Publications by authors named "G Da Prato"

96 Publications

Hemispheric surgery for severe epilepsy in early childhood: a case series.

Epileptic Disord 2021 Aug;23(4):611-622

Unit of Neurosurgery, IRCCS Istituto Giannina Gaslini, Genoa, Italy.

Hemispheric surgery is an effective and cost-effective option for hemispheric epilepsy. Data specifically focusing on very early infancy are scant. In our study, we report the results of hemispheric surgery in children under three years of age, along with clinical, neuroradiological and EEG features, from two Italian epilepsy surgery centres. After reviewing our epilepsy surgery databases (2008-2018), we identified 14 patients (seven males) submitted to hemispheric surgery, under three years (range: 2-29 months), with a follow-up of at least 12 months. No deaths occurred, and surgical complications were observed in 3/17 procedures. At final follow-up visit (mean: 30.8 months; range: 12-90), 10/14 patients (71.4%) achieved Engel Class I (eight Class 1A, one Class 1B, and one Class 1C). Antiepileptic drugs were completely discontinued in three and reduced in eight, thus a significant decrease in drug regimen after surgery was achieved in 11/14 patients (78.6%). Before surgery, severe developmental delay was present in 10 patients, moderate in two and mild in two. At the last follow-up visit, the degree of developmental delay changed from severe to moderate in five patients, remained unchanged in six cases (four severe and two moderate), and changed from mild to moderate in two following surgery. In many cases, hemispheric surgery in children under three years is effective in achieving seizure freedom or reducing seizure frequency, with the possibility of simplifying complex drug regimens. Moreover, it appears to be a safe and well tolerated procedure, leading to improvement in cognition and posture.
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http://dx.doi.org/10.1684/epd.2021.1303DOI Listing
August 2021

Double connective tissue graft to treat deep coronal-radicular abrasion: A 19-year follow-up case report.

Clin Adv Periodontics 2021 Jul 8. Epub 2021 Jul 8.

Department of Periodontics and Oral Medicine, School of Dentistry, University of Michigan, Ann Arbor, Michigan, USA.

Introduction: When gingival recession is combined with cervical abrasion, root coverage outcomes are less predictable due to the challenging adaptation of the connective tissue graft (CTG) to the marked root step. Removing additional tooth structure can improve soft-tissue adaptation with the downside of a possible increase in dental hypersensitivity or pulpitis. Therefore, the aim of this report was to demonstrate a surgical technique using two grafts which does not require any further modification of the root surface, in order to successfully treat recession associated with deep cervical abrasion.

Case Presentation: A case of gingival recession associated with a deep root step and cemento-enamel junction alteration (B+; abrasion depth > 1 mm) was successfully treated via a bilaminar grafting technique using two CTG layers covered by a coronally advanced flap (CAF). The tooth surface was polished and did not receive any grinding, blending, planing, or other alterations. Complete recession coverage, complete abrasion coverage, and resolution of baseline sensitivity were achieved 1 year after surgical intervention and were maintained for 19 years with further coronal displacement of the gingival margin due to creeping attachment.

Conclusions: The double CTG technique showed optimal clinical results in terms of coverage and resolution of hypersensitivity of a recession associated with a deep cervical abrasion. No additional removal of dental tissue was needed, and the clinical outcomes were stably maintained over a long-term follow-up.
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http://dx.doi.org/10.1002/cap.10176DOI Listing
July 2021

Accuracy of CGM Systems During Continuous and Interval Exercise in Adults with Type 1 Diabetes.

J Diabetes Sci Technol 2021 Jun 11:19322968211023522. Epub 2021 Jun 11.

Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, University and Hospital of Verona, Verona, Italy.

Background: continuous glucose monitoring systems (CGMs) play an important role in the management of T1D, but their accuracy may reduce during rapid glucose excursions. The aim of study was to assess the accuracy of recent rt-CGMs available in Italy, in subjects with T1D during 2 sessions of physical activity: moderate continuous (CON) and interval exercise (IE).

Method: we recruited 22 patients with T1D, on CSII associated or integrated with a CGM, to which a second different sensor was applied. Data recorded by CGMs were compared with the corresponding plasma glucose (PG) values, measured every 5 minutes with the glucose analyzer. To assess the accuracy of the CGMs, we evaluated the Sensor Bias (SB), the Mean Absolute Relative Difference (MARD) and the Clarke error grid (CEG).

Results: a total of 2355 plasma-sensor glucose paired points were collected. Both average plasma and interstitial glucose concentrations did not significantly differ during CON and IE. During CON: 1. PG change at the end of exercise was greater than during IE ( = .034); 2. all sensors overestimated PG more than during IE, as shown by SB ( < .001) and MARD ( < .001) comparisons. Classifying the performance according to the CEG, significant differences were found between the 2 sessions in distribution of points in A and B zones.

Conclusions: the exercise affects the accuracy of currently available CGMs, especially during CON, suggesting, in this circumstance, the need to maintain blood glucose in a "prudent" range, above that generally recommended. Further studies are needed to investigate additional types of activities.
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http://dx.doi.org/10.1177/19322968211023522DOI Listing
June 2021

Expanding the clinical and neuroimaging features of post-varicella arteriopathy of childhood.

J Neurol 2021 May 27. Epub 2021 May 27.

Neuroradiology Unit, IRCCS Istituto Giannina Gaslini, Genoa, Italy.

Objective: Post-varicella arterial ischemic stroke (AIS) is considered an uncommon cause of pediatric stroke that is considered a self-limiting, monophasic disease. However, in a subset of patients, disease recurs; the prevalence of vasculopathy or AIS recurrence, severity of clinical outcomes, and standardized therapies have not been well characterized. Herein, we determined the clinical-neuroradiological features, long-term evolution, and relationship between acute phase treatment and vasculopathy recurrence in a pediatric population with post-varicella AIS.

Methods: Clinical, laboratory, and neuroradiological features of 22 children with post-varicella AIS between 2010 and 2019 (16 males, mean age at stroke 4 years, range 1.7-10) were reviewed. Statistical analyses were performed using χ and Fisher exact tests.

Results: Of the 22 cases, mean time from varicella to stroke was 4.5 months with 3 cases presenting more than 12 months after rash; 21 (95%) were not vaccinated for varicella; 3 (13.6%) had posterior circulation involvement; and 5 (22.7%) had AIS or vasculopathy recurrence, of which 4 recurred 6.1 months to 2.8 years after initial clinical onset. Recurrence was associated with lack of antiviral treatment during the first episode (p = 0.02).

Conclusions: Post-varicella AIS can occur months after rash making diagnosis challenging. Because recurrent vasculopathy was seen predominantly in cases not treated with antiviral therapy during initial presentation, it is important to rapidly diagnose post-varicella AIS through clinical criteria and/or virological testing then treat with antivirals to prevent recurrence.
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http://dx.doi.org/10.1007/s00415-021-10606-6DOI Listing
May 2021

Periodontal Plastic Surgery for Reshaping the Mucogingival Junction Following Grafting Procedures: Case Reports.

Int J Periodontics Restorative Dent 2021 Mar-Apr;41(2):207-214

The present clinical and histologic case reports describe the periodontal plastic approaches used for the correction of gingival deformities following free gingival grafting (FGG) procedures. Five patients with poor esthetic and functional outcomes following soft tissue grafting voluntarily requested corrective treatment due to differences in color, texture, thickness, and mucogingival junction (MGJ) alignment between grafted and adjacent tissue, or because of food retention apical to the grafted site. Plastic surgical approaches included eliminating the thick borders the graft, aligning the MGJ, and reducing the excessive apicocoronal dimension of the graft. Histologic images confirmed the morphologic differences between the graft and adjacent alveolar mucosa. After intervention, all treated sites achieved a satisfactory esthetic appearance and function, with a soft tissue anatomy indistinguishable from those of adjacent sites. All patients agreed that their goals for the treatment were completely fulfilled.
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http://dx.doi.org/10.11607/prd.5221DOI Listing
April 2021
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