Gary Luker

Gary Luker

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Gary Luker

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Organotypic breast tumor model elucidates dynamic remodeling of tumor microenvironment.

Biomaterials 2020 Apr 7;238:119853. Epub 2020 Feb 7.

Department of Biomedical Engineering, The University of Akron, Akron, OH, 44325, USA. Electronic address:

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http://dx.doi.org/10.1016/j.biomaterials.2020.119853DOI Listing
April 2020

Single-cell RNA-sequencing of migratory breast cancer cells: discovering genes associated with cancer metastasis.

Analyst 2019 Dec;144(24):7296-7309

Department of Electrical Engineering and Computer Science, University of Michigan, 1301 Beal Avenue, Ann Arbor, MI 48109-2122, USA.

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http://dx.doi.org/10.1039/c9an01358jDOI Listing
December 2019

Short-Term Environmental Conditioning Enhances Tumorigenic Potential of Triple-Negative Breast Cancer Cells.

Tomography 2019 12;5(4):346-357

Department of Biomedical Engineering, University of Michigan College of Engineering and Medical School, Ann Arbor, MI.

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http://dx.doi.org/10.18383/j.tom.2019.00019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6935992PMC
December 2019

Engineered Fibrillar Fibronectin Networks as Three-Dimensional Tissue Scaffolds.

Adv Mater 2019 Nov 30;31(46):e1904580. Epub 2019 Sep 30.

Biointerfaces Institute, Departments of Chemical Engineering, Materials Science and Engineering, Biomedical Engineering, and Macromolecular Science and Engineering, University of Michigan, 2800 Plymouth Road, Ann Arbor, MI, 48109, USA.

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http://dx.doi.org/10.1002/adma.201904580DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6851443PMC
November 2019

Short-term cellular memory tunes the signaling responses of the chemokine receptor CXCR4.

Sci Signal 2019 07 9;12(589). Epub 2019 Jul 9.

Department of Radiology Center for Molecular Imaging, University of Michigan Medical School, Ann Arbor, MI 48109, USA.

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http://dx.doi.org/10.1126/scisignal.aaw4204DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7059217PMC
July 2019

Monitoring implantable immunoisolation devices with intrinsic fluorescence of genipin.

J Biophotonics 2019 04 25;12(4):e201800170. Epub 2018 Sep 25.

NanoBioCel Group, Laboratory of Pharmaceutics, School of Pharmacy, University of the Basque Country (UPV/EHU), Vitoria-Gasteiz, Spain.

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http://dx.doi.org/10.1002/jbio.201800170DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351221PMC
April 2019

Cyclical Treatment of Colorectal Tumor Spheroids Induces Resistance to MEK Inhibitors.

Transl Oncol 2019 Mar 14;12(3):404-416. Epub 2018 Dec 14.

Department of Biomedical Engineering, The University of Akron, Akron, OH 44325, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S19365233183058
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http://dx.doi.org/10.1016/j.tranon.2018.11.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6299152PMC
March 2019

Dual Reporter Bioluminescence Imaging with NanoLuc and Firefly Luciferase.

Methods Mol Biol 2018 ;1790:41-50

Department of Radiology, Center for Molecular Imaging, University of Michigan, Ann Arbor, MI, USA.

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http://dx.doi.org/10.1007/978-1-4939-7860-1_4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6083827PMC
February 2019

Needs Assessment Using a Structured Prioritization Schema: An Open Letter to PACS Vendors.

J Am Coll Radiol 2019 Feb 13;16(2):170-177. Epub 2018 Sep 13.

Department of Radiology, Michigan Medicine, Ann Arbor, Michigan; Michigan Radiology Quality Collaborative, Ann Arbor, Michigan. Electronic address:

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http://dx.doi.org/10.1016/j.jacr.2018.07.014DOI Listing
February 2019

Mammary fibroblasts remodel fibrillar collagen microstructure in a biomimetic nanocomposite hydrogel.

Acta Biomater 2019 01 7;83:221-232. Epub 2018 Nov 7.

Department of Chemical Engineering and Materials Science, Michigan State University, United States. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S17427061183066
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http://dx.doi.org/10.1016/j.actbio.2018.11.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6291359PMC
January 2019

Morphology-based prediction of cancer cell migration using an artificial neural network and a random decision forest.

Integr Biol (Camb) 2018 12;10(12):758-767

Department of Electrical Engineering and Computer Science, University of Michigan, 1301 Beal Avenue, Ann Arbor, MI 48109-2122, USA.

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http://xlink.rsc.org/?DOI=C8IB00106E
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http://dx.doi.org/10.1039/c8ib00106eDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329292PMC
December 2018

The effect of mechanosensitive channel MscL expression in cancer cells on 3D confined migration.

APL Bioeng 2018 Sep 8;2(3):032001. Epub 2018 Jun 8.

Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan 48109, USA.

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http://dx.doi.org/10.1063/1.5019770DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324216PMC
September 2018

Hybrid collagen alginate hydrogel as a platform for 3D tumor spheroid invasion.

Acta Biomater 2018 07 5;75:213-225. Epub 2018 Jun 5.

Center for Molecular Imaging, Department of Radiology, University of Michigan Medical School, 109 Zina Pitcher Place, Ann Arbor, MI 48109-2200, United States; Department of Biomedical Engineering, University of Michigan Medical School, United States; Department of Microbiology and Immunology, University of Michigan Medical School, United States. Electronic address:

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http://dx.doi.org/10.1016/j.actbio.2018.06.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6119473PMC
July 2018

Primary myelofibrosis evolving to an aplastic appearing marrow.

Clin Case Rep 2018 Jul 31;6(7):1393-1395. Epub 2018 May 31.

Division of Hematology/Oncology Department of Internal Medicine University of Michigan Ann Arbor MI USA.

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http://dx.doi.org/10.1002/ccr3.1618DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6028358PMC
July 2018

A Facile, In Vitro 384-Well Plate System to Model Disseminated Tumor Cells in the Bone Marrow Microenvironment.

Methods Mol Biol 2018 ;1686:201-213

Department of Radiology, Center for Molecular Imaging, University of Michigan, Ann Arbor, MI, USA.

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http://link.springer.com/10.1007/978-1-4939-7371-2_15
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http://dx.doi.org/10.1007/978-1-4939-7371-2_15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5953149PMC
June 2018

Multimodal imaging provides insight into targeted therapy response in metastatic prostate cancer to the bone.

Am J Nucl Med Mol Imaging 2018 5;8(3):189-199. Epub 2018 Jun 5.

Department of Radiology, University of Michigan Ann Arbor, Michigan, United States of America.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6056245PMC
June 2018

A Caspase-3 Reporter for Fluorescence Lifetime Imaging of Single-Cell Apoptosis.

Cells 2018 Jun 13;7(6). Epub 2018 Jun 13.

Center for Molecular Imaging, Department of Radiology, University of Michigan, Ann Arbor, MI 48190, USA.

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http://dx.doi.org/10.3390/cells7060057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6025355PMC
June 2018

Biomaterials-Based Approaches to Tumor Spheroid and Organoid Modeling.

Adv Healthc Mater 2018 03 4;7(6):e1700980. Epub 2017 Dec 4.

Department of Biomedical Engineering, The University of Akron, Akron, OH, 44325, USA.

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http://doi.wiley.com/10.1002/adhm.201700980
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http://dx.doi.org/10.1002/adhm.201700980DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5867257PMC
March 2018

Three-dimensional tumor model mimics stromal - breast cancer cells signaling.

Oncotarget 2018 Jan 5;9(1):249-267. Epub 2017 Dec 5.

Department of Biomedical Engineering, The University of Akron, Akron, OH 44325, USA.

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http://dx.doi.org/10.18632/oncotarget.22922DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5787462PMC
January 2018

Fluorescence Lifetime Imaging of a Caspase-3 Apoptosis Reporter.

Curr Protoc Cell Biol 2017 Dec 11;77:21.12.1-21.12.12. Epub 2017 Dec 11.

Center for Molecular Imaging, Department of Radiology, University of Michigan, Ann Arbor, Michigan.

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http://dx.doi.org/10.1002/cpcb.36DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5729923PMC
December 2017

Dual-Color Luciferase Complementation for Chemokine Receptor Signaling.

Methods Enzymol 2016 14;570:119-29. Epub 2015 Nov 14.

Department of Radiology, Center for Molecular Imaging, University of Michigan, Ann Arbor, Michigan, USA; Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan, USA; Department of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S00766879150049
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http://dx.doi.org/10.1016/bs.mie.2015.08.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5245831PMC
November 2017

A Bifunctional MAPK/PI3K Antagonist for Inhibition of Tumor Growth and Metastasis.

Mol Cancer Ther 2017 11 3;16(11):2340-2350. Epub 2017 Aug 3.

Center for Molecular Imaging, The University of Michigan Medical School, Ann Arbor, Michigan.

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http://dx.doi.org/10.1158/1535-7163.MCT-17-0207DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5669819PMC
November 2017

The CXCL12/CXCR7 signaling axis, isoforms, circadian rhythms, and tumor cellular composition dictate gradients in tissue.

PLoS One 2017 8;12(11):e0187357. Epub 2017 Nov 8.

Department of Chemical Engineering, University of Michigan, Ann Arbor, Michigan, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0187357PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5678865PMC
November 2017

Structure-Guided Design and Initial Studies of a Bifunctional MEK/PI3K Inhibitor (ST-168).

ACS Med Chem Lett 2017 Aug 24;8(8):808-813. Epub 2017 Jul 24.

Center for Molecular Imaging, Department of Radiology, Departments of Chemical and Biomedical Engineering, and Department of Ophthalmology and Visual Sciences, The University of Michigan Medical School, Ann Arbor, Michigan 48109, United States.

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http://dx.doi.org/10.1021/acsmedchemlett.7b00111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5554897PMC
August 2017

Semiautomated Workflow for Clinically Streamlined Glioma Parametric Response Mapping.

Tomography 2016 Dec;2(4):267-275

Department of Radiology, Center for Molecular Imaging, University of Michigan, Ann Arbor, Michigan.

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http://dx.doi.org/10.18383/j.tom.2016.00181DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5345939PMC
December 2016

Engineered Breast Cancer Cell Spheroids Reproduce Biologic Properties of Solid Tumors.

Adv Healthc Mater 2016 11 7;5(21):2788-2798. Epub 2016 Sep 7.

Department of Biomedical Engineering, The University of Akron, Akron, OH, 44325, USA.

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http://dx.doi.org/10.1002/adhm.201600644DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5142748PMC
November 2016

Multiparametric Analysis of Oncology Drug Screening with Aqueous Two-Phase Tumor Spheroids.

Mol Pharm 2016 11 4;13(11):3724-3735. Epub 2016 Oct 4.

Department of Biomedical Engineering, The University of Akron , Akron, Ohio 44325 United States.

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http://dx.doi.org/10.1021/acs.molpharmaceut.6b00527DOI Listing
November 2016

In vivo targeting of metastatic breast cancer via tumor vasculature-specific nano-graphene oxide.

Biomaterials 2016 10 26;104:361-71. Epub 2016 Jul 26.

Center for Molecular Imaging, Department of Radiology, University of Michigan - Ann Arbor, MI 48109-2200, United States; University of Michigan Comprehensive Cancer Center, MI 48109-0944, United States. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01429612163036
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http://dx.doi.org/10.1016/j.biomaterials.2016.07.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5644339PMC
October 2016

Macrophage Migration Inhibitory Factor-CXCR4 Receptor Interactions: EVIDENCE FOR PARTIAL ALLOSTERIC AGONISM IN COMPARISON WITH CXCL12 CHEMOKINE.

J Biol Chem 2016 Jul 19;291(30):15881-95. Epub 2016 May 19.

the Institute of Biochemistry and Molecular Cell Biology, Rheinisch-Westfälische Technische Hochschule (RWTH), Aachen University, Pauwelsstrasse 30, 52074 Aachen, Germany, Vascular Biology, Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-University of Munich, Feodor-Lynen-Strasse 17, and the Munich Cluster for Systems Neurology (SyNergy), 81377 Munich, Germany

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http://dx.doi.org/10.1074/jbc.M116.717751DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4957068PMC
July 2016

Targeted Imaging of the Atypical Chemokine Receptor 3 (ACKR3/CXCR7) in Human Cancer Xenografts.

J Nucl Med 2016 06 23;57(6):981-8. Epub 2016 Feb 23.

Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, Maryland Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland

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http://dx.doi.org/10.2967/jnumed.115.167932DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5261856PMC
June 2016

Imaging Sensitivity of Quiescent Cancer Cells to Metabolic Perturbations in Bone Marrow Spheroids.

Tomography 2016 Jun;2(2):146-157

Department of Biomedical Engineering, University of Michigan College of Engineering, Ann Arbor, Michigan, 48109, USA; Center for Molecular Imaging, Department of Radiology, University of Michigan Medical School, Ann Arbor, Michigan, 48109, USA; Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, 48109, USA.

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http://dx.doi.org/10.18383/j.tom.2016.00157DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4963031PMC
June 2016

A Pilot Study of Quantitative MRI Parametric Response Mapping of Bone Marrow Fat for Treatment Assessment in Myelofibrosis.

Tomography 2016 Mar;2(1):67-78

Center for Molecular Imaging, Department of Radiology, University of Michigan, Ann Arbor, MI, USA; Department of Biological Chemistry, University of Michigan, Ann Arbor, MI, USA.

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http://dx.doi.org/10.18383/j.tom.2016.00115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4872873PMC
March 2016

Cell, isoform, and environment factors shape gradients and modulate chemotaxis.

PLoS One 2015 24;10(4):e0123450. Epub 2015 Apr 24.

Department of Chemical Engineering, University of Michigan, Ann Arbor, Michigan, United States of America; Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0123450PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4409393PMC
January 2016

Fluorescence Lifetime Imaging of Apoptosis.

Tomography 2015 Dec;1(2):115-124

University of Michigan Center for Molecular Imaging, 109 Zina Pitcher Place, Ann Arbor, MI, USA, 48109-2200.

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http://flipbook.tomography.org/publication/?i=456839&ver
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http://dx.doi.org/10.18383/j.tom.2015.00163DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4710058PMC
December 2015

CXCR4-Targeted Nanocarriers for Triple Negative Breast Cancers.

Biomacromolecules 2015 Aug 22;16(8):2412-7. Epub 2015 Jul 22.

§Institute of Functional Interfaces, Karlsruhe Institute of Technology, Hermann-von-Helmholtz-Platz 1, 76344 Eggenstein-Leopoldshafen, Germany.

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http://pubs.acs.org/doi/10.1021/acs.biomac.5b00653
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http://dx.doi.org/10.1021/acs.biomac.5b00653DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5474759PMC
August 2015

Modeling selective elimination of quiescent cancer cells from bone marrow.

Neoplasia 2015 Aug;17(8):625-33

Department of Biomedical Engineering, University of Michigan College of Engineering, Ann Arbor, MI 48109; Department of Radiology, University of Michigan School of Medicine, Ann Arbor, MI 48109; Center for Molecular Imaging, Department of Radiology, University of Michigan Medical School, Ann Arbor, MI 48109; Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109. Electronic address:

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http://dx.doi.org/10.1016/j.neo.2015.08.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4674483PMC
August 2015

Microscale 3D collagen cell culture assays in conventional flat-bottom 384-well plates.

J Lab Autom 2015 Apr 15;20(2):138-45. Epub 2014 Dec 15.

Department of Biomedical Engineering, Biointerfaces Institute, University of Michigan, Ann Arbor, MI, USA Department of Macromolecular Science and Engineering, University of Michigan, Ann Arbor, MI, USA Division of Nano-Bio and Chemical Engineering WCU Project, UNIST, Republic of Korea

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http://journals.sagepub.com/doi/10.1177/2211068214563793
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http://dx.doi.org/10.1177/2211068214563793DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4478447PMC
April 2015

CXCR7 controls competition for recruitment of β-arrestin 2 in cells expressing both CXCR4 and CXCR7.

PLoS One 2014 4;9(6):e98328. Epub 2014 Jun 4.

Center for Molecular Imaging, Department of Radiology, Department of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan, United States of America; Department of Biomedical Engineering, Department of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan, United States of America; Department of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0098328PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4045718PMC
March 2015

Surface-templated hydrogel patterns prompt matrix-dependent migration of breast cancer cells towards chemokine-secreting cells.

Acta Biomater 2015 Feb 24;13:68-77. Epub 2014 Nov 24.

Macromolecular Science and Engineering Program, University of Michigan, Ann Arbor, MI, USA; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA; Biointerfaces Institute, University of Michigan, Ann Arbor, MI, USA. Electronic address:

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http://dx.doi.org/10.1016/j.actbio.2014.11.033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4293228PMC
February 2015

Expansion of CTCs from early stage lung cancer patients using a microfluidic co-culture model.

Oncotarget 2014 Dec;5(23):12383-97

Department of Chemical Engineering, Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109. Translational Oncology Program, University of Michigan, Ann Arbor, MI 48109.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4323004PMC
http://dx.doi.org/10.18632/oncotarget.2592DOI Listing
December 2014

High Throughput, Polymeric Aqueous Two-Phase Printing of Tumor Spheroids.

Adv Funct Mater 2014 Nov;24(41):6509-6515

Department of Biomedical Engineering, The University of Akron, Akron, OH 44325 USA.

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http://dx.doi.org/10.1002/adfm.201401302DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4233147PMC
November 2014

Optimization of Aqueous Biphasic Tumor Spheroid Microtechnology for Anti-Cancer Drug Testing in 3D Culture.

Cell Mol Bioeng 2014 Sep;7(3):344-354

Department of Biomedical Engineering, The University of Akron, Akron, Ohio 44325, United States.

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http://dx.doi.org/10.1007/s12195-014-0349-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4159185PMC
September 2014

Macroscopic stiffness of breast tumors predicts metastasis.

Sci Rep 2014 Jul 1;4:5512. Epub 2014 Jul 1.

1] University of Michigan Medical School, College of Engineering, and School of Public Health. University of Michigan Center for Molecular Imaging, Department of Radiology [2] University of Michigan Medical School, College of Engineering, and School of Public Health. University of Michigan Center for Molecular Imaging, Department of Biomedical Engineering [3] University of Michigan Medical School, College of Engineering, and School of Public Health. University of Michigan Center for Molecular Imaging, Department of Microbiology and Immunology.

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http://dx.doi.org/10.1038/srep05512DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4076689PMC
July 2014

Split Gaussia luciferase for imaging ligand-receptor binding.

Methods Mol Biol 2014 ;1098:59-69

Center for Molecular Imaging, Department of Radiology, University of Michigan, Ann Arbor, MI, USA.

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http://link.springer.com/10.1007/978-1-62703-718-1_5
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http://dx.doi.org/10.1007/978-1-62703-718-1_5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4122980PMC
May 2014

A Comprehensive Analysis of CXCL12 Isoforms in Breast Cancer

Transl Oncol 2014 May 13. Epub 2014 May 13.

Radiology, University of Michigan, Ann Arbor, MI, USA; Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA; Microbiology and Immunology, University of Michigan, Ann Arbor, MI, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S19365233140002
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http://dx.doi.org/10.1016/j.tranon.2014.04.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4145355PMC
May 2014

Transfer, imaging, and analysis plate for facile handling of 384 hanging drop 3D tissue spheroids.

J Lab Autom 2014 Apr 19;19(2):208-14. Epub 2013 Sep 19.

1Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA.

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http://dx.doi.org/10.1177/2211068213504296DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4141680PMC
April 2014

Allosteric peptide regulators of chemokine receptors CXCR4 and CXCR7.

Biochem Pharmacol 2013 Nov 22;86(9):1263-71. Epub 2013 Aug 22.

Center for Molecular Imaging, Department of Radiology, University of Michigan Medical School, Ann Arbor, MI 48109-2200, USA.

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http://dx.doi.org/10.1016/j.bcp.2013.08.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3819144PMC
November 2013

Simple Multi-level Microchannel Fabrication by Pseudo-Grayscale Backside Diffused Light Lithography.

RSC Adv 2013 Nov;3(42):19467-19473

Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA ; Reproductive Sciences Program, University of Michigan, Ann Arbor, MI, USA ; Department of Macromolecular Science and Engineering, University of Michigan, Ann Arbor, MI, USA ; Division of Nano-Bio and Chemical Engineering WCU Project, UNIST, Ulsan, Republic of Korea.

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http://dx.doi.org/10.1039/C3RA43834ADOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4066982PMC
November 2013

Imaging CXCL12-CXCR4 signaling in ovarian cancer therapy.

PLoS One 2013 23;8(1):e51500. Epub 2013 Jan 23.

Center for Molecular Imaging, Department of Radiology, University of Michigan Medical School, Ann Arbor, Michigan, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0051500PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3553093PMC
July 2013

Advancing the translation of optical imaging agents for clinical imaging.

Biomed Opt Express 2013 Jan 18;4(1):160-70. Epub 2012 Dec 18.

The University of Texas Health Science Center at Houston, Center for Molecular Imaging, The Brown Foundation Institute of Molecular Medicine, 1825 Pressler Street, Houston, TX 77030, USA.

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http://dx.doi.org/10.1364/BOE.4.000160DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3539189PMC
January 2013

Opportunities and challenges for use of tumor spheroids as models to test drug delivery and efficacy.

J Control Release 2012 Dec 18;164(2):192-204. Epub 2012 May 18.

Department of Biomedical Engineering, The University of Michigan, Ann Arbor, MI 48109-2099, USA.

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http://dx.doi.org/10.1016/j.jconrel.2012.04.045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3436947PMC
December 2012

Rapid generation of multiplexed cell cocultures using acoustic droplet ejection followed by aqueous two-phase exclusion patterning.

Tissue Eng Part C Methods 2012 Sep 18;18(9):647-57. Epub 2012 Apr 18.

Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48104, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3427642PMC
September 2012

Cell-based and in vivo spectral analysis of fluorescent proteins for multiphoton microscopy.

J Biomed Opt 2012 Sep;17(9):96001

University of Michigan Medical School, Department of Radiology, 109 Zina Pitcher Place, A526 BSRB, Ann Arbor, Michigan 48109-2200, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3438408PMC
September 2012

Carboxy-terminus of CXCR7 regulates receptor localization and function.

Int J Biochem Cell Biol 2012 Apr 25;44(4):669-78. Epub 2012 Jan 25.

Center for Molecular Imaging, Department of Radiology, University of Michigan Medical School, Ann Arbor, MI 48109-2200, USA.

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http://dx.doi.org/10.1016/j.biocel.2012.01.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3294180PMC
April 2012

Secreted CXCL12 (SDF-1) forms dimers under physiological conditions.

Biochem J 2012 Mar;442(2):433-42

Center for Molecular Imaging, Department of Radiology, University of Michigan, Ann Arbor, MI 48109, U.S.A.

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http://dx.doi.org/10.1042/BJ20111341DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4419379PMC
March 2012

Targeted non-covalent self-assembled nanoparticles based on human serum albumin.

Biomaterials 2012 Jan 22;33(3):867-75. Epub 2011 Oct 22.

Division of Diagnostic Oncology, the Netherlands Cancer Institute Antoni van Leeuwenhoek Hospital, 1066 CX Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.biomaterials.2011.10.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4461197PMC
January 2012

Synthesis and investigation of a radioiodinated F3 peptide analog as a SPECT tumor imaging radioligand.

PLoS One 2011 19;6(7):e22418. Epub 2011 Jul 19.

Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan, United States of America.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3139646PMC
December 2011

In vivo imaging of ligand receptor binding with Gaussia luciferase complementation.

Nat Med 2011 Dec 4;18(1):172-7. Epub 2011 Dec 4.

Center for Molecular Imaging, Department of Radiology, University of Michigan Medical School, Ann Arbor, Michigan, USA.

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http://dx.doi.org/10.1038/nm.2590DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3253890PMC
December 2011

Noninvasive imaging reveals inhibition of ovarian cancer by targeting CXCL12-CXCR4.

Neoplasia 2011 Dec;13(12):1152-61

Center for Molecular Imaging, Department of Radiology, University of Michigan Medical School, Ann Arbor, MI 48109-2200, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3257190PMC
http://dx.doi.org/10.1593/neo.111076DOI Listing
December 2011

Development of a baited oral vaccine for use in reservoir-targeted strategies against Lyme disease.

Vaccine 2011 Oct 2;29(44):7818-25. Epub 2011 Aug 2.

Program in Molecular Microbiology, Sackler School of Graduate Biomedical Sciences, Tufts University, Boston, MA 02111, USA.

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http://dx.doi.org/10.1016/j.vaccine.2011.07.100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3577423PMC
October 2011

Polymeric Aqueous Biphasic System Rehydration Facilitates High Throughput Cell Exclusion Patterning For Cell Migration Studies.

Adv Funct Mater 2011 Aug 24;21(15):2920-2926. Epub 2011 May 24.

Department of Biomedical Engineering, University of Akron, Akron, OH 44325 ; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109.

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http://dx.doi.org/10.1002/adfm.201002559DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3601801PMC
August 2011

Applications of molecular imaging.

Prog Mol Biol Transl Sci 2010 ;95:237-98

Department of Radiology, University of Michigan, Center for Molecular Imaging, Ann Arbor, Michigan, USA.

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http://dx.doi.org/10.1016/B978-0-12-385071-3.00009-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4327770PMC
July 2011

Luciferase protein complementation assays for bioluminescence imaging of cells and mice.

Methods Mol Biol 2011 ;680:29-43

Department of Radiology, University of Michigan, Ann Arbor, MI 48109-2200, USA.

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http://dx.doi.org/10.1007/978-1-60761-901-7_2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4467521PMC
March 2011

Microfluidic platform for chemotaxis in gradients formed by CXCL12 source-sink cells.

Integr Biol (Camb) 2010 Nov 27;2(11-12):680-6. Epub 2010 Sep 27.

Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.

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http://dx.doi.org/10.1039/c0ib00041hDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4128891PMC
November 2010

Multiplexed spectral signature detection for microfluidic color-coded bioparticle flow.

Anal Chem 2010 Nov 27;82(22):9506-12. Epub 2010 Oct 27.

Department of Mechanical Engineering, University of Michigan, Ann Arbor, 48109, United States.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2998408PMC
November 2010

Bioluminescence imaging of reporter mice for studies of infection and inflammation.

Antiviral Res 2010 Apr;86(1):93-100

Center for Molecular Imaging, Department of Radiology, University of Michigan Medical School, Ann Arbor, MI 48019-2200, USA.

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http://dx.doi.org/10.1016/j.antiviral.2010.02.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2863000PMC
April 2010

Real-time bioluminescence imaging of viral pathogenesis.

Methods Mol Biol 2009 ;574:125-35

Department of Radiology, University of Michigan Medical School, Ann Arbor, MI, USA.

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http://link.springer.com/10.1007/978-1-60327-321-3_11
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4427191PMC
January 2010

Microfluidic hydrodynamic cellular patterning for systematic formation of co-culture spheroids.

Integr Biol (Camb) 2009 Dec 22;1(11-12):649-54. Epub 2009 Oct 22.

Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.

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http://dx.doi.org/10.1039/b915965gDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2825702PMC
December 2009

Imaging ligand-dependent activation of CXCR7.

Neoplasia 2009 Oct;11(10):1022-35

Center for Molecular Imaging, Department of Radiology, University of Michigan Medical School, Ann Arbor, MI 48109-2200, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2745668PMC
http://dx.doi.org/10.1593/neo.09724DOI Listing
October 2009

Bioluminescent CXCL12 fusion protein for cellular studies of CXCR4 and CXCR7.

Biotechniques 2009 Jul;47(1):625-32

Center for Molecular Imaging, Department of Radiology, University of Michigan Medical School, Ann Arbor, MI, USA.

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http://dx.doi.org/10.2144/000113126DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4418468PMC
July 2009

Imaging chemokine receptor dimerization with firefly luciferase complementation.

FASEB J 2009 Mar 10;23(3):823-34. Epub 2008 Nov 10.

Center for Molecular Imaging, Department of Radiology, University of Michigan Medical School, 109 Zina Pitcher Pl., A526 BSRB, Ann Arbor, MI 48109-2200, USA.

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http://www.fasebj.org/doi/10.1096/fj.08-116749
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2653984PMC
March 2009

Extended cavity laser enhanced two-photon flow cytometry.

J Biomed Opt 2008 Jul-Aug;13(4):041319

University of Michigan, Center for Ultrafast Optical Science, Electrical Engineering & Computer Science Department, Ann Arbor, Michigan 48109-2099, USA.

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http://dx.doi.org/10.1117/1.2967983DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4469470PMC
January 2009

Generation of a highly inducible Gal4-->Fluc universal reporter mouse for in vivo bioluminescence imaging.

Proc Natl Acad Sci U S A 2008 Oct 8;105(41):15932-7. Epub 2008 Oct 8.

Molecular Imaging Center, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0801075105
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2572923PMC
October 2008

Protective effect of Toll-like receptor 4 in pulmonary vaccinia infection.

PLoS Pathog 2008 Sep 19;4(9):e1000153. Epub 2008 Sep 19.

Graduate Program in Immunology, University of Michigan Medical School, Ann Arbor, Michigan, United States of America.

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https://dx.plos.org/10.1371/journal.ppat.1000153
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http://dx.doi.org/10.1371/journal.ppat.1000153DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2529451PMC
September 2008

Imaging CXCR4 signaling with firefly luciferase complementation.

Anal Chem 2008 Jul 6;80(14):5565-73. Epub 2008 Jun 6.

Center for Molecular Imaging, Department of Radiology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA.

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http://dx.doi.org/10.1021/ac8005457DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5258185PMC
July 2008

Monitoring serial changes in circulating human breast cancer cells in murine xenograft models.

Cancer Res 2008 Jul;68(14):5529-32

Breast Oncology Program, Comprehensive Cancer Center, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan 48109-0942, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-08-0630DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2789403PMC
July 2008

Applications of bioluminescence imaging to antiviral research and therapy: multiple luciferase enzymes and quantitation.

Antiviral Res 2008 Jun 5;78(3):179-87. Epub 2008 Mar 5.

Department of Radiology, University of Michigan Medical School, 109 Zina Pitcher Place, A526 BSRB, Ann Arbor, MI 48109-2200, United States.

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http://dx.doi.org/10.1016/j.antiviral.2008.01.158DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2430099PMC
June 2008

In Vivo Monitoring of Multiple Circulating Cell Populations Using Two-photon Flow Cytometry.

Opt Commun 2008 Feb;281(4):888-894

Center for Ultrafast Optical Science, EECS Department, University of Michigan, 2200 Bonisteel Blvd., Ann Arbor, MI 48109-2099.

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http://dx.doi.org/10.1016/j.optcom.2007.10.106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2352153PMC
February 2008

TLR3 increases disease morbidity and mortality from vaccinia infection.

J Immunol 2008 Jan;180(1):483-91

Graduate Program in Immunology, Department of Radiology, Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor 48109-2200, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4470388PMC
http://dx.doi.org/10.4049/jimmunol.180.1.483DOI Listing
January 2008

Type I interferon regulates respiratory virus infected dendritic cell maturation and cytokine production.

Viral Immunol 2007 Dec;20(4):531-40

Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA.

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http://dx.doi.org/10.1089/vim.2007.0057DOI Listing
December 2007