Gabor Tigyi

Gabor Tigyi

UNVERIFIED PROFILE

Are you Gabor Tigyi?   Register this Author

Register author
Gabor Tigyi

Gabor Tigyi

Publications by authors named "Gabor Tigyi"

Are you Gabor Tigyi?   Register this Author

100Publications

1916Reads

41Profile Views

Osteoclast-Derived Autotaxin, a Distinguishing Factor for Inflammatory Bone Loss.

Arthritis Rheumatol 2019 Jun 4. Epub 2019 Jun 4.

INSERM UMR 1033 LYOS and University of Lyon I, Lyon, France, and Lyon Sud Hospital, Pierre-Bénite, France.

View Article

Download full-text PDF

Source
https://onlinelibrary.wiley.com/doi/abs/10.1002/art.41005
Publisher Site
http://dx.doi.org/10.1002/art.41005DOI Listing
June 2019

LPA Is an Inhibitory Receptor That Suppresses CD8 T-Cell Cytotoxic Function via Disruption of Early TCR Signaling.

Front Immunol 2019 28;10:1159. Epub 2019 May 28.

Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, CO, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fimmu.2019.01159DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6558414PMC
May 2019

Regulation of tumor cell - Microenvironment interaction by the autotaxin-lysophosphatidic acid receptor axis.

Adv Biol Regul 2019 Jan 16;71:183-193. Epub 2018 Sep 16.

Department of Physiology, University of Tennessee Health Science Center Memphis, Memphis, TN, 38163, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jbior.2018.09.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433480PMC
January 2019

The LPA receptor agonist Radioprotectin-1 spares Lgr5-positive intestinal stem cells from radiation injury in murine enteroids.

Cell Signal 2018 11 29;51:23-33. Epub 2018 Jul 29.

Research Division, VA Medical Center, 1030 Jefferson Avenue, Memphis, TN 38104, United States; Department of Physiology, University of Tennessee Health Science Center Memphis, 3N Dunlap Street, Memphis, TN 38163, United States. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cellsig.2018.07.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6163127PMC
November 2018

Role of autotaxin in cancer stem cells.

Cancer Metastasis Rev 2018 09;37(2-3):509-518

Department of Physiology, Pusan National University School of Medicine, Yangsan, 50612, Gyeongsangnam-do, Republic of Korea.

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s10555-018-9745-x
Publisher Site
http://dx.doi.org/10.1007/s10555-018-9745-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6309296PMC
September 2018

Highly Potent Non-Carboxylic Acid Autotaxin Inhibitors Reduce Melanoma Metastasis and Chemotherapeutic Resistance of Breast Cancer Stem Cells.

J Med Chem 2017 02 10;60(4):1309-1324. Epub 2017 Feb 10.

Department of Pharmaceutical Sciences, College of Pharmacy, ‡Department of Physiology, College of Medicine, University of Tennessee Health Science Center , Memphis, Tennessee 38163, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.jmedchem.6b01270DOI Listing
February 2017

Discovery and synthetic optimization of a novel scaffold for hydrophobic tunnel-targeted autotaxin inhibition.

Bioorg Med Chem 2016 10 4;24(19):4660-4674. Epub 2016 Aug 4.

Department of Chemistry, University of Memphis, 3744 Walker Avenue, Memphis, TN 38152, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmc.2016.08.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5023007PMC
October 2016

Novel Inhibitory Effect of a Lysophosphatidic Acid 2 Agonist on Allergen-Driven Airway Inflammation.

Am J Respir Cell Mol Biol 2016 Mar;54(3):402-9

1 Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1165/rcmb.2015-0124OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4821034PMC
March 2016

A reflection of the lasting contributions from Dr. Robert Bittman to sterol trafficking, sphingolipid and phospholipid research.

Prog Lipid Res 2016 Jan 14;61:19-29. Epub 2015 Nov 14.

Department of Physiology, University of Tennessee, Health Science Center, 894 Union Avenue, Memphis, TN 38163, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.plipres.2015.10.003DOI Listing
January 2016

Sphingosine 1-phosphate is a ligand for peroxisome proliferator-activated receptor-γ that regulates neoangiogenesis.

FASEB J 2015 Sep 18;29(9):3638-53. Epub 2015 May 18.

*Centre for Cancer Biology, SA Pathology and University of South Australia, Adelaide, South Australia, Australia; School of Medicine, University of Adelaide, Adelaide, South Australia, Australia; Co-operative Research Centre for Biomarker Translation, La Trobe University, Melbourne, Victoria, Australia; and Department of Physiology, The University of Tennessee Health Science Center, Memphis, Tennessee, USA

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1096/fj.14-261289DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6137673PMC
September 2015

Doxycycline inducible Krüppel-like factor 4 lentiviral vector mediates mesenchymal to epithelial transition in ovarian cancer cells.

PLoS One 2014 19;9(8):e105331. Epub 2014 Aug 19.

Department of Pathology and Laboratory Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America; Center for Cancer Research, University of Tennessee Health Science Center, Memphis, Tennessee, United States of America.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0105331PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4138168PMC
May 2015

Opposing regulation of megakaryopoiesis by LPA receptors 2 and 3 in K562 human erythroleukemia cells.

Biochim Biophys Acta 2015 Feb 21;1851(2):172-83. Epub 2014 Nov 21.

Department of Life Science, National Taiwan University, Taipei, Taiwan, ROC; Department of Electrical Engineering, National Taiwan University, Taipei, Taiwan, ROC; Angiogenesis Research Center, National Taiwan University, Taipei, Taiwan, ROC; Research Center for Developmental Biology and Regenerative Medicine, National Taiwan University, Taipei, Taiwan, ROC; Center for Biotechnology, National Taiwan University, Taipei, Taiwan, ROC. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbalip.2014.11.009DOI Listing
February 2015

Uncovering unique roles of LPA receptors in the tumor microenvironment.

Receptors Clin Investig 2015;2(1)

Department of Physiology, College of Medicine, University of Tennessee Health Science Center, 894 Union Avenue, Memphis, TN 38163, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.14800/rci.440DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4438998PMC
January 2015

miR-203 Functions as a Tumor Suppressor by Inhibiting Epithelial to Mesenchymal Transition in Ovarian Cancer.

J Cancer Sci Ther 2015;7(2):34-43

Department of Pathology and Laboratory Medicine, University of Tennessee Health Science Center, USA; Center for Cancer Research, University of Tennessee Health Science Center, Memphis, TN, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4172/1948-5956.1000322DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4725318PMC
January 2015

Asymmetrical macromolecular complex formation of lysophosphatidic acid receptor 2 (LPA2) mediates gradient sensing in fibroblasts.

J Biol Chem 2014 Dec 5;289(52):35757-69. Epub 2014 Nov 5.

From the Department of Physiology, University of Tennessee Health Science Center, Memphis, Tennessee 38163, the Division of Pulmonary Medicine, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229,

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M114.595512DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4276845PMC
December 2014

In honor of Robert Bittman 1942-2014.

Authors:
Gabor Tigyi

Biochim Biophys Acta 2014 Dec;1841(12):1752-3

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbalip.2014.10.005DOI Listing
December 2014

Interaction of platelet-derived autotaxin with tumor integrin αVβ3 controls metastasis of breast cancer cells to bone.

Blood 2014 Nov 2;124(20):3141-50. Epub 2014 Oct 2.

Institut National de la Santé et de la Recherche Médicale, Unité Mixte de Recherche 1033, Université Claude Bernard Lyon 1, Faculté de Médecine Lyon Est, Lyon, France;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1182/blood-2014-04-568683DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4231421PMC
November 2014

Structural determinants of the transient receptor potential 1 (TRPV1) channel activation by phospholipid analogs.

J Biol Chem 2014 Aug 17;289(35):24079-90. Epub 2014 Jul 17.

From the Departamento de Neurodesarrollo y Fisiología, División de Neurociencias, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, México D.F. 04510, México,

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M114.572503DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4148841PMC
August 2014

Design and synthesis of sulfamoyl benzoic acid analogues with subnanomolar agonist activity specific to the LPA2 receptor.

J Med Chem 2014 Aug 12;57(16):7136-40. Epub 2014 Aug 12.

Departments of Pharmaceutical Sciences and ‡Physiology, The University of Tennessee Health Science Center , Memphis, Tennessee 894 Union Avenue 38163 United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/jm5007116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4148159PMC
August 2014

Lysophosphatidic acid inhibits CD8 T cell activation and control of tumor progression.

Cancer Immunol Res 2013 Oct;1(4):245-55

Integrated Department of Immunology, University of Colorado Denver and National Jewish Health, Denver, Colorado.

View Article

Download full-text PDF

Source
http://cancerimmunolres.aacrjournals.org/cgi/doi/10.1158/232
Publisher Site
http://dx.doi.org/10.1158/2326-6066.CIR-13-0043-TDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3893823PMC
October 2013

The transcription factor CREB enhances interleukin-17A production and inflammation in a mouse model of atherosclerosis.

Sci Signal 2013 Sep 17;6(293):ra83. Epub 2013 Sep 17.

Department of Physiology, University of Tennessee Health Science Center, 894 Union Avenue, Memphis, TN 38163, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1126/scisignal.2004214DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3931132PMC
September 2013

Regulation of interleukin-6 secretion by the two-pore-domain potassium channel Trek-1 in alveolar epithelial cells.

Am J Physiol Lung Cell Mol Physiol 2013 Feb 28;304(4):L276-86. Epub 2012 Dec 28.

Department of Pediatrics, University of Tennessee Health Science Center, Memphis, TN 38103, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/ajplung.00299.2012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3567358PMC
February 2013

Role of the autotaxin-lysophosphatidate axis in cancer resistance to chemotherapy and radiotherapy.

Biochim Biophys Acta 2013 Jan 29;1831(1):74-85. Epub 2012 Aug 29.

Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbalip.2012.08.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3584168PMC
January 2013

Integrating the puzzle pieces: the current atomistic picture of phospholipid-G protein coupled receptor interactions.

Biochim Biophys Acta 2013 Jan 12;1831(1):2-12. Epub 2012 Sep 12.

Department of Chemistry, The University of Memphis, Memphis, TN 38152, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbalip.2012.09.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3591812PMC
January 2013

New trends in lysophospholipid research.

Authors:
Gabor Tigyi

Biochim Biophys Acta 2013 Jan 23;1831(1). Epub 2012 Sep 23.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbalip.2012.09.011DOI Listing
January 2013

High-throughput assays to measure intracellular Ca²⁺ mobilization in cells that express recombinant S1P receptor subtypes.

Methods Mol Biol 2012 ;874:77-87

Department of Physiology, The University of Tennessee Health Science Center, Memphis, TN, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-1-61779-800-9_7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3617928PMC
November 2012

Controlling cancer through the autotaxin-lysophosphatidic acid receptor axis.

Biochem Soc Trans 2012 Feb;40(1):31-6

Department of Physiology, College of Medicine, University of Tennessee Health Science Center, 894 Union Avenue, Memphis, TN 38163, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1042/BST20110608DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3590848PMC
February 2012

Lipids: LPA activates TRPV1--and it hurts.

Authors:
Gabor Tigyi

Nat Chem Biol 2011 Dec 15;8(1):22-3. Epub 2011 Dec 15.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nchembio.738DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3584167PMC
December 2011

Conditional deletion of Dicer in vascular smooth muscle cells leads to the developmental delay and embryonic mortality.

Biochem Biophys Res Commun 2011 May 28;408(3):369-74. Epub 2011 Feb 28.

Department of Physiology, University of Tennessee Health Science Center, Memphis, TN 38163, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbrc.2011.02.119DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3595544PMC
May 2011

Location, location, location: a crystal-clear view of autotaxin saturating LPA receptors.

Nat Struct Mol Biol 2011 Feb;18(2):117-8

Department of Systems Biology, Kleberg Center for Molecular Markers, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nsmb0211-117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3584164PMC
February 2011

Lysophosphatidic acid-activated Cl- current activity in human systemic sclerosis skin fibroblasts.

Rheumatology (Oxford) 2010 Dec 7;49(12):2290-7. Epub 2010 Sep 7.

Department of Physiology, University of Tennessee Health Science Center, 894 Union Ave., Memphis, TN 38163, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/rheumatology/keq260DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2981513PMC
December 2010

Synthesis and pharmacological evaluation of the stereoisomers of 3-carba cyclic-phosphatidic acid.

Bioorg Med Chem Lett 2010 Dec 8;20(24):7525-8. Epub 2010 Oct 8.

Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, Memphis, TN 38163, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmcl.2010.09.115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3040411PMC
December 2010

Sphingosine 1-phosphate receptor 4 uses HER2 (ERBB2) to regulate extracellular signal regulated kinase-1/2 in MDA-MB-453 breast cancer cells.

J Biol Chem 2010 Nov 13;285(46):35957-66. Epub 2010 Sep 13.

Cell Biology Group, Strathclyde Institute of Pharmacy and Biomedical Science, Univesity of Strathclyde, 161 Cathedral Street, Glasgow G4 0RE, Scotland, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M110.117945DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2975218PMC
November 2010

Development of an LC-MS/MS assay to determine plasma pharmacokinetics of the radioprotectant octadecenyl thiophosphate (OTP) in monkeys.

J Chromatogr B Analyt Technol Biomed Life Sci 2010 Sep 18;878(26):2379-83. Epub 2010 Jul 18.

Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Advanced Cancer Detection Center, Samuel Lunenfeld Research Institute, Toronto, ON, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jchromb.2010.07.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2965032PMC
September 2010

Aiming drug discovery at lysophosphatidic acid targets.

Authors:
Gabor Tigyi

Br J Pharmacol 2010 Sep;161(2):241-70

Department of Physiology, University of Tennessee Health Science Center, Memphis, TN, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1476-5381.2010.00815.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2989581PMC
September 2010

Autotaxin delays apoptosis induced by carboplatin in ovarian cancer cells.

Cell Signal 2010 Jun 25;22(6):926-35. Epub 2010 Jan 25.

Section of Medicine, The Institute of Cancer Research, 15 Cotswold Road, Sutton, SM2 5NG, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cellsig.2010.01.017DOI Listing
June 2010

2D binary QSAR modeling of LPA3 receptor antagonism.

J Mol Graph Model 2010 Jun 7;28(8):828-33. Epub 2010 Mar 7.

Department of Chemistry and Computational Research on Materials Institute, The University of Memphis, Memphis, TN 38152, United States.

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S10933263100004
Publisher Site
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2873117PMC
http://dx.doi.org/10.1016/j.jmgm.2010.03.002DOI Listing
June 2010

Conservation of miR-15a/16-1 and miR-15b/16-2 clusters.

Mamm Genome 2010 Feb 16;21(1-2):88-94. Epub 2009 Dec 16.

Department of Physiology, University of Tennessee Health Science Center, CRB, 19 S. Manassas St, Memphis, TN, 38163, USA.

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s00335-009-9240-3
Publisher Site
http://dx.doi.org/10.1007/s00335-009-9240-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2820079PMC
February 2010

Lysophosphatidic acid-induced arterial wall remodeling: requirement of PPARgamma but not LPA1 or LPA2 GPCR.

Cell Signal 2009 Dec 23;21(12):1874-84. Epub 2009 Aug 23.

Department of Physiology, University of Tennessee Health Science Center, 894 Union Ave., Suite 426, Memphis, TN 38163, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cellsig.2009.08.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2760670PMC
December 2009

Structure-based drug design identifies novel LPA3 antagonists.

Bioorg Med Chem 2009 Nov 18;17(21):7457-64. Epub 2009 Sep 18.

Department of Chemistry and Computational Research on Materials Institute, The University of Memphis, Memphis, TN 38152, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmc.2009.09.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2771199PMC
November 2009

Unique ligand selectivity of the GPR92/LPA5 lysophosphatidate receptor indicates role in human platelet activation.

J Biol Chem 2009 Jun 14;284(25):17304-19. Epub 2009 Apr 14.

Department of Chemistry and Computational Research on Materials Institute, University of Memphis, Memphis, Tennessee 38152, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M109.003194DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2719366PMC
June 2009

Lysophosphatidic acid 2 receptor-mediated supramolecular complex formation regulates its antiapoptotic effect.

J Biol Chem 2009 May 17;284(21):14558-71. Epub 2009 Mar 17.

Department of Physiology, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M900185200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2682904PMC
May 2009

Chiral vinylphosphonate and phosphonate analogues of the immunosuppressive agent FTY720.

J Org Chem 2009 Apr;74(8):3192-5

Department of Chemistry and Biochemistry, Queens College of The City University of New York, Flushing, New York 11367-1597, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/jo900023uDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2747615PMC
April 2009

The early- and late stages in phenotypic modulation of vascular smooth muscle cells: differential roles for lysophosphatidic acid.

Biochim Biophys Acta 2008 Sep 13;1781(9):571-81. Epub 2008 Jun 13.

Department of Physiology, University of Tennessee Health Science Center, 894 Union Avenue, Suite 426, Memphis, TN 38163, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbalip.2008.06.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3446793PMC
September 2008

Preface to the special issue: Lysophospholipids in health and disease.

Authors:
Gábor Tigyi

Biochim Biophys Acta 2008 Sep;1781(9):423

Department of Physiology, University of Tennessee Health Science Center, 894 Union Avenue, Memphis TN 38163, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbalip.2008.08.003DOI Listing
September 2008

Identification of non-lipid LPA3 antagonists by virtual screening.

Bioorg Med Chem 2008 Jun 18;16(11):6207-17. Epub 2008 Apr 18.

Department of Chemistry and Computational Research on Materials Institute, The University of Memphis, Memphis, TN 38152, USA.

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S09680896080036
Publisher Site
http://dx.doi.org/10.1016/j.bmc.2008.04.035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2483252PMC
June 2008

Lysophosphatidic acid (LPA)-induced vasodilator-stimulated phosphoprotein mediates lamellipodia formation to initiate motility in PC-3 prostate cancer cells.

Mol Oncol 2008 Jun;2(1):54-69

Department of Systems Biology, The University of Texas M. D. Anderson Cancer Center, 7435 Fannin Street, Houston, TX 77054, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.molonc.2008.03.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2597858PMC
June 2008

Lysophospholipid signaling: beyond the EDGs.

Biochim Biophys Acta 2008 Mar 25;1780(3):597-605. Epub 2007 Aug 25.

Department of Physiology, The University of Tennessee Health Science Center Memphis, 894 Union Avenue, Memphis, TN 38163, USA.

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S03044165070018
Publisher Site
http://dx.doi.org/10.1016/j.bbagen.2007.08.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2751795PMC
March 2008

Synthesis, pharmacology, and cell biology of sn-2-aminooxy analogues of lysophosphatidic acid.

Org Lett 2008 Mar 20;10(6):1111-4. Epub 2008 Feb 20.

Department of Medicinal Chemistry, The University of Utah, 419 Wakara Way, Salt Lake City, UT 84108-1257, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/ol7030747DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3510981PMC
March 2008

A glance at the structural and functional diversity of membrane lipids.

Methods Mol Biol 2007 ;400:1-13

Department of Pharmacology, The University of Tennessee Health Science Center, Memphis, TN, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-1-59745-519-0_1DOI Listing
December 2007

Alkoxymethylenephosphonate analogues of (Lyso) phosphatidic acid stimulate signaling networks coupled to the LPA2 receptor.

ChemMedChem 2007 Dec;2(12):1789-98

Department of Medicinal Chemistry, University of Utah, 419 Wakara Way, Suite 205, Salt Lake City, UT 84108-1257, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cmdc.200700111DOI Listing
December 2007

The lysophosphatidic acid 2 receptor mediates down-regulation of Siva-1 to promote cell survival.

J Biol Chem 2007 Dec 26;282(52):37759-69. Epub 2007 Oct 26.

Department of Cell Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M705025200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3496872PMC
December 2007

Receptor tyrosine kinase-G-protein coupled receptor complex signaling in mammalian cells.

Adv Enzyme Regul 2007 6;47:271-80. Epub 2007 Mar 6.

Department of Physiology and Pharmacology, Strathclyde Institute for Biomedical Sciences, University of Strathclyde, 27 Taylor St, Glasgow G4 0NR, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.advenzreg.2006.12.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3446785PMC
November 2007

Sphingosine 1-phosphate pKa and binding constants: intramolecular and intermolecular influences.

J Mol Graph Model 2007 Sep 14;26(2):519-28. Epub 2007 Mar 14.

Department of Chemistry and Computational Research on Materials Institute, The University of Memphis, Memphis, TN 38152, United States.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jmgm.2007.03.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2040500PMC
September 2007

Lysophosphatidic acid induces prostate cancer PC3 cell migration via activation of LPA(1), p42 and p38alpha.

Biochim Biophys Acta 2007 Jul 24;1771(7):883-92. Epub 2007 Apr 24.

Department of Pathobiology, College of Veterinary Medicine, The University of Tennessee, Knoxville, TN 37996, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbalip.2007.04.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3446792PMC
July 2007

Alpha-substituted phosphonate analogues of lysophosphatidic acid (LPA) selectively inhibit production and action of LPA.

ChemMedChem 2007 May;2(5):679-90

Department of Medicinal Chemistry, The University of Utah, 419 Wakara Way, Suite 205, Salt Lake City, UT 84108-1257, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cmdc.200600280DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3505595PMC
May 2007

Identification of the hydrophobic ligand binding pocket of the S1P1 receptor.

J Biol Chem 2007 Jan 18;282(4):2374-85. Epub 2006 Nov 18.

Department of Physiology, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M609648200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3446783PMC
January 2007

Lipid phosphate phosphatase-1 regulates lysophosphatidate-induced fibroblast migration by controlling phospholipase D2-dependent phosphatidate generation.

J Biol Chem 2006 Dec 21;281(50):38418-29. Epub 2006 Oct 21.

Signal Transduction Research Group, Department of Biochemistry, University of Alberta, Edmonton, Alberta T6G 2S2, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1074/jbc.M601670200DOI Listing
December 2006

Farnesyl phosphates are endogenous ligands of lysophosphatidic acid receptors: inhibition of LPA GPCR and activation of PPARs.

Biochim Biophys Acta 2006 Dec 3;1761(12):1506-14. Epub 2006 Oct 3.

Institute of Enzymology, Biological Research Center, Hungarian Academy of Sciences, H-1518 Budapest P.O. Box 7, Hungary.

View Article

Download full-text PDF

Source
http://linkinghub.elsevier.com/retrieve/pii/S138819810600283
Publisher Site
http://dx.doi.org/10.1016/j.bbalip.2006.09.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1766556PMC
December 2006

Protean agonism of the lysophosphatidic acid receptor-1 with Ki16425 reduces nerve growth factor-induced neurite outgrowth in pheochromocytoma 12 cells.

J Neurochem 2006 Sep;98(6):1920-9

Department of Physiology and Pharmacology, Strathclyde Institute for Biomedical Sciences, University of Strathclyde, Glasgow, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1471-4159.2006.04009.xDOI Listing
September 2006

Integrin signalling regulates the nuclear localization and function of the lysophosphatidic acid receptor-1 (LPA1) in mammalian cells.

Biochem J 2006 Aug;398(1):55-62

Department of Physiology and Pharmacology, Strathclyde Institute for Biomedical Sciences, University of Strathclyde, 27 Taylor St, Glasgow, G4 0NR, UK.

View Article

Download full-text PDF

Source
http://biochemj.org/lookup/doi/10.1042/BJ20060155
Publisher Site
http://dx.doi.org/10.1042/BJ20060155DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1525019PMC
August 2006

Synthesis of cyclic phosphonate analogues of (lyso)phosphatidic acid using a ring-closing metathesis reaction.

J Org Chem 2006 Aug;71(16):6061-6

Department of Medicinal Chemistry, University of Utah, 419 Wakara Way, Suite 205, Salt Lake City, Utah 84108-1257, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/jo0607919DOI Listing
August 2006

Phosphonothioate and fluoromethylene phosphonate analogues of cyclic phosphatidic acid: Novel antagonists of lysophosphatidic acid receptors.

J Med Chem 2006 Aug;49(17):5309-15

Department of Medicinal Chemistry, The University of Utah, 419 Wakara Way, Suite 205, Salt Lake City, Utah 84108-1257, USA.

View Article

Download full-text PDF

Source
http://pubs.acs.org/journals/jmcmar/index.html
Publisher Site
http://dx.doi.org/10.1021/jm060351+DOI Listing
August 2006

The functional PDGFbeta receptor-S1P1 receptor signaling complex is involved in regulating migration of mouse embryonic fibroblasts in response to platelet derived growth factor.

Prostaglandins Other Lipid Mediat 2006 Jul 21;80(1-2):74-80. Epub 2006 Jun 21.

Department of Physiology and Pharmacology, Strathclyde Institute for Biomedical Sciences, University of Strathclyde, 27 Taylor Street, Glasgow G4 0NR, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.prostaglandins.2006.05.001DOI Listing
July 2006

MicroRNA trafficking and human cancer.

Cancer Biol Ther 2006 Jun 2;5(6):573-8. Epub 2006 Jun 2.

Pittsburgh Development Center, Magee Womens Hospital Research Institute, The University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4161/cbt.5.6.2872DOI Listing
June 2006

Cell migration activated by platelet-derived growth factor receptor is blocked by an inverse agonist of the sphingosine 1-phosphate receptor-1.

FASEB J 2006 Mar 30;20(3):509-11. Epub 2005 Nov 30.

Department of Physiology and Pharmacology, Strathclyde Institute for Biomedical Sciences, University of Strathclyde, Glasgow, UK.

View Article

Download full-text PDF

Source
http://www.fasebj.org/doi/10.1096/fj.05-4810fje
Publisher Site
http://dx.doi.org/10.1096/fj.05-4810fjeDOI Listing
March 2006

Lipid phosphate phosphatase-1 regulates lysophosphatidic acid- and platelet-derived-growth-factor-induced cell migration.

Biochem J 2006 Mar;394(Pt 2):495-500

Department of Physiology and Pharmacology, Strathclyde Institute for Biomedical Sciences, University of Strathclyde, 27 Taylor Street, Glasgow G4 0NR, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1042/BJ20051674DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1408680PMC
March 2006

Phosphorothioate analogues of alkyl lysophosphatidic acid as LPA3 receptor-selective agonists.

ChemMedChem 2006 Mar;1(3):376-83

Department of Medicinal Chemistry, The University of Utah, 419 Wakara Way, Suite 205, Salt Lake City, Utah 84108-1257, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cmdc.200500042DOI Listing
March 2006

Synthesis of photoactivatable analogues of lysophosphatidic acid and covalent labeling of plasma proteins.

J Org Chem 2006 Jan;71(2):629-35

Department of Chemistry and Biochemistry, Queens College of the City University of New York, Flushing, New York 11367-1597, USA.

View Article

Download full-text PDF

Source
http://pubs.acs.org/doi/abs/10.1021/jo052030w
Publisher Site
http://dx.doi.org/10.1021/jo052030wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2533437PMC
January 2006