G. Johan Offerhaus

G. Johan Offerhaus

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G. Johan Offerhaus

Publications by authors named "G. Johan Offerhaus"

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Why is pancreatic cancer so deadly? The pathologist's view.

J Pathol 2019 Jun 15;248(2):131-141. Epub 2019 Apr 15.

Sol Goldman Pancreatic Cancer Research Center, Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.

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http://dx.doi.org/10.1002/path.5260DOI Listing
June 2019

Efficacy and Safety of Curcumin in Treatment of Intestinal Adenomas in Patients With Familial Adenomatous Polyposis.

Gastroenterology 2018 09 23;155(3):668-673. Epub 2018 May 23.

Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland; Department of Oncology, The Johns Hopkins University School of Medicine, Baltimore, Maryland; Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00165085183456
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http://dx.doi.org/10.1053/j.gastro.2018.05.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120769PMC
September 2018

Associations of Epstein-Barr Virus-Positive Gastric Adenocarcinoma with Circulating Mediators of Inflammation and Immune Response.

Cancers (Basel) 2018 Aug 23;10(9). Epub 2018 Aug 23.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 9609 Medical Center Dr., BG 9609/6E338, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.3390/cancers10090284DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6162799PMC
August 2018

Immunolabeling of Cleared Human Pancreata Provides Insights into Three-Dimensional Pancreatic Anatomy and Pathology.

Am J Pathol 2018 07 22;188(7):1530-1535. Epub 2018 Apr 22.

Department of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, Maryland; Department of Oncology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, Maryland. Electronic address:

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http://dx.doi.org/10.1016/j.ajpath.2018.04.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6024186PMC
July 2018

Gastric cancer: epidemiology, prevention, classification, and treatment.

Cancer Manag Res 2018 7;10:239-248. Epub 2018 Feb 7.

Department of Surgical Oncology, Medical University of Lublin, Lublin, Poland.

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http://dx.doi.org/10.2147/CMAR.S149619DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5808709PMC
February 2018

Pathology and genetics of hereditary colorectal cancer.

Pathology 2018 Jan 21;50(1):49-59. Epub 2017 Nov 21.

Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD, United States.

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http://dx.doi.org/10.1016/j.pathol.2017.09.004DOI Listing
January 2018

Absence of mutation in juvenile polyposis syndrome.

J Clin Pathol 2017 07 19;70(7):640. Epub 2017 Apr 19.

Department of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands.

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http://dx.doi.org/10.1136/jclinpath-2017-204449DOI Listing
July 2017

Sending family history questionnaires to patients before a colonoscopy improves genetic counseling for hereditary colorectal cancer.

J Dig Dis 2017 Jun;18(6):343-348

Department of Gastroenterology and Hepatology, Utrecht University Medical Center, Utrecht, The Netherlands.

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http://dx.doi.org/10.1111/1751-2980.12491DOI Listing
June 2017

Genetic dissection of colorectal cancer progression by orthotopic transplantation of engineered cancer organoids.

Proc Natl Acad Sci U S A 2017 03 7;114(12):E2357-E2364. Epub 2017 Mar 7.

Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences and University Medical Center (UMC) Utrecht, 3584 CT Utrecht, The Netherlands;

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http://dx.doi.org/10.1073/pnas.1701219114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5373343PMC
March 2017

Low Rate of Dysplasia Detection in Mucosa Surrounding Dysplastic Lesions in Patients Undergoing Surveillance for Inflammatory Bowel Diseases.

Clin Gastroenterol Hepatol 2017 02 6;15(2):222-228.e2. Epub 2016 Sep 6.

Department of Gastroenterology and Hepatology, University Medical Center Utrecht, Utrecht, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.cgh.2016.08.035DOI Listing
February 2017

Discordance Among Pathologists in the United States and Europe in Diagnosis of Low-Grade Dysplasia for Patients With Barrett's Esophagus.

Gastroenterology 2017 02 3;152(3):564-570.e4. Epub 2016 Nov 3.

Gastroenterology and Hepatology, Veterans Affairs Medical Center, Kansas City, Missouri; Gastroenterology Department, Kansas University Medical Center, Kansas City, Kansas. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2016.10.041DOI Listing
February 2017

Prognostic Value of Pretreatment Pathological Tumor Extent in Patients Treated With Neoadjuvant Chemoradiotherapy Plus Surgery for Esophageal or Junctional Cancer.

Ann Surg 2017 02;265(2):356-362

*Department of Surgery †Department of Pathology ‡Department of Public Health, Rotterdam §Department of Pathology, University Medical Center Utrecht, Utrecht ¶Department of Pathology ||Department of Surgery, Academic Medical Center, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1097/SLA.0000000000001630DOI Listing
February 2017

Syndromic Gastric Polyps: At the Crossroads of Genetic and Environmental Cancer Predisposition.

Adv Exp Med Biol 2016;908:347-69

Department of Pathology, The Johns Hopkins University School of Medicine, 401 N Broadway Weinberg 2242, Baltimore, MD, 21231, USA.

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http://dx.doi.org/10.1007/978-3-319-41388-4_17DOI Listing
January 2017

Generation of an inducible colon-specific Cre enzyme mouse line for colon cancer research.

Proc Natl Acad Sci U S A 2016 10 5;113(42):11859-11864. Epub 2016 Oct 5.

Hubrecht Institute for Developmental Biology and Stem Cell Research, Royal Netherlands Academy of Arts and Sciences (KNAW), 3584 CT Utrecht, The Netherlands; University Medical Centre Utrecht, 3584 CT Utrecht, The Netherlands;

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http://dx.doi.org/10.1073/pnas.1614057113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5081651PMC
October 2016

Patients With Barrett's Esophagus and Persistent Low-grade Dysplasia Have an Increased Risk for High-grade Dysplasia and Cancer.

Clin Gastroenterol Hepatol 2016 07 31;14(7):956-962.e1. Epub 2015 Dec 31.

Department of Gastroenterology and Hepatology, University Medical Center Utrecht, Utrecht, The Netherlands.

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http://dx.doi.org/10.1016/j.cgh.2015.12.027DOI Listing
July 2016

Surgical and molecular pathology of pancreatic neoplasms.

Diagn Pathol 2016 Jun 7;11(1):47. Epub 2016 Jun 7.

Department of Pathology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands.

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http://dx.doi.org/10.1186/s13000-016-0497-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4897815PMC
June 2016

Pathology and Genetics of Syndromic Gastric Polyps.

Int J Surg Pathol 2016 May 31;24(3):185-99. Epub 2015 Dec 31.

The Johns Hopkins University School of Medicine, Baltimore, MD, USA.

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http://dx.doi.org/10.1177/1066896915620013DOI Listing
May 2016

Molecular alterations in gastric cancer with special reference to the early-onset subtype.

World J Gastroenterol 2016 Feb;22(8):2460-74

Małgorzata Skierucha, Ryszard Maciejewski, Robert Sitarz, Department of Human Anatomy, Medical University of Lublin, 20-950 Lublin, Poland.

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http://dx.doi.org/10.3748/wjg.v22.i8.2460DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4768192PMC
February 2016

Pathologic Evaluation and Reporting of Intraductal Papillary Mucinous Neoplasms of the Pancreas and Other Tumoral Intraepithelial Neoplasms of Pancreatobiliary Tract: Recommendations of Verona Consensus Meeting.

Ann Surg 2016 Jan;263(1):162-77

*Department of Pathology, Emory University School of Medicine and Winship Cancer Institute, Atlanta, GA †Department of Pathology, Massachusetts General Hospital, Boston, MA ‡Department of Pathology, Tokyo Women's Medical University, Tokyo, Japan §Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY ¶Department of Pathology, University of Verona, Verona, Italy ||Department of Surgery, Massachusetts General Hospital, Boston, MA **Department of Surgery, University of Verona, Verona, Italy ††Department of Surgery, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, MD ‡‡Departments of Surgery, University of Bonn, Bonn, Germany §§Departments of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands ¶¶Department of Surgery, Edouard Herriot Hospital, HCL, Lyon, France ||||Department of Gastroenterology and Hepatology, Erasmus University Medical Center, Rotterdam, The Netherlands ***Departments of Pathology, Technical University, Munich, Germany †††Department of Pathology, Showa University Fujigaoka Hospital, Yokohama, Japan ‡‡‡Department of Pathology, Tokai University Hachioji Hospital, Tokyo, Japan §§§Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea ¶¶¶Department of Pathology, Pontificia Universidad Católica de Chile, Santiago, Chile ||||||Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY ****Department of Surgery, Massachusetts General Hospital, Boston, MA ††††Department of Surgery, Seoul National University Hospital, Seoul, Korea ‡‡‡‡Department of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, MD.

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http://pdfs.journals.lww.com/annalsofsurgery/2016/01000/Path
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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
Publisher Site
http://dx.doi.org/10.1097/SLA.0000000000001173DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4568174PMC
January 2016

Simultaneous juvenile polyposis syndrome and neurofibromatosis type 1.

Histopathology 2016 Jan 18;68(2):313-5. Epub 2015 Jun 18.

Departments of Medicine Oncology Center, and Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

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http://dx.doi.org/10.1111/his.12734DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4636475PMC
January 2016

A Revised Classification System and Recommendations From the Baltimore Consensus Meeting for Neoplastic Precursor Lesions in the Pancreas.

Am J Surg Pathol 2015 Dec;39(12):1730-41

*Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY ‡Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, MD §Department of Pathology and Laboratory Medicine, Emory University Hospital, Atlanta, GA §§Department of Pathology, Dartmouth-Hitchcock Medical Center, Lebanon, NH †Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Ulsan, Korea ∥Department of Pathology, Medica Sur Clinic and Foundation, Mexico City, Mexico ¶Wolfson Wohl Cancer Research Centre, University of Glasgow, Glasgow, UK #Department of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands **Department of Pathology, Jichi Medical University, Shimotsuke ††Department of Pathology, Cancer Institute, Japanese Foundation for Cancer Research ¶¶Department of Pathology, Hakujikai Memorial Hospital †††Division of Cancer Genomics, National Cancer Center Research Institute §§§Institute for Integrated Medical Sciences, Tokyo Women's Medical University, Tokyo ##Department of Surgery, Kyoto University, Kyoto, Japan ‡‡Department of Pathology, Technical University Munich, Munich ∥∥Department of General, Visceral, Thoracic and Vascular Surgery, University of Bonn, Bonn ‡‡‡Institute of Pathology, Heinrich-Heine University and University Hospital of Düsseldorf, Düsseldorf, Germany ***Service d'Anatomie Pathologique, Hôpital Cochin, Paris, France.

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http://dx.doi.org/10.1097/PAS.0000000000000533DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4646710PMC
December 2015

Hereditary Colorectal Cancer: Genetics and Screening.

Surg Clin North Am 2015 Oct 16;95(5):1067-80. Epub 2015 Jun 16.

Department of Medicine, Oncology Center, The Johns Hopkins University School of Medicine, 1830 East Monument Street, Room 431, Baltimore, MD 21205, USA; Department of Pathology, The Johns Hopkins University School of Medicine, 1830 East Monument Street, Room 431, Baltimore, MD 21205, USA. Electronic address:

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http://dx.doi.org/10.1016/j.suc.2015.05.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4555838PMC
October 2015

Low interobserver agreement among endoscopists in differentiating dysplastic from non-dysplastic lesions during inflammatory bowel disease colitis surveillance.

Scand J Gastroenterol 2015 Aug 20;50(8):1011-7. Epub 2015 Mar 20.

Department of Gastroenterology and Hepatology, Academic Medical Centre , Amsterdam , Netherlands.

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http://dx.doi.org/10.3109/00365521.2015.1016449DOI Listing
August 2015

Pancreatic adenocarcinoma pathology: changing "landscape".

J Gastrointest Oncol 2015 Aug;6(4):358-74

1 Department of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands ; 2 Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.

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http://dx.doi.org/10.3978/j.issn.2078-6891.2015.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4502163PMC
August 2015

Effective Therapeutic Intervention and Comprehensive Genetic Analysis of mTOR Signaling in PEComa: A Case Report.

Anticancer Res 2015 Jun;35(6):3399-403

Department of Molecular Oncology, Netherlands Cancer Institute, Amsterdam, the Netherlands.

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June 2015

Risk of neoplastic progression in Barrett's esophagus diagnosed as indefinite for dysplasia: a nationwide cohort study.

Endoscopy 2015 May 18;47(5):409-14. Epub 2014 Dec 18.

Department of Gastroenterology and Hepatology, University Medical Center Utrecht, Utrecht, The Netherlands.

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http://dx.doi.org/10.1055/s-0034-1391091DOI Listing
May 2015

Sequential cancer mutations in cultured human intestinal stem cells.

Nature 2015 May 29;521(7550):43-7. Epub 2015 Apr 29.

1] Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and UMC Utrecht, 3584CT Utrecht, The Netherlands [2] Cancer Genomics Netherlands, UMC Utrecht, 3584CG Utrecht, The Netherlands.

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http://dx.doi.org/10.1038/nature14415DOI Listing
May 2015

Establishing a clinical and molecular diagnosis for hereditary colorectal cancer syndromes: Present tense, future perfect?

Gastrointest Endosc 2014 Dec;80(6):1145-55

Department of Pathology, University Medical Centre Utrecht, Utrecht, the Netherlands.

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https://linkinghub.elsevier.com/retrieve/pii/S00165107140204
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http://dx.doi.org/10.1016/j.gie.2014.07.049DOI Listing
December 2014

Loss of SMAD4 alters BMP signaling to promote colorectal cancer cell metastasis via activation of Rho and ROCK.

Gastroenterology 2014 Jul 3;147(1):196-208.e13. Epub 2014 Apr 3.

Department of Gastroenterology and Hepatology, Cancer Genomics Centre Netherlands and Centre for Biomedical Genetics, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1053/j.gastro.2014.03.052DOI Listing
July 2014

Epithelial-specific loss of PTEN results in colorectal juvenile polyp formation and invasive cancer.

Am J Pathol 2014 Jan 6;184(1):86-91. Epub 2013 Nov 6.

European Cancer Stem Cell Research Institute, Cardiff School of Biosciences, Cardiff University, Cardiff, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.ajpath.2013.10.003DOI Listing
January 2014

Adherence to microsatellite instability testing in young-onset colorectal cancer patients.

Dis Colon Rectum 2013 Jul;56(7):825-33

Department of Gastroenterology and Hepatology, University Medical Center Utrecht, Utrecht, The Netherlands.

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http://dx.doi.org/10.1097/DCR.0b013e31828b6617DOI Listing
July 2013

Monoclonal origin of primary unilateral multifocal pleomorphic adenoma of the parotid gland.

Hum Pathol 2013 May 17;44(5):923-6. Epub 2013 Jan 17.

Department of Otorhinolaryngology and Head & Neck Surgery, University Medical Center Utrecht, The Netherlands.

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http://dx.doi.org/10.1016/j.humpath.2012.10.008DOI Listing
May 2013

Recording of family history is associated with colorectal cancer stage.

Eur J Gastroenterol Hepatol 2013 Apr;25(4):482-7

Department of Gastroenterology and Hepatology, Sint Antonius Hospital, 3508 GA trecht, The Netherlands.

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http://dx.doi.org/10.1097/MEG.0b013e32835c45a3DOI Listing
April 2013

Gastroenterostoma after Billroth antrectomy as a premalignant condition.

World J Gastroenterol 2012 Jul;18(25):3201-6

Department of Pathology, University Medical Centre, Utrecht, 3584 CX Utrecht, The Netherlands.

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http://dx.doi.org/10.3748/wjg.v18.i25.3201DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3391756PMC
July 2012

Whole slide images for primary diagnostics of gastrointestinal tract pathology: a feasibility study.

Hum Pathol 2012 May 19;43(5):702-7. Epub 2011 Sep 19.

Department of Pathology, University Medical Center Utrecht, 3508 GA Utrecht, The Netherlands.

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http://dx.doi.org/10.1016/j.humpath.2011.06.017DOI Listing
May 2012

Role of immunohistochemical markers in predicting progression of dysplasia to advanced neoplasia in patients with ulcerative colitis.

Inflamm Bowel Dis 2012 Mar 20;18(3):480-8. Epub 2011 Apr 20.

University Medical Center Utrecht, Department of Gastroenterology and Hepatology, Utrecht, The Netherlands.

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http://dx.doi.org/10.1002/ibd.21722DOI Listing
March 2012

Pancreatic ductal adenocarcinoma in hereditary diffuse gastric cancer. A case report.

Hum Pathol 2012 Mar 10;43(3):457-61. Epub 2011 Oct 10.

Department of Pathology, University Medical Center Utrecht, 3584CX Utrecht, The Netherlands.

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http://dx.doi.org/10.1016/j.humpath.2011.06.008DOI Listing
March 2012

Analysis of LKB1 mutations and other molecular alterations in pancreatic acinar cell carcinoma.

Mod Pathol 2011 Sep 13;24(9):1229-36. Epub 2011 May 13.

Department of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands.

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http://dx.doi.org/10.1038/modpathol.2011.83DOI Listing
September 2011

LKB1 as the ghostwriter of crypt history.

Fam Cancer 2011 Sep;10(3):437-46

Department of Pathology, Academic Medical Center, PO Box 22660, 1100 DD, Amsterdam, The Netherlands.

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http://link.springer.com/10.1007/s10689-011-9469-3
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http://dx.doi.org/10.1007/s10689-011-9469-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3175351PMC
September 2011

Diversity counts. Visualizing pretumor progression in the gastrointestinal tract.

Am J Clin Pathol 2011 Jun;135(6):878-88

Dept. of Pathology, University Medical Center Utrecht, Utrecht, the Netherlands.

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http://dx.doi.org/10.1309/AJCPP3I5HDYWMHJADOI Listing
June 2011

Low frequency of HER2 amplification and overexpression in early onset gastric cancer.

Cell Oncol (Dordr) 2011 Apr 11;34(2):89-95. Epub 2011 Mar 11.

Department of Pathology, University Medical Center Utrecht, Heidelberglaan 100, PO Box 85500, 3508GA, Utrecht, The Netherlands.

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http://dx.doi.org/10.1007/s13402-011-0021-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3063579PMC
April 2011

Molecular characteristics of pancreatic ductal adenocarcinoma.

Patholog Res Int 2011 Mar 27;2011:620601. Epub 2011 Mar 27.

Department of Pathology, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands.

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http://dx.doi.org/10.4061/2011/620601DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3068308PMC
March 2011

Her-2/neu testing and therapy in gastroesophageal adenocarcinoma.

Patholog Res Int 2010 Dec 6;2011:674182. Epub 2010 Dec 6.

Department of Pathology, University Medical Center Utrecht, Heidelberglaan 100, P.O. Box 85500, 3508 GA Utrecht, The Netherlands.

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http://dx.doi.org/10.4061/2011/674182DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3005843PMC
December 2010

Early-onset gastric cancer: Learning lessons from the young.

World J Gastrointest Oncol 2010 Feb;2(2):59-64

Anya N Milne, Department of Pathology, University Medical Centre Utrecht, Postbus 85500, 3508 GA, Utrecht, The Netherlands.

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http://dx.doi.org/10.4251/wjgo.v2.i2.59DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2998932PMC
February 2010

WNT-pathway activation in IBD-associated colorectal carcinogenesis: potential biomarkers for colonic surveillance.

Cell Oncol 2010 Jan;32(4):303-10

Department of Gastroenterology and Hepatology, University Medical Center Utrecht, Utrecht, The Netherlands.

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http://dx.doi.org/10.3233/CLO-2009-0503DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4619233PMC
January 2010