Gabriel E Hoffman

Gabriel E Hoffman

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Gabriel E Hoffman

Gabriel E Hoffman

Publications by authors named "Gabriel E Hoffman"

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decorate: Differential Epigenetic Correlation Test.

Bioinformatics 2020 Jan 31. Epub 2020 Jan 31.

Pamela Sklar Division of Psychiatric Genomics.

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http://dx.doi.org/10.1093/bioinformatics/btaa067DOI Listing
January 2020

Functional interpretation of genetic variants using deep learning predicts impact on chromatin accessibility and histone modification.

Nucleic Acids Res 2019 Nov;47(20):10597-10611

Pamela Sklar Division of Psychiatric Genomics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

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http://dx.doi.org/10.1093/nar/gkz808DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6847046PMC
November 2019

Integrative transcriptome imputation reveals tissue-specific and shared biological mechanisms mediating susceptibility to complex traits.

Nat Commun 2019 08 23;10(1):3834. Epub 2019 Aug 23.

Department of Psychiatry, Pamela Sklar Division of Psychiatric Genomics and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.

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http://dx.doi.org/10.1038/s41467-019-11874-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6707297PMC
August 2019

New considerations for hiPSC-based models of neuropsychiatric disorders.

Mol Psychiatry 2019 01 26;24(1):49-66. Epub 2018 Feb 26.

Department of Genetics and Genomics, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.

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http://dx.doi.org/10.1038/s41380-018-0029-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109625PMC
January 2019

A Nasal Brush-based Classifier of Asthma Identified by Machine Learning Analysis of Nasal RNA Sequence Data.

Sci Rep 2018 06 11;8(1):8826. Epub 2018 Jun 11.

Icahn Institute for Genomics and Multiscale Biology and Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

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http://dx.doi.org/10.1038/s41598-018-27189-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5995932PMC
June 2018

Mapping regulatory variants in hiPSC models.

Nat Genet 2018 01;50(1):1-2

Department of Genetics and Genomics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

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http://dx.doi.org/10.1038/s41588-017-0017-4DOI Listing
January 2018

Analysis of Transcriptional Variability in a Large Human iPSC Library Reveals Genetic and Non-genetic Determinants of Heterogeneity.

Cell Stem Cell 2017 04 22;20(4):518-532.e9. Epub 2016 Dec 22.

Department of Developmental and Regenerative Biology, Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

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http://dx.doi.org/10.1016/j.stem.2016.11.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5384872PMC
April 2017

variancePartition: interpreting drivers of variation in complex gene expression studies.

BMC Bioinformatics 2016 Nov 25;17(1):483. Epub 2016 Nov 25.

Department of Genetics and Genomic Sciences, Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, USA.

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http://dx.doi.org/10.1186/s12859-016-1323-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5123296PMC
November 2016

Comparative analyses of population-scale phenomic data in electronic medical records reveal race-specific disease networks.

Bioinformatics 2016 06;32(12):i101-i110

Department of Genetics and Genomic Sciences Icahn Institute for Genomics and Multiscale Biology Harris Center for Precision Wellness, Icahn School of Medicine at Mount Sinai, New York City, NY 10029, USA Department of Population Health Science and Policy, New York City, NY 10029, USA.

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https://academic.oup.com/bioinformatics/article-lookup/doi/1
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http://dx.doi.org/10.1093/bioinformatics/btw282DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4908366PMC
June 2016

Improved integrative framework combining association data with gene expression features to prioritize Crohn's disease genes.

Hum Mol Genet 2015 Jul 1;24(14):4147-57. Epub 2015 May 1.

Department of Genetics and Genomic Sciences, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA,

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http://dx.doi.org/10.1093/hmg/ddv142DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4560067PMC
July 2015

lrgpr: interactive linear mixed model analysis of genome-wide association studies with composite hypothesis testing and regression diagnostics in R.

Bioinformatics 2014 Nov 16;30(21):3134-5. Epub 2014 Jul 16.

Department of Genetics and Genomic Sciences, Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY, USA, Department of Biological Statistics and Computational Biology, Cornell University, Ithaca, USA and Department of Genetic Medicine, Weill Cornell Medical College, New York, NY, USA Department of Genetics and Genomic Sciences, Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY, USA, Department of Biological Statistics and Computational Biology, Cornell University, Ithaca, USA and Department of Genetic Medicine, Weill Cornell Medical College, New York, NY, USA.

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http://dx.doi.org/10.1093/bioinformatics/btu435DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4201153PMC
November 2014

Correcting for population structure and kinship using the linear mixed model: theory and extensions.

PLoS One 2013 28;8(10):e75707. Epub 2013 Oct 28.

Department of Biological Statistics and Computational Biology, Cornell University, Ithaca, New York, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0075707PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3810480PMC
August 2014

PUMA: a unified framework for penalized multiple regression analysis of GWAS data.

PLoS Comput Biol 2013 27;9(6):e1003101. Epub 2013 Jun 27.

Department of Biological Statistics and Computational Biology, Cornell University, Ithaca, New York, United States of America.

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http://dx.doi.org/10.1371/journal.pcbi.1003101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3694815PMC
January 2014

Mouse obesity network reconstruction with a variational Bayes algorithm to employ aggressive false positive control.

BMC Bioinformatics 2012 Apr 2;13:53. Epub 2012 Apr 2.

1Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.

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http://dx.doi.org/10.1186/1471-2105-13-53DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3338387PMC
April 2012

Evolution of light-harvesting complex proteins from Chl c-containing algae.

BMC Evol Biol 2011 Apr 15;11:101. Epub 2011 Apr 15.

Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742, USA.

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http://dx.doi.org/10.1186/1471-2148-11-101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3096602PMC
April 2011

A variational Bayes algorithm for fast and accurate multiple locus genome-wide association analysis.

BMC Bioinformatics 2010 Jan 27;11:58. Epub 2010 Jan 27.

Department of Biological Statistics and Computational Biology, Cornell University, Ithaca, NY, USA.

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http://bmcbioinformatics.biomedcentral.com/articles/10.1186/
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http://dx.doi.org/10.1186/1471-2105-11-58DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2824680PMC
January 2010