Publications by authors named "G Feng"

3,646 Publications

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Utilizing waste duckweed from phytoremediation to synthesize highly efficient FeNC catalysts for oxygen reduction reaction electrocatalysis.

Sci Total Environ 2022 Jan 15:153115. Epub 2022 Jan 15.

School of Mechanical Engineering, Tianjin University of Commerce, Tianjin 300134, PR China.

Duckweed is a universal aquatic plant to remove nitrogen source pollutants in the field of phytoremediation. Due to the naturally abundant nitrogen, synthesis of carbon materials from duckweed would be a high-value approach. In oxygen reduction reaction (ORR) of metal-air batteries and fuel cells, non-noble metals and heteroatoms co-doped electrocatalysts with excellent catalytic activity and remarkable stability are promising substitutes for Pt-based catalysts. The first-class ORR performance is determined by appropriate pore structure and active sites, which are strongly associated with the feasible synthesis methods. Herein, a facile one-step synthesis strategy for the transition metals- and nitrogen-codoped carbon (MNC) based catalysts with hierarchically porous structure was developed. The MNC (M = Fe, Co, Ni, and Mn) active sites were constructed and FeNC (D-ZB-Fe) was the best electrocatalyst with fine ORR performance. Results showed that D-ZB-Fe exhibited an obvious honeycomb porous structure with specific surface area of 1342.91 m·g and total pore volume of 1.085 cm·g. It also possessed considerable active atoms and sites, where the proportion of pyridine N and graphite N was up to 72.9%. The above feature made for a superior ORR electrocatalytic activity. In specific, the onset and half-wave potential were 0.974 V and 0.857 V vs. RHE (Reversible Hydrogen Electrode), respectively. When compared with performances of commercial Pt/C, the four-electron pathway and relatively low peroxide yield, ca. 5%, were almost equivalent. Furthermore, D-ZB-Fe showed an excellent stability and remarkably methanol tolerance by the durability test. In conclusion, this research provides a new synthesis strategy of electrocatalysts with porous structures and active sites.
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http://dx.doi.org/10.1016/j.scitotenv.2022.153115DOI Listing
January 2022

Corallococcus silvisoli sp. nov., a novel myxobacterium isolated from subtropical forest soil.

Arch Microbiol 2022 Jan 18;204(2):141. Epub 2022 Jan 18.

Key Laboratory of Agricultural Microbiomics and Precision Application - Ministry of Agriculture and Rural Affairs, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, State Key Laboratory of Applied Microbiology Southern China, Guangdong Microbial Culture Collection Center (GDMCC), Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou, 510070, China.

An orange-pigmented myxobacterium, designated strain c25j21, was isolated from subtropical forest soil collected from the Chebaling National Nature Reserve in Guangdong Province, China. Phylogenetic analysis based on the 16S rRNA gene and core genes clearly showed that the novel strain was affiliated within the genus Corallococcus and most closely related to Corallococcus aberystwythensis DSM 108846 (99.3% 16S rRNA gene sequence similarity), while C. exercitus DSM 108849 (99.2%) and C. carmarthensis DSM 108842 (99.0%) were the next most closely related type strains. The draft genome sequence of strain c25j21 was 9.23 Mb in length with a G + C content of 70.7 mol%. The average nucleotide identity (ANI) and digital DNA-DNA hybridization (dDDH) values between strain c25j21 and its closely related type strains were 88.1-89.1 and 34.1-36.3%, respectively. The major fatty acids contained iso-C, iso-C, iso-Cω5c and iso-C 2-OH. The predominant respiratory quinone was menaquinone 7. Based on phylogenetic, phenotypic and chemotaxonomic analysis, strain c25j21 represents a novel species of the genus Corallococcus, for which the name Corallococcus silvisoli sp. nov. is proposed. The type strain is c25j21 (= GDMCC 1.1387 = KCTC 62437).
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http://dx.doi.org/10.1007/s00203-021-02725-5DOI Listing
January 2022

Activatable Persistent Luminescence from Porphyrin Derivatives and Supramolecular Probes with Imaging-Modality Transformable Characteristics for Improved Biological Applications.

Angew Chem Int Ed Engl 2022 Jan 14. Epub 2022 Jan 14.

Nankai University, College of Life Sciences, 94 Weijin Road, 300071, Tianjin, CHINA.

Persistent luminescence without excitation light and tissue autofluorescence interference holds great promise for biological applications, but is limited by available materials with long-wavelength emission and excellent clinical potential. Here, we report that porphyrin derivatives can emit near-infrared persistent luminescence over 60 min after cessation of excitation light or on interaction with peroxynitrite. A plausible mechanism of the successive oxidation of vinylene bonds was demonstrated. A supramolecular probe with a β-sheet structure was constructed to enhance the tumor targeting ability and the photoacoustic and persistent luminescence signals. Such probes featuring light-triggered function transformation from photoacoustic imaging to persistent luminescence imaging permit advanced image-guided cancer surgery. Furthermore, peroxynitrite-activated persistent luminescence of the supramolecular probe also enables rapid and precise screening of immunogenic cell death drugs.
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http://dx.doi.org/10.1002/anie.202116174DOI Listing
January 2022

PKCβII phosphorylates ACSL4 to amplify lipid peroxidation to induce ferroptosis.

Nat Cell Biol 2022 Jan 13;24(1):88-98. Epub 2022 Jan 13.

State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou, China.

The accumulation of lipid peroxides is recognized as a determinant of the occurrence of ferroptosis. However, the sensors and amplifying process of lipid peroxidation linked to ferroptosis remain obscure. Here we identify PKCβII as a critical contributor of ferroptosis through independent genome-wide CRISPR-Cas9 and kinase inhibitor library screening. Our results show that PKCβII senses the initial lipid peroxides and amplifies lipid peroxidation linked to ferroptosis through phosphorylation and activation of ACSL4. Lipidomics analysis shows that activated ACSL4 catalyses polyunsaturated fatty acid-containing lipid biosynthesis and promotes the accumulation of lipid peroxidation products, leading to ferroptosis. Attenuation of the PKCβII-ACSL4 pathway effectively blocks ferroptosis in vitro and impairs ferroptosis-associated cancer immunotherapy in vivo. Our results identify PKCβII as a sensor of lipid peroxidation, and the lipid peroxidation-PKCβII-ACSL4 positive-feedback axis may provide potential targets for ferroptosis-associated disease treatment.
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http://dx.doi.org/10.1038/s41556-021-00818-3DOI Listing
January 2022

Shp2 in uterine stromal cells critically regulates on time embryo implantation and stromal decidualization by multiple pathways during early pregnancy.

PLoS Genet 2022 Jan 13;18(1):e1010018. Epub 2022 Jan 13.

School of Pharmaceutical Sciences, State Key Laboratory of Cellular Stress Biology, Xiamen University, Xiamen, Fujian, China.

Approximately 75% of failed pregnancies are considered to be due to embryo implantation failure or defects. Nevertheless, the explicit signaling mechanisms governing this process have not yet been elucidated. Here, we found that conditional deletion of the Shp2 gene in mouse uterine stromal cells deferred embryo implantation and inhibited the decidualization of stromal cells, which led to embryonic developmental delay and to the death of numerous embryos mid-gestation, ultimately reducing female fertility. The absence of Shp2 in stromal cells increased the proliferation of endometrial epithelial cells, thereby disturbing endometrial epithelial remodeling. However, Shp2 deletion impaired the proliferation and polyploidization of stromal cells, which are distinct characteristics of decidualization. In human endometrial stromal cells (hESCs), Shp2 expression gradually increased during the decidualization process. Knockout of Shp2 blocked the decidual differentiation of hESCs, while Shp2 overexpression had the opposite effect. Shp2 knockout inhibited the proliferation of hESCs during decidualization. Whole gene expression profiling analysis of hESCs during the decidualization process showed that Shp2 deficiency disrupted many signaling transduction pathways and gene expression. Analyses of hESCs and mouse uterine tissues confirmed that the signaling pathways extracellular regulated protein kinases (ERK), protein kinase B (AKT), signal transducer and activator of transcription 3 (STAT3) and their downstream transcription factors CCAAT/enhancer binding protein β (C/EBPβ) and Forkhead box transcription factor O1 (FOXO-1) were involved in the Shp2 regulation of decidualization. In summary, these results demonstrate that Shp2 plays a crucial role in stromal decidualization by mediating and coordinating multiple signaling pathways in uterine stromal cells. Our discovery possibly provides a novel key regulator of embryo implantation and novel therapeutic target for pregnancy failure.
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http://dx.doi.org/10.1371/journal.pgen.1010018DOI Listing
January 2022
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