Gabriel Krigsfeld

Gabriel Krigsfeld

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Gabriel Krigsfeld

Gabriel Krigsfeld

Publications by authors named "Gabriel Krigsfeld"

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17Publications

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Distinct vascular genomic response of proton and gamma radiation-A pilot investigation.

PLoS One 2019 11;14(2):e0207503. Epub 2019 Feb 11.

Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0207503PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370185PMC
February 2019

CancerInSilico: An R/Bioconductor package for combining mathematical and statistical modeling to simulate time course bulk and single cell gene expression data in cancer.

PLoS Comput Biol 2018 Jun 19;14(4):e1006935. Epub 2019 Apr 19.

Department of Oncology, Division of Biostatistics and Bioinformatics, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD United States of America.

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http://dx.doi.org/10.1371/journal.pcbi.1006935DOI Listing
June 2018

Taselisib (GDC-0032), a Potent β-Sparing Small Molecule Inhibitor of PI3K, Radiosensitizes Head and Neck Squamous Carcinomas Containing Activating PIK3CA Alterations.

Clin Cancer Res 2016 Apr 20;22(8):2009-19. Epub 2015 Nov 20.

Memorial Sloan Kettering Cancer Center, Human Oncology and Pathogenesis Program, New York, New York. Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.

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http://dx.doi.org/10.1158/1078-0432.CCR-15-2245DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4870591PMC
April 2016

Identification of TRAIL-inducing compounds highlights small molecule ONC201/TIC10 as a unique anti-cancer agent that activates the TRAIL pathway.

Mol Cancer 2015 May 1;14:99. Epub 2015 May 1.

Departments of Medicine, Genetics, and Pharmacology, Laboratory of Molecular Oncology and Cell Cycle Regulation, University of Pennsylvania School of Medicine, Philadelphia, 19104, PA, USA.

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http://dx.doi.org/10.1186/s12943-015-0346-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4428111PMC
May 2015

Novel targets in head and neck cancer: should we be optimistic?

Clin Cancer Res 2015 Feb 9;21(3):495-7. Epub 2014 Oct 9.

Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland. Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.

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http://dx.doi.org/10.1158/1078-0432.CCR-14-1776DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4316824PMC
February 2015

Leukocyte activity is altered in a ground based murine model of microgravity and proton radiation exposure.

PLoS One 2013 14;8(8):e71757. Epub 2013 Aug 14.

Department of Radiation Oncology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0071757PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3743739PMC
April 2014

Evidence for radiation-induced disseminated intravascular coagulation as a major cause of radiation-induced death in ferrets.

Int J Radiat Oncol Biol Phys 2014 Mar 1;88(4):940-6. Epub 2014 Feb 1.

Department of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania. Electronic address:

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http://dx.doi.org/10.1016/j.ijrobp.2013.12.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4039181PMC
March 2014

Mechanism of hypocoagulability in proton-irradiated ferrets.

Int J Radiat Biol 2013 Oct 10;89(10):823-31. Epub 2013 Jun 10.

Department of Radiation Oncology, University of Pennsylvania , Philadelphia, PA.

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http://dx.doi.org/10.3109/09553002.2013.802394DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4030682PMC
October 2013

The Effects of Gamma and Proton Radiation Exposure on Hematopoietic Cell Counts in the Ferret Model.

Gravit Space Res 2013 Oct;1(1):79-94

Department of Radiation Oncology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4209750PMC
October 2013

Is disseminated intravascular coagulation the major cause of mortality from radiation at relatively low whole body doses?

Radiat Res 2013 Sep 14;180(3):231-4. Epub 2013 Aug 14.

Department of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6072.

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http://dx.doi.org/10.1667/RR3321.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4160037PMC
September 2013

Dual inactivation of Akt and ERK by TIC10 signals Foxo3a nuclear translocation, TRAIL gene induction, and potent antitumor effects.

Sci Transl Med 2013 Feb;5(171):171ra17

Laboratory of Translational Oncology and Experimental Cancer Therapeutics, Department of Medicine-Hematology/Oncology, Penn State Hershey Cancer Institute, Hershey, PA 17033, USA.

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http://dx.doi.org/10.1126/scitranslmed.3004828DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4535715PMC
February 2013

The effects of proton radiation on the prothrombin and partial thromboplastin times of irradiated ferrets.

Int J Radiat Biol 2012 Apr 6;88(4):327-34. Epub 2012 Feb 6.

Department of Radiation Oncology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.3109/09553002.2012.652727DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3589974PMC
April 2012

Comparison of hindlimb unloading and partial weight suspension models for spaceflight-type condition induced effects on white blood cells.

Adv Space Res 2012 Jan;49(2):237-248

University Laboratory Animal Resources, University of Pennsylvania, Philadelphia, PA 19104, USA ; Department of Radiation Oncology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1016/j.asr.2011.09.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3678840PMC
January 2012

TNFSF10 (TRAIL), a p53 target gene that mediates p53-dependent cell death.

Cancer Biol Ther 2008 Dec;7(12):2034-8

Laboratory of Molecular Oncology and Cell Cycle Regulation, Institute for Translational Medicine and Therapeutics, Abramson Comprehensive Cancer Center, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.

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http://dx.doi.org/10.4161/cbt.7.12.7460DOI Listing
December 2008