Annette Oxenius Raghavendra Palankar Isabel Panse Kovit Pattanapanyasat Malte Paulsen Dinko Pavlinic Livius Penter Pärt Peterson Christian Peth Jordi Petriz Federica Piancone Winfried F Pickl Silvia Piconese Marcello Pinti A Graham Pockley Malgorzata Justyna Podolska Zhiyong Poon Katharina Pracht Immo Prinz Carlo E M Pucillo Sally A Quataert Linda Quatrini Kylie M Quinn Helena Radbruch Tim R D J Radstake Susann Rahmig Hans-Peter Rahn Bartek Rajwa Gevitha Ravichandran Yotam Raz Jonathan A Rebhahn Diether Recktenwald Dorothea Reimer Caetano Reis E Sousa Ester B M Remmerswaal Lisa Richter Laura G Rico Andy Riddell Aja M Rieger J Paul Robinson Chiara Romagnani Anna Rubartelli Jürgen Ruland Armin Saalmüller Yvan Saeys Takashi Saito Shimon Sakaguchi Francisco Sala-de-Oyanguren Yvonne Samstag Sharon Sanderson Inga Sandrock Angela Santoni Ramon Bellmàs Sanz Marina Saresella Catherine Sautes-Fridman Birgit Sawitzki Linda Schadt Alexander Scheffold Hans U Scherer Matthias Schiemann Frank A Schildberg Esther Schimisky Andreas Schlitzer Josephine Schlosser Stephan Schmid Steffen Schmitt Kilian Schober Daniel Schraivogel Wolfgang Schuh Thomas Schüler Reiner Schulte Axel Ronald Schulz Sebastian R Schulz Cristiano Scottá Daniel Scott-Algara David P Sester T Vincent Shankey Bruno Silva-Santos Anna Katharina Simon Katarzyna M Sitnik Silvano Sozzani Daniel E Speiser Josef Spidlen Anders Stahlberg Alan M Stall Natalie Stanley Regina Stark Christina Stehle Tobit Steinmetz Hannes Stockinger Yousuke Takahama Kiyoshi Takeda Leonard Tan Attila Tárnok Gisa Tiegs Gergely Toldi Julia Tornack Elisabetta Traggiai Mohamed Trebak Timothy I M Tree Joe Trotter John Trowsdale Maria Tsoumakidou Henning Ulrich Sophia Urbanczyk Willem van de Veen Maries van den Broek Edwin van der Pol Sofie Van Gassen Gert Van Isterdael René A W van Lier Marc Veldhoen Salvador Vento-Asturias Paulo Vieira David Voehringer Hans-Dieter Volk Anouk von Borstel Konrad von Volkmann Ari Waisman Rachael V Walker Paul K Wallace Sa A Wang Xin M Wang Michael D Ward Kirsten A Ward-Hartstonge Klaus Warnatz Gary Warnes Sarah Warth Claudia Waskow James V Watson Carsten Watzl Leonie Wegener Thomas Weisenburger Annika Wiedemann Jürgen Wienands Anneke Wilharm Robert John Wilkinson Gerald Willimsky James B Wing Rieke Winkelmann Thomas H Winkler Oliver F Wirz Alicia Wong Peter Wurst Jennie H M Yang Juhao Yang Maria Yazdanbakhsh Liping Yu Alice Yue Hanlin Zhang Yi Zhao Susanne Maria Ziegler Christina Zielinski Jakob Zimmermann Arturo Zychlinsky

Eur J Immunol 2019 Oct;49(10):1457-1973

Max Planck Institute for Infection Biology, Berlin, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/eji.201970107DOI Listing
October 2019

Loss of NLRP6 expression increases the severity of acute kidney injury.

Nephrol Dial Transplant 2019 Aug 29. Epub 2019 Aug 29.

Nephrology and Hypertension Laboratory, IIS-Fundacion Jimenez Diaz-Universidad Autonoma de Madrid and Fundacion Renal Iñigo Alvarez de Toledo-IRSIN, Madrid, Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/ndt/gfz169DOI Listing
August 2019

Pathogen Colonization Resistance in the Gut and Its Manipulation for Improved Health.

Am J Pathol 2019 Jul 14;189(7):1300-1310. Epub 2019 May 14.

Department of Pathology and the Rogel Cancer Center, University of Michigan Medical School, Ann Arbor, Michigan. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ajpath.2019.03.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6617533PMC
July 2019

Dynamic and Asymmetric Changes of the Microbial Communities after Cohousing in Laboratory Mice.

Cell Rep 2019 Jun;27(11):3401-3412.e3

Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.celrep.2019.05.042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6690056PMC
June 2019

Structural mechanism for NEK7-licensed activation of NLRP3 inflammasome.

Nature 2019 06 12;570(7761):338-343. Epub 2019 Jun 12.

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41586-019-1295-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6774351PMC
June 2019

Neutrophils Restrict Tumor-Associated Microbiota to Reduce Growth and Invasion of Colon Tumors in Mice.

Gastroenterology 2019 Apr 11;156(5):1467-1482. Epub 2018 Dec 11.

Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan; Rogel Cancer Center, University of Michigan Medical School, Ann Arbor, Michigan; Internal Medicine Division of Gastroenterology, University of Michigan Medical School, Ann Arbor, Michigan. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1053/j.gastro.2018.12.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441634PMC
April 2019

Maternal Immunization Confers Protection to the Offspring against an Attaching and Effacing Pathogen through Delivery of IgG in Breast Milk.

Cell Host Microbe 2019 02 24;25(2):313-323.e4. Epub 2019 Jan 24.

Department of Pathology and Rogel Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.chom.2018.12.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375740PMC
February 2019

Myc-Associated Zinc Finger Protein Regulates the Proinflammatory Response in Colitis and Colon Cancer via STAT3 Signaling.

Mol Cell Biol 2018 11 29;38(22). Epub 2018 Oct 29.

Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan, USA

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/MCB.00386-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6206459PMC
November 2018

The NLRP6 Inflammasome Recognizes Lipoteichoic Acid and Regulates Gram-Positive Pathogen Infection.

Cell 2018 11 1;175(6):1651-1664.e14. Epub 2018 Nov 1.

Department of Pathology and Rogel Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00928674183125
Publisher Site
http://dx.doi.org/10.1016/j.cell.2018.09.047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294477PMC
November 2018

Involvement of aquaporin NIP1;1 in the contrasting tolerance response to root hypoxia in Prunus rootstocks.

J Plant Physiol 2018 Sep 12;228:19-28. Epub 2018 May 12.

Centro de Estudios Avanzados en Fruticultura (CEAF), Camino Las Parcelas 882, km 105 Ruta 5 Sur, Sector Los Choapinos, Rengo, 2940000 Chile. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jplph.2018.05.001DOI Listing
September 2018

Application of an agr-Specific Antivirulence Compound as Therapy for Staphylococcus aureus-Induced Inflammatory Skin Disease.

J Infect Dis 2018 08;218(6):1009-1013

Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Frederiksberg, Denmark.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/infdis/jiy259DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6093339PMC
August 2018

Innate Nutritional Immunity.

J Immunol 2018 07;201(1):11-18

Instituto Gulbenkian de Ciência, 2780-156 Oeiras, Portugal.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4049/jimmunol.1800325DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6028930PMC
July 2018

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

Authors:
Lorenzo Galluzzi Ilio Vitale Stuart A Aaronson John M Abrams Dieter Adam Patrizia Agostinis Emad S Alnemri Lucia Altucci Ivano Amelio David W Andrews Margherita Annicchiarico-Petruzzelli Alexey V Antonov Eli Arama Eric H Baehrecke Nickolai A Barlev Nicolas G Bazan Francesca Bernassola Mathieu J M Bertrand Katiuscia Bianchi Mikhail V Blagosklonny Klas Blomgren Christoph Borner Patricia Boya Catherine Brenner Michelangelo Campanella Eleonora Candi Didac Carmona-Gutierrez Francesco Cecconi Francis K-M Chan Navdeep S Chandel Emily H Cheng Jerry E Chipuk John A Cidlowski Aaron Ciechanover Gerald M Cohen Marcus Conrad Juan R Cubillos-Ruiz Peter E Czabotar Vincenzo D'Angiolella Ted M Dawson Valina L Dawson Vincenzo De Laurenzi Ruggero De Maria Klaus-Michael Debatin Ralph J DeBerardinis Mohanish Deshmukh Nicola Di Daniele Francesco Di Virgilio Vishva M Dixit Scott J Dixon Colin S Duckett Brian D Dynlacht Wafik S El-Deiry John W Elrod Gian Maria Fimia Simone Fulda Ana J García-Sáez Abhishek D Garg Carmen Garrido Evripidis Gavathiotis Pierre Golstein Eyal Gottlieb Douglas R Green Lloyd A Greene Hinrich Gronemeyer Atan Gross Gyorgy Hajnoczky J Marie Hardwick Isaac S Harris Michael O Hengartner Claudio Hetz Hidenori Ichijo Marja Jäättelä Bertrand Joseph Philipp J Jost Philippe P Juin William J Kaiser Michael Karin Thomas Kaufmann Oliver Kepp Adi Kimchi Richard N Kitsis Daniel J Klionsky Richard A Knight Sharad Kumar Sam W Lee John J Lemasters Beth Levine Andreas Linkermann Stuart A Lipton Richard A Lockshin Carlos López-Otín Scott W Lowe Tom Luedde Enrico Lugli Marion MacFarlane Frank Madeo Michal Malewicz Walter Malorni Gwenola Manic Jean-Christophe Marine Seamus J Martin Jean-Claude Martinou Jan Paul Medema Patrick Mehlen Pascal Meier Sonia Melino Edward A Miao Jeffery D Molkentin Ute M Moll Cristina Muñoz-Pinedo Shigekazu Nagata Gabriel Nuñez Andrew Oberst Moshe Oren Michael Overholtzer Michele Pagano Theocharis Panaretakis Manolis Pasparakis Josef M Penninger David M Pereira Shazib Pervaiz Marcus E Peter Mauro Piacentini Paolo Pinton Jochen H M Prehn Hamsa Puthalakath Gabriel A Rabinovich Markus Rehm Rosario Rizzuto Cecilia M P Rodrigues David C Rubinsztein Thomas Rudel Kevin M Ryan Emre Sayan Luca Scorrano Feng Shao Yufang Shi John Silke Hans-Uwe Simon Antonella Sistigu Brent R Stockwell Andreas Strasser Gyorgy Szabadkai Stephen W G Tait Daolin Tang Nektarios Tavernarakis Andrew Thorburn Yoshihide Tsujimoto Boris Turk Tom Vanden Berghe Peter Vandenabeele Matthew G Vander Heiden Andreas Villunger Herbert W Virgin Karen H Vousden Domagoj Vucic Erwin F Wagner Henning Walczak David Wallach Ying Wang James A Wells Will Wood Junying Yuan Zahra Zakeri Boris Zhivotovsky Laurence Zitvogel Gerry Melino Guido Kroemer

Cell Death Differ 2018 03 23;25(3):486-541. Epub 2018 Jan 23.

Paris Descartes/Paris V University, Paris, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41418-017-0012-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5864239PMC
March 2018

Selective Biological Responses of Phagocytes and Lungs to Purified Histones.

J Innate Immun 2017 8;9(3):300-317. Epub 2017 Feb 8.

University of Michigan Medical School, Department of Pathology, Ann Arbor, MI, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000452951DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5413366PMC
February 2018

Role of the microbiota in skin immunity and atopic dermatitis.

Allergol Int 2017 Oct 4;66(4):539-544. Epub 2017 Sep 4.

Department of Pathology and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.alit.2017.08.004DOI Listing
October 2017

Gut microbiota: Role in pathogen colonization, immune responses, and inflammatory disease.

Immunol Rev 2017 Sep;279(1):70-89

Department of Pathology and Comprehensive Cancer Center, The University of Michigan Medical School, Ann Arbor, MI, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/imr.12567DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5657496PMC
September 2017

A bioluminescent caspase-1 activity assay rapidly monitors inflammasome activation in cells.

J Immunol Methods 2017 08 6;447:1-13. Epub 2017 Mar 6.

Promega Corporation, 2800 Woods Hollow Rd, Madison, WI 53711, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jim.2017.03.004DOI Listing
August 2017

Mesenchymal Cell-Specific MyD88 Signaling Promotes Systemic Dissemination of via Inflammatory Monocytes.

J Immunol 2017 08 3;199(4):1362-1371. Epub 2017 Jul 3.

Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4049/jimmunol.1601527DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5548622PMC
August 2017

Linking Pathogen Virulence, Host Immunity and The Microbiota at the Intestinal Barrier.

Authors:
Gabriel Nunez

Keio J Med 2017 ;66(1):14

Department of Pathology and Comprehensive Cancer Center, University of Michigan, Michigan, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2302/kjm.66-001-ABSTDOI Listing
July 2017

The interplay between host immune cells and gut microbiota in chronic inflammatory diseases.

Exp Mol Med 2017 05 26;49(5):e339. Epub 2017 May 26.

Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/emm.2017.24DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5454439PMC
May 2017

IL-22 Controls Iron-Dependent Nutritional Immunity Against Systemic Bacterial Infections.

Sci Immunol 2017 Feb 3;2(8). Epub 2017 Feb 3.

Department of Pathology and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1126/sciimmunol.aai8371DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5345941PMC
February 2017

Identification and functional characterization of EseH, a new effector of the type III secretion system of Edwardsiella piscicida.

Cell Microbiol 2017 01 26;19(1). Epub 2016 Jul 26.

State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, 200237, China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cmi.12638DOI Listing
January 2017

Induction of Pulmonary Granuloma Formation by Propionibacterium acnes Is Regulated by MyD88 and Nox2.

Am J Respir Cell Mol Biol 2017 01;56(1):121-130

1 Department of Pathology and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, Michigan; and.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1165/rcmb.2016-0035OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5248957PMC
January 2017

Mechanism and Regulation of NLRP3 Inflammasome Activation.

Trends Biochem Sci 2016 12 23;41(12):1012-1021. Epub 2016 Sep 23.

Department of Pathology and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.tibs.2016.09.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5123939PMC
December 2016

Élie Metchnikoff (1845-1916): celebrating 100 years of cellular immunology and beyond.

Nat Rev Immunol 2016 10 1;16(10):651-6. Epub 2016 Aug 1.

Institut Pasteur, Dynamics of Immune Responses Unit, 75015 Paris, France, and INSERM U1223, Rue du Dr Roux, 75015 Paris, France.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nri.2016.89DOI Listing
October 2016

TLR4: The Winding Road to the Discovery of the LPS Receptor.

J Immunol 2016 10;197(7):2561-2

Department of Pathology and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4049/jimmunol.1601400DOI Listing
October 2016

Innate Immunity: ER Stress Recruits NOD1 and NOD2 for Delivery of Inflammation.

Curr Biol 2016 06;26(12):R508-R511

Department of Pathology and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cub.2016.05.021DOI Listing
June 2016

Role of nucleotide-binding oligomerization domain 1 (NOD1) in pericyte-mediated vascular inflammation.

J Cell Mol Med 2016 May 24;20(5):980-6. Epub 2016 Feb 24.

Molecular Immunology Unit, Hospital Universitario Puerta de Hierro Majadahonda, Majadahonda, Madrid, Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jcmm.12804DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4831361PMC
May 2016

Gut Microbiota-Induced Immunoglobulin G Controls Systemic Infection by Symbiotic Bacteria and Pathogens.

Immunity 2016 Mar 2;44(3):647-658. Epub 2016 Mar 2.

Department of Pathology and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.immuni.2016.02.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4794373PMC
March 2016

Spontaneous atopic dermatitis is mediated by innate immunity, with the secondary lung inflammation of the atopic march requiring adaptive immunity.

J Allergy Clin Immunol 2016 Feb 20;137(2):482-91. Epub 2015 Aug 20.

Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland; National Children's Research Centre, Our Lady's Children's Hospital, Dublin, Ireland; Institute of Molecular Medicine, St James's Hospital, Dublin, Ireland. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaci.2015.06.045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4735016PMC
February 2016

NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux.

Nature 2016 Feb 27;530(7590):354-7. Epub 2016 Jan 27.

Department of Pathology and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nature16959DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4810788PMC
February 2016

Redundant and cooperative interactions between TLR5 and NLRC4 in protective lung mucosal immunity against Pseudomonas aeruginosa.

J Innate Immun 2015 12;7(2):177-86. Epub 2014 Nov 12.

Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Michigan Medical Center, Ann Arbor, Mich., USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000367790DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4348217PMC
December 2015

Functional characteristics of the Staphylococcus aureus δ-toxin allelic variant G10S.

Sci Rep 2015 Dec 10;5:18023. Epub 2015 Dec 10.

Pathogen Molecular Genetics Section, Laboratory of Bacteriology, National Institute of Allergy and Infectious Diseases, The National Institutes of Health, Bethesda, MD 20892, United States of America.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/srep18023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4674873PMC
December 2015

Caspase-11 Requires the Pannexin-1 Channel and the Purinergic P2X7 Pore to Mediate Pyroptosis and Endotoxic Shock.

Immunity 2015 Nov 10;43(5):923-32. Epub 2015 Nov 10.

Department of Pathology and Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.immuni.2015.10.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4795157PMC
November 2015

Th17 Cell Induction by Adhesion of Microbes to Intestinal Epithelial Cells.

Cell 2015 Oct 24;163(2):367-80. Epub 2015 Sep 24.

RIKEN Center for Integrative Medical Sciences (IMS), 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan; Department of Microbiology and Immunology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan; CREST, JST, 4-1-8 Honcho Kawaguchi, Saitama 332-0012, Japan. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cell.2015.08.058DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4765954PMC
October 2015

Endoplasmic Reticulum Stress Activates the Inflammasome via NLRP3- and Caspase-2-Driven Mitochondrial Damage.

Immunity 2015 Sep 1;43(3):451-62. Epub 2015 Sep 1.

Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109 USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.immuni.2015.08.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4582788PMC
September 2015

Intestinal macrophages arising from CCR2(+) monocytes control pathogen infection by activating innate lymphoid cells.

Nat Commun 2015 Aug 13;6:8010. Epub 2015 Aug 13.

Division of Gastroenterology, Department of Internal Medicine, University of Michigan Medical School, 1150 W Medical Center Dr, Ann Arbor, Michigan 48109, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ncomms9010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4536571PMC
August 2015

Iron Toxicity in the Retina Requires Alu RNA and the NLRP3 Inflammasome.

Cell Rep 2015 Jun 11;11(11):1686-93. Epub 2015 Jun 11.

Department of Ophthalmology and Visual Sciences, University of Kentucky, Lexington, KY 40536, USA; Department of Physiology, University of Kentucky, Lexington, KY 40536, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.celrep.2015.05.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4481133PMC
June 2015

Humoral Immunity in the Gut Selectively Targets Phenotypically Virulent Attaching-and-Effacing Bacteria for Intraluminal Elimination.

Cell Host Microbe 2015 May 30;17(5):617-27. Epub 2015 Apr 30.

Department of Pathology and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S19313128150015
Publisher Site
http://dx.doi.org/10.1016/j.chom.2015.04.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4433422PMC
May 2015

RNase L activates the NLRP3 inflammasome during viral infections.

Cell Host Microbe 2015 Apr 26;17(4):466-77. Epub 2015 Mar 26.

Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.chom.2015.02.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4393362PMC
April 2015

NOD1 and NOD2: signaling, host defense, and inflammatory disease.

Immunity 2014 Dec 6;41(6):898-908. Epub 2014 Dec 6.

Department of Pathology and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.immuni.2014.12.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4272446PMC
December 2014

Alcohol-induced liver injury is modulated by Nlrp3 and Nlrc4 inflammasomes in mice.

Mediators Inflamm 2013 16;2013:751374. Epub 2013 Dec 16.

Departments of Nutrition, Case Western Reserve University School of Medicine, 10900 Euclid Avenue, Cleveland, OH 44106, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2013/751374DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3876912PMC
October 2014

A genome-wide small interfering RNA (siRNA) screen reveals nuclear factor-κB (NF-κB)-independent regulators of NOD2-induced interleukin-8 (IL-8) secretion.

J Biol Chem 2014 Oct 28;289(41):28213-24. Epub 2014 Aug 28.

From the Department of Pathology and the Comprehensive Cancer Center, University of Michigan, Ann Arbor, Michigan 48109 and

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M114.574756DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4192477PMC
October 2014

A comparative study of the effect of α-, β-, and γ-cyclodextrins as stabilizing agents in the synthesis of silver nanoparticles using a green chemistry method.

Mater Sci Eng C Mater Biol Appl 2014 Oct 10;43:21-6. Epub 2014 Jul 10.

Centro de Graduados e Investigación, Instituto Tecnológico de Tijuana, Apartado Postal 1166, Tijuana, B. C., Mexico. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.msec.2014.07.006DOI Listing
October 2014

Cytosolic double-stranded RNA activates the NLRP3 inflammasome via MAVS-induced membrane permeabilization and K+ efflux.

J Immunol 2014 Oct 15;193(8):4214-4222. Epub 2014 Sep 15.

Department of Pathology and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4049/jimmunol.1400582DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4185247PMC
October 2014

Shigella IpaH7.8 E3 ubiquitin ligase targets glomulin and activates inflammasomes to demolish macrophages.

Proc Natl Acad Sci U S A 2014 Oct 22;111(40):E4254-63. Epub 2014 Sep 22.

Department of Microbiology and Immunology, Division of Bacterial Infection Biology, and Nippon Institute for Biological Science, Tokyo 198-0024, Japan; and Medical Mycology Research Center, Chiba University, Chiba 260-8673, Japan

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1324021111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4210038PMC
October 2014

In vivo mapping of a protective linear neutralizing epitope at the N-terminus of alpha hemolysin from Staphylococcus aureus.

Mol Immunol 2014 Jul 24;60(1):62-71. Epub 2014 Apr 24.

Division of Hematology-Oncology, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48105, USA; VA Ann Arbor Healthcare System, 2215 Fuller Road, Ann Arbor, MI 48105, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.molimm.2014.03.012DOI Listing
July 2014

Infection mobilizes hematopoietic stem cells through cooperative NOD-like receptor and Toll-like receptor signaling.

Cell Host Microbe 2014 Jun 29;15(6):779-91. Epub 2014 May 29.

Department of Pathology and Comprehensive Cancer Center, University of Michigan, 1500 E. Medical Center Drive, Ann Arbor, MI 48109, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.chom.2014.05.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4085166PMC
June 2014

Regulation of the immune system by the resident intestinal bacteria.

Gastroenterology 2014 May 4;146(6):1477-88. Epub 2014 Feb 4.

Department of Pathology and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, Michigan. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1053/j.gastro.2014.01.060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3995843PMC
May 2014

Shigella type III secretion protein MxiI is recognized by Naip2 to induce Nlrc4 inflammasome activation independently of Pkcδ.

PLoS Pathog 2014 Feb 6;10(2):e1003926. Epub 2014 Feb 6.

Department of Pathology and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, Michigan, United States of America.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1371/journal.ppat.1003926DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3916413PMC
February 2014

3,4-methylenedioxy-β-nitrostyrene inhibits NLRP3 inflammasome activation by blocking assembly of the inflammasome.

J Biol Chem 2014 Jan 21;289(2):1142-50. Epub 2013 Nov 21.

From the Department of Pathology and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, Michigan 48109.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M113.515080DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3887181PMC
January 2014

Gut dysbiosis promotes M2 macrophage polarization and allergic airway inflammation via fungi-induced PGE₂.

Cell Host Microbe 2014 Jan;15(1):95-102

Department of Immunology, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan; Japan Science and Technology Agency, Core Research for Evolutional Science and Technology (CREST), University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan; Life Science Center of Tsukuba Advanced Research Alliance (TARA), University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.chom.2013.12.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3957200PMC
January 2014

Human umbilical cord blood mesenchymal stem cells reduce colitis in mice by activating NOD2 signaling to COX2.

Gastroenterology 2013 Dec 21;145(6):1392-403.e1-8. Epub 2013 Aug 21.

Adult Stem Cell Research Center, College of Veterinary Medicine, Seoul National University, Seoul, South Korea.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1053/j.gastro.2013.08.033DOI Listing
December 2013

Gut microbiota protects against gastrointestinal tumorigenesis caused by epithelial injury.

Cancer Res 2013 Dec 28;73(24):7199-210. Epub 2013 Oct 28.

Authors' Affiliations: Division of Hematology and Oncology, Department of Internal Medicine, Department of Pathology, Comprehensive Cancer Center, Unit for Laboratory Animal Medicine, and Department of Microbiology and Immunology, University of Michigan Medical School, University of Michigan, Ann Arbor, Michigan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/0008-5472.CAN-13-0827DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3883499PMC
December 2013

Staphylococcus δ-toxin induces allergic skin disease by activating mast cells.

Nature 2013 Nov 30;503(7476):397-401. Epub 2013 Oct 30.

Department of Pathology and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nature12655DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4090780PMC
November 2013

The Cag pathogenicity island and interaction between TLR2/NOD2 and NLRP3 regulate IL-1β production in Helicobacter pylori infected dendritic cells.

Eur J Immunol 2013 Oct 25;43(10):2650-8. Epub 2013 Jul 25.

Department of Pathology and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI, USA; World Class Institute, Korea Research Institute of Bioscience and Biotechnology, Ochang-Eup, Cheongwon-Gun, Choongbuk, Korea.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/eji.201243281DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3797179PMC
October 2013

Multiple effects of dendritic cell depletion on murine norovirus infection.

J Gen Virol 2013 Aug 1;94(Pt 8):1761-8. Epub 2013 May 1.

Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1099/vir.0.052134-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3749526PMC
August 2013

Control of pathogens and pathobionts by the gut microbiota.

Nat Immunol 2013 Jul;14(7):685-90

Department of Pathology, University of Michigan, Ann Arbor, Michigan, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ni.2608DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4083503PMC
July 2013

K⁺ efflux is the common trigger of NLRP3 inflammasome activation by bacterial toxins and particulate matter.

Immunity 2013 Jun;38(6):1142-53

Department of Pathology and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.immuni.2013.05.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3730833PMC
June 2013

The protein kinase PKR is critical for LPS-induced iNOS production but dispensable for inflammasome activation in macrophages.

Eur J Immunol 2013 May 15;43(5):1147-52. Epub 2013 Mar 15.

Department of Pathology and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/eji.201243187DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3757543PMC
May 2013

Role of the gut microbiota in immunity and inflammatory disease.

Nat Rev Immunol 2013 May;13(5):321-35

Department of Pathology and Comprehensive Cancer Center, University of Michigan, Ann Arbor 48109, Michigan, USA.

View Article

Download full-text PDF

Source
http://www.ufjf.br/imunologia/files/2009/05/Flavia-Role-of-t
Web Search
http://www.nature.com/doifinder/10.1038/nri3430
Publisher Site
http://dx.doi.org/10.1038/nri3430DOI Listing
May 2013

Understanding the microbiota in the midst of Renaissance architecture and olive groves.

Nat Immunol 2013 Feb;14(2):101-5

Digestive System Research Unit, University Hospital Vall d'Hebron, Centro de Investigación Biomédica en Red en Área temática de Enfermedades Hepáticas y Digestivas, Barcelona, Spain.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ni.2512DOI Listing
February 2013

Role of the gut microbiota in the development and function of lymphoid cells.

J Immunol 2013 Feb;190(4):1389-95

Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4049/jimmunol.1203100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3564600PMC
February 2013

TLR agonists stimulate Nlrp3-dependent IL-1β production independently of the purinergic P2X7 receptor in dendritic cells and in vivo.

J Immunol 2013 Jan 7;190(1):334-9. Epub 2012 Dec 7.

Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.

View Article

Download full-text PDF

Source
http://www.jimmunol.org/cgi/doi/10.4049/jimmunol.1202737
Publisher Site
http://dx.doi.org/10.4049/jimmunol.1202737DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3531812PMC
January 2013

MyD88: a critical adaptor protein in innate immunity signal transduction.

J Immunol 2013 Jan;190(1):3-4

Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4049/jimmunol.1203103DOI Listing
January 2013