Publications by authors named "G Chandrasekhar"

35 Publications

Low-Temperature Operating Black SnO-Based VOC Sensor Setup.

ACS Omega 2021 Sep 26;6(35):22900-22908. Epub 2021 Aug 26.

Nanomaterials and Polymer Physics Lab, Department of Physics, Manipal Institute of Technology, Manipal Academy of Higher Education, Manipal, Karnataka 576104, India.

Volatile organic compounds (VOCs) are harmful to human beings and animals. VOCs include a carbon compound and its derivatives. VOCs irritate the eyes, ears, and throat, ahigh concentration of VOCs may cause cancer; also, it affects the central nervous system. A concentration below 0.3 mg/m is harmless, above which it is harmful to human beings. The present work discusses the detection of harmful VOCs using a lab-made portable device setup. Hydrothermally synthesized tin oxide (SnO) nanocubes are used as an active material for VOC detection. The SnO pellet is prepared using a hydraulic press method and is used in the portable setup. Temperature-dependent VOC detection is carried out using a microheater. An external potential is applied to the microheater, which stimulates the active material to sense ethanol at 40 °C. SnO and EA deposited on graphite interdigitated electrodes projected on cellulose are used to detect isopropanol, ethanol, and acetone at room temperature. Temperature-dependent studies on acetone are carried out. A significant change in the current levels is observed for different VOCs. A positive shift in the Dirac point is noticed upon VOC exposure. The developed portable device plays a vital role in analyzing sensors based on various active materials for VOC detection.
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http://dx.doi.org/10.1021/acsomega.1c03399DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8427796PMC
September 2021

Investigating the pernicious effects of heparan sulfate in serum amyloid A1 protein aggregation: a structural bioinformatics approach.

J Biomol Struct Dyn 2020 Oct 14:1-15. Epub 2020 Oct 14.

Bioinformatics Lab, Department of Biotechnology, School of Bio Sciences and Technology, Vellore Institute of Technology (Deemed to be University), Vellore, Tamil Nadu, India.

Amyloid-A mediated (AA) amyloidosis is the pathogenic byproduct of body's prolonged exposure to inflammatory conditions. It is described by the aggregation of mutated/misfolded serum amyloid A1 (SAA1) protein in various tissues and organs. Genetic polymorphism G90D is suspected to cause AA amyloidosis, although the causal mechanism remains cryptic. Recent experimental findings insinuate that heparan sulphate (HS), a glycosaminoglycans, exhibits binding with SAA1 to promote its aggregation. To foster the enhanced binding of HS, we computationally determined the pernicious modifications in G90D mutant SAA1 protein. Also, we examined the influence of HS on the dynamic conformation of mutant SAA1 that could potentially succor amyloidosis. Accordingly, the protein-ligand binding studies indicate that upon SNP G90D, SAA1 protein exhibited an augmented association with HS. Further, the simulation of HS bound mutant SAA1 complex delineates an increase in RMSD, Rg, and RMSF. Also, both RMSD and Rg evinced a fluctuating trajectory. Further, the complex showed increase of beta turn in its secondary structural composition. Additionally, the free energy landscape of mutant SAA1-HS complex posits the occurrence of multiple global minima conformers as opposed to the presence of a single global energy minima conformation in native SAA1 protein. In conclusion, the aforementioned conformational ramifications induced by HS on SAA1 could potentially be the proteopathic incendiary behind AA amyloidosis; this incendiary will need to be considered in future studies for developing effective therapeutics against AA amyloidosis.Communicated by Ramaswamy H. Sarma.
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http://dx.doi.org/10.1080/07391102.2020.1833756DOI Listing
October 2020

Comparison of Rebound Tonometry and Handheld Applanation Tonometry in Pediatric Glaucoma with Clear and Scarred Corneas.

Ophthalmology 2019 09 20;126(9):1330-1332. Epub 2019 Mar 20.

VST Centre for Glaucoma, L V Prasad Eye Institute, Hyderabad, India. Electronic address:

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http://dx.doi.org/10.1016/j.ophtha.2019.03.021DOI Listing
September 2019

Recurrent uveitis and pigment dispersion in an eye with in-the-bag acrylic foldable intraocular lens.

BMJ Case Rep 2016 Feb 26;2016. Epub 2016 Feb 26.

Department of Glaucoma, L V Prasad Eye Institute, Hyderabad, Andhra Pradesh, India.

Phacoemulsification with in-the-bag intraocular lens (IOL) implantation is the standard procedure for cataract surgery. Pigment dispersion and uveitis can result when an IOL is placed in the sulcus. We report a case of a 64-year-old woman, with pigmentary glaucoma, who developed recurrent uveitis following uneventful cataract surgery and an in-the-bag hydrophobic acrylic IOL implant. Recurrent uveitis did not subside despite use of topical steroids over 3 months. Dilated examination revealed capsulophimosis with anterior dislocation of the IOL haptic. The mechanical trauma to the iris due to the displaced haptic was implicated as the cause of recurrent uveitis, which completely resolved after capsular excision and IOL repositioning. This case illustrates a rare cause of recurrent uveitis due to IOL haptic dislocation following severe capsulophimosis.
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http://dx.doi.org/10.1136/bcr-2015-213968DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4769451PMC
February 2016

Administration of bisphosphonate (ibandronate) impedes molar tooth movement in rabbits: A radiographic assessment.

J Pharm Bioallied Sci 2014 Jul;6(Suppl 1):S165-70

Department of Orthodontics, Panineeya Mahavidhyalaya Institute of Dental Sciences, Dilshuknagar, Hyderabad, Andhra Pradesh, India.

Introduction: Bisphosphonate (Bp)-ibandronate is a pharmacological agent, exhibits antiosteoclastic or antiresorptive activity and used to treat osteolytic or osteopenic disorders. BP-ibandronate may also interfere during orthodontic tooth movement. The aim of this study was to examine the influence of locally administered Bp-ibandronate on experimental tooth movement in rabbits.

Materials And Methods: Twenty rabbits were divided into two groups- "10" served as Group-1 (control) and other "10" as Group-2 (experimental). Both groups received nickel-titanium closed coil springs with 100 g force between mandibular molar and incisors. Group-1 animals received 1 ml normal saline and Group-2 animals received ibandronate solution (0.3 mg/kg body weight) locally, mesial to the mandibular molar on the 1(st), 7(th), and 14(th) day of the experiment. A total of "40" lateral cephalograms were taken from both groups on the 1(st) and 21(st) day using a digital X-ray unit (Siemens X-ray systems, 300 mA Pleomophos analog, 2008, Germany). Individually, each animal's radiograph was traced manually and superimposed. The molar tooth movement was measured with the help of a standard metric scale.

Results: The Student's t-test has been done to compare the mean values of Group-1 (4.650 ± 0.363) and Group-2 (2.030 ± 0.291) and the difference was statistically significant (P < 0.001).

Conclusion: The retarded molar tooth movement was noticed in local drug administered rabbits, which could be beneficial in orthodontics to control the undesired tooth movement.
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http://dx.doi.org/10.4103/0975-7406.137440DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4157260PMC
July 2014
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