Fuyuhiko Inagaki

Fuyuhiko Inagaki

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Fuyuhiko Inagaki

Publications by authors named "Fuyuhiko Inagaki"

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Activation of disulfide bond cleavage triggered by hydrophobization and lipophilization of functionalized dihydroasparagusic acid.

Org Biomol Chem 2018 06;16(23):4320-4324

Division of Pharmaceutical Sciences, Graduate School of Medical Sciences, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan.

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http://dx.doi.org/10.1039/c8ob01055bDOI Listing
June 2018

Atg7 Activates an Autophagy-Essential Ubiquitin-like Protein Atg8 through Multi-Step Recognition.

J Mol Biol 2018 02 10;430(3):249-257. Epub 2017 Dec 10.

Institute of Microbial Chemistry (BIKAKEN), Tokyo 141-0021, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.jmb.2017.12.002DOI Listing
February 2018

Ynol Ethers as Ketene Equivalents in Rhodium-Catalyzed Intermolecular [5 + 2] Cycloaddition Reactions.

Org Lett 2017 11;19(21):5810-5813

Departments of Chemistry and Chemical and Systems Biology, Stanford University , Stanford, California 94305, United States.

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http://dx.doi.org/10.1021/acs.orglett.7b02765DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833981PMC
November 2017

Substrate Specific Silver(I)-Catalyzed Cycloisomerization of Diene Involving Alkyl Rearrangements: Syntheses of 1,2,5,6-Tetrahydrocuminic Acid, p-Menth-3-en-7-ol, and p-Menth-3-en-7-al.

Chem Pharm Bull (Tokyo) 2017 ;65(9):822-825

Division of Pharmaceutical Sciences, Graduate School of Medical Sciences, Kanazawa University.

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http://dx.doi.org/10.1248/cpb.c17-00433DOI Listing
October 2017

Functional interfaces between TICAM-2/TRAM and TICAM-1/TRIF in TLR4 signaling.

Biochem Soc Trans 2017 08 19;45(4):929-935. Epub 2017 Jun 19.

Department of Microbiology and Immunology, Graduate School of Medicine, Hokkaido University, Sapporo 060-8638, Japan

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http://dx.doi.org/10.1042/BST20160259DOI Listing
August 2017

CO-Selective Absorbents in Air: Reverse Lipid Bilayer Structure Forming Neutral Carbamic Acid in Water without Hydration.

J Am Chem Soc 2017 04 24;139(13):4639-4642. Epub 2017 Mar 24.

Division of Pharmaceutical Sciences, Graduate School of Medical Sciences, Kanazawa University , Kakuma-machi, Kanazawa 920-1192, Japan.

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http://pubs.acs.org/doi/10.1021/jacs.7b01049
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http://dx.doi.org/10.1021/jacs.7b01049DOI Listing
April 2017

Biophysical characterization of drug-resistant mutants of fibroblast growth factor receptor 1.

Genes Cells 2016 Oct 25;21(10):1049-1058. Epub 2016 Aug 25.

Department of Structural Biology, Faculty of Advanced Life Science, Hokkaido University, Sapporo, Hokkaido, 060-0810, Japan.

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http://dx.doi.org/10.1111/gtc.12405DOI Listing
October 2016

Energyless CO2 Absorption, Generation, and Fixation Using Atmospheric CO2.

Chem Pharm Bull (Tokyo) 2016 20;64(1):8-13. Epub 2015 Nov 20.

Division of Pharmaceutical Sciences, Graduate School of Medical Sciences, Kanazawa University.

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https://www.jstage.jst.go.jp/article/cpb/64/1/64_c15-00793/_
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http://dx.doi.org/10.1248/cpb.c15-00793DOI Listing
September 2016

Distinct Roles for the N- and C-terminal Regions of M-Sec in Plasma Membrane Deformation during Tunneling Nanotube Formation.

Sci Rep 2016 09 15;6:33548. Epub 2016 Sep 15.

Structural Biology Laboratory, Life Science Division, Synchrotron Radiation Research Organization and Institute of Molecular and Cellular Biosciences, The University of Tokyo, Tokyo 113-0032, Japan.

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http://dx.doi.org/10.1038/srep33548DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5024327PMC
September 2016

Structural Basis for Receptor-Mediated Selective Autophagy of Aminopeptidase I Aggregates.

Cell Rep 2016 06 16;16(1):19-27. Epub 2016 Jun 16.

Institute of Microbial Chemistry (BIKAKEN), Tokyo 141-0021, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.05.066DOI Listing
June 2016

Nuclear magnetic resonance analysis of the conformational state of cancer mutant of fibroblast growth factor receptor 1 tyrosine kinase domain.

Genes Cells 2016 Apr 10;21(4):350-7. Epub 2016 Feb 10.

Department of Structural Biology, Faculty of Advanced Life Science, Hokkaido University, Sapporo, 060-0810, Japan.

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http://dx.doi.org/10.1111/gtc.12345DOI Listing
April 2016

Mechanisms of Autophagy.

Annu Rev Biophys 2015 26;44:101-22. Epub 2015 Feb 26.

Institute of Microbial Chemistry (BIKAKEN), Tokyo 141-0021, Japan; email:

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http://dx.doi.org/10.1146/annurev-biophys-060414-034248DOI Listing
January 2016

Investigation of the redox-dependent modulation of structure and dynamics in human cytochrome c.

Biochem Biophys Res Commun 2016 Jan 22;469(4):978-84. Epub 2015 Dec 22.

Graduate School of Chemical Sciences and Engineering, Hokkaido University, Sapporo 060-0810, Japan; Department of Chemistry, Faculty of Science, Hokkaido University, Sapporo 060-0810, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2015.12.079DOI Listing
January 2016

Identification of a Regulatory Acidic Motif as the Determinant of Membrane Localization of TICAM-2.

J Immunol 2015 Nov 25;195(9):4456-65. Epub 2015 Sep 25.

Department of Microbiology and Immunology, Graduate School of Medicine, Hokkaido University, Sapporo 060-8638, Japan; and

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http://www.jimmunol.org/content/early/2015/09/25/jimmunol.14
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http://www.jimmunol.org/cgi/doi/10.4049/jimmunol.1402628
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http://dx.doi.org/10.4049/jimmunol.1402628DOI Listing
November 2015

Ligand-driven conformational changes of MurD visualized by paramagnetic NMR.

Sci Rep 2015 Nov 19;5:16685. Epub 2015 Nov 19.

Department of Structural Biology, Faculty of Advanced Life Science, Hokkaido University, Sapporo 001-0021, Japan.

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http://dx.doi.org/10.1038/srep16685DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4652230PMC
November 2015

Structural analysis of the mechanism of phosphorylation of a critical autoregulatory tyrosine residue in FGFR1 kinase domain.

Genes Cells 2015 Oct 24;20(10):860-70. Epub 2015 Aug 24.

Department of Structural Biology, Faculty of Advanced Life Science, Hokkaido University, Sapporo, Hokkaido, 060-0810, Japan.

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http://dx.doi.org/10.1111/gtc.12277DOI Listing
October 2015

Oncogenic and RASopathy-associated K-RAS mutations relieve membrane-dependent occlusion of the effector-binding site.

Proc Natl Acad Sci U S A 2015 May 4;112(21):6625-30. Epub 2015 May 4.

Department of Medical Biophysics, Campbell Family Cancer Research Institute, Princess Margaret Cancer Centre, University of Toronto, Toronto, ON, Canada M5G 2M9;

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http://dx.doi.org/10.1073/pnas.1419895112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4450377PMC
May 2015

Air-stable cationic gold(I) catalyst featuring a Z-type ligand: promoting enyne cyclizations.

Angew Chem Int Ed Engl 2015 Jan 2;54(3):818-22. Epub 2014 Dec 2.

Division of Pharmaceutical Sciences, Graduate School of Medical Sciences, Kanazawa University, Kakuma-machi, Kanazawa 920-1192 (Japan).

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http://dx.doi.org/10.1002/anie.201408037DOI Listing
January 2015

Rh(I)-catalyzed intramolecular carbonylative [2+2+1] cycloaddition reaction: preparation of bicyclo[5.3.0]decadienones with substituted cyclopentenone frameworks.

Chem Pharm Bull (Tokyo) 2014 ;62(1):84-7

Division of Pharmaceutical Sciences, Graduate School of Medical Sciences, Kanazawa University.

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http://dx.doi.org/10.1248/cpb.c13-00711DOI Listing
August 2014

Structural basis of starvation-induced assembly of the autophagy initiation complex.

Nat Struct Mol Biol 2014 Jun 4;21(6):513-21. Epub 2014 May 4.

1] Institute of Microbial Chemistry (BIKAKEN), Tokyo, Japan. [2] Core Research for Evolutionary Science and Technology (CREST), Japan Science and Technology Agency, Tokyo, Japan.

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http://dx.doi.org/10.1038/nsmb.2822DOI Listing
June 2014

Propargyltrimethylsilanes as allene equivalents in transition metal-catalyzed [5 + 2] cycloadditions.

Org Lett 2014 Jun 12;16(11):2923-5. Epub 2014 May 12.

Department of Chemistry, Department of Chemical and Systems Biology, Stanford University , Stanford, California 94305-5080, United States.

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http://dx.doi.org/10.1021/ol501114qDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4051429PMC
June 2014

Structural complexity through multicomponent cycloaddition cascades enabled by dual-purpose, reactivity regenerating 1,2,3-triene equivalents.

Nat Chem 2014 May 13;6(5):448-52. Epub 2014 Apr 13.

Department of Chemistry, Department of Chemical and Systems Biology, Stanford University, Stanford, California 94305-5080, USA.

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http://dx.doi.org/10.1038/nchem.1917DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4059072PMC
May 2014

The N-terminal domain of TIR domain-containing adaptor molecule-1, TICAM-1.

J Biomol NMR 2014 Mar 6;58(3):227-30. Epub 2014 Feb 6.

Department of Structural Biology, Faculty of Advanced Life Science, Hokkaido University, N-21, W-11, Kita-ku, Sapporo, 001-0021, Japan.

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http://dx.doi.org/10.1007/s10858-014-9819-1DOI Listing
March 2014

Structures and interface mapping of the TIR domain-containing adaptor molecules involved in interferon signaling.

Proc Natl Acad Sci U S A 2013 Dec 19;110(49):19908-13. Epub 2013 Nov 19.

Department of Structural Biology, Faculty of Advanced Life Science, Hokkaido University, N-21, W-11, Kita-ku, Sapporo 001-0021, Japan.

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http://dx.doi.org/10.1073/pnas.1222811110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3856793PMC
December 2013

High-throughput evaluation method for drug association with pregnane X receptor (PXR) using differential scanning fluorometry.

J Biomol Screen 2013 Oct 7;18(9):1084-91. Epub 2013 Jun 7.

1Analysis and Pharmacokinetics Research Labs, Department of Drug Discovery, Astellas Pharma Inc., Tsukuba, Japan.

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http://dx.doi.org/10.1177/1087057113491826DOI Listing
October 2013

Rhodium(I)-catalyzed cycloisomerization of alkene-substituted allenylcyclopropanes: stereoselective formation of bicyclo[4.3.0]nonadienes.

Angew Chem Int Ed Engl 2013 Oct 2;52(43):11369-72. Epub 2013 Sep 2.

Division of Pharmaceutical Sciences, Graduate School of Medical Sciences, Kanazawa University, Kakuma-machi, Kanazawa 920-1192 (Japan) http://www.p.kanazawa-u.ac.jp/∼yakuzou/11indexen.html.

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http://dx.doi.org/10.1002/anie.201305958DOI Listing
October 2013

Progress in carbonylative [2+2+1] cycloaddition: utilization of a nitrile group as the π component.

Angew Chem Int Ed Engl 2013 Oct 28;52(42):11138-42. Epub 2013 Aug 28.

Division of Pharmaceutical Sciences, Graduate School of Medical Sciences, Kanazawa University, Kakuma-machi, Kanazawa 920-1192 (Japan).

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http://dx.doi.org/10.1002/anie.201305729DOI Listing
October 2013

[Structural basis for phosphorylation induced regulation mechanism of human cancer and autoimmune diseases related ubiquitin ligase Cbl].

Seikagaku 2013 Sep;85(9):794-8

Department of Structural Biology, Faculty of Advanced Life Science, Hokkaido University, N-21, W-11, Kita-ku, Sapporo 001-0021, Japan.

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September 2013

Atg18 phosphoregulation controls organellar dynamics by modulating its phosphoinositide-binding activity.

J Cell Biol 2013 Aug 12;202(4):685-98. Epub 2013 Aug 12.

Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Kyoto 606-8502, Japan.

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http://dx.doi.org/10.1083/jcb.201302067DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3747300PMC
August 2013

Practical applications of hydrostatic pressure to refold proteins from inclusion bodies for NMR structural studies.

Protein Eng Des Sel 2013 Jun 22;26(6):409-16. Epub 2013 Mar 22.

Department of Structural Biology, Faculty of Advanced Life Science, Hokkaido University, Kita 21 Nishi 11, Kita, Sapporo 001-0021, Japan.

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http://dx.doi.org/10.1093/protein/gzt012DOI Listing
June 2013

Total syntheses of (±)-fawcettimine, (±)-fawcettidine, (±)-lycoflexine, and (±)-lycoposerramine-Q.

Chemistry 2013 Jun 6;19(26):8665-72. Epub 2013 May 6.

Division of Pharmaceutical Sciences, Graduate School of Medical Sciences, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan.

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http://dx.doi.org/10.1002/chem.201300364DOI Listing
June 2013

Atg12-Atg5 conjugate enhances E2 activity of Atg3 by rearranging its catalytic site.

Nat Struct Mol Biol 2013 Apr 17;20(4):433-9. Epub 2013 Mar 17.

Frontier Research Center, Tokyo Institute of Technology, Yokohama, Japan.

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http://dx.doi.org/10.1038/nsmb.2527DOI Listing
April 2013

Membrane-dependent modulation of the mTOR activator Rheb: NMR observations of a GTPase tethered to a lipid-bilayer nanodisc.

J Am Chem Soc 2013 Mar 20;135(9):3367-70. Epub 2013 Feb 20.

Department of Medical Biophysics, Campbell Family Cancer Research Institute, Princess Margaret Cancer Center, University Health Network, University of Toronto, Toronto, Ontario M5G 2M9, Canada.

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http://pubs.acs.org/doi/10.1021/ja312508w
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http://dx.doi.org/10.1021/ja312508wDOI Listing
March 2013

Structure of the Atg12-Atg5 conjugate reveals a platform for stimulating Atg8-PE conjugation.

EMBO Rep 2013 Feb 14;14(2):206-11. Epub 2012 Dec 14.

Microbial Chemistry Research Foundation, Laboratory of Molecular Structure, Institute of Microbial Chemistry, 3-14-23, Kamiosaki, Shinagawa-ku, Tokyo 141-0021, Japan.

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http://dx.doi.org/10.1038/embor.2012.208DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3596133PMC
February 2013

NMR structure note: a defective isoform and its activity-improved variant of a type III antifreeze protein from Zoarces elongates Kner.

J Biomol NMR 2013 Feb 4;55(2):225-30. Epub 2013 Jan 4.

Faculty of Advanced Life Science, Department of Structural Biology, Hokkaido University, Kita21 Nishi11, Kita-ku, Sapporo, 001-0021, Japan.

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http://dx.doi.org/10.1007/s10858-012-9703-9DOI Listing
February 2013

Crystallographic and NMR evidence for flexibility in oligosaccharyltransferases and its catalytic significance.

Structure 2013 Jan 21;21(1):32-41. Epub 2012 Nov 21.

Division of Structural Biology, Medical Institute of Bioregulation, Kyushu University, Fukuoka 812-8582, Japan; Research Center for Advanced Immunology, Kyushu University, Fukuoka 812-8582, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.str.2012.10.011DOI Listing
January 2013

Noncanonical recognition and UBL loading of distinct E2s by autophagy-essential Atg7.

Nat Struct Mol Biol 2012 Dec 11;19(12):1250-6. Epub 2012 Nov 11.

Department of Structural Biology, Faculty of Advanced Life Science, Hokkaido University, Sapporo, Japan.

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http://dx.doi.org/10.1038/nsmb.2451DOI Listing
December 2012

C(sp3)-C(sp3) and C(sp3)-H bond activation of 1,1-disubstituted cyclopentane.

J Am Chem Soc 2012 Dec 16;134(48):19580-3. Epub 2012 Nov 16.

Division of Pharmaceutical Sciences, Graduate School of Medical Sciences, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan.

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http://pubs.acs.org/doi/10.1021/ja309830p
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http://dx.doi.org/10.1021/ja309830pDOI Listing
December 2012

Regioselective intramolecular [3+2] annulation of allene-nitrones.

Chem Pharm Bull (Tokyo) 2012 ;60(3):381-4

Division of Pharmaceutical Sciences, Graduate School of Natural Science and Technology, Kanazawa University, Kanazawa, Japan.

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http://dx.doi.org/10.1248/cpb.60.381DOI Listing
September 2012

A low-cost affinity purification system using β-1,3-glucan recognition protein and curdlan beads.

Protein Eng Des Sel 2012 Aug 15;25(8):405-13. Epub 2012 Jun 15.

Laboratory of Biomolecular Science, Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita-ku, Sapporo, Japan.

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http://dx.doi.org/10.1093/protein/gzs028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3390167PMC
August 2012

Structural insights into Atg10-mediated formation of the autophagy-essential Atg12-Atg5 conjugate.

Structure 2012 Jul 7;20(7):1244-54. Epub 2012 Jun 7.

Department of Structural Biology, Faculty of Advanced Life Science, Hokkaido University, Sapporo 001-0021, Japan.

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http://dx.doi.org/10.1016/j.str.2012.04.018DOI Listing
July 2012

Conformational dynamics of yeast calmodulin in the Ca(2+)-bound state probed using NMR relaxation dispersion.

FEBS Lett 2012 Jul 28;586(16):2548-54. Epub 2012 Jun 28.

Department of Structural Biology, Faculty of Advanced Life Science, Hokkaido University, Kita 21 Nishi 11, Sapporo 001-0021, Japan.

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http://dx.doi.org/10.1016/j.febslet.2012.06.031DOI Listing
July 2012

First total synthesis of (+)-indicanone.

Org Biomol Chem 2012 Jun 15;10(24):4747-51. Epub 2012 May 15.

Division of Pharmaceutical Sciences, Graduate School of Natural Science and Technology, Kanazawa University, Kakuma-machi, Kanazawa, 920-1192, Japan.

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http://xlink.rsc.org/?DOI=c2ob25500f
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http://dx.doi.org/10.1039/c2ob25500fDOI Listing
June 2012

Crystal structure of the C-terminal globular domain of oligosaccharyltransferase from Archaeoglobus fulgidus at 1.75 Å resolution.

Biochemistry 2012 May 14;51(20):4157-66. Epub 2012 May 14.

Division of Structural Biology, Kyushu University, Maidashi 3-1-1, Fukuoka 812-8582, Japan.

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http://dx.doi.org/10.1021/bi300076uDOI Listing
May 2012

Structural biology: CrkL is not Crk-like.

Nat Chem Biol 2012 May 17;8(6):504-5. Epub 2012 May 17.

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http://dx.doi.org/10.1038/nchembio.963DOI Listing
May 2012

Solution structures of yeast Saccharomyces cerevisiae calmodulin in calcium- and target peptide-bound states reveal similarities and differences to vertebrate calmodulin.

Genes Cells 2012 Mar 27;17(3):159-72. Epub 2012 Jan 27.

Department of Structural Biology, Faculty of Advanced Life Science, Hokkaido University, Kita 21 Nishi 11, Kita-ku, Sapporo 001-0021, Japan.

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http://dx.doi.org/10.1111/j.1365-2443.2012.01580.xDOI Listing
March 2012

[Intramolecular cyclization reaction of multiple bonds and its application].

Authors:
Fuyuhiko Inagaki

Yakugaku Zasshi 2011 ;131(10):1437-43

Division of Pharmaceutical Sciences, Graduate School of Natural Science and Technology, Kanazawa University, Kanazawa, Japan.

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http://dx.doi.org/10.1248/yakushi.131.1437DOI Listing
February 2012

Autoinhibition and phosphorylation-induced activation mechanisms of human cancer and autoimmune disease-related E3 protein Cbl-b.

Proc Natl Acad Sci U S A 2011 Dec 7;108(51):20579-84. Epub 2011 Dec 7.

Department of Structural Biology, Faculty of Advanced Life Science, and Graduate School of Life Science, Hokkaido University, Sapporo, Hokkaido 001-0021, Japan.

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http://dx.doi.org/10.1073/pnas.1110712108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3251137PMC
December 2011

An evaluation tool for FKBP12-dependent and -independent mTOR inhibitors using a combination of FKBP-mTOR fusion protein, DSC and NMR.

Protein Eng Des Sel 2011 Nov 6;24(11):811-7. Epub 2011 Sep 6.

Analysis and Pharmacokinetics Research Labs, Department of Drug Discovery, Astellas Pharma Inc., Tsukuba 350-8585, Japan.

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http://dx.doi.org/10.1093/protein/gzr045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3196870PMC
November 2011

An NMR strategy for fragment-based ligand screening utilizing a paramagnetic lanthanide probe.

J Biomol NMR 2011 Nov 17;51(3):395-408. Epub 2011 Sep 17.

Department of Structural Biology, Faculty of Advanced Life Science, Hokkaido University, N-21, W-11, Sapporo 001-0021, Japan.

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http://dx.doi.org/10.1007/s10858-011-9566-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3193990PMC
November 2011

Structural basis of Atg8 activation by a homodimeric E1, Atg7.

Mol Cell 2011 Nov;44(3):462-75

Institute of Microbial Chemistry, Tokyo, Tokyo 141-0021, Japan.

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http://dx.doi.org/10.1016/j.molcel.2011.08.035DOI Listing
November 2011

Rh(I)-catalyzed [6+2] cycloaddition of alkyne-allenylcyclobutanes: a new entry for the synthesis of bicyclo[6.m.0] skeletons.

Chemistry 2011 Aug 15;17(33):9062-5. Epub 2011 Jul 15.

Division of Pharmaceutical Sciences, Graduate School of Natural Science and Technology, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan.

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http://doi.wiley.com/10.1002/chem.201101441
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http://dx.doi.org/10.1002/chem.201101441DOI Listing
August 2011

Total syntheses of (-)- and (+)-goniomitine.

Org Lett 2011 Apr 4;13(7):1796-9. Epub 2011 Mar 4.

Division of Pharmaceutical Sciences, Graduate School of Natural Science and Technology, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan.

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http://dx.doi.org/10.1021/ol200320zDOI Listing
April 2011

Total synthesis of (±)-meloscine.

Org Lett 2011 Apr 7;13(7):1778-80. Epub 2011 Mar 7.

Division of Pharmaceutical Sciences, Graduate School of Natural Science and Technology, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan.

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http://dx.doi.org/10.1021/ol200311yDOI Listing
April 2011

Rh(I)-catalyzed intramolecular [2 + 2 + 1] cycloaddition of allenenes: Construction of bicyclo[4.3.0]nonenones with an angular methyl group and tricyclo[6.4.0.0]dodecenone.

Beilstein J Org Chem 2011 Apr 7;7:404-9. Epub 2011 Apr 7.

Division of Pharmaceutical Sciences, Graduate School of Natural Science and Technology, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan.

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http://www.beilstein-journals.org/bjoc/content/7/1/52
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http://dx.doi.org/10.3762/bjoc.7.52DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3079109PMC
April 2011

Phosphoinositide-incorporated lipid-protein nanodiscs: A tool for studying protein-lipid interactions.

Anal Biochem 2011 Mar 19;410(1):77-83. Epub 2010 Nov 19.

Department of Structural Biology, Faculty of Advanced Life Science, Hokkaido University, N-21, W-11, Kita-ku, Sapporo 001-0021, Japan.

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http://dx.doi.org/10.1016/j.ab.2010.11.021DOI Listing
March 2011

[On the occasion of retirement from Graduate School of Pharmaceutical Sciences, Hokkaido University].

Authors:
Fuyuhiko Inagaki

Yakugaku Zasshi 2010 Oct;130(10):1251-62

Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita-ku, Sapporo, Japan.

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http://dx.doi.org/10.1248/yakushi.130.1251DOI Listing
October 2010

Autophagy-related protein 8 (Atg8) family interacting motif in Atg3 mediates the Atg3-Atg8 interaction and is crucial for the cytoplasm-to-vacuole targeting pathway.

J Biol Chem 2010 Sep 8;285(38):29599-607. Epub 2010 Jul 8.

Department of Structural Biology, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan.

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http://dx.doi.org/10.1074/jbc.M110.113670DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2937991PMC
September 2010

Selective transport of alpha-mannosidase by autophagic pathways: structural basis for cargo recognition by Atg19 and Atg34.

J Biol Chem 2010 Sep 21;285(39):30026-33. Epub 2010 Jul 21.

Department of Structural Biology, Graduate School of Pharmaceutical Sciences, Hokkaido University, N-12, W-6 Kita-ku, Sapporo 060-0812, Japan.

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http://dx.doi.org/10.1074/jbc.M110.143545DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2943322PMC
September 2010

Structure determination of proteins in 2H2O solution aided by a deuterium-decoupled 3D HCA(N)CO experiment.

J Biomol NMR 2010 Aug 24;47(4):243-8. Epub 2010 Jun 24.

Department of Structural Biology, Faculty of Advanced Life Science, Hokkaido University, Kita-ku, Sapporo, Japan.

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http://dx.doi.org/10.1007/s10858-010-9431-yDOI Listing
August 2010

Ser386 phosphorylation of transcription factor IRF-3 induces dimerization and association with CBP/p300 without overall conformational change.

Genes Cells 2010 Aug 6;15(8):901-10. Epub 2010 Jul 6.

Department of Structural Biology, Graduate School of Pharmaceutical Sciences, Hokkaido University, N-12W-6 Kita-ku, Sapporo 060-0812, Japan.

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http://dx.doi.org/10.1111/j.1365-2443.2010.01427.xDOI Listing
August 2010

The NMR structure of the autophagy-related protein Atg8.

J Biomol NMR 2010 Jul 29;47(3):237-41. Epub 2010 Apr 29.

Laboratory of Structural Biology, Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita 12 Nishi 6, Kita-ku, Sapporo, 060-0812, Japan.

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http://dx.doi.org/10.1007/s10858-010-9420-1DOI Listing
July 2010

Solution structure of a novel Cdc42 binding module of Bem1 and its interaction with Ste20 and Cdc42.

J Biol Chem 2010 Jun 21;285(25):19346-53. Epub 2010 Apr 21.

Laboratory of Structural Biology, Graduate School of Life Science, Hokkaido University, N-12, W-6 Kita-ku, Sapporo 060-0812, Japan.

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http://dx.doi.org/10.1074/jbc.M110.116749DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2885214PMC
June 2010

A molecular mechanism for Toll-IL-1 receptor domain-containing adaptor molecule-1-mediated IRF-3 activation.

J Biol Chem 2010 Jun 23;285(26):20128-36. Epub 2010 Apr 23.

Department of Microbiology and Immunology, Hokkaido University Graduate School of Medicine, Kita 15, Nishi 7, Kita-ku, Sapporo 060-8638, Japan.

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http://dx.doi.org/10.1074/jbc.M109.099101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2888425PMC
June 2010

Rhodium(I)-catalyzed intramolecular carbonylative [2+2+1] cycloadditions and cycloisomerizations of bis(sulfonylallene)s.

Chemistry 2010 May;16(17):5173-83

Division of Pharmaceutical Sciences, Graduate School of Natural Science and Technology, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan.

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http://doi.wiley.com/10.1002/chem.200903568
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May 2010

Total syntheses of (+)-fawcettimine and (+)-lycoposerramine-B.

J Org Chem 2010 May;75(10):3420-6

Division of Pharmaceutical Sciences, Graduate School of Natural Science and Technology, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan.

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http://pubs.acs.org/doi/abs/10.1021/jo100499h
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May 2010

Atg8-family interacting motif crucial for selective autophagy.

FEBS Lett 2010 Apr 17;584(7):1379-85. Epub 2010 Jan 17.

Department of Structural Biology, Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita-ku, Sapporo, Japan.

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http://dx.doi.org/10.1016/j.febslet.2010.01.018DOI Listing
April 2010

Systematic characterization by mass spectrometric analysis of phosphorylation sites in IRF-3 regulatory domain activated by IKK-i.

J Proteomics 2010 Apr 16;73(6):1196-203. Epub 2010 Feb 16.

Department of Structural Biology, Graduate School of Pharmaceutical Sciences, Hokkaido University, N-12, W-6, Kita-ku, Sapporo 060-0812, Japan.

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http://dx.doi.org/10.1016/j.jprot.2010.02.009DOI Listing
April 2010

A novel copper(II) coordination at His186 in full-length murine prion protein.

Biochem Biophys Res Commun 2010 Apr 4;394(3):522-8. Epub 2010 Mar 4.

Laboratory of Radiation Biology, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060-0818, Japan.

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http://dx.doi.org/10.1016/j.bbrc.2010.03.003DOI Listing
April 2010

Formal synthesis of (+)-nakadomarin A.

Org Lett 2010 Apr;12(8):1800-3

Division of Pharmaceutical Sciences, Graduate School of Natural Science and Technology, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan.

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http://dx.doi.org/10.1021/ol100412fDOI Listing
April 2010

PCS-based structure determination of protein-protein complexes.

J Biomol NMR 2010 Apr 19;46(4):271-80. Epub 2010 Mar 19.

Graduate School of Life Science, Hokkaido University, Sapporo, 001-0021, Japan.

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http://dx.doi.org/10.1007/s10858-010-9401-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2844537PMC
April 2010

Rhodium(I)-catalyzed intramolecular [5+2] cycloaddition reactions of alkynes and allenylcyclopropanes: construction of bicyclo[5.4.0]undecatrienes and bicyclo[5.5.0]dodecatrienes.

Angew Chem Int Ed Engl 2010 Mar;49(12):2206-10

Division of Pharmaceutical Sciences, Graduate School of Natural Science and Technology, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan.

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http://doi.wiley.com/10.1002/anie.200906994
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March 2010

The NMR structure of protein-glutaminase from Chryseobacterium proteolyticum.

J Biomol NMR 2010 Mar 27;46(3):251-5. Epub 2010 Feb 27.

Laboratory of Structural Biology, Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita 12 Nishi 6, Kita-ku, Sapporo, 060-0812, Japan.

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http://dx.doi.org/10.1007/s10858-010-9399-7DOI Listing
March 2010

Dimeric coiled-coil structure of Saccharomyces cerevisiae Atg16 and its functional significance in autophagy.

J Biol Chem 2010 Jan 4;285(2):1508-15. Epub 2009 Nov 4.

Department of Structural Biology, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan.

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http://dx.doi.org/10.1074/jbc.M109.053520DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2801276PMC
January 2010

The NMR structure of the p62 PB1 domain, a key protein in autophagy and NF-kappaB signaling pathway.

J Biomol NMR 2009 Nov;45(3):335-41

Graduate School of Life Science, Hokkaido University, Sapporo 001-0021, Japan.

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http://dx.doi.org/10.1007/s10858-009-9370-7DOI Listing
November 2009

Characterization of the Atg17-Atg29-Atg31 complex specifically required for starvation-induced autophagy in Saccharomyces cerevisiae.

Biochem Biophys Res Commun 2009 Nov 13;389(4):612-5. Epub 2009 Sep 13.

Advanced Research Organization, Integrated Research Institute, Tokyo Institute of Technology, 4259 Nagatsuta-cho, Midori-ku, Yokohama, Japan.

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http://dx.doi.org/10.1016/j.bbrc.2009.09.034DOI Listing
November 2009

NMR structure of the heterodimer of Bem1 and Cdc24 PB1 domains from Saccharomyces cerevisiae.

J Biochem 2009 Sep 18;146(3):317-25. Epub 2009 May 18.

Department of Structural Biology, Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita 12 Nishi 6, Kita-ku, Sapporo 060-0812, Japan.

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http://dx.doi.org/10.1093/jb/mvp075DOI Listing
September 2009

Synthesis of a core carbon framework of cyanosporasides A and B.

J Org Chem 2009 Aug;74(15):5590-4

Division of Pharmaceutical Sciences, Graduate School of Natural Science and Technology, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan.

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http://dx.doi.org/10.1021/jo901141tDOI Listing
August 2009

Differential LC-MS-based proteomics of surgical human cholangiocarcinoma tissues.

J Proteome Res 2009 Aug;8(8):4092-103

Department of Surgical Oncology, Hokkaido University Graduate School of Medicine, Kita-ku, Sapporo, Japan.

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http://dx.doi.org/10.1021/pr900468kDOI Listing
August 2009

Generation of N-(tert-butoxycarbonyl)indole-2,3-quinodimethane and its [4+2]-type cycloaddition.

J Org Chem 2009 Aug;74(16):6402-5

Division of Pharmaceutical Sciences, Graduate School of Natural Science and Technology, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan.

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http://dx.doi.org/10.1021/jo901325dDOI Listing
August 2009

Two-point anchoring of a lanthanide-binding peptide to a target protein enhances the paramagnetic anisotropic effect.

J Biomol NMR 2009 Jul 26;44(3):157-66. Epub 2009 May 26.

Graduate School of Life Science, Hokkaido University, Sapporo, 001-0021, Japan.

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http://dx.doi.org/10.1007/s10858-009-9325-zDOI Listing
July 2009

Solution structure of the silkworm betaGRP/GNBP3 N-terminal domain reveals the mechanism for beta-1,3-glucan-specific recognition.

Proc Natl Acad Sci U S A 2009 Jul 26;106(28):11679-84. Epub 2009 Jun 26.

Department of Structural Biology, Graduate School of Pharmaceutical Sciences, Hokkaido University, N-21, W-11, Kita-ku, Sapporo 001-0021, Japan.

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http://dx.doi.org/10.1073/pnas.0901671106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2710696PMC
July 2009

Solution structures of cytosolic RNA sensor MDA5 and LGP2 C-terminal domains: identification of the RNA recognition loop in RIG-I-like receptors.

J Biol Chem 2009 Jun 20;284(26):17465-74. Epub 2009 Apr 20.

Department of Structural Biology, Graduate School of Pharmaceutical Sciences, Hokkaido University, N-21, W-11, Kita-ku, Sapporo 001-0021, Japan.

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http://dx.doi.org/10.1074/jbc.M109.007179DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2719387PMC
June 2009

The NMR structure of the TC10- and Cdc42-interacting domain of CIP4.

J Biomol NMR 2009 Jun 22;44(2):113-8. Epub 2009 Apr 22.

Laboratory of Structural Biology, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Hokkaido 060-0812, Japan.

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http://link.springer.com/10.1007/s10858-009-9317-z
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June 2009

Crystallization of Saccharomyces cerevisiae alpha-mannosidase, a cargo protein of the Cvt pathway.

Acta Crystallogr Sect F Struct Biol Cryst Commun 2009 Jun 22;65(Pt 6):571-3. Epub 2009 May 22.

Department of Structural Biology, Graduate School of Pharmaceutical Sciences, Hokkaido University, N-12, W-6, Kita-ku, Sapporo 060-0812, Japan.

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http://scripts.iucr.org/cgi-bin/paper?S1744309109015826
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http://dx.doi.org/10.1107/S1744309109015826DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2688412PMC
June 2009

Crk and CrkL adaptor proteins: networks for physiological and pathological signaling.

Cell Commun Signal 2009 May 10;7:13. Epub 2009 May 10.

Department of Biochemistry & Molecular Biology, UMDNJ-New Jersey Medical School, 185 South Orange Ave, Newark, NJ 07103, USA.

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http://biosignaling.biomedcentral.com/articles/10.1186/1478-
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http://dx.doi.org/10.1186/1478-811X-7-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2689226PMC
May 2009