Fuyuhiko Tamanoi

Fuyuhiko Tamanoi

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Fuyuhiko Tamanoi

Publications by authors named "Fuyuhiko Tamanoi"

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Anticancer Drug Delivery Capability of Biodegradable PMO in the Chicken Egg Tumor Model.

Enzymes 2018 12;44:103-116. Epub 2018 Oct 12.

Institute for Integrated Cell-Material Sciences, Institute for Advanced Study, Kyoto University, Kyoto, Japan; Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, CA, United States. Electronic address:

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http://dx.doi.org/10.1016/bs.enz.2018.09.003DOI Listing
October 2018

Tumor Targeting and Tumor Growth Inhibition Capability of Mesoporous Silica Nanoparticles in Mouse Models.

Enzymes 2018 12;44:61-82. Epub 2018 Oct 12.

Institute for Integrated Cell-Material Sciences, Institute for Advanced Study, Kyoto University, Kyoto, Japan; Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, CA, United States. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S18746047183001
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http://dx.doi.org/10.1016/bs.enz.2018.09.002DOI Listing
October 2018

Miniaturization of thiol-organosilica nanoparticles induced by an anionic surfactant.

J Colloid Interface Sci 2018 Sep 25;526:51-62. Epub 2018 Apr 25.

Department of Organ Anatomy and Nanomedicine, Yamaguchi University Graduate School of Medicine, 1-1-1 Minami-Kogushi, Ube, Yamaguchi 755-8505, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.jcis.2018.04.090DOI Listing
September 2018

Overview of Studies Regarding Mesoporous Silica Nanomaterials and Their Biomedical Application.

Enzymes 2018 10;43:1-10. Epub 2018 Sep 10.

Integrated Institute for Cell-Materials Science, Institute for Advanced Study, Kyoto University, Kyoto, Japan; Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, CA, United States. Electronic address:

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http://dx.doi.org/10.1016/bs.enz.2018.07.001DOI Listing
September 2018

Hyaluronic acid conjugated nanoparticle delivery of siRNA against TWIST reduces tumor burden and enhances sensitivity to cisplatin in ovarian cancer.

Nanomedicine 2018 Apr 14;14(4):1381-1394. Epub 2018 Apr 14.

Irell & Manella Graduate School of Biological Sciences, City of Hope - Beckman Research Institute, Duarte, California, USA; Department of Stem Cell and Developmental Biology, City of Hope - Beckman Research Institute, Duarte, California, USA. Electronic address:

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http://dx.doi.org/10.1016/j.nano.2018.04.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6186509PMC
April 2018

An oncogenic mutant of RHEB, RHEB Y35N, exhibits an altered interaction with BRAF resulting in cancer transformation.

BMC Cancer 2018 01 10;18(1):69. Epub 2018 Jan 10.

Department of Microbiology, Immunology, and Molecular Genetics, University of California, 1602 Molecular Sciences Bldg, 609 Charles E. Young Dr. East, Los Angeles, CA, 90095-1489, USA.

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https://bmccancer.biomedcentral.com/articles/10.1186/s12885-
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http://dx.doi.org/10.1186/s12885-017-3938-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5763582PMC
January 2018

Preface.

Authors:
Fuyuhiko Tamanoi

Enzymes 2018 ;43:xi

Kyoto and Los Angeles.

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https://linkinghub.elsevier.com/retrieve/pii/S18746047183002
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http://dx.doi.org/10.1016/S1874-6047(18)30025-8DOI Listing
January 2018

Preface.

Authors:
Fuyuhiko Tamanoi

Enzymes 2018 ;44:xi

Kyoto and Los Angeles.

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http://dx.doi.org/10.1016/S1874-6047(18)30035-0DOI Listing
January 2018

Exploiting Enzyme Alterations in Cancer for Drug Activation, Drug Delivery, and Nanotherapy.

Enzymes 2017 10;42:153-172. Epub 2017 Oct 10.

Jonsson Comprehensive Cancer Center, Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA, United States; Institute for Integrated Cell-Material Sciences, Institute for Advanced Study, Kyoto University, Kyoto, Japan. Electronic address:

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http://dx.doi.org/10.1016/bs.enz.2017.08.005DOI Listing
October 2017

A novel inhibitor of farnesyltransferase with a zinc site recognition moiety and a farnesyl group.

Bioorg Med Chem Lett 2017 08 20;27(16):3862-3866. Epub 2017 Jun 20.

Department of Bioorganic Medicinal Chemistry, Faculty of Life Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-ku, Kumamoto 862-0973, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2017.06.047DOI Listing
August 2017

Mevalonate Pathway and Human Cancers.

Curr Mol Pharmacol 2017 ;10(2):77-85

Department of Microbiology, Immunology and Molecular Genetics, Jonsson Comprehensive Cancer Center, Molecular Biology Institute, University of California, Los Angeles (UCLA), United States.

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http://dx.doi.org/10.2174/1874467209666160112123205DOI Listing
July 2017

Nanoparticle delivery of siRNA against TWIST to reduce drug resistance and tumor growth in ovarian cancer models.

Nanomedicine 2017 04 25;13(3):965-976. Epub 2016 Nov 25.

Department of Stem Cell and Developmental Biology, City of Hope-Beckman Research Institute Duarte, California, USA. Electronic address:

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http://dx.doi.org/10.1016/j.nano.2016.11.010DOI Listing
April 2017

Preface.

Enzymes 2017 ;42:xi

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http://dx.doi.org/10.1016/S1874-6047(17)30034-3DOI Listing
January 2017

Biodegradable Oxamide-Phenylene-Based Mesoporous Organosilica Nanoparticles with Unprecedented Drug Payloads for Delivery in Cells.

Chemistry 2016 Oct 30;22(42):14806-14811. Epub 2016 Jun 30.

Smart Hybrid Materials Laboratory, Advanced Membranes and Porous Materials Center, King Abdullah University of Science and Technology, Thuwal, Saudi Arabia.

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http://dx.doi.org/10.1002/chem.201601714DOI Listing
October 2016

Periodic Mesoporous Organosilica Nanoparticles with Controlled Morphologies and High Drug/Dye Loadings for Multicargo Delivery in Cancer Cells.

Chemistry 2016 07 1;22(28):9607-15. Epub 2016 Jun 1.

Smart Hybrid Materials Laboratory (SHMs), Advanced Membranes and Porous Materials Center, King Abdullah University of Science and Technology, Thuwal, Saudi Arabia.

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http://dx.doi.org/10.1002/chem.201600587DOI Listing
July 2016

Preface.

Enzymes 2012 29;31:x-xii. Epub 2012 Sep 29.

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http://dx.doi.org/10.1016/B978-0-12-404740-2.09991-2DOI Listing
May 2016

Nanoformulation of Geranylgeranyltransferase-I Inhibitors for Cancer Therapy: Liposomal Encapsulation and pH-Dependent Delivery to Cancer Cells.

PLoS One 2015 9;10(9):e0137595. Epub 2015 Sep 9.

Dept. of Microbiology, Immunology and Molecular Genetics, Jonsson Comprehensive Cancer Center, University of California Los Angeles, Los Angeles, CA 90095, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0137595PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4564137PMC
May 2016

Protein-gold clusters-capped mesoporous silica nanoparticles for high drug loading, autonomous gemcitabine/doxorubicin co-delivery, and in-vivo tumor imaging.

J Control Release 2016 05 23;229:183-191. Epub 2016 Mar 23.

Smart Hybrid Materials (SHMs) Laboratory, Advanced Membranes and Porous Materials Center, King Abdullah University of Science and Technology, Thuwal 23955-6900, Kingdom of Saudi Arabia. Electronic address:

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http://dx.doi.org/10.1016/j.jconrel.2016.03.030DOI Listing
May 2016

Development of mesoporous silica-based nanoparticles with controlled release capability for cancer therapy.

Adv Drug Deliv Rev 2015 Dec 3;95:40-9. Epub 2015 Oct 3.

Dept. of Microbio., Immunol. & Molec. Genet. Jonsson Comprehensive Cancer Center Molecular Biology Institute , University of California, Los Angeles, CA, United States. Electronic address:

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http://dx.doi.org/10.1016/j.addr.2015.09.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4663124PMC
December 2015

Mesoporous silica nanoparticle delivery of chemically modified siRNA against TWIST1 leads to reduced tumor burden.

Nanomedicine 2015 Oct 24;11(7):1657-66. Epub 2015 Jun 24.

Department of Neurosciences, City of Hope, Beckman Research Institute, Duarte, CA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.nano.2015.05.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4587301PMC
October 2015

Significance of filamin A in mTORC2 function in glioblastoma.

Mol Cancer 2015 Jul 2;14:127. Epub 2015 Jul 2.

Department of Microbiology, Immunology & Molecular Genetics, University of California, Los Angeles, CA, 90095, USA.

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http://dx.doi.org/10.1186/s12943-015-0396-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4489161PMC
July 2015

How Phytochemicals Prevent Chemical Carcinogens and/or Suppress Tumor Growth?

Enzymes 2015;37:1-42. Epub 2015 Jul 29.

Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, California, USA.

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http://dx.doi.org/10.1016/bs.enz.2015.06.003DOI Listing
July 2015

Functional nanovalves on protein-coated nanoparticles for in vitro and in vivo controlled drug delivery.

Small 2015 Jan 5;11(3):319-328. Epub 2014 Sep 5.

Department of Chemistry and Biochemistry, California NanoSystems Institute, Jonsson Comprehensive Cancer Center, University of California Los Angeles, Los Angeles, California, USA.

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http://dx.doi.org/10.1002/smll.201400765DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4327898PMC
January 2015

Preface.

Enzymes 2015;37:xiii

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http://dx.doi.org/10.1016/S1874-6047(15)00017-7DOI Listing
January 2015

Preface.

Enzymes 2015;38:xi

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http://dx.doi.org/10.1016/S1874-6047(15)00040-2DOI Listing
January 2015

Recent progress in the study of the Rheb family GTPases.

Cell Signal 2014 Sep 24;26(9):1950-7. Epub 2014 May 24.

Department of Microbiology, Immunology and Molecular Genetics, Jonsson Comprehensive Cancer Center, Molecular Biology Institute, University of California, Los Angeles, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cellsig.2014.05.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4134338PMC
September 2014

The Ras superfamily G-proteins.

Enzymes 2013 8;33 Pt A:1-14. Epub 2013 Aug 8.

Department of Microbiology, Immunology and Molecular Genetics, Molecular Biology Institute, Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, California, USA. Electronic address:

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http://dx.doi.org/10.1016/B978-0-12-416749-0.00001-4DOI Listing
August 2014

A two-hybrid approach to identify inhibitors of the RAS-RAF interaction.

Enzymes 2013 8;33 Pt A:213-48. Epub 2013 Aug 8.

Program in Biology, Priaxon Inc., Philadelphia, Pennsylvania, USA; Program in Developmental Therapeutics, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA. Electronic address:

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http://dx.doi.org/10.1016/B978-0-12-416749-0.00010-5DOI Listing
August 2014

Preface.

Authors:
Fuyuhiko Tamanoi

Enzymes 2013 8;33 Pt A:ix. Epub 2013 Aug 8.

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http://dx.doi.org/10.1016/B978-0-12-416749-0.10000-4DOI Listing
August 2014

Recent progress in developing small molecule inhibitors designed to interfere with ras membrane association: toward inhibiting K-Ras and N-Ras functions.

Enzymes 2013 7;34 Pt. B:181-200. Epub 2013 Nov 7.

Department of Microbiology, Immunology & Molecular Genetics, Jonsson Comprehensive Cancer Center, Molecular Biology Institute, University of California, Los Angeles, California, USA.

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http://dx.doi.org/10.1016/B978-0-12-420146-0.00008-1DOI Listing
August 2014

Inhibitors of the Ras superfamily of small G-proteins. Preface.

Enzymes 2013 7;34 Pt. B:ix. Epub 2013 Nov 7.

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http://dx.doi.org/10.1016/B978-0-12-420146-0.09985-6DOI Listing
August 2014

Hybrid mesoporous silica nanoparticles with pH-operated and complementary H-bonding caps as an autonomous drug-delivery system.

Chemistry 2014 Jul 1;20(30):9372-80. Epub 2014 Jul 1.

Institut Charles Gerhardt Montpellier UMR-5253 CNRS-UM2-ENSCM-UM1, Ecole Nationale Supérieure de Chimie de Montpellier, 8 rue de l'école normale, 34296 Montpellier Cedex 05 (France); Department of Chemistry and Biochemistry, University of California Los Angeles, 405 Hilgard Avenue, Los Angeles, CA 90095 (USA).

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http://dx.doi.org/10.1002/chem.201402864DOI Listing
July 2014

Two-photon-triggered drug delivery via fluorescent nanovalves.

Small 2014 May 20;10(9):1752-5. Epub 2014 Feb 20.

Institut Charles Gerhardt Montpellier, UMR-5253 CNRS-UM2-ENSCM-UM1, cc 1701, Place Eugène Bataillon, F-34095, Montpellier cedex 05, France.

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http://dx.doi.org/10.1002/smll.201400042DOI Listing
May 2014

[Recent developments in targeted therapy for cancers and drug discovery].

Authors:
Fuyuhiko Tamanoi

Nihon Yakurigaku Zasshi 2014 May;143(5):236-42

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May 2014

Characterization of the Raptor/4E-BP1 interaction by chemical cross-linking coupled with mass spectrometry analysis.

J Biol Chem 2014 Feb 8;289(8):4723-34. Epub 2014 Jan 8.

From the Department of Microbiology, Immunology, and Molecular Genetics, Jonsson Comprehensive Cancer Center, Molecular Biology Institute, University of California, Los Angeles, California 90095.

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http://dx.doi.org/10.1074/jbc.M113.482067DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3931034PMC
February 2014

Preface.

Enzymes 2014;35:xi-xiii

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http://dx.doi.org/10.1016/B978-0-12-801922-1.09991-7DOI Listing
January 2014

Introduction.

Enzymes 2014;36:1-6

Department of Microbiology, Immunology and Molecular Genetics, Jonsson Comprehensive Cancer Center, Molecular Biology Institute, University of California, Los Angeles, California, USA. Electronic address:

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http://dx.doi.org/10.1016/B978-0-12-802215-3.00001-XDOI Listing
January 2014

Anticancer Effect and Molecular Targets of Saffron Carotenoids.

Enzymes 2014;36:57-86

Department of Microbiology, Immunology and Molecular Genetics, Jonsson Comprehensive Cancer Center, Molecular Biology Institute, University of California, Los Angeles, California, USA.

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http://dx.doi.org/10.1016/B978-0-12-802215-3.00004-5DOI Listing
January 2014

In vitro and in vivo effects of geranylgeranyltransferase I inhibitor P61A6 on non-small cell lung cancer cells.

BMC Cancer 2013 Apr 22;13:198. Epub 2013 Apr 22.

Molecular Cytogenetics Section, Lab. of Experimental Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1186/1471-2407-13-198DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3639152PMC
April 2013

Involvement of lysosomal exocytosis in the excretion of mesoporous silica nanoparticles and enhancement of the drug delivery effect by exocytosis inhibition.

Small 2013 Mar 14;9(5):697-704. Epub 2012 Nov 14.

Department of Microbiology, California NanoSystems Institute, Jonsson Comprehensive Cancer Center, University of California, Los Angeles, 405 Hilgard Avenue, Los Angeles, CA 90095, USA.

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http://doi.wiley.com/10.1002/smll.201201811
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http://dx.doi.org/10.1002/smll.201201811DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3767416PMC
March 2013

Tailoring the biodegradability of porous silicon nanoparticles.

J Biomed Mater Res A 2012 Dec 6;100(12):3416-21. Epub 2012 Jul 6.

Electrical Engineering Department, California NanoSystems Institute, University of California, Los Angeles, California 90095-1489, USA.

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http://dx.doi.org/10.1002/jbm.a.34294DOI Listing
December 2012

Psk1, an AGC kinase family member in fission yeast, is directly phosphorylated and controlled by TORC1 and functions as S6 kinase.

J Cell Sci 2012 Dec 12;125(Pt 23):5840-9. Epub 2012 Sep 12.

Department of Microbiology, Immunology and Molecular Genetics, Molecular Biology Institute, Jonsson Comprehensive Cancer Center, University of California, Los Angeles, CA 90095-1489, USA.

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http://jcs.biologists.org/cgi/doi/10.1242/jcs.111146
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http://dx.doi.org/10.1242/jcs.111146DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3575713PMC
December 2012

Continuous spectroscopic measurements of photo-stimulated release of molecules by nanomachines in a single living cell.

Nanoscale 2012 Jun 3;4(11):3482-9. Epub 2012 May 3.

Department of Chemistry & Biochemistry, University of California Los Angeles, Los Angeles, CA 90095-1569, USA.

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http://xlink.rsc.org/?DOI=c2nr30524k
Publisher Site
http://dx.doi.org/10.1039/c2nr30524kDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3388114PMC
June 2012

Development of mesoporous silica nanomaterials as a vehicle for anticancer drug delivery.

Ther Deliv 2012 Mar;3(3):389-404

Department of Microbiology, Immunology & Molecular Genetics, California NanoSystems Institute, Jonsson Comprehensive Cancer Center, University of California, 405 Hilgard Avenue, Los Angeles, CA 90095, USA.

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http://dx.doi.org/10.4155/tde.12.9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3324307PMC
March 2012

In vivo tumor suppression efficacy of mesoporous silica nanoparticles-based drug-delivery system: enhanced efficacy by folate modification.

Nanomedicine 2012 Feb 15;8(2):212-20. Epub 2011 Jun 15.

California NanoSystems Institute, Department of Microbiology, Immunology and Molecular Genetics, Jonsson Comprehensive Cancer Center, University of California Los Angeles, Los Angeles, California 90095, USA.

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http://dx.doi.org/10.1016/j.nano.2011.06.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3221805PMC
February 2012

Identification and characterization of mechanism of action of P61-E7, a novel phosphine catalysis-based inhibitor of geranylgeranyltransferase-I.

PLoS One 2011 18;6(10):e26135. Epub 2011 Oct 18.

Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, California, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0026135PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3196516PMC
February 2012

Synthesis of biomolecule-modified mesoporous silica nanoparticles for targeted hydrophobic drug delivery to cancer cells.

Small 2011 Jul 19;7(13):1816-26. Epub 2011 May 19.

Department of Chemistry and Biochemistry, University of California, Los Angeles, 405 Hilgard Avenue, Los Angeles, California 90095-1569, USA.

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http://dx.doi.org/10.1002/smll.201002300DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3155389PMC
July 2011

pH-Operated mechanized porous silicon nanoparticles.

J Am Chem Soc 2011 Jun 24;133(23):8798-801. Epub 2011 May 24.

Department of Chemistry and Biochemistry, University of California, Los Angeles, California 90095, USA.

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http://dx.doi.org/10.1021/ja201252eDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3431915PMC
June 2011

Ras signaling in yeast.

Authors:
Fuyuhiko Tamanoi

Genes Cancer 2011 Mar;2(3):210-5

Department of Microbiology, Immunology & Molecular Genetics, Jonsson Comprehensive Cancer Center, University of California, Los Angeles, CA, USA.

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http://dx.doi.org/10.1177/1947601911407322DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3128628PMC
March 2011

Activating mutations of TOR (target of rapamycin).

Genes Cells 2011 Feb 7;16(2):141-51. Epub 2011 Jan 7.

Department of Microbiology, Immunology and Molecular Genetics, Jonsson Comprehensive Cancer Center, Molecular Biology Institute, University of California, Los Angeles, CA 90095-1489, USA.

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http://dx.doi.org/10.1111/j.1365-2443.2010.01482.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3116645PMC
February 2011

Autonomous in vitro anticancer drug release from mesoporous silica nanoparticles by pH-sensitive nanovalves.

J Am Chem Soc 2010 Sep;132(36):12690-7

Division of NanoMedicine, Department of Medicine, University of California, Los Angeles, California 90095, USA.

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http://pubs.acs.org/doi/abs/10.1021/ja104501a
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http://dx.doi.org/10.1021/ja104501aDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3116646PMC
September 2010

Biocompatibility, biodistribution, and drug-delivery efficiency of mesoporous silica nanoparticles for cancer therapy in animals.

Small 2010 Aug;6(16):1794-805

California NanoSystems Institute, Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, 405 Hilgard Avenue, Los Angeles, CA 90095, USA.

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http://dx.doi.org/10.1002/smll.201000538DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2952648PMC
August 2010

Mesoporous silica nanoparticles facilitate delivery of siRNA to shutdown signaling pathways in mammalian cells.

Small 2010 Jun;6(11):1185-90

Department of Microbiology, Immunology, and Molecular Genetics California NanoSystems Institute, JCCC University of California, Los Angeles 609 Charles E. Young Drive East, Los Angeles, CA 90095, USA.

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http://dx.doi.org/10.1002/smll.200901966DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2953950PMC
June 2010

Quantitative 3D imaging of whole, unstained cells by using X-ray diffraction microscopy.

Proc Natl Acad Sci U S A 2010 Jun 4;107(25):11234-9. Epub 2010 Jun 4.

Department of Physics and Astronomy and California NanoSystems Institute, University of California, Los Angeles, CA 90095, USA.

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http://dx.doi.org/10.1073/pnas.1000156107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2895086PMC
June 2010

Fission yeast TORC1 regulates phosphorylation of ribosomal S6 proteins in response to nutrients and its activity is inhibited by rapamycin.

J Cell Sci 2010 Mar 9;123(Pt 5):777-86. Epub 2010 Feb 9.

Department of Microbiology, Immunology and Molecular Genetics, Molecular Biology Institute, Jonsson Comprehensive Cancer Center, University of California, Los Angeles, CA 90095-1489, USA.

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http://dx.doi.org/10.1242/jcs.060319DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2823578PMC
March 2010

Rheb G-Proteins and the Activation of mTORC1.

Enzymes 2010 ;27:39-56

Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, California, USA.

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http://dx.doi.org/10.1016/S1874-6047(10)27003-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4241847PMC
January 2010

Conservation of the Tsc/Rheb/TORC1/S6K/S6 Signaling in Fission Yeast.

Enzymes 2010;28:167-187

Department of Microbiology, Immunology and Molecular Genetics Molecular Biology Institute, Jonsson Comprehensive Cancer Center University of California, Los Angeles, California, USA.

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http://dx.doi.org/10.1016/S1874-6047(10)28008-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4371861PMC
January 2010

[Rheb-mTOR signaling pathway involved in tumor formation].

Tanpakushitsu Kakusan Koso 2010 Jan;55(1):11-7

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January 2010

A novel approach to tag and identify geranylgeranylated proteins.

Electrophoresis 2009 Oct;30(20):3598-606

Departments of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, CA 90095-1489, USA.

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http://doi.wiley.com/10.1002/elps.200900259
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http://dx.doi.org/10.1002/elps.200900259DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2855049PMC
October 2009

Specific activation of mTORC1 by Rheb G-protein in vitro involves enhanced recruitment of its substrate protein.

J Biol Chem 2009 May 19;284(19):12783-91. Epub 2009 Mar 19.

Department of Microbiology, Immunology & Molecular Genetics, Molecular Biology Institute, Jonsson Comprehensive Cancer Center, University of California, Los Angeles, CA 90095, USA.

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http://dx.doi.org/10.1074/jbc.M809207200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2676008PMC
May 2009

In vivo antitumor effect of a novel inhibitor of protein geranylgeranyltransferase-I.

Mol Cancer Ther 2009 May 5;8(5):1218-26. Epub 2009 May 5.

Department of Microbiology, University of California-Los Angeles, Los Angeles, California 90095, USA.

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http://dx.doi.org/10.1158/1535-7163.MCT-08-1122DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2888841PMC
May 2009

The protein farnesyltransferase regulates HDAC6 activity in a microtubule-dependent manner.

J Biol Chem 2009 Apr 18;284(15):9648-55. Epub 2009 Feb 18.

Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia 30322, USA.

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http://dx.doi.org/10.1074/jbc.M808708200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2665085PMC
April 2009

Silica nanoparticles as a delivery system for nucleic acid-based reagents.

J Mater Chem 2009 Jan;19(35):6308-6316

Department of Microbiology, Immunology, and Molecular Genetics, California NanoSystems Institute, JCCC, University of California, 609 Charles E. Young Drive East, Los Angeles, CA, 90095, USA. ; ; Tel: (+310) 206-7318.

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http://dx.doi.org/10.1039/b904197dDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2927014PMC
January 2009

Mesostructured Silica for Optical Functionality, Nanomachines, and Drug Delivery.

J Am Ceram Soc 2009 Jan;92(s1):s2-s10

Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, California 90095.

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http://doi.wiley.com/10.1111/j.1551-2916.2008.02722.x
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http://dx.doi.org/10.1111/j.1551-2916.2008.02722.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2761636PMC
January 2009

Using Drosophila and yeast genetics to investigate a role for the Rheb GTPase in cell growth.

Methods Enzymol 2006 ;407:443-54

Molecular Biology Institute, University of California Los Angeles, Los Angeles, California, USA.

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http://dx.doi.org/10.1016/S0076-6879(05)07036-9DOI Listing
June 2008

Characterization of the Rheb-mTOR signaling pathway in mammalian cells: constitutive active mutants of Rheb and mTOR.

Methods Enzymol 2008 ;438:307-20

Department of Microbiology, Immunology and Molecular Genetics, Jonsson Comprehensive Cancer Center, Molecular Biology Institute, University of California, Los Angeles, California, USA.

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http://dx.doi.org/10.1016/S0076-6879(07)38021-XDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2693245PMC
June 2008

The Tsc/Rheb signaling pathway controls basic amino acid uptake via the Cat1 permease in fission yeast.

Mol Genet Genomics 2008 May;279(5):441-50

Department of Microbiology, Immunology and Molecular Genetics, Jonsson Comprehensive Cancer Center, Molecular Biology Institute, University of California, Los Angeles, 1602 Molecular Sciences Building, Los Angeles, CA 90095-1489, USA.

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http://dx.doi.org/10.1007/s00438-008-0320-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2670428PMC
May 2008

Multifunctional inorganic nanoparticles for imaging, targeting, and drug delivery.

ACS Nano 2008 May;2(5):889-96

Department of Chemistry and Biochemistry, University of California, Los Angeles, California 90095, USA.

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http://pubs.acs.org/doi/10.1021/nn800072t
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2751731PMC
May 2008

Inhibitors of protein geranylgeranyltransferase I and Rab geranylgeranyltransferase identified from a library of allenoate-derived compounds.

J Biol Chem 2008 Apr 28;283(15):9571-9. Epub 2008 Jan 28.

Microbiology, Immunology, and Molecular Genetics, Jonsson Comprehensive Cancer Center, University of California-Los Angeles, 609 Charles E. Young Drive, Los Angeles, CA 90095, USA.

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http://dx.doi.org/10.1074/jbc.M706229200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2442295PMC
April 2008

Light-activated nanoimpeller-controlled drug release in cancer cells.

Small 2008 Apr;4(4):421-6

Department of Microbiology, Immunology and Molecular Genetics, California NanoSystems Institute, Jonsson Comprehensive Cancer Center, University of California, Los Angeles, 405 Hilgard Avenue, Los Angeles, CA 90095, USA.

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http://dx.doi.org/10.1002/smll.200700903DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2712492PMC
April 2008

Fission yeast TOR complex 2 activates the AGC-family Gad8 kinase essential for stress resistance and cell cycle control.

Cell Cycle 2008 Feb 1;7(3):358-64. Epub 2007 Nov 1.

Section of Microbiology, College of Biological Sciences, University of California, Davis, California, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2274895PMC
http://dx.doi.org/10.4161/cc.7.3.5245DOI Listing
February 2008

Mesoporous silica nanoparticles as a delivery system for hydrophobic anticancer drugs.

Small 2007 Aug;3(8):1341-6

Department of Microbiology, Immunology, and Molecular Genetics, California NanoSystems Institute, JCCC, University of California, Los Angeles, 609 Charles E. Young Drive East, Los Angeles, CA 90095, USA.

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http://web.ics.purdue.edu/~jfleary/nanomedicine_course_2011/
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http://doi.wiley.com/10.1002/smll.200700005
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August 2007

The TSC/Rheb/TOR signaling pathway in fission yeast and mammalian cells: temperature sensitive and constitutive active mutants of TOR.

Cell Cycle 2007 Jul 21;6(14):1692-5. Epub 2007 May 21.

Department of Microbiology, Immunology & Molecular Genetics, University of California, Los Angeles, Los Angeles, California 90095-1489, USA.

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http://www.tandfonline.com/doi/abs/10.4161/cc.6.14.4478
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July 2007

Small-molecule inhibitors of protein geranylgeranyltransferase type I.

J Am Chem Soc 2007 May 17;129(18):5843-5. Epub 2007 Apr 17.

Department of Chemistry and Biochemistry, Jonsson Comprehensive Cancer Center and Molecular Biology Institute, University of California, Los Angeles, California 90095-1569, USA.

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http://dx.doi.org/10.1021/ja070274nDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2543057PMC
May 2007

Mesoporous Silica Nanoparticles for Cancer Therapy: Energy-Dependent Cellular Uptake and Delivery of Paclitaxel to Cancer Cells.

Nanobiotechnology 2007 May;3(2):89-95

Department of Microbiology, Immunology and Molecular Genetics, Jonsson Comprehensive Cancer Center, Molecular Biology Institute, University of California Los Angeles, 405 Hilgard Avenue, Los Angeles, CA 90095, USA, California NanoSystems Institute, University of California Los Angeles, 405 Hilgard Avenue, Los Angeles, CA 90095, USA.

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http://dx.doi.org/10.1007/s12030-008-9003-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2779038PMC
May 2007

Loss of the TOR kinase Tor2 mimics nitrogen starvation and activates the sexual development pathway in fission yeast.

Mol Cell Biol 2007 Apr 29;27(8):3154-64. Epub 2007 Jan 29.

Department of Biophysics and Biochemistry, Graduate School of Science, University of Tokyo, Tokyo 113-0033, Japan.

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http://dx.doi.org/10.1128/MCB.01039-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1899950PMC
April 2007

Point mutations in TOR confer Rheb-independent growth in fission yeast and nutrient-independent mammalian TOR signaling in mammalian cells.

Proc Natl Acad Sci U S A 2007 Feb 20;104(9):3514-9. Epub 2007 Feb 20.

Department of Microbiology, Immunology, and Molecular Genetics, Jonsson Comprehensive Cancer Center, Molecular Biology Institute, University of California, Los Angeles, CA 90095, USA.

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http://dx.doi.org/10.1073/pnas.0608510104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1805553PMC
February 2007

Increased Rheb-TOR signaling enhances sensitivity of the whole organism to oxidative stress.

J Cell Sci 2006 Oct;119(Pt 20):4285-92

Molecular Biology Institute, Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, CA 90095-1489, USA.

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http://dx.doi.org/10.1242/jcs.03199DOI Listing
October 2006

Identification of novel single amino acid changes that result in hyperactivation of the unique GTPase, Rheb, in fission yeast.

Mol Microbiol 2005 Nov;58(4):1074-86

Department of Microbiology, Immunology and Molecular Genetics, Jonsson Comprehensive Cancer Center, Molecular Biology Institute, University of California, Los Angeles, CA 90095-1489, USA.

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http://dx.doi.org/10.1111/j.1365-2958.2005.04877.xDOI Listing
November 2005

Farnesyltransferase inhibitors reverse altered growth and distribution of actin filaments in Tsc-deficient cells via inhibition of both rapamycin-sensitive and -insensitive pathways.

Mol Cancer Ther 2005 Jun;4(6):918-26

Department of Microbiology, Immunology, and Molecular Genetics, Jonsson Comprehensive Cancer Center, Molecular Biology Institute, University of California at Los Angeles, 90095, USA.

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http://mct.aacrjournals.org/cgi/doi/10.1158/1535-7163.MCT-04
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June 2005

The Rheb family of GTP-binding proteins.

Cell Signal 2004 Oct;16(10):1105-12

Department of Microbiology, Immunology & Molecular Genetics, Molecular Biology Institute, Jonsson Comprehensive Cancer Center, University of California, Los Angeles, CA 90095, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S089865680400057
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http://dx.doi.org/10.1016/j.cellsig.2004.03.019DOI Listing
October 2004

Loss of tuberous sclerosis complex 1 (Tsc1) expression results in increased Rheb/S6K pathway signaling important for astrocyte cell size regulation.

Glia 2004 Aug;47(2):180-8

Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1002/glia.20036DOI Listing
August 2004

A tagging-via-substrate technology for detection and proteomics of farnesylated proteins.

Proc Natl Acad Sci U S A 2004 Aug 12;101(34):12479-84. Epub 2004 Aug 12.

Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390-9038.

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http://dx.doi.org/10.1073/pnas.0403413101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC515085PMC
August 2004

Fighting cancer by disrupting C-terminal methylation of signaling proteins.

J Clin Invest 2004 Feb;113(4):513-5

Department of Chemistry and Biochemistry, University of California, Los Angeles 90095-1569, USA.

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http://dx.doi.org/10.1172/JCI21059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC338270PMC
February 2004

Identification of dominant negative mutants of Rheb GTPase and their use to implicate the involvement of human Rheb in the activation of p70S6K.

J Biol Chem 2003 Oct 17;278(41):39921-30. Epub 2003 Jul 17.

Department of Microbiology, Immunology, and Molecular Genetics, Jonsson Comprehensive Cancer Center, Molecular Biology Institute, University of California, Los Angeles, California 90095-1489, USA.

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http://dx.doi.org/10.1074/jbc.M306553200DOI Listing
October 2003

Drosophila Rheb GTPase is required for cell cycle progression and cell growth.

J Cell Sci 2003 Sep;116(Pt 17):3601-10

Molecular Biology Institute, Jonsson Comprehensive Cancer Center, University of California, Los Angeles, CA 90095-1489, USA.

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http://dx.doi.org/10.1242/jcs.00661DOI Listing
September 2003