Publications by authors named "Fuu-Jen Tsai"

100Publications

Phosphorylation of PDHA by AMPK Drives TCA Cycle to Promote Cancer Metastasis.

Mol Cell 2020 Oct 5;80(2):263-278.e7. Epub 2020 Oct 5.

Department of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA; Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Graduate Institute of Basic Medical Science, China Medical University, Taichung 404, Taiwan; Department of Biotechnology, Asia University, Taichung 41354, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2020.09.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7534735PMC
October 2020

NT5C2 methylation regulatory interplay between DNMT1 and insulin receptor in type 2 diabetes.

Sci Rep 2020 Sep 30;10(1):16087. Epub 2020 Sep 30.

Human Genetic Center, Department of Medical Research, China Medical University Hospital, China Medical University, Taichung, Taiwan.

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http://dx.doi.org/10.1038/s41598-020-71336-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7527562PMC
September 2020

Contribution of Matrix Metalloproteinase-9 rs3918242 Genotypes to Childhood Leukemia Risk.

Anticancer Res 2020 Oct;40(10):5751-5756

Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan, R.O.C.

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http://dx.doi.org/10.21873/anticanres.14591DOI Listing
October 2020

Effects of Chinese herbal medicines on dementia risk in patients with sleep disorders in Taiwan.

J Ethnopharmacol 2020 Aug 18;264:113267. Epub 2020 Aug 18.

Genetic Center, Proteomics Core Laboratory, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan; School of Chinese Medicine, China Medical University, Taichung, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.jep.2020.113267DOI Listing
August 2020

Cannabinoid receptor type 1 antagonist inhibits progression of obesity-associated nonalcoholic steatohepatitis in a mouse model by remodulating immune system disturbances.

Immun Inflamm Dis 2020 Aug 15. Epub 2020 Aug 15.

School of Chinese Medicine, China Medical University, Taichung, Taiwan, ROC.

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http://dx.doi.org/10.1002/iid3.338DOI Listing
August 2020

Association of variant on the promoter of cluster of differentiation 74 in graves disease and graves ophthalmopathy.

Biosci Rep 2020 08;40(8)

Department of Medical Genetics and Medical Research, China Medical University Hospital, Taichung, Taiwan.

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http://dx.doi.org/10.1042/BSR20202072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7432997PMC
August 2020

Sensitivity of allyl isothiocyanate to induce apoptosis via ER stress and the mitochondrial pathway upon ROS production in colorectal adenocarcinoma cells.

Oncol Rep 2020 Oct 21;44(4):1415-1424. Epub 2020 Jul 21.

Department of Medical Research, China Medical University Hospital, China Medical University, Taichung 40442, Taiwan, R.O.C.

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http://dx.doi.org/10.3892/or.2020.7700DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7448487PMC
October 2020

Mitochondrial Dysfunction as a Novel Target for Neuroprotective Nutraceuticals in Ocular Diseases.

Nutrients 2020 Jun 30;12(7). Epub 2020 Jun 30.

School of Chinese Medicine, College of Chinese Medicine, China Medical University, Taichung 404, Taiwan.

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http://dx.doi.org/10.3390/nu12071950DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7400242PMC
June 2020

Potential effects of allyl isothiocyanate on inhibiting cellular proliferation and inducing apoptotic pathway in human cisplatin-resistant oral cancer cells.

J Formos Med Assoc 2020 Jul 3. Epub 2020 Jul 3.

Environment-Omics-Disease Research Center, China Medical University Hospital, Taichung, Taiwan; Department of Public Health, College of Public Health, China Medical University, Taichung, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.jfma.2020.06.025DOI Listing
July 2020

Usefulness of Machine Learning-Based Detection and Classification of Cardiac Arrhythmias With 12-Lead Electrocardiograms.

Can J Cardiol 2020 Mar 5. Epub 2020 Mar 5.

Department of Biomedical Imaging and Radiologic Science, China Medical University, Taichung, Taiwan; Artificial Intelligence Center, China Medical University Hospital, Taichung, Taiwan; Department of Bioinformatics and Medical Engineering, Asia University, Taichung, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.cjca.2020.02.096DOI Listing
March 2020

Identification of type 2 diabetes loci in 433,540 East Asian individuals.

Authors:
Cassandra N Spracklen Momoko Horikoshi Young Jin Kim Kuang Lin Fiona Bragg Sanghoon Moon Ken Suzuki Claudia H T Tam Yasuharu Tabara Soo-Heon Kwak Fumihiko Takeuchi Jirong Long Victor J Y Lim Jin-Fang Chai Chien-Hsiun Chen Masahiro Nakatochi Jie Yao Hyeok Sun Choi Apoorva K Iyengar Hannah J Perrin Sarah M Brotman Martijn van de Bunt Anna L Gloyn Jennifer E Below Michael Boehnke Donald W Bowden John C Chambers Anubha Mahajan Mark I McCarthy Maggie C Y Ng Lauren E Petty Weihua Zhang Andrew P Morris Linda S Adair Masato Akiyama Zheng Bian Juliana C N Chan Li-Ching Chang Miao-Li Chee Yii-Der Ida Chen Yuan-Tsong Chen Zhengming Chen Lee-Ming Chuang Shufa Du Penny Gordon-Larsen Myron Gross Xiuqing Guo Yu Guo Sohee Han Annie-Green Howard Wei Huang Yi-Jen Hung Mi Yeong Hwang Chii-Min Hwu Sahoko Ichihara Masato Isono Hye-Mi Jang Guozhi Jiang Jost B Jonas Yoichiro Kamatani Tomohiro Katsuya Takahisa Kawaguchi Chiea-Chuen Khor Katsuhiko Kohara Myung-Shik Lee Nanette R Lee Liming Li Jianjun Liu Andrea O Luk Jun Lv Yukinori Okada Mark A Pereira Charumathi Sabanayagam Jinxiu Shi Dong Mun Shin Wing Yee So Atsushi Takahashi Brian Tomlinson Fuu-Jen Tsai Rob M van Dam Yong-Bing Xiang Ken Yamamoto Toshimasa Yamauchi Kyungheon Yoon Canqing Yu Jian-Min Yuan Liang Zhang Wei Zheng Michiya Igase Yoon Shin Cho Jerome I Rotter Ya-Xing Wang Wayne H H Sheu Mitsuhiro Yokota Jer-Yuarn Wu Ching-Yu Cheng Tien-Yin Wong Xiao-Ou Shu Norihiro Kato Kyong-Soo Park E-Shyong Tai Fumihiko Matsuda Woon-Puay Koh Ronald C W Ma Shiro Maeda Iona Y Millwood Juyoung Lee Takashi Kadowaki Robin G Walters Bong-Jo Kim Karen L Mohlke Xueling Sim

Nature 2020 06 6;582(7811):240-245. Epub 2020 May 6.

Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore.

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http://dx.doi.org/10.1038/s41586-020-2263-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7292783PMC
June 2020

Genetic Architecture Associated With Familial Short Stature.

J Clin Endocrinol Metab 2020 Jun;105(6)

Genetic Center, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan.

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http://dx.doi.org/10.1210/clinem/dgaa131DOI Listing
June 2020

Protective effects of valproic acid on 6-hydroxydopamine-induced neuroinjury.

Environ Toxicol 2020 Aug 13;35(8):840-848. Epub 2020 Mar 13.

Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan.

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http://dx.doi.org/10.1002/tox.22920DOI Listing
August 2020

Low ambient temperatures correlate with increased risk of hypoglycemia in patients with type 2 diabetes: An ecological study in Taiwan.

Medicine (Baltimore) 2020 Feb;99(8):e19287

Experimental Forest, College of Bio-Resources and Agriculture, National Taiwan University, Nantou County, Taiwan.

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http://dx.doi.org/10.1097/MD.0000000000019287DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7034721PMC
February 2020

The role of genotype/phenotype at apurinic/apyrimidinic endonuclease Rs1130409 in renal cell carcinoma.

Chin J Physiol 2020 Jan-Feb;63(1):43-49

Graduate Institute of Biomedical Sciences, China Medical University; Terry Fox Cancer Research Laboratory, Translational Medicine Research Center, China Medical University Hospital; Department of Bioinformatics and Medical Engineering, Asia University, Taichung, Taiwan.

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http://dx.doi.org/10.4103/CJP.CJP_72_19DOI Listing
February 2020

Effects of Casein Kinase 2 Alpha 1 Gene Expression on Mice Liver Susceptible to Type 2 Diabetes Mellitus and Obesity.

Int J Med Sci 2020 1;17(1):13-20. Epub 2020 Jan 1.

School of Chinese Medicine, China Medical University, 40402 Taichung, Taiwan.

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http://dx.doi.org/10.7150/ijms.37110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6945564PMC
October 2020

Integrated analysis of gene modulation profile identifies pathogenic factors and pathways in the liver of diabetic mice.

J Diabetes Metab Disord 2019 Dec 12;18(2):471-485. Epub 2019 Nov 12.

3Genetics Center, Department of Medical Research, China Medical University Hospital, Taichung, 404 Taiwan.

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http://dx.doi.org/10.1007/s40200-019-00453-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6915200PMC
December 2019

Combinational treatment of all-trans retinoic acid (ATRA) and bisdemethoxycurcumin (BDMC)-induced apoptosis in liver cancer Hep3B cells.

J Food Biochem 2020 02 14;44(2):e13122. Epub 2019 Dec 14.

Department of Biological Science and Technology, China Medical University, Taichung, Taiwan.

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http://dx.doi.org/10.1111/jfbc.13122DOI Listing
February 2020

A rapid, multiplexed kinase activity assay using 8-plex iTRAQ labeling, SPE, and MALDI-TOF/TOF MS.

Analyst 2020 Feb;145(3):992-1000

Graduate Institute of Integrated Medicine, China Medical University, Taichung 40402, Taiwan.

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http://dx.doi.org/10.1039/c9an01810gDOI Listing
February 2020

Chinese herbal medicine therapy and the risk of overall mortality for patients with liver cancer who underwent surgical resection in Taiwan.

Complement Ther Med 2019 Dec 16;47:102213. Epub 2019 Oct 16.

School of Chinese Medicine, China Medical University, Taichung, Taiwan; Genetic Center, Proteomics Core Laboratory, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.ctim.2019.102213DOI Listing
December 2019

Mild osteochondrodysplasia with acanthosis nigricans in a short-statured Taiwanese family due to the p.Lys650Gln mutation in FGFR3.

Pediatr Neonatol 2019 12 17;60(6):686-688. Epub 2019 Sep 17.

Division of Genetics and Metabolism, Children's Hospital of China Medical University, Taichung, Taiwan; School of Medicine, China Medical University, Taichung, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.pedneo.2019.09.008DOI Listing
December 2019

Antizyme inhibitor 1 genetic polymorphisms associated with diabetic patients validated in the livers of diabetic mice.

Exp Ther Med 2019 Oct 20;18(4):3139-3146. Epub 2019 Aug 20.

School of Chinese Medicine, China Medical University, Taichung 40402, Taiwan, R.O.C.

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http://dx.doi.org/10.3892/etm.2019.7919DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6755439PMC
October 2019

C-Reactive Protein Gene Variants and Their Serum Levels in Early Adult-onset Type 2 Diabetes Mellitus.

In Vivo 2019 Sep-Oct;33(5):1685-1690

Department of Medical Research, Medical Genetics and Pediatrics, China Medical University Hospital, Taichung, Taiwan, R.O.C.

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http://dx.doi.org/10.21873/invivo.11656DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6754999PMC
February 2020

Oridonin, A natural diterpenoid, protected NGF-differentiated PC12 cells against MPP- and kainic acid-induced injury.

Food Chem Toxicol 2019 Nov 17;133:110765. Epub 2019 Aug 17.

Department of Medical Research, China Medical University Hospital, China Medical University, Taichung, Taiwan; Department of Food Nutrition and Health Biotechnology, Asia University, Taichung, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.fct.2019.110765DOI Listing
November 2019

Casticin inhibits human prostate cancer DU 145 cell migration and invasion via Ras/Akt/NF-κB signaling pathways.

J Food Biochem 2019 07 16;43(7):e12902. Epub 2019 May 16.

Department of Biological Science and Technology, China Medical University, Taichung, Taiwan.

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http://dx.doi.org/10.1111/jfbc.12902DOI Listing
July 2019

Protective effects and network analysis of natural compounds obtained from Radix dipsaci, Eucommiae cortex, and Rhizoma drynariae against RANKL-induced osteoclastogenesis in vitro.

J Ethnopharmacol 2019 Nov 7;244:112074. Epub 2019 Jul 7.

Genetic Center, Proteomics Core Laboratory, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan; School of Chinese Medicine, China Medical University, Taichung, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.jep.2019.112074DOI Listing
November 2019

Cantharidin decreased viable cell number in human osteosarcoma U-2 OS cells through G/M phase arrest and induction of cell apoptosis.

Biosci Biotechnol Biochem 2019 Oct 12;83(10):1912-1923. Epub 2019 Jun 12.

Department of Biological Science and Technology, China Medical University , Taichung , Taiwan.

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http://dx.doi.org/10.1080/09168451.2019.1627182DOI Listing
October 2019

Characterization of in vitro and in vivo bioactivity of a ferulic acid-2-Hydroxypropyl-β-cyclodextrin inclusion complex.

Colloids Surf B Biointerfaces 2019 Aug 20;180:68-74. Epub 2019 Apr 20.

Graduate Institute of Chinese Medicine, China Medical University, Taichung, Taiwan; School of Chinese Medicine, China Medical University, No.91 Hsueh-Shih Road, Taichung, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.colsurfb.2019.04.020DOI Listing
August 2019

Lupeol suppresses migration and invasion p38/MAPK and PI3K/Akt signaling pathways in human osteosarcoma U-2 OS cells.

Biosci Biotechnol Biochem 2019 Sep 22;83(9):1729-1739. Epub 2019 Apr 22.

a Department of Biological Science and Technology, China Medical University , Taichung , Taiwan.

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http://dx.doi.org/10.1080/09168451.2019.1606693DOI Listing
September 2019

Dystonin/BPAG1 modulates diabetes and Alzheimer's disease cross-talk: a meta-analysis.

Neurol Sci 2019 Aug 8;40(8):1577-1582. Epub 2019 Apr 8.

Department of Medical Research, China Medical University Hospital, Taichung, 40447, Taiwan.

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http://dx.doi.org/10.1007/s10072-019-03879-3DOI Listing
August 2019

Network analysis and mechanisms of action of Chinese herb-related natural compounds in lung cancer cells.

Phytomedicine 2019 May 13;58:152893. Epub 2019 Mar 13.

School of Chinese Medicine, China Medical University, Taichung, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.phymed.2019.152893DOI Listing
May 2019

Effects of Chinese herbal medicine therapy on survival and hepatic outcomes in patients with hepatitis C virus infection in Taiwan.

Phytomedicine 2019 Apr 3;57:30-38. Epub 2018 Oct 3.

School of Chinese Medicine, China Medical University, Taichung, Taiwan; Genetic Center, Proteomics Core Laboratory, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.phymed.2018.09.237DOI Listing
April 2019

Multilocus genetic risk score for diabetic retinopathy in the Han Chinese population of Taiwan.

Sci Rep 2018 09 28;8(1):14535. Epub 2018 Sep 28.

Human Genetic Center, Department of Medical Research, China Medical University Hospital, China Medical University, Taichung, 404, Taiwan.

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http://www.nature.com/articles/s41598-018-32916-y
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http://dx.doi.org/10.1038/s41598-018-32916-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6162301PMC
September 2018

Identification of Urinary Metabolite Biomarkers of Type 2 Diabetes Nephropathy Using an Untargeted Metabolomic Approach.

J Proteome Res 2018 11 15;17(11):3997-4007. Epub 2018 Oct 15.

Human Genetic Laboratory, Department of Medical Research , China Medical University Hospital , Taichung 40447 , Taiwan.

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http://dx.doi.org/10.1021/acs.jproteome.8b00644DOI Listing
November 2018

Long-term effects of enzyme replacement therapy for Taiwanese patients with mucopolysaccharidosis IVA.

Pediatr Neonatol 2019 06 23;60(3):342-343. Epub 2018 Aug 23.

Department of Medicine, Mackay Medical College, New Taipei City, Taiwan; Department of Pediatrics, Mackay Memorial Hospital, Taipei, Taiwan; Department of Medical Research, Mackay Memorial Hospital, Taipei, Taiwan; Department of Infant and Child Care, National Taipei University of Nursing and Health Sciences, Taipei, Taiwan. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S18759572183027
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http://dx.doi.org/10.1016/j.pedneo.2018.08.005DOI Listing
June 2019

β-Sitosterol-2-hydroxypropyl-β-cyclodextrin inclusion complex: Characterization and inhibitory effect on adipogenesis in 3T3-L1 pre-adipocytes.

Steroids 2018 12 31;140:196-201. Epub 2018 Aug 31.

Graduate Institute of Chinese Medicine, China Medical University, Taichung, Taiwan; School of Chinese Medicine, China Medical University, Taichung, Taiwan. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0039128X183016
Publisher Site
http://dx.doi.org/10.1016/j.steroids.2018.08.010DOI Listing
December 2018

Hematopoietically expressed homeobox gene is associated with type 2 diabetes in KK Cg-A/J mice and a Taiwanese Han Chinese population.

Exp Ther Med 2018 Jul 10;16(1):185-191. Epub 2018 May 10.

Human Genetics Center, Department of Medical Research, China Medical University Hospital, China Medical University, Taichung 40447, Taiwan, R.O.C.

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http://dx.doi.org/10.3892/etm.2018.6152DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5995076PMC
July 2018

A novel PIGA mutation in a Taiwanese family with early-onset epileptic encephalopathy.

Seizure 2018 May 7;58:52-54. Epub 2018 Apr 7.

Division of Pediatrics Neurology, China Medical University, Children's Hospital, Taichung, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.seizure.2018.03.025DOI Listing
May 2018

Disruption of IGF‑1R signaling by a novel quinazoline derivative, HMJ‑30, inhibits invasiveness and reverses epithelial-mesenchymal transition in osteosarcoma U‑2 OS cells.

Int J Oncol 2018 May 16;52(5):1465-1478. Epub 2018 Mar 16.

Department of Medical Research, China Medical University Hospital, China Medical University, Taichung 404, Taiwan, R.O.C.

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http://dx.doi.org/10.3892/ijo.2018.4325DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5873869PMC
May 2018

Kaempferol inhibits angiogenic ability by targeting VEGF receptor-2 and downregulating the PI3K/AKT, MEK and ERK pathways in VEGF-stimulated human umbilical vein endothelial cells.

Oncol Rep 2018 May 14;39(5):2351-2357. Epub 2018 Mar 14.

Department of Medical Research, China Medical University Hospital, China Medical University, Taichung 40447, Taiwan, R.O.C.

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http://dx.doi.org/10.3892/or.2018.6312DOI Listing
May 2018

Effects of Chinese herbal medicine on hyperlipidemia and the risk of cardiovascular disease in HIV-infected patients in Taiwan.

J Ethnopharmacol 2018 Jun 10;219:71-80. Epub 2018 Mar 10.

School of Chinese Medicine, China Medical University, Taichung, Taiwan; Genetic Center, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.jep.2018.03.006DOI Listing
June 2018

Identification of one novel homozygous mutation in the NPR2 gene in a patient from Taiwan with acromesomelic dysplasia Maroteaux type.

Pediatr Neonatol 2018 06 7;59(3):322-323. Epub 2017 Dec 7.

Department of Medical Research, China Medical University Hospital, Taichung, Taiwan; Division of Genetics and Metabolism, Children's Hospital of China Medical University, Taichung, Taiwan; School of Chinese Medicine, China Medical University, Taichung, Taiwan; Department of Medical Genetics, China Medical University Hospital, Taichung, Taiwan; Department of Health and Nutrition Biotechnology, Asia University, Taichung, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.pedneo.2017.11.017DOI Listing
June 2018

Late onset of biliopleural fistula following percutaneous transhepatic biliary drainage: a case report.

Biomedicine (Taipei) 2018 Mar 26;8(1). Epub 2018 Feb 26.

Department of Medical Research, China Medical University Hospital, China Medical University, Taichung 404, Taiwan.

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http://dx.doi.org/10.1051/bmdcn/2018080106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5826039PMC
March 2018

The molecular mechanism of contrast-induced nephropathy (CIN) and its link to in vitro studies on iodinated contrast media (CM).

Biomedicine (Taipei) 2018 Mar 26;8(1). Epub 2018 Feb 26.

Genetics Center, Department of Medical Research, China Medical University Hospital, Taichung 404, Taiwan - School of Chinese Medicine, China Medical University, Taichung 404, Taiwan - Department of Medical Genetics, China Medical University Hospital, Taichung 404, Taiwan.

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http://dx.doi.org/10.1051/bmdcn/2018080101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5826038PMC
March 2018

Congenital generalized lipodystrophy in Taiwan.

J Formos Med Assoc 2019 Jan 1;118(1 Pt 1):142-147. Epub 2018 Mar 1.

Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.jfma.2018.02.003DOI Listing
January 2019

A water-based topical Chinese traditional medicine (Zicao) for wound healing developed using 2-hydroxypropyl-β-cyclodextrin.

Colloids Surf B Biointerfaces 2018 May 10;165:67-73. Epub 2018 Feb 10.

Graduate Institute of Chinese Medicine, China Medical University, Taichung, Taiwan; School of Chinese Medicine, China Medical University, Taichung, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.colsurfb.2018.02.013DOI Listing
May 2018

Relaxant and vasoprotective effects of ginger extracts on porcine coronary arteries.

Int J Mol Med 2018 Apr 11;41(4):2420-2428. Epub 2018 Jan 11.

Department of Medical Research, China Medical University Hospital, China Medical University, Taichung 40447, Taiwan, R.O.C.

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http://dx.doi.org/10.3892/ijmm.2018.3380DOI Listing
April 2018

2-Phenyl-4-quinolone (YT-1) induces G2/M phase arrest and an intrinsic apoptotic mechanism in human leukemia cells.

Oncol Rep 2018 Mar 20;39(3):1331-1337. Epub 2017 Dec 20.

Department of Biochemistry, China Medical University, Taichung 404, Taiwan, R.O.C.

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http://dx.doi.org/10.3892/or.2017.6170DOI Listing
March 2018

Inhibition of HSF2 SUMOylation via MEL18 upregulates IGF-IIR and leads to hypertension-induced cardiac hypertrophy.

Int J Cardiol 2018 04 10;257:283-290. Epub 2017 Nov 10.

School of Chinese Medicine, China Medical University, Taichung, Taiwan; Graduate Institute of Basic Medical Science, China Medical University, Taichung, Taiwan; Department of Health and Nutrition Biotechnology, Asia University, Taichung, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.ijcard.2017.10.102DOI Listing
April 2018

Novel mutations in the cartilage oligomeric matrix protein gene identified in two Taiwanese patients with pseudoachondroplasia and multiple epiphyseal dysplasia.

Pediatr Neonatol 2018 08 19;59(4):412-414. Epub 2017 Oct 19.

Department of Medical Research, China Medical University Hospital, Taichung, Taiwan; Graduate Institute of Integrated Medicine, China Medical University, Taichung, Taiwan; School of Chinese Medicine, China Medical University, Taichung, Taiwan; Department of Medical Genetics, China Medical University Hospital, Taichung, Taiwan; Department of Health and Nutrition Biotechnology, Asia University, Taichung, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.pedneo.2017.10.006DOI Listing
August 2018

ITR‑284 modulates cell differentiation in human chronic myelogenous leukemia K562 cells.

Oncol Rep 2018 Jan 9;39(1):383-391. Epub 2017 Nov 9.

Department of Biological Science and Technology, China Medical University, Taichung, Taiwan, R.O.C.

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http://dx.doi.org/10.3892/or.2017.6090DOI Listing
January 2018

Matrix metalloproteinase 14 modulates diabetes and Alzheimer's disease cross-talk: a meta-analysis.

Neurol Sci 2018 Feb 4;39(2):267-274. Epub 2017 Nov 4.

Department of Medical Research, China Medical University Hospital, Taichung, 40447, Taiwan.

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http://dx.doi.org/10.1007/s10072-017-3166-4DOI Listing
February 2018

Characteristics of Chinese herbal medicine usage and its effect on survival of lung cancer patients in Taiwan.

J Ethnopharmacol 2018 Mar 31;213:92-100. Epub 2017 Oct 31.

School of Chinese Medicine, China Medical University, Taichung, Taiwan; Genetic Center, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.jep.2017.10.031DOI Listing
March 2018

The differential regulation of microRNAs is associated with oral cancer.

Oncol Rep 2017 Sep 12;38(3):1613-1620. Epub 2017 Jul 12.

Department of Medical Research, China Medical University Hospital, China Medical University, Taichung, Taiwan, R.O.C.

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http://dx.doi.org/10.3892/or.2017.5811DOI Listing
September 2017

YC-1 induces G/G phase arrest and mitochondria-dependent apoptosis in cisplatin-resistant human oral cancer CAR cells.

Biomedicine (Taipei) 2017 Jun 14;7(2):12. Epub 2017 Jun 14.

Genetics Center, Department of Medical Research, China Medical University Hospital, Taichung 404, Taiwan - School of Chinese Medicine, China Medical University, Taichung 404, Taiwan - Department of Medical Genetics, China Medical University Hospital, Taichung 404, Taiwan.

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http://dx.doi.org/10.1051/bmdcn/2017070205DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5479426PMC
June 2017

Autophagy and its link to type II diabetes mellitus.

Biomedicine (Taipei) 2017 Jun 14;7(2). Epub 2017 Jun 14.

Genetics Center, Department of Medical Research, China Medical University Hospital, Taichung 404, Taiwan - School of Chinese Medicine, China Medical University, Taichung 404, Taiwan - Department of Medical Genetics, China Medical University Hospital, China Medical University, Taichung 404, Taiwan.

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http://dx.doi.org/10.1051/bmdcn/2017070201DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5479440PMC
June 2017

Genetic epidemiological study doesn't support GLA IVS4+919G>A variant is a significant mutation in Fabry disease.

Mol Genet Metab 2017 05 24;121(1):22-27. Epub 2017 Mar 24.

Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan; Graduate Institute of Chinese Medical Science, China Medical University, Taichung, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.ymgme.2017.03.005DOI Listing
May 2017

Genome-Wide Association Study Meta-Analysis of Long-Term Average Blood Pressure in East Asians.

Circ Cardiovasc Genet 2017 Apr;10(2):e001527

From the Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA (C.L., J.H., J.Z., T.N.K.); Center for Genome Science, Korea National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk-do, Korea (Y.K.K., J.L., S.H., B.-G.H., S.M., B.-J.K.); Genome Institute of Singapore, Agency for Science, Technology and Research (R.D., J.L., Y.-Y.T.); Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Graduate University of the Chinese Academy of Sciences (H.L., Y.H., Y.W., L.S., X.L.); National Yang-Ming University Hospital, Taipei, Taiwan (I-T.L.); National Yang-Ming University Hospital, Taipei, Taiwan; Singapore Eye Research Institute, Singapore National Eye Center (Y.C., Y.K., Y.Z., N.K., T.Y.W.); Duke-NUS Graduate Medical School, National University of Singapore, (Y.C., N.K., T.Y.W., E-S.T.); Department of Ophthalmology (Y.C., T.Y.W.), Department of Statistics and Applied Probability (Y.-Y.T.), Life Sciences Institute (Y.-Y.T.), NUS Graduate School for Integrative Science and Engineering (Y.-Y.T.), Department of Medicine, National University Health System, Singapore (E-S.T.); MOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (M.H., H.H., L.G., Y.H., T.W.); Division of Endocrine and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taipei, Taiwan (I-T.L., W.H-h.S); School of Medicine, National Yang-Ming University, Taipei, Taiwan (W.H-h.S., K.-W.L.); Institute for Translational Genomics and Population Sciences, Department of Pediatrics, LABioMed at Harbor-UCLA Medical Center, Torrance, CA (X.G., J.Y., K.D.T., J.I.R., Y.-d.I.C.); Division of Cardiovascular Medicine, Department of Internal Medicine, Department of Human Genetics, University of Michigan, Ann Arbor (S.K.G.); Department of Medicine, Tulane University School of Medicine, New Orleans, LA (J.H., J.C.); Saw Swee Hock School of Public Health, National University of Singapore and National University Health System (J.L., Y.-Y.T., X.S., E-S.T.); Division of Biostatistics, Washington University School of Medicine, St. Louis, MO (D.C.R.); Department of Medical Genetics (F.-J.T.) and School of Chinese Medicine (C.-H.C., J.-Y.W.), China Medical University Hospital, Taichung, Taiwan; Department of Medicine, Columbia University Medical Center, New York, NY (W.P.); Department of Epidemiology, Human Genetics and Environmental Sciences, University of Texas School of Public Health, Houston (J.E.H.); Department of Internal Medicine, Ditmanson Medical Foundation, Chiayi Christian Hospital, Taiwan (C.H.L.); Department of Business Administration, National Chung Cheng University, Chia-yi, Taiwan (C.H.L.); Department of Nursing, DaYeh University, Changhua, Taiwan (C.H.L.); Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan (W.-J.L.); State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center of Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (D.G.); National Center for Genome Medicine, Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan (C.-H.C., J.-Y.W.); Department of Ophthalmology and Visual Science, Khoo Teck Puat Hospital, Singapore, Singapore (N.K.); Medical Genetics Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA (L.J.R.); and Department of Epidemiology and Biostatistics, University of Georgia at Athens, Athens (C.L.); Department of Cardiovascular Center, Taichung Veterans General Hospital, Taichung, Taiwan (K.-W.L.).

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http://dx.doi.org/10.1161/CIRCGENETICS.116.001527DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5704911PMC
April 2017

H3 ubiquitination by NEDD4 regulates H3 acetylation and tumorigenesis.

Nat Commun 2017 03 16;8:14799. Epub 2017 Mar 16.

Department of Cancer Biology, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, North Carolina 27157, USA.

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http://dx.doi.org/10.1038/ncomms14799DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5357315PMC
March 2017

Molecular pathways related to the longevity promotion and cognitive improvement of Cistanche tubulosa in Drosophila.

Phytomedicine 2017 Mar 17;26:37-44. Epub 2017 Jan 17.

Graduate Institute of Acupuncture Science, China Medical University, Taichung, Taiwan; Department of Bioinformatics and Medical Engineering, Asia University, Taichung, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.phymed.2017.01.006DOI Listing
March 2017

Effect of Chinese herbal medicine on stroke patients with type 2 diabetes.

J Ethnopharmacol 2017 Mar 16;200:31-44. Epub 2017 Feb 16.

School of Chinese Medicine, China Medical University, Taichung, Taiwan; Genetic Center, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.jep.2017.02.024DOI Listing
March 2017

Resveratrol-induced autophagy and apoptosis in cisplatin-resistant human oral cancer CAR cells: A key role of AMPK and Akt/mTOR signaling.

Int J Oncol 2017 Mar 30;50(3):873-882. Epub 2017 Jan 30.

School of Pharmacy, College of Pharmacy, Taipei Medical University, Taipei 110, Taiwan, R.O.C.

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http://dx.doi.org/10.3892/ijo.2017.3866DOI Listing
March 2017