Publications by authors named "Gabriel Mbalaviele"

50Publications

NF-κB-mediated effects on behavior and cartilage pathology in a non-invasive loading model of post-traumatic osteoarthritis.

Osteoarthritis Cartilage 2020 Nov 24. Epub 2020 Nov 24.

Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO 63130; Department of Orthopaedic Surgery, Washington University School of Medicine, St. Louis, MO 63110; Musculoskeletal Research Center, Washington University School of Medicine, St. Louis, MO 63110. Electronic address:

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http://dx.doi.org/10.1016/j.joca.2020.10.008DOI Listing
November 2020

LDHA-mediated ROS generation in chondrocytes is a potential therapeutic target for osteoarthritis.

Nat Commun 2020 07 9;11(1):3427. Epub 2020 Jul 9.

Department of Orthopaedic Surgery and Cell Biology & Physiology, Washington University School of Medicine, St. Louis, MO, 63110, USA.

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http://dx.doi.org/10.1038/s41467-020-17242-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7347613PMC
July 2020

Inflammatory osteolysis is regulated by site-specific ISGylation of the scaffold protein NEMO.

Elife 2020 Mar 23;9. Epub 2020 Mar 23.

Department of Orthopaedic Surgery and Cell Biology & Physiology, Washington University School of Medicine, St. Louis, United States.

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http://dx.doi.org/10.7554/eLife.56095DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7145425PMC
March 2020

PARP1 Hinders Histone H2B Occupancy at the NFATc1 Promoter to Restrain Osteoclast Differentiation.

J Bone Miner Res 2020 Apr 7;35(4):776-788. Epub 2020 Jan 7.

Division of Bone and Mineral Diseases, Washington University School of Medicine, St. Louis, MO, USA.

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http://dx.doi.org/10.1002/jbmr.3927DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7465553PMC
April 2020

Hematopoietic stem cell transplantation-induced bone remodeling in autosomal recessive osteopetrosis: Interaction between skeleton and hematopoietic and sensory nervous systems.

Bone 2020 01 6;130:115144. Epub 2019 Nov 6.

Division of Bone and Mineral Diseases, Department of Medicine, Washington University School of Medicine, 660 S. Euclid Ave, CB 8301, St. Louis, MO 63110, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bone.2019.115144DOI Listing
January 2020

Role of APD-Ribosylation in Bone Health and Disease.

Cells 2019 10 5;8(10). Epub 2019 Oct 5.

Division of Bone and Mineral Diseases, Washington University School of Medicine, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.3390/cells8101201DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6829334PMC
October 2019

Omnipresence of inflammasome activities in inflammatory bone diseases.

Semin Immunopathol 2019 09 13;41(5):607-618. Epub 2019 Sep 13.

Division of Bone and Mineral Diseases, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8301, St. Louis, MO, 63110, USA.

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http://dx.doi.org/10.1007/s00281-019-00753-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6814643PMC
September 2019

Inflammatory Responses Reprogram T Through Impairment of Neuropilin-1.

Sci Rep 2019 07 18;9(1):10429. Epub 2019 Jul 18.

Department of Orthopaedic Surgery, Washington University School of Medicine, St. Louis, MO, 63110, USA.

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http://dx.doi.org/10.1038/s41598-019-46934-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6639378PMC
July 2019

Attenuation of NF-κB in Intestinal Epithelial Cells Is Sufficient to Mitigate the Bone Loss Comorbidity of Experimental Mouse Colitis.

J Bone Miner Res 2019 10 25;34(10):1880-1893. Epub 2019 Jul 25.

Department of Orthopaedic Surgery and Cell Biology and Physiology, Washington University School of Medicine, St. Louis, MO, USA.

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http://dx.doi.org/10.1002/jbmr.3759DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6813857PMC
October 2019

Inflammasomes in Bone Diseases.

Exp Suppl 2018;108:269-279

Division of Bone and Mineral Diseases, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.

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http://dx.doi.org/10.1007/978-3-319-89390-7_11DOI Listing
May 2019

Gasdermin D mediates the pathogenesis of neonatal-onset multisystem inflammatory disease in mice.

PLoS Biol 2018 11 2;16(11):e3000047. Epub 2018 Nov 2.

Division of Bone and Mineral Diseases, Washington University School of Medicine, St. Louis, Missouri, United States of America.

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http://dx.plos.org/10.1371/journal.pbio.3000047
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http://dx.doi.org/10.1371/journal.pbio.3000047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6235378PMC
November 2018

NUMBL Interacts with TAK1, TRAF6 and NEMO to Negatively Regulate NF-κB Signaling During Osteoclastogenesis.

Sci Rep 2017 10 3;7(1):12600. Epub 2017 Oct 3.

Department of Orthopaedic Surgery and Cell Biology & Physiology, Washington University School of Medicine, St. Louis, MO, 63110, USA.

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http://dx.doi.org/10.1038/s41598-017-12707-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5626749PMC
October 2017

Bone matrix components activate the NLRP3 inflammasome and promote osteoclast differentiation.

Sci Rep 2017 07 26;7(1):6630. Epub 2017 Jul 26.

Division of Bone and Mineral Diseases, Washington University School of Medicine, St. Louis, MO, 63110, United States.

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http://dx.doi.org/10.1038/s41598-017-07014-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5529467PMC
July 2017

Inflammatory osteolysis: a conspiracy against bone.

J Clin Invest 2017 Jun 1;127(6):2030-2039. Epub 2017 Jun 1.

Department of Medicine, Division of Bone and Mineral Diseases, and.

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http://dx.doi.org/10.1172/JCI93356DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5451216PMC
June 2017

N-cadherin Regulation of Bone Growth and Homeostasis Is Osteolineage Stage-Specific.

J Bone Miner Res 2017 Jun 29;32(6):1332-1342. Epub 2017 Mar 29.

Department of Internal Medicine, Division of Bone and Mineral Diseases, Musculoskeletal Research Center, Washington University School of Medicine, St. Louis, MO, USA.

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http://dx.doi.org/10.1002/jbmr.3112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5466462PMC
June 2017

Myeloid Deletion of Nemo Causes Osteopetrosis in Mice Owing to Upregulation of Transcriptional Repressors.

Sci Rep 2016 07 20;6:29896. Epub 2016 Jul 20.

Department of Orthopaedic Surgery, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA.

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http://dx.doi.org/10.1038/srep29896DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4951754PMC
July 2016

Osteoclasts-Key Players in Skeletal Health and Disease.

Microbiol Spectr 2016 06;4(3)

Musculoskeletal Research Center, Division of Bone and Mineral Diseases, Department of Medicine.

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http://dx.doi.org/10.1128/microbiolspec.MCHD-0011-2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4920143PMC
June 2016

Osteopetrosis in TAK1-deficient mice owing to defective NF-κB and NOTCH signaling.

Proc Natl Acad Sci U S A 2015 Jan 22;112(1):154-9. Epub 2014 Dec 22.

Department of Orthopaedic Surgery and Cell Biology & Physiology and

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http://www.pnas.org/lookup/doi/10.1073/pnas.1415213112
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http://dx.doi.org/10.1073/pnas.1415213112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4291677PMC
January 2015

NLRP3 mediates osteolysis through inflammation-dependent and -independent mechanisms.

FASEB J 2015 Apr 4;29(4):1269-79. Epub 2014 Dec 4.

*Division of Bone and Mineral Diseases and Department of Orthopaedic Surgery, Washington University School of Medicine, St. Louis, Missouri, USA; and Division of Allergy, Immunology, and Rheumatology, University of California, San Diego, La Jolla, California, USA

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http://dx.doi.org/10.1096/fj.14-264804DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4396608PMC
April 2015

N-cadherin restrains PTH activation of Lrp6/β-catenin signaling and osteoanabolic action.

J Bone Miner Res 2015 Feb;30(2):274-85

Department of Internal Medicine, Division of Bone and Mineral Disease, Washington University School of Medicine, St. Louis, MO, USA.

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http://doi.wiley.com/10.1002/jbmr.2323
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http://dx.doi.org/10.1002/jbmr.2323DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4315770PMC
February 2015

Constitutive activation of IKK2/NF-κB impairs osteogenesis and skeletal development.

PLoS One 2014 11;9(3):e91421. Epub 2014 Mar 11.

Department of Orthopedics, Washington University School of Medicine, Saint Louis, Missouri, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0091421PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3949987PMC
May 2015

Renal effects induced by prolonged mPGES1 inhibition.

Am J Physiol Renal Physiol 2014 Jan 6;306(1):F68-74. Epub 2013 Nov 6.

Dept. of Physiology, School of Medicine, Univ. of Murcia, Murcia 30100, Spain.

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http://dx.doi.org/10.1152/ajprenal.00492.2013DOI Listing
January 2014

Postnatal ablation of osteoblast Smad4 enhances proliferative responses to canonical Wnt signaling through interactions with β-catenin.

J Cell Sci 2013 Dec 7;126(Pt 24):5598-609. Epub 2013 Oct 7.

Department of Internal Medicine, Division of Bone and Mineral Disease, Washington University School of Medicine, 660 South Euclid, Campus Box 8301, Saint Louis, MO 63110, USA.

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http://jcs.biologists.org/lookup/doi/10.1242/jcs.132233
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http://dx.doi.org/10.1242/jcs.132233DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3860308PMC
December 2013

Embryonic ablation of osteoblast Smad4 interrupts matrix synthesis in response to canonical Wnt signaling and causes an osteogenesis-imperfecta-like phenotype.

J Cell Sci 2013 Nov 4;126(Pt 21):4974-84. Epub 2013 Sep 4.

Washington University School of Medicine, Division of Bone and Mineral Disease, Departments of Internal Medicine and Cell Biology and Physiology, 660 South Euclid, Campus Box 8301, Saint Louis, MO 63110, USA.

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http://dx.doi.org/10.1242/jcs.131953DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3820242PMC
November 2013

Cadherin-mediated cell-cell adhesion and signaling in the skeleton.

Calcif Tissue Int 2014 Jan 9;94(1):46-54. Epub 2013 May 9.

Laboratory of Osteoblast Biology and Pathology, Inserm UMR-606, Hôpital Lariboisière, 2 rue Ambroise Paré, 75475, Paris Cedex 10, France,

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http://dx.doi.org/10.1007/s00223-013-9733-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4272239PMC
January 2014

Critical role for apoptosis signal-regulating kinase 1 in the development of inflammatory K/BxN serum-induced arthritis.

Int Immunopharmacol 2010 Oct 6;10(10):1170-6. Epub 2010 Jul 6.

Discovery Biology, Global Research and Development, St. Louis Laboratories Pfizer Inc., 700 Chesterfield Parkway West, mail zone AA3C, Chesterfield, MO 63017, USA.

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http://dx.doi.org/10.1016/j.intimp.2010.06.023DOI Listing
October 2010

N-cadherin and cadherin 11 modulate postnatal bone growth and osteoblast differentiation by distinct mechanisms.

J Cell Sci 2010 Aug 6;123(Pt 15):2640-8. Epub 2010 Jul 6.

Division of Bone and Mineral Diseases, Department of Internal Medicine, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8301, St Louis, MO 63110, USA.

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http://jcs.biologists.org/cgi/doi/10.1242/jcs.067777
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http://dx.doi.org/10.1242/jcs.067777DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2908051PMC
August 2010

Expression, purification and functional characterization of IkappaB kinase-2 (IKK-2) mutants.

Protein Expr Purif 2010 Aug 20;72(2):254-61. Epub 2010 Feb 20.

Pfizer Inc., 700 Chesterfield Parkway West, Chesterfield, MO 63017, USA.

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http://dx.doi.org/10.1016/j.pep.2010.02.009DOI Listing
August 2010

Selective inducible microsomal prostaglandin E(2) synthase-1 (mPGES-1) inhibitors derived from an oxicam template.

Bioorg Med Chem Lett 2010 Mar 25;20(5):1604-9. Epub 2010 Jan 25.

Pfizer Inc. St. Louis Laboratory, PGRD Research, 700 Chesterfield PKWY W, Chesterfield, MO 63017, USA.

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http://dx.doi.org/10.1016/j.bmcl.2010.01.060DOI Listing
March 2010

The pro-osteogenic action of beta-catenin requires interaction with BMP signaling, but not Tcf/Lef transcriptional activity.

J Cell Biochem 2008 Jun;104(3):942-52

Division of Bone and Mineral Diseases, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

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http://doi.wiley.com/10.1002/jcb.21679
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http://dx.doi.org/10.1002/jcb.21679DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3811910PMC
June 2008

Mechanisms of the joint-protective effects of p38 MAPK inhibitors in rodent arthritis.

Expert Opin Drug Discov 2008 Feb;3(2):163-72

Pfizer, Inc., St. Louis Laboratories, Pfizer Global Research & Development, Department of Inflammation, 700 Chesterfield Parkway West, Mail Stop BB3N, Chesterfield, MO 63017, USA +1 636 247 5361 ;

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http://dx.doi.org/10.1517/17460441.3.2.163DOI Listing
February 2008

Accentuated ovariectomy-induced bone loss and altered osteogenesis in heterozygous N-cadherin null mice.

J Bone Miner Res 2006 Dec;21(12):1897-906

Division of Bone and Mineral Diseases, Department of Internal Medicine, Washington School of Medicine, St Louis, Missouri 63110, USA.

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http://doi.wiley.com/10.1359/jbmr.060906
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http://dx.doi.org/10.1359/jbmr.060906DOI Listing
December 2006

Cell-cell adhesion and signaling through cadherins: connecting bone cells in their microenvironment.

J Bone Miner Res 2006 Dec;21(12):1821-7

Division of Bone and Mineral Diseases, Department of Internal Medicine, Washington University, St Louis, Missouri 63110, USA.

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http://dx.doi.org/10.1359/jbmr.060811DOI Listing
December 2006

Inhibition of p38 mitogen-activated protein kinase prevents inflammatory bone destruction.

J Pharmacol Exp Ther 2006 Jun 24;317(3):1044-53. Epub 2006 Feb 24.

Department of Inflammation, Pfizer Inc., 700 Chesterfield Parkway West, Mail Stop AA5G, Chesterfield, MO 63017, USA.

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http://dx.doi.org/10.1124/jpet.105.100362DOI Listing
June 2006

Beta-catenin and BMP-2 synergize to promote osteoblast differentiation and new bone formation.

J Cell Biochem 2005 Feb;94(2):403-18

Division of Bone and Mineral Diseases, Department of Internal Medicine, St. Louis, Missouri 63110, USA.

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http://dx.doi.org/10.1002/jcb.20253DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2647989PMC
February 2005

Targeted expression of a dominant-negative N-cadherin in vivo delays peak bone mass and increases adipogenesis.

J Cell Sci 2004 Jun;117(Pt 13):2853-64

Division of Bone and Mineral Diseases, Department of Internal Medicine, Washington University School of Medicine, 216 S. Kingshighway Blvd, St Louis, MO 63110, USA.

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http://dx.doi.org/10.1242/jcs.01133DOI Listing
June 2004