Gabriel Haddad

Gabriel Haddad

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Gabriel Haddad

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Complex Oscillatory Waves Emerging from Cortical Organoids Model Early Human Brain Network Development.

Cell Stem Cell 2019 Oct 29;25(4):558-569.e7. Epub 2019 Aug 29.

Department of Pediatrics/Rady Children's Hospital San Diego, School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA; Department of Cellular & Molecular Medicine, School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA; Kavli Institute for Brain and Mind and Halıcıoğlu Data Science Institute, University of California, San Diego, La Jolla, CA 92093, USA; Center for Academic Research and Training in Anthropogeny (CARTA), La Jolla, CA 92093, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2019.08.002DOI Listing
October 2019

Increased hypoxic proliferative response and gene expression in erythroid progenitor cells of Andean highlanders with Chronic Mountain Sickness.

Am J Physiol Regul Integr Comp Physiol 2019 Oct 16. Epub 2019 Oct 16.

Laboratorio de Fisiología Comparada. Departamento de Ciencias Biológicas y Fisiológicas. Facultad de Ciencias y Filosofía., Universidad Peruana Cayetano Heredia, Peru.

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http://dx.doi.org/10.1152/ajpregu.00250.2019DOI Listing
October 2019

Intermittent Hypoxia and Hypercapnia Induces Inhibitor of Nuclear Factor Kappa-B Kinase Subunit Beta-dependent Atherosclerosis in Pulmonary Arteries.

Am J Physiol Regul Integr Comp Physiol 2019 Oct 16. Epub 2019 Oct 16.

Department of Pediatrics, University of California, San Diego, United States.

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http://dx.doi.org/10.1152/ajpregu.00056.2019DOI Listing
October 2019

High fat diet induces sex-specific differential gene expression in Drosophila melanogaster.

PLoS One 2019 12;14(3):e0213474. Epub 2019 Mar 12.

Department of Pediatrics, Division of Respiratory Medicine, University of California San Diego, La Jolla, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0213474PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413938PMC
March 2019

Commentary: Novel Insight into the Genetic Basis of High Altitude Pulmonary Hypertension in Kyrgyz Highlanders.

J Lung Health Dis 2019 19;3(2):29-30. Epub 2019 Mar 19.

Division of Respiratory Medicine, Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6625522PMC
March 2019

Exploring miRNA-mRNA regulatory network in cardiac pathology in Na/H exchanger isoform 1 transgenic mice.

Physiol Genomics 2018 10 20;50(10):846-861. Epub 2018 Jul 20.

Department of Pediatrics, University of California San Diego , La Jolla, California.

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http://dx.doi.org/10.1152/physiolgenomics.00048.2018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6230871PMC
October 2018

Mitochondrial dysfunction in iPSC-derived neurons of subjects with chronic mountain sickness.

J Appl Physiol (1985) 2018 09 21;125(3):832-840. Epub 2017 Dec 21.

Department of Pediatrics (Respiratory Medicine), University of California San Diego , La Jolla, California.

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https://www.physiology.org/doi/10.1152/japplphysiol.00689.20
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http://dx.doi.org/10.1152/japplphysiol.00689.2017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6734077PMC
September 2018

Cardiac-specific knockout and pharmacological inhibition of Endothelin receptor type B lead to cardiac resistance to extreme hypoxia.

J Mol Med (Berl) 2018 09 1;96(9):975-982. Epub 2018 Aug 1.

Division of Respiratory Medicine, Department of Pediatrics, University of California, San Diego, 9500 Gilman Drive, MC 0735, La Jolla, CA, 92093, USA.

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http://dx.doi.org/10.1007/s00109-018-1673-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374051PMC
September 2018

Intracellular pH Regulation in iPSCs-derived Astrocytes from Subjects with Chronic Mountain Sickness.

Neuroscience 2018 04 10;375:25-33. Epub 2018 Feb 10.

Department of Pediatrics, University of California San Diego, La Jolla, CA 92093, United States; Department of Neurosciences, University of California San Diego, La Jolla, CA 92093, United States; Rady Children's Hospital-San Diego, San Diego, CA 92123, United States. Electronic address:

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http://dx.doi.org/10.1016/j.neuroscience.2018.02.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5851838PMC
April 2018

Down-regulation of Inwardly Rectifying K Currents in Astrocytes Derived from Patients with Monge's Disease.

Neuroscience 2018 03 2;374:70-79. Epub 2018 Feb 2.

Department of Pediatrics, University of California San Diego, La Jolla, CA 92093, United States; Department of Neurosciences, University of California San Diego, La Jolla, CA 92093, United States; Rady Children's Hospital-San Diego, San Diego, CA 92123, United States. Electronic address:

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http://dx.doi.org/10.1016/j.neuroscience.2018.01.016DOI Listing
March 2018

High-altitude adaptation in humans: from genomics to integrative physiology.

J Mol Med (Berl) 2017 Dec 26;95(12):1269-1282. Epub 2017 Sep 26.

Division of Respiratory Medicine, Department of Pediatrics, University of California San Diego, 9500 Gilman Drive, MC 0735, La Jolla, CA, 92093, USA.

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http://link.springer.com/10.1007/s00109-017-1584-7
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http://dx.doi.org/10.1007/s00109-017-1584-7DOI Listing
December 2017

The Na/HCO co-transporter is protective during ischemia in astrocytes.

Neuroscience 2016 Dec 4;339:329-337. Epub 2016 Oct 4.

Departments of Pediatrics & Neuroscience, University of California-San Diego, La Jolla, CA 92093, United States; Rady Children's Hospital-San Diego, San Diego, CA 92123, United States. Electronic address:

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http://dx.doi.org/10.1016/j.neuroscience.2016.09.050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5118130PMC
December 2016

Senp1 drives hypoxia-induced polycythemia via GATA1 and Bcl-xL in subjects with Monge's disease.

J Exp Med 2016 11 7;213(12):2729-2744. Epub 2016 Nov 7.

Division of Respiratory Medicine, Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093

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http://dx.doi.org/10.1084/jem.20151920DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5110013PMC
November 2016

Intermittent hypoxia induces murine macrophage foam cell formation by IKK-β-dependent NF-κB pathway activation.

J Appl Physiol (1985) 2016 09 28;121(3):670-7. Epub 2016 Jul 28.

Department of Pediatrics, Division of Respiratory Medicine, University of California, San Diego, California; Department of Neurosciences, University of California, San Diego, California; and Rady Children's Hospital, San Diego, California.

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http://www.physiology.org/doi/10.1152/japplphysiol.00307.201
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http://dx.doi.org/10.1152/japplphysiol.00307.2016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5142255PMC
September 2016

Shared Genetic Signals of Hypoxia Adaptation in Drosophila and in High-Altitude Human Populations.

Mol Biol Evol 2016 Feb 17;33(2):501-17. Epub 2015 Nov 17.

Institute for Genomics and Systems Biology, The University of Chicago Department of Human Genetics, The University of Chicago Department of Ecology and Evolution, The University of Chicago Committee on Genetics, Genomics and Systems Biology, The University of Chicago.

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http://dx.doi.org/10.1093/molbev/msv248DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4866538PMC
February 2016

Cardiac responses to hypoxia and reoxygenation in Drosophila.

Am J Physiol Regul Integr Comp Physiol 2015 Dec 16;309(11):R1347-57. Epub 2015 Sep 16.

Development, Aging and Regeneration Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California;

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http://dx.doi.org/10.1152/ajpregu.00164.2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4698404PMC
December 2015

Endothelin receptor B, a candidate gene from human studies at high altitude, improves cardiac tolerance to hypoxia in genetically engineered heterozygote mice.

Proc Natl Acad Sci U S A 2015 Aug 3;112(33):10425-30. Epub 2015 Aug 3.

Department of Pediatrics, Division of Respiratory Medicine, University of California, San Diego, La Jolla, CA 92093; Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093; Rady Children's Hospital, San Diego, CA 92123

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http://www.pnas.org/lookup/doi/10.1073/pnas.1507486112
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http://dx.doi.org/10.1073/pnas.1507486112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4547246PMC
August 2015

High-throughput cell death assays.

Methods Mol Biol 2015 ;1254:153-63

Department of Zoology, University of British Columbia, #4200-6270 University Blvd, Vancouver, BC, V6T 1Z4, Canada,

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http://dx.doi.org/10.1007/978-1-4939-2152-2_12DOI Listing
July 2015

Wnt pathway activation increases hypoxia tolerance during development.

PLoS One 2014 5;9(8):e103292. Epub 2014 Aug 5.

Bioinformatics and Systems Biology Graduate Program, University of California San Diego, La Jolla, California, United States of America; Department of Bioengineering, University of California San Diego, La Jolla, California, United States of America; Departments of Cellular and Molecular Medicine, Chemistry and Biochemistry and Nanoengineering, University of California San Diego, La Jolla, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0103292PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4122365PMC
April 2015

Novel Genes Critical for Hypoxic Preconditioning in Zebrafish Are Regulators of Insulin and Glucose Metabolism.

G3 (Bethesda) 2015 Apr 3;5(6):1107-16. Epub 2015 Apr 3.

Division of Neonatology, University of California San Diego School of Medicine, La Jolla, California 92093 Department of Pediatrics, University of California San Diego School of Medicine, La Jolla, California 92093 Rady Children's Hospital-San Diego, San Diego, California 92123

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http://dx.doi.org/10.1534/g3.115.018010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4478541PMC
April 2015

A Drosophila ABC transporter regulates lifespan.

PLoS Genet 2014 Dec 4;10(12):e1004844. Epub 2014 Dec 4.

Department of Pediatrics (Division of Respiratory Medicine), University of California San Diego, La Jolla, California, United States of America; Rady Children's Hospital San Diego, San Diego, California, United States of America.

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https://dx.plos.org/10.1371/journal.pgen.1004844
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http://dx.doi.org/10.1371/journal.pgen.1004844DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4256198PMC
December 2014

The genetic basis of chronic mountain sickness.

Physiology (Bethesda) 2014 Nov;29(6):403-12

Department of Pediatrics, Division of Respiratory Medicine, University of California San Diego, La Jolla, California; Department of Neurosciences, University of California San Diego, La Jolla, California; and Rady Children's Hospital, San Diego, California.

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http://dx.doi.org/10.1152/physiol.00008.2014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4280153PMC
November 2014

Long-lasting changes in DNA methylation following short-term hypoxic exposure in primary hippocampal neuronal cultures.

PLoS One 2013 25;8(10):e77859. Epub 2013 Oct 25.

Division of Respiratory Medicine, Department of Pediatrics and Biomedical Sciences Graduate Program, University of California San Diego, La Jolla, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0077859PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3808424PMC
September 2014

Hematopoietic stem cells: potential new applications for translational medicine.

J Stem Cells 2014 ;9(3):163-97

University of California San Diego, California, USA

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http://dx.doi.org/jsc.2014.9.3.163DOI Listing
September 2014

Quantitative evaluation of the mitochondrial proteomes of Drosophila melanogaster adapted to extreme oxygen conditions.

PLoS One 2013 12;8(9):e74011. Epub 2013 Sep 12.

Chinese Academy of Sciences Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China ; University of Chinese Academy of Sciences, Beijing, China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0074011PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3771901PMC
May 2014

Fine tuning of the UPR by the ubiquitin ligases Siah1/2.

PLoS Genet 2014 May 8;10(5):e1004348. Epub 2014 May 8.

Tumor Initiation and Maintenance Program, Cancer Center, Sanford-Burnham Medical Research Institute, La Jolla, California, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1004348DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4014425PMC
May 2014

Mitochondrial but not plasmalemmal BK channels are hypoxia-sensitive in human glioma.

Glia 2014 Apr 20;62(4):504-13. Epub 2014 Jan 20.

Section of Respiratory Medicine, Department of Pediatrics, University of California San Diego, La Jolla, California.

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http://dx.doi.org/10.1002/glia.22620DOI Listing
April 2014

MAAMD: a workflow to standardize meta-analyses and comparison of affymetrix microarray data.

BMC Bioinformatics 2014 Mar 12;15:69. Epub 2014 Mar 12.

Department of Pharmacology, University of California, San Diego, La Jolla, CA, USA.

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http://dx.doi.org/10.1186/1471-2105-15-69DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3975178PMC
March 2014

Metabolic and transcriptional response to a high-fat diet in Drosophila melanogaster.

Mol Metab 2014 Feb 23;3(1):42-54. Epub 2013 Oct 23.

Department of Pediatrics (Division of Respiratory Medicine), University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA ; Department of Neurosciences, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA ; Biomedical Sciences Graduate Program, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA ; Rady Children's Hospital, 3020 Children's Way, San Diego, CA 92123, USA.

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http://dx.doi.org/10.1016/j.molmet.2013.10.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3929909PMC
February 2014

Genetic analysis of hypoxia tolerance and susceptibility in Drosophila and humans.

Annu Rev Genomics Hum Genet 2013 26;14:25-43. Epub 2013 Jun 26.

Department of Pediatrics (Division of Respiratory Medicine) and.

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http://www.annualreviews.org/doi/10.1146/annurev-genom-09121
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http://dx.doi.org/10.1146/annurev-genom-091212-153439DOI Listing
December 2013

Multiscale modeling of the causal functional roles of nsSNPs in a genome-wide association study: application to hypoxia.

BMC Genomics 2013 28;14 Suppl 3:S9. Epub 2013 May 28.

Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA 92093, USA.

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http://dx.doi.org/10.1186/1471-2164-14-S3-S9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3665574PMC
October 2013

Role of high-fat diet in stress response of Drosophila.

PLoS One 2012 1;7(8):e42587. Epub 2012 Aug 1.

Department of Pediatrics (Division of Respiratory Medicine) and Biomedical Sciences Graduate Program, University of California San Diego, La Jolla, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0042587PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3411628PMC
February 2013

DIDS prevents ischemic membrane degradation in cultured hippocampal neurons by inhibiting matrix metalloproteinase release.

PLoS One 2012 24;7(8):e43995. Epub 2012 Aug 24.

Division of Respiratory Medicine, Department of Pediatrics, University of California San Diego, La Jolla, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0043995PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3427179PMC
February 2013

Genetic animal models of preconditioning.

Transl Stroke Res 2013 Feb 22;4(1):51-5. Epub 2012 Nov 22.

Department of Pediatrics (Section of Respiratory Medicine), University of California-San Diego, La Jolla, CA 92093, USA.

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http://dx.doi.org/10.1007/s12975-012-0218-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3614364PMC
February 2013

Chemokine receptor-like 2 is involved in ischemic brain injury.

J Exp Stroke Transl Med 2013 Feb;6:1-6

Department of Pediatrics, University of California-San Diego, La Jolla, CA 92093.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3705577PMC
February 2013

Sudden and unexpected death in early life: proceedings of a symposium in honor of Dr. Henry F. Krous.

Forensic Sci Med Pathol 2012 Dec 1;8(4):414-25. Epub 2012 Sep 1.

Department of Pathology, Boston Children's Hospital and Harvard Medical School, 300 Longwood Avenue, Enders Building 1112, Boston, MA 02115, USA.

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http://dx.doi.org/10.1007/s12024-012-9376-4DOI Listing
December 2012

Painted turtle cortex is resistant to an in vitro mimic of the ischemic mammalian penumbra.

J Cereb Blood Flow Metab 2012 Nov 18;32(11):2033-43. Epub 2012 Jul 18.

Division of Respiratory Medicine, Department of Pediatrics, University of California San Diego, La Jolla, California 92093-0735, USA.

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http://dx.doi.org/10.1038/jcbfm.2012.103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3493991PMC
November 2012

Tests of selection in pooled case-control data: an empirical study.

Front Genet 2011 28;2:83. Epub 2011 Nov 28.

Bioinformatics and Systems Biology Graduate Program, University of California San Diego La Jolla, CA, USA.

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http://dx.doi.org/10.3389/fgene.2011.00083DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3268381PMC
October 2012

Identification of genes underlying hypoxia tolerance in Drosophila by a P-element screen.

G3 (Bethesda) 2012 Oct 1;2(10):1169-78. Epub 2012 Oct 1.

Department of Pediatrics, University of California-San Diego, La Jolla, California 92093, USA.

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http://dx.doi.org/10.1534/g3.112.003681DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3464109PMC
October 2012

Hypoxia-adaptation involves mitochondrial metabolic depression and decreased ROS leakage.

PLoS One 2012 4;7(5):e36801. Epub 2012 May 4.

Department of Medicine, University of California San Diego, San Diego, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0036801PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3344937PMC
September 2012

Clinical effectiveness and safety of permissive hypercapnia.

Clin Perinatol 2012 Sep;39(3):603-12

Department of Pediatrics, Rady Children's Hospital, University of California San Diego, 9500 Gilman Drive, MC 0735, La Jolla, CA 92093, USA.

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http://dx.doi.org/10.1016/j.clp.2012.06.001DOI Listing
September 2012

The utility of a portable recording device for screening of obstructive sleep apnea in obese adolescents.

J Clin Sleep Med 2012 Jun 15;8(3):271-7. Epub 2012 Jun 15.

Departments of Pediatrics (Division of Pediatric Respiratory Medicine), University of California-San Diego School of Medicine, San Diego, CA, USA.

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http://dx.doi.org/10.5664/jcsm.1912DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3365085PMC
June 2012

Does hyperoxia selection cause adaptive alterations of mitochondrial electron transport chain activity leading to a reduction of superoxide production?

Antioxid Redox Signal 2012 May 23;16(10):1071-6. Epub 2012 Feb 23.

Department of Pediatrics, University of California-San Diego, La Jolla, California, USA.

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http://dx.doi.org/10.1089/ars.2011.4504DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3315163PMC
May 2012

An in vitro ischemic penumbral mimic perfusate increases NADPH oxidase-mediated superoxide production in cultured hippocampal neurons.

Brain Res 2012 May 9;1452:165-72. Epub 2012 Mar 9.

Department of Pediatrics, Division of Respiratory Medicine, University of California San Diego, La Jolla, CA 92093, USA.

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http://dx.doi.org/10.1016/j.brainres.2012.03.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3326196PMC
May 2012

Hypoxia induces Kv channel current inhibition by increased NADPH oxidase-derived reactive oxygen species.

Free Radic Biol Med 2012 Mar 16;52(6):1033-42. Epub 2011 Dec 16.

Excellence Cluster Cardio-Pulmonary System, University of Giessen Lung Center, Justus-Liebig-University, Medical Clinic II/V, Aulweg 130, Giessen 35392, Germany.

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https://linkinghub.elsevier.com/retrieve/pii/S08915849110122
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http://dx.doi.org/10.1016/j.freeradbiomed.2011.12.004DOI Listing
March 2012

Distinct role of Hsp70 in Drosophila hemocytes during severe hypoxia.

Free Radic Biol Med 2011 Jul 13;51(2):530-8. Epub 2011 May 13.

Section of Respiratory Medicine, Department of Pediatrics, University of California at San Diego, La Jolla, CA 92093, USA.

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http://dx.doi.org/10.1016/j.freeradbiomed.2011.05.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3138732PMC
July 2011

Does the brain gain back energy during sleep? But what does it mean?

Authors:
Gabriel G Haddad

Sleep 2011 Jul 1;34(7):835-6. Epub 2011 Jul 1.

University of California, San Diego and Rady Children's Hospital, San Diego, CA 92093-0735 , USA.

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https://academic.oup.com/sleep/article-lookup/doi/10.5665/SL
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http://dx.doi.org/10.5665/SLEEP.1104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3119555PMC
July 2011

Antimicrobial peptides increase tolerance to oxidant stress in Drosophila melanogaster.

J Biol Chem 2011 Feb 9;286(8):6211-8. Epub 2010 Dec 9.

Division of Respiratory Medicine, Department of Pediatrics, University of California San Diego, La Jolla, California 92093, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M110.181206
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http://dx.doi.org/10.1074/jbc.M110.181206DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3057857PMC
February 2011

Experimental selection of hypoxia-tolerant Drosophila melanogaster.

Proc Natl Acad Sci U S A 2011 Feb 24;108(6):2349-54. Epub 2011 Jan 24.

Department of Pediatrics, University of California at San Diego, La Jolla, CA 92093, USA.

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http://dx.doi.org/10.1073/pnas.1010643108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3038716PMC
February 2011

Severe Hypoxia: Consequences to Neural Stem Cells and Neurons.

J Neurol Res 2011 ;1(5)

Departments of Pediatrics, University of California San Diego, School of Medicine, USA ; Departments of Neuroscience, University of California San Diego, School of Medicine, USA ; Rady Children's Hospital-San Diego, USA.

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http://dx.doi.org/10.4021/jnr70wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3858017PMC
January 2011

Hematopoietic stem cell transplantation protects mice from lethal stroke.

Exp Neurol 2010 Oct 12;225(2):284-93. Epub 2010 Jun 12.

University of California San Diego, School of Medicine, Departments of Pediatrics, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S001448861000202
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http://dx.doi.org/10.1016/j.expneurol.2010.06.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2963425PMC
October 2010

Elevated myocardial Na+/H+ exchanger isoform 1 activity elicits gene expression that leads to cardiac hypertrophy.

Physiol Genomics 2010 Aug 11;42(3):374-83. Epub 2010 May 11.

Department of Pediatrics, University of California San Diego, La Jolla, California 92093-0735, USA.

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http://dx.doi.org/10.1152/physiolgenomics.00064.2010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2929882PMC
August 2010

Chronic hypercapnia alters lung matrix composition in mouse pups.

J Appl Physiol (1985) 2010 Jul 1;109(1):203-10. Epub 2010 Apr 1.

University of California, San Diego, Department of Pediatrics, Section of Respiratory Medicine, 9500 Gilman Dr., MC 0735, La Jolla, CA 92093, USA.

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http://dx.doi.org/10.1152/japplphysiol.00610.2009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2904197PMC
July 2010

Experimental selection for Drosophila survival in extremely high O2 environments.

PLoS One 2010 Jul 23;5(7):e11701. Epub 2010 Jul 23.

Division of Respiratory Medicine, Department of Pediatrics, University of California San Diego, La Jolla, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0011701PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2909141PMC
July 2010

Neuronal death during combined intermittent hypoxia/hypercapnia is due to mitochondrial dysfunction.

Am J Physiol Cell Physiol 2010 Jun 31;298(6):C1594-602. Epub 2010 Mar 31.

Department of Medicine, University of California, San Diego School of Medicine, La Jolla, CA 92093, USA.

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http://dx.doi.org/10.1152/ajpcell.00298.2009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2889641PMC
June 2010

The asparaginyl hydroxylase factor inhibiting HIF-1alpha is an essential regulator of metabolism.

Cell Metab 2010 May 15;11(5):364-78. Epub 2010 Apr 15.

Molecular Biology Section, Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA.

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http://dx.doi.org/10.1016/j.cmet.2010.03.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2893150PMC
May 2010

Insulin/PI3K signaling protects dentate neurons from oxygen-glucose deprivation in organotypic slice cultures.

J Neurochem 2010 Jan 26;112(2):377-88. Epub 2009 Oct 26.

Department of Pediatrics (Section of Respiratory Medicine), University of California, San Diego, La Jolla, California 92037-0735, USA.

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http://dx.doi.org/10.1111/j.1471-4159.2009.06450.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4524356PMC
January 2010

Heart rhythm genomic fabric in hypoxia.

Biochem Biophys Res Commun 2010 Jan 31;391(4):1769-74. Epub 2009 Dec 31.

DP Purupura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

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http://dx.doi.org/10.1016/j.bbrc.2009.12.151DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2849310PMC
January 2010

Epidermal growth factor receptor translocation to the mitochondria: regulation and effect.

J Biol Chem 2009 Dec 19;284(52):36592-604. Epub 2009 Oct 19.

Department of Microbiology and the Cancer Center, University of Virginia, Charlottesville, Virginia 22908, USA.

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http://dx.doi.org/10.1074/jbc.M109.000760DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2794774PMC
December 2009

Introduction to hypoxia and consequences: from molecule to malady.

Ann N Y Acad Sci 2009 Oct;1177

University of Leeds, Leeds, United Kingdom.

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http://dx.doi.org/10.1111/j.1749-6632.2009.05044.xDOI Listing
October 2009

Survival in acute and severe low o environment: use of a genetic model system.

Ann N Y Acad Sci 2009 Oct;1177:39-47

Department of Pediatrics (Section of Respiratory Medicine), 9500 Gilman Dr. MC0735, La Jolla, CA 92093, USA.

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October 2009

Hypoxia selectively inhibits KCNA5 channels in pulmonary artery smooth muscle cells.

Ann N Y Acad Sci 2009 Oct;1177:101-11

Department of Medicine, University of California, San Diego, La Jolla, CA 92093-0725, USA.

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http://dx.doi.org/10.1111/j.1749-6632.2009.05040.xDOI Listing
October 2009

Drosophila, a golden bug, for the dissection of the genetic basis of tolerance and susceptibility to hypoxia.

Pediatr Res 2009 Sep;66(3):239-47

Department of Pediatrics, University of California, San Diego, California 92093, USA.

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http://dx.doi.org/10.1203/PDR.0b013e3181b27275DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6620046PMC
September 2009

Metabolism as means for hypoxia adaptation: metabolic profiling and flux balance analysis.

BMC Syst Biol 2009 Sep 9;3:91. Epub 2009 Sep 9.

Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1186/1752-0509-3-91DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2749811PMC
September 2009

Distinct mechanisms underlying tolerance to intermittent and constant hypoxia in Drosophila melanogaster.

PLoS One 2009 29;4(4):e5371. Epub 2009 Apr 29.

Department of Pediatrics, Section of Respiratory Medicine, University of California San Diego, La Jolla, California, United States of America.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2670512PMC
July 2009

Genetic and pharmacological inhibition of JNK ameliorates hypoxia-induced retinopathy through interference with VEGF expression.

Proc Natl Acad Sci U S A 2009 May 11;106(21):8760-5. Epub 2009 May 11.

Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0723, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0902659106
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2688966PMC
May 2009

DIDS protects against neuronal injury by blocking Toll-like receptor 2 activated-mechanisms.

J Neurochem 2009 Feb 10;108(3):835-46. Epub 2008 Dec 10.

Department of Pediatrics (Section of Respiratory Medicine), University of California San Diego, La Jolla, California 92093-0735, USA.

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http://dx.doi.org/10.1111/j.1471-4159.2008.05838.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2782475PMC
February 2009

Can O2 dysregulation induce premature aging?

Physiology (Bethesda) 2008 Dec;23:333-49

Department of Pediatrics, University of California San Diego, and Rady Children's Hospital-San Diego, San Diego, La Jolla, CA, USA.

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http://dx.doi.org/10.1152/physiol.00023.2008DOI Listing
December 2008

Hypoxia increases activity of the BK-channel in the inner mitochondrial membrane and reduces activity of the permeability transition pore.

Cell Physiol Biochem 2008 25;22(1-4):127-36. Epub 2008 Jul 25.

Dept. of Neurology, Otto-von-Guericke-University, Magdeburg, Germany.

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http://dx.doi.org/10.1159/000149790DOI Listing
November 2008

Effects of chronic continuous hypoxia on the expression of SLC4A8 (NDCBE) in neonatal versus adult mouse brain.

Brain Res 2008 Oct 23;1238:85-92. Epub 2008 Aug 23.

Department of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, OH 44106-4970, USA.

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http://dx.doi.org/10.1016/j.brainres.2008.08.033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3222586PMC
October 2008

Mechanisms underlying hypoxia tolerance in Drosophila melanogaster: hairy as a metabolic switch.

PLoS Genet 2008 Oct 17;4(10):e1000221. Epub 2008 Oct 17.

Department of Pediatrics, University of California San Diego, La Jolla, California, United States of America.

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https://dx.plos.org/10.1371/journal.pgen.1000221
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2556400PMC
October 2008

Integrated transcriptomic response to cardiac chronic hypoxia: translation regulators and response to stress in cell survival.

Funct Integr Genomics 2008 Aug 1;8(3):265-75. Epub 2008 May 1.

DP Purpura Department of Neuroscience, Kennedy Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

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http://dx.doi.org/10.1007/s10142-008-0082-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2856931PMC
August 2008

NF-kappaB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1alpha.

Nature 2008 Jun 23;453(7196):807-11. Epub 2008 Apr 23.

Laboratory of Gene Regulation and Signal Transduction, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0723, USA.

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http://dx.doi.org/10.1038/nature06905DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2669289PMC
June 2008

Modulation of hSlo BK current inactivation by fatty acid esters of CoA.

J Neurochem 2008 Mar 14;104(5):1394-403. Epub 2007 Nov 14.

Department of Pediatrics (Section of Respiratory Medicine), University of California San Diego, La Jolla, California 92037-0735, USA.

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http://doi.wiley.com/10.1111/j.1471-4159.2007.05083.x
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March 2008

Role of transporters and ion channels in neuronal injury under hypoxia.

Am J Physiol Regul Integr Comp Physiol 2008 Feb 31;294(2):R451-7. Epub 2007 Oct 31.

Department of Pediatrics, University of California-San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0735, USA.

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http://dx.doi.org/10.1152/ajpregu.00528.2007DOI Listing
February 2008

Gene expression in mouse brain following chronic hypoxia: role of sarcospan in glial cell death.

Physiol Genomics 2008 Feb 4;32(3):370-9. Epub 2007 Dec 4.

Department of Pediatrics (Section of Respiratory Medicine) and Neuroscience, University of California San Diego, La Jolla, CA 92093-0735, USA.

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http://dx.doi.org/10.1152/physiolgenomics.00147.2007DOI Listing
February 2008

Differential effects of chronic intermittent and chronic constant hypoxia on postnatal growth and development.

Pediatr Pulmonol 2008 Jan;43(1):20-8

Department of Pediatrics, New York Medical College, Valhalla, New York, USA.

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http://doi.wiley.com/10.1002/ppul.20729
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January 2008