Gabriel Lander

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Gabriel Lander

Publications by authors named "Gabriel Lander"

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62Publications

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Exploring applications of crowdsourcing to cryo-EM.

J Struct Biol 2018 Jul 24;203(1):37-45. Epub 2018 Feb 24.

Integrative Structural and Computational Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037 USA. Electronic address:

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July 2018

Cryo-EM structure of a mitochondrial calcium uniporter.

Science 2018 Jun 28. Epub 2018 Jun 28.

Department of Biochemistry, Duke University School of Medicine, Durham, NC 27710, USA.

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June 2018

Author Correction: Cryo-electron tomography reveals that dynactin recruits a team of dyneins for processive motility.

Nat Struct Mol Biol 2018 Apr;25(4):355

Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA.

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April 2018

Cryo-electron tomography reveals that dynactin recruits a team of dyneins for processive motility.

Nat Struct Mol Biol 2018 Mar 7;25(3):203-207. Epub 2018 Feb 7.

Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA.

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March 2018

Structure of the cold- and menthol-sensing ion channel TRPM8.

Science 2018 01 7;359(6372):237-241. Epub 2017 Dec 7.

Department of Biochemistry, Duke University School of Medicine, Durham, NC 27710, USA.

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January 2018

The peroxisomal AAA-ATPase Pex1/Pex6 unfolds substrates by processive threading.

Nat Commun 2018 01 10;9(1):135. Epub 2018 Jan 10.

Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, 94720, USA.

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January 2018

Achieving better-than-3-Å resolution by single-particle cryo-EM at 200 keV.

Nat Methods 2017 Nov 9;14(11):1075-1078. Epub 2017 Oct 9.

Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, USA.

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November 2017

Structure of the mitochondrial inner membrane AAA+ protease YME1 gives insight into substrate processing.

Science 2017 11;358(6363)

Department of Integrative Structural and Computational Biology, The Scripps Research Institute HZ 175, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

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November 2017

Cryo-electron microscopy structure of the lysosomal calcium-permeable channel TRPML3.

Nature 2017 10 11;550(7676):411-414. Epub 2017 Oct 11.

Department of Biochemistry, Duke University School of Medicine, Durham, North Carolina 27710, USA.

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October 2017

The endoplasmic reticulum HSP40 co-chaperone ERdj3/DNAJB11 assembles and functions as a tetramer.

EMBO J 2017 08 27;36(15):2296-2309. Epub 2017 Jun 27.

Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA, USA

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August 2017

Cas1 and the Csy complex are opposing regulators of Cas2/3 nuclease activity.

Proc Natl Acad Sci U S A 2017 06 24;114(26):E5113-E5121. Epub 2017 Apr 24.

Department of Microbiology and Immunology, Montana State University, Bozeman, MT 59717;

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June 2017

Isolation of yeast complex IV in native lipid nanodiscs.

Biochim Biophys Acta 2016 12 13;1858(12):2984-2992. Epub 2016 Sep 13.

Department of Biochemistry and Biophysics, The Arrhenius Laboratories for Natural Sciences, Stockholm University, SE-106 91 Stockholm, Sweden. Electronic address:

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December 2016

What's the Key to Unlocking the Proteasome's Gate?

Structure 2016 12;24(12):2037-2038

Department of Integrative Structural and Computational Biology, The Scripps Research Institute, 10550 N. Torrey Pines Rd, La Jolla, CA 92037, USA. Electronic address:

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December 2016

Cryo-electron microscopy structure of the TRPV2 ion channel.

Nat Struct Mol Biol 2016 Feb 18;23(2):180-186. Epub 2016 Jan 18.

Department of Biochemistry, Duke University Medical Center, Durham, North Carolina, USA.

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February 2016

Atomic structure of the 26S proteasome lid reveals the mechanism of deubiquitinase inhibition.

Elife 2016 Jan 8;5:e13027. Epub 2016 Jan 8.

Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, United States.

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January 2016

Site-specific labeling of proteins for electron microscopy.

J Struct Biol 2015 Nov 25;192(2):151-8. Epub 2015 Sep 25.

Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA. Electronic address:

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November 2015

Protein domain mapping by internal labeling and single particle electron microscopy.

J Struct Biol 2015 Nov 30;192(2):159-62. Epub 2015 Sep 30.

Department of Molecular and Cell Biology, University of California, Berkeley, United States; Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, United States; Howard Hughes Medical Institute, UC Berkeley, Berkeley, United States.

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November 2015

Architecture of the Complex Formed by Large and Small Terminase Subunits from Bacteriophage P22.

J Mol Biol 2015 Oct 21;427(20):3285-3299. Epub 2015 Aug 21.

Department of Biochemistry and Molecular Biology, Thomas Jefferson University, 233 South 10th Street Philadelphia, PA 19107, USA. Electronic address:

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October 2015

Thermodynamic Interrogation of the Assembly of a Viral Genome Packaging Motor Complex.

Biophys J 2015 Oct;109(8):1663-75

Department of Medicinal Chemistry, School of Pharmacy, University of Washington, Seattle, Washington. Electronic address:

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October 2015

Ubp6 deubiquitinase controls conformational dynamics and substrate degradation of the 26S proteasome.

Nat Struct Mol Biol 2015 Sep 24;22(9):712-9. Epub 2015 Aug 24.

Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California, USA.

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September 2015

Multivalent Microtubule Recognition by Tubulin Tyrosine Ligase-like Family Glutamylases.

Cell 2015 May 7;161(5):1112-1123. Epub 2015 May 7.

Cell Biology and Biophysics Unit, Porter Neuroscience Research Center, National Institute of Neurological Disorders and Stroke, Bethesda, MD 20892, USA; National Heart, Lung and Blood Institute, Bethesda, MD 20892, USA. Electronic address:

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May 2015

Structural organization of the dynein-dynactin complex bound to microtubules.

Nat Struct Mol Biol 2015 Apr 9;22(4):345-7. Epub 2015 Mar 9.

Department of Integrative Structural and Computational Biology, Scripps Research Institute, La Jolla, California, USA.

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April 2015

Characterization of virus-like particles in GARDASIL® by cryo transmission electron microscopy.

Hum Vaccin Immunother 2014 3;10(3):734-9. Epub 2013 Dec 3.

Vaccine Manufacturing Science and Commercialization; Merck Manufacturing Division; West Point, PA USA.

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March 2015

The Pex1/Pex6 complex is a heterohexameric AAA+ motor with alternating and highly coordinated subunits.

J Mol Biol 2015 Mar 7;427(6 Pt B):1375-1388. Epub 2015 Feb 7.

Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720-3200, USA; California Institute for Quantitative Biosciences, University of California, Berkeley, Berkeley, CA 94720-3220, USA. Electronic address:

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March 2015

Solid-to-fluid-like DNA transition in viruses facilitates infection.

Proc Natl Acad Sci U S A 2014 Oct 30;111(41):14675-80. Epub 2014 Sep 30.

Department of Physics, Carnegie Mellon University, Pittsburgh, PA 15213; Department of Biochemistry and Structural Biology, Lund University, SE-221 00 Lund, Sweden

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October 2014

High-resolution microtubule structures reveal the structural transitions in αβ-tubulin upon GTP hydrolysis.

Cell 2014 May;157(5):1117-29

Life Sciences Division, Lawrence Berkeley National Lab, Berkeley, CA 94720, USA; Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA. Electronic address:

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May 2014

Conformational switching of the 26S proteasome enables substrate degradation.

Nat Struct Mol Biol 2013 Jul 16;20(7):781-8. Epub 2013 Jun 16.

Department of Molecular and Cell Biology, University of California, Berkeley, California, USA.

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July 2013

DNA bending-induced phase transition of encapsidated genome in phage λ.

Nucleic Acids Res 2013 Apr 28;41(8):4518-24. Epub 2013 Feb 28.

Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.

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April 2013

The proteasome under the microscope: the regulatory particle in focus.

Curr Opin Struct Biol 2013 Apr 13;23(2):243-51. Epub 2013 Mar 13.

Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.

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April 2013

Go hybrid: EM, crystallography, and beyond.

Curr Opin Struct Biol 2012 Oct 24;22(5):627-35. Epub 2012 Jul 24.

Life Science Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.

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October 2012

Molecular architecture of human polycomb repressive complex 2.

Elife 2012 Oct 30;1:e00005. Epub 2012 Oct 30.

Department of Molecular and Cell Biology , University of California , Berkeley , United States.

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October 2012

Small terminase couples viral DNA binding to genome-packaging ATPase activity.

Structure 2012 Aug 5;20(8):1403-13. Epub 2012 Jul 5.

Department of Biochemistry and Molecular Biology, Thomas Jefferson University, 233 South 10th Street, Philadelphia, PA 19107, USA.

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August 2012

Capsomer dynamics and stabilization in the T = 12 marine bacteriophage SIO-2 and its procapsid studied by CryoEM.

Structure 2012 Mar;20(3):498-503

National Resource for Automated Molecular Microscopy, The Scripps Research Institute, La Jolla, CA 92037, USA.

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March 2012

Complete subunit architecture of the proteasome regulatory particle.

Nature 2012 Jan 11;482(7384):186-91. Epub 2012 Jan 11.

Life Sciences Division, Lawrence Berkeley National Laboratory, University of California, Berkeley, California 94720, USA.

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January 2012

Structures of the RNA-guided surveillance complex from a bacterial immune system.

Nature 2011 Sep 21;477(7365):486-489. Epub 2011 Sep 21.

Howard Hughes Medical Institute, University of California, Berkeley, California 94720, USA.

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September 2011

Peering down the barrel of a bacteriophage portal: the genome packaging and release valve in p22.

Structure 2011 Apr;19(4):496-502

Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093-0378, USA.

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April 2011

Molecular architecture and connectivity of the budding yeast Mtw1 kinetochore complex.

J Mol Biol 2011 Jan 12;405(2):548-59. Epub 2010 Nov 12.

Research Institute of Molecular Pathology, Dr. Bohr Gasse 7, 1030 Vienna, Austria.

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January 2011

Subunits fold at position-dependent rates during maturation of a eukaryotic RNA virus.

Proc Natl Acad Sci U S A 2010 Aug 26;107(32):14111-5. Epub 2010 Jul 26.

Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.

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August 2010

An automated procedure for detecting protein folds from sub-nanometer resolution electron density.

J Struct Biol 2010 Jun 22;170(3):513-21. Epub 2009 Dec 22.

Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.

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June 2010

A toolbox for ab initio 3-D reconstructions in single-particle electron microscopy.

J Struct Biol 2010 Mar 16;169(3):389-98. Epub 2009 Dec 16.

National Resource for Automated Molecular Microscopy and Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.

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March 2010

Drosophila A virus is an unusual RNA virus with a T=3 icosahedral core and permuted RNA-dependent RNA polymerase.

J Gen Virol 2009 Sep 27;90(Pt 9):2191-200. Epub 2009 May 27.

School of Biological Sciences, The University of Queensland, Brisbane, Australia.

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September 2009

The P22 tail machine at subnanometer resolution reveals the architecture of an infection conduit.

Structure 2009 Jun;17(6):789-99

National Resource for Automated Molecular Microscopy, The Scripps Institute, La Jolla, CA 92037, USA.

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June 2009

Appion: an integrated, database-driven pipeline to facilitate EM image processing.

J Struct Biol 2009 Apr;166(1):95-102

National Resource for Automated Molecular Microscopy, The Scripps Research Institute, CB 129, 10550 North Torrey Pines Rd, La Jolla, CA 92037, USA.

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April 2009

VIPERdb2: an enhanced and web API enabled relational database for structural virology.

Nucleic Acids Res 2009 Jan 3;37(Database issue):D436-42. Epub 2008 Nov 3.

Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

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January 2009

Characterization of large conformational changes and autoproteolysis in the maturation of a T=4 virus capsid.

J Virol 2009 Jan 5;83(2):1126-34. Epub 2008 Nov 5.

Department of Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA.

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January 2009

Assembly architecture and DNA binding of the bacteriophage P22 terminase small subunit.

J Mol Biol 2008 Nov 27;383(3):494-501. Epub 2008 Aug 27.

School of Biological Sciences, University of Missouri-Kansas City, Kansas City, MO 64110-2499, USA.

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November 2008

Bacteriophage lambda stabilization by auxiliary protein gpD: timing, location, and mechanism of attachment determined by cryo-EM.

Structure 2008 Sep;16(9):1399-406

National Resource for Automated Molecular Microscopy, The Scripps Research Institute, La Jolla, CA 92037, USA.

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September 2008

A test-bed for optimizing high-resolution single particle reconstructions.

J Struct Biol 2008 Jul 6;163(1):29-39. Epub 2008 May 6.

The National Resource for Automated Molecular Microscopy, Department of Cell Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

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July 2008

Unnatural amino acid incorporation into virus-like particles.

Bioconjug Chem 2008 Apr 5;19(4):866-75. Epub 2008 Mar 5.

Department of Chemistry, The Scripps Research Institute, La Jolla, California 92037, USA.

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April 2008

Development of bacteriophage p22 as a platform for molecular display: genetic and chemical modifications of the procapsid exterior surface.

Chembiochem 2008 Mar;9(4):514-8

Department of Microbiology, University of Alabama at Birmingham, BBRB 416 845 19th St South, Birmingham, AL 35294-2170, USA.

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March 2008

Macromolecular mass spectrometry and electron microscopy as complementary tools for investigation of the heterogeneity of bacteriophage portal assemblies.

J Struct Biol 2007 Feb 19;157(2):371-83. Epub 2006 Sep 19.

Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

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February 2007

Capsid conformational sampling in HK97 maturation visualized by X-ray crystallography and cryo-EM.

Structure 2006 Nov;14(11):1655-65

Department of Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA.

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November 2006

Automated cryoEM data acquisition and analysis of 284742 particles of GroEL.

J Struct Biol 2006 Sep 22;155(3):470-81. Epub 2006 May 22.

The National Resource for Automated Molecular Microscopy, Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.

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September 2006

The structure of an infectious P22 virion shows the signal for headful DNA packaging.

Science 2006 Jun 18;312(5781):1791-5. Epub 2006 May 18.

Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

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June 2006

VIPERdb: a relational database for structural virology.

Nucleic Acids Res 2006 Jan;34(Database issue):D386-9

Department of Molecular Biology, TPC-6 The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

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January 2006

Exploring icosahedral virus structures with VIPER.

Nat Rev Microbiol 2005 Oct;3(10):809-17

Department of Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA.

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October 2005