Publications by authors named "G Mansurova"

12 Publications

[COMPLEX TREATMENT OF PATIENTS WITH VENOUS TROPHIC ULCER IN THE CONDITIONS OF COVID-19 HOSPITAL].

Georgian Med News 2021 Mar(312):7-14

Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University (Sechenov University) of the Ministry of Health of the Russian Federation.

The aim of the study was to study the effectiveness of complex treatment of decompensated chronic venous insufficiency (CVI) using innovative techniques and proteolysis inhibitors with a wide spectrum of activity in patients with SARS-CoV-2 (COVID-19) in COVID hospital. This study was performed in the surgical department of COVID hospital on the basis of the Clinical Hospital No. 4 of the First Moscow State Medical University named I.M. Sechenov (Sechenov University). During the period from April 2020 to February 2021, 32 patients with confirmed SARS-CoV-2 (COVID-19) and the presence of venous trophic ulcers (VTU) of the lower extremities were treated. All patients underwent complex therapy for viral pneumonia in accordance with the order of the Ministry of Health of the Russian Federation. The protease inhibitor Aprotinin (Gordox ™) was used to improve microcirculation and prevent the development of a "cytokine storm". To accelerate the cleansing and epithelialization of venous trophic ulcers, the surface of the trophic ulcer was treated with an air plasma flow of NO and injections into the trophic ulcer of autoplasma. Against the background of complex treatment, all patients showed positive dynamics of the clinical picture: relief of hyperthermia, increase or stabilization of SpO2 values from 95% and above, significant decrease in CRP, LDH, D-dimer indices, increase in the number of lymphocytes, decrease in the VTU area by 1.5 times, active granulation and marginal epithelialization of the ulcer. In 14 patients (43.8%), complete epithelialization of the VTU defect was noted by the end of the third week. According to the CIVIQ-20 questionnaire, all 32 patients participating in the study showed positive dynamics. There were no lethal outcomes. Multicomponent therapy of decompensated forms of CVI of the lower extremities in the COVID hospital in patients with moderate severity of coronavirus infection with the use of proteolysis inhibitors leads to a rapid relief of symptoms of intoxication, prevents the progression of lung tissue and parenchymal organ damage and contributes to the positive dynamics of healing of ulcerative defects in the vast majority of patients.
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March 2021

[SUBACUTE THYROIDITIS AND COVID-19 (REVIEW)].

Georgian Med News 2021 Feb(311):98-103

2I.M. Sechenov First Moscow State Medical University (Sechenov University), Russian Federation, Department of Faculty Surgery N2, Russian Federation.

The COVID-19 pandemia has shown that there is not enough knowledge today to fully control it. Along with severe respiratory syndrome, attention has recently been paid to extrapulmonary lesions, including endocrinopathies. The aim of the study was to summarize the current literature data about the effects of the SARS-CoV-2 coronavirus on the thyroid gland. One of the most striking manifestations of viral aggression is de Quervain's subacute thyroiditis. The analysis of works from the most authoritative international abstract bibliographic databases was carried out using methods of analysis and processing of scientific resources. Based on the analysis, it was concluded that subacute thyroiditis can be both a clinical manifestation and a complication of COVID-19. The SARS-CoV-2 coronavirus can also trigger other thyroid diseases. The causes of subacute thyroiditis are considered to be the direct effect of the SARS-CoV-2 coronavirus on thyroid cells due to the use of ACE2 receptors, the subsequent inflammatory reaction and apoptosis, as well as central hypothalamus-pituitary mechanisms. The clinical variants of subacute thyroiditis in COVID-19 are diverse and have not been fully evaluated. In this regard, it can be concluded that the true incidence of subacute thyroiditis in COVID-19 is much greater, since it is masked by severe lesions of other organs.
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February 2021

[Ultrasound assessment of vocal cords function after thyroid surgery].

Khirurgiia (Mosk) 2019 (7):24-28

Sechenov First Moscow State Medical University of Ministry of Health of the Russia, Moscow, Russia.

Objective: To analyze vocal cords function after thyroid surgery by using of ultrasound examination.

Material And Methods: Assessment of voice quality according to GRBAS scale, ultrasound examination of vocal cords and indirect laryngoscopy were performed in 57 patients after thyroid surgery.

Results: Postoperative indirect laryngoscopy and ultrasound revealed normal mobility of vocal cords in all patients. However, 98.3% of patients subjectively noted deterioration of voice quality due to hoarseness and fatiguein early and long-term period, respectively. Complete restoration of vocal function occurred after 6 months postoperatively. Impaired voice quality is probably due to edema of vocal cords after intubation that is manifested by unclear contours during ultrasound. Ultrasound is useful to diagnose shortening and displacement of paretic vocal cords.

Conclusion: Ultrasound of vocal cords could be alternative to indirect laryngoscopy for postoperative assessment of vocal cords function in patients after thyroid surgery.
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http://dx.doi.org/10.17116/hirurgia201907124DOI Listing
September 2019

Evaluation Criteria and Surgical Technique for Transoral Access to the Thyroid Gland: Experimental Study.

J Invest Surg 2019 Aug 25;32(5):421-427. Epub 2018 Jan 25.

c Department of Gastrointestinal Surgery, Akershus University Hospital , Lørenskog , Norway.

: The development of endoscopic techniques motivated surgeons to search for alternative and more cosmetic approaches for thyroid and parathyroid surgery. Several variations of transoral access to the anterior neck areas were applied in recent years. One of them is a premandibular access proposed by Nakajo et al, it is performed through the oral vestibule by creating the working space by means of the lifting method. : Nineteen unfixed human cadavers were used to develop the endoscopic access to the thyroid gland and surgical techniques of its resection. The Nakajo access was modified by altering the spatial location of the working instruments, resulting in practically no impact on the cosmetic outcome but providing a more comfortable operation for the thyroid gland. We determined evaluation criteria of the cadaver model before initiation of the experimental trial. Parameters that influence on alteration of these criteria were registered. : Of the 19 operated objects, the first 7 were used to practice the access technique from the incision in the oral vestibule to the thyroid gland in order to evaluate the possibility of endoscopic dissection of the important anatomical. The next 12 surgeries were carried out by manipulating the thyroid gland in the settings maximally close to real. Access implied good cosmetic results, less surgical traumatic due to a smaller area of detachment of the musculocutaneous flap. : The achieved results show feasibility of introducing the described modification of transoral thyroidectomy into clinical practice.
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http://dx.doi.org/10.1080/08941939.2018.1424271DOI Listing
August 2019

[Transoral approach to thyroid gland in the experiment].

Khirurgiia (Mosk) 2017(2):25-31

Chair of Faculty Surgery #2, Sechenov First Moscow State Medical University.

Aim: To develop minimally invasive and safe endoscopic access to thyroid gland.

Material And Methods: Transoral pre-mandibular video-assisted gas-free access to thyroid gland was developed in experimental study that included 19 human cadavers. Stereometric modeling defined the evaluation criteria including the form of basal arch of lower jaw and its height. There was no conflict of instruments in working chamber under platysma. Additional trocar was deployed to resolve the conflict between working parts of instruments during thyroid gland mobilization. The angle of operative action between the instruments is close to 90°. Trocar hole is used for drainage.

Results: The access provides good visualization of recurrent laryngeal nerve, upper and lower thyroid arteries and parathyroid gland. It is less traumatic compared with other extra-cervical accesses to thyroid glands.
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http://dx.doi.org/10.17116/hirurgia2017225-31DOI Listing
July 2017