Publications by authors named "Furong Li"

101 Publications

Single-cell Long Non-coding RNA Landscape of T Cells in Human Cancer Immunity.

Genomics Proteomics Bioinformatics 2021 Jul 17. Epub 2021 Jul 17.

Translational Medicine Collaborative Innovation Center, The Second Clinical Medical College (Shenzhen People's Hospital), Jinan University, Shenzhen 518020, China; Shenzhen Key Laboratory of Stem Cell Research and Clinical Transformation, Shenzhen 518020, China. Electronic address:

The development of new biomarkers or therapeutic targets for cancer immunotherapies requires deep understanding of T cells. To date, the complete landscape and systematic characterization of long noncoding RNAs (lncRNAs) in T cells in cancer immunity are lacking. Here, by systematically analyzing full-length single-cell RNA sequencing (scRNA-seq) data of more than 20,000 libraries of T cells across three cancer types, we provide the first comprehensive catalog and the functional repertoires of lncRNAs in human T cells. Specifically, we developed a custom pipeline for de novo transcriptome assembly and obtained a novel lncRNA catalog containing 9433 genes. This increased the number of current human lncRNA catalog by 16% and nearly doubled the number of lncRNAs expressed in T cells. We found that a portion of expressed genes in single T cells were lncRNAs which had been overlooked by the majority of previous studies. Based on metacell maps constructed by the MetaCell algorithm that partitions scRNA-seq datasets into disjointed and homogenous groups of cells (metacells), 154 signature lncRNAs were identified. They associated with effector, exhausted, and regulatory T cell states. 84 of them were functionally annotated based on the co-expression network, indicating that lncRNAs might broadly participate in the regulation of T cell functions. Our findings provide a new point of view and resource for investigating the mechanisms of T cell regulation in cancer immunity as well as for novel cancer-immune biomarker development and cancer immunotherapies.
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http://dx.doi.org/10.1016/j.gpb.2021.02.006DOI Listing
July 2021

Economic status and catastrophic health expenditures in China in the last decade of health reform: a systematic review and meta-analysis.

BMC Health Serv Res 2021 Jun 24;21(1):600. Epub 2021 Jun 24.

Department of Health Policy and Management, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, China.

Background: In order to solve the problem of "expensive medical treatment and difficult medical treatment" for patients and improve the equity of medical services, China started the health-care reform in 2009, and proposed ambitious goals of providing fair and high-quality basic medical and health services to all citizens and reducing economic burden of diseases. This study was to systematically explore the association between population economic status and incidence of catastrophic health expenditures (CHE) in mainland China in the last decade since 2009 health reform.

Methods: This systematic review was reported according to the standard of preferred reporting items for systematic reviews and meta-analyses (PRISMA). We systematically searched Chinese Electronic literature Database of China Journal Full Text Database, Chinese Biomedical Journal Database, Wan fang Data Resource System, VIP Database, and English literature databases of PubMed, SCI, EMbase and Cochrane Library from January 2000 to June 2020, and references of included studies. Two reviewers independently selected all reports from 2000 to 2020 for empirical studies of CHE in mainland China, extracted data and evaluated the quality of the study. We conducted meta-analysis of the incidence of CHE and subgroup analysis according to the time of the study and the economic characteristics of residents.

Results: Four thousand eight hundred seventy-four records were retrieved and eventually 47 studies with 151,911 participants were included. The quality scores of most of studies were beyond 4 points (91.49%). The pooled incidence of CHE of Chinese residents in the last two decades was 23.3% (95% CI: 21.1 to 25.6%). The CHE incidence increased from 2000 to 2017, then decreased over time from 2017 to 2020. From 2000 to 2020, the CHE incidence in rural areas was 25.0% (95% CI: 20.9 to 29.1%) compared to urban 20.9% (95% CI: 18.3 to 23.4%); the CHE incidence in eastern, central and western China was 25.0% (95% CI: 19.2 to 30.8%), 25.4% (95% CI: 18.4 to 32.3%), and 23.1% (95% CI: 17.9 to 28.2%), respectively; the CHE incidence was 30.9% (95% CI: 22.4 to 39.5%), 20.3% (95% CI: 17.0 to 23.6%), 19.9% (95% CI: 15.6 to 24.1%), and 23.7% (95% CI: 18.0 to 29.3%) in poverty group, low-income group, middle-income group, and high-income group, respectively.

Conclusions: In the past two decade, the incidence of CHE in rural areas is higher than that of urban residents; higher in central areas than in eastern, western and other regions; in poverty households than in low-income, middle-income and high-income regions. Further measures should be taken to reduce the incidence of CHE in susceptible people.
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http://dx.doi.org/10.1186/s12913-021-06408-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8229446PMC
June 2021

MicroRNA-326 attenuates immune escape and prevents metastasis in lung adenocarcinoma by targeting PD-L1 and B7-H3.

Cell Death Discov 2021 Jun 15;7(1):145. Epub 2021 Jun 15.

Translational Medicine Collaborative Innovation Center, Shenzhen People's Hospital (The Second Clinical Medical College, Jinan University; The First Affifiliated Hospital, Southern University of Science and Technology), Shenzhen, 518020, China.

Tumor-infiltrating T cells are highly expressive of inhibitory receptor/immune checkpoint molecules that bind to ligand expressed by tumor cells and antigen-presenting cells, and eventually lead to T cell dysfunction. It is a hot topic to restore T cell function by targeting immune checkpoint. In recent years, immunotherapy of blocking immune checkpoint and its receptor, such as PD-L1/PD-1 targeted therapy, has made effective progress, which brings hope for patients with advanced malignant tumor. However, only a few patients benefit from directly targeting these checkpoints or their receptors by small compounds or antibodies. Since the complexity of the regulation of immune checkpoints in tumor cells, further research is needed to identify the novel endogenous regulators of immune checkpoints which can help for developing effective drug target to improve the effect of immunotherapy. Here, we verified that microRNA-326 (miR-326) repressed the gene expression of immune checkpoint molecules PD-L1 and B7-H3 in lung adenocarcinoma (LUAD). We detected that the expression of miR-326 in LUAD tissue was negatively correlated with PD-L1/B7-H3. The repression of PD-L1 and B7-H3 expression through miR-326 overexpression leads to the modification the cytokine profile of CD8 T cells and decreased migration capability of tumor cells. Meanwhile, the downregulation of miR-326 promoted tumor cell migration. Moreover, blocking PD-L1 and B7-H3 attenuated the tumor-promoting effect induced by miR-326 inhibitor. In tumor-bearing mice, the infiltration of CD8 T cells was significantly increased and the expression of TNF-α, and IFN-γ was significantly enhanced which contributed to tumor progression after miR-326 overexpression. Collectively, miR-326 restrained tumor progression by downregulating PD-L1 and B7-H3 expression and increasing T cell cytotoxic function in LUAD. Our findings revealed a novel perspective on the complex regulation of immune checkpoint molecules. A new strategy of using miR-326 in tumor immunotherapy is proposed.
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http://dx.doi.org/10.1038/s41420-021-00527-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8206349PMC
June 2021

Bacterial Skin Infections in Hospitalized Patients with Bullous Pemphigoid.

Adv Skin Wound Care 2021 Jul;34(7):365-370

In the Dermatology Department, Peking University First Hospital, Beijing, China, Furong Li, MB, is a medical student; Xuejun Zhu, MD, is a professor; Xixue Chen, MD, is an associate professor; Mingyue Wang, MD, PhD, is an associate professor. In the Eight-year Clinical Medical Education Department, Wenjie Bian, MB and Yejun Wu, MB, are medical students. Acknowledgment: This study was supported by the National Natural Science Foundation of China (grant no. 81000694 and 81130030) and the Beijing Natural Science Foundation (grant no. 7172214). The funders played no role in study design, data collection, data analysis, manuscript writing, or publication. The authors have disclosed no other financial relationships related to this article. Submitted May 9, 2020; accepted in revised form October 2, 2020.

Objective: To explore the features and risk factors of bacterial skin infections (BSIs) in hospitalized patients with bullous pemphigoid (BP).

Methods: Records were retrospectively reviewed for 110 hospitalized patients with BP admitted to Peking University First Hospital between 2013 and 2019. Bacterial species and drug resistance were assessed, and then the underlying risk factors for BSIs were evaluated.

Results: Infections were present in 40% (44/110) of the patients. Staphylococcus aureus (72.7%, 32/44) was the most common bacterium, and it was highly resistant to penicillin (81.3%, 26/32), erythromycin (62.5%, 20/32), and clindamycin (56.3%, 18/32), but 100.0% sensitive to vancomycin and tigecycline. Coronary heart disease (P = .02; odds ratio [OR], 12.68), multisystem comorbidities (P = .02; OR, 3.67), hypoalbuminemia (P = .04; OR, 3.70), high levels of anti-BP180 antibodies (>112.4 U/mL; P = .003; OR, 6.43), and season (spring: reference; summer: P = .002; OR, 23.58; autumn: P = .02; OR, 12.19; winter: P = .02; OR, 13.19) were significantly associated with BSIs.

Conclusions: Hospitalized patients with BP had a high incidence of BSIs, and those patients with underlying risk factors require careful management to prevent and control BSIs.
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http://dx.doi.org/10.1097/01.ASW.0000752704.10152.30DOI Listing
July 2021

Elucidating the relationship between nutrition indices and coronary artery calcification in patients undergoing maintenance hemodialysis.

Ther Apher Dial 2021 May 26. Epub 2021 May 26.

Department of Nephrology, the Affiliated Huaihai Hospital of Xuzhou Medical University, Xuzhou, China.

Cardiovascular diseases (CVD) are common in maintenance hemodialysis (MHD) patients, and vascular calcification is associated with the incidence of CVD. Malnourished MHD patients are particularly prone to CVD events. Thus far, there is no clear explanation for the relationship of nutrition status with vascular calcification; therefore, we investigated the relationship between malnutrition and vascular calcification. One hundred thirty-one patients underwent laboratory testing, assessment of vascular calcification, modified quantitative subjective global assessment (MQSGA), bioelectrical impedance analysis (BIA), and anthropometric measurements. The patients were divided into two groups based on the presence or absence of coronary artery calcification (CAC), and nutritional statuses were compared between the two groups. The MQSGA score was higher in the CAC group (mean 10.9 ± 1.81) than in the no-CAC group (mean 10.2 ± 1.51); in addition, the mean phase angle (PA) value was significantly lower in the CAC group than in the no-CAC group. Stratification according to CAC score showed that age, Kt/V, incidence of valve calcification, incidence of abdominal aortic calcification, MQSGA score, and blood cell mass were related to the severity of CAC. In addition, quartile analysis revealed that MQSGA score and PA value were related to the incidence and severity of vascular calcification. Binary regression analysis showed that MQSGA score, age, hemoglobin level, and high-density lipoprotein level were independent risk factors for dialysis-related CAC. Patients on MHD who exhibited malnutrition were more likely to have vascular calcification, especially CAC. Namely, the higher the MQSGA score, the lower the PA, and the more likely the occurrence of CAC.
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http://dx.doi.org/10.1111/1744-9987.13693DOI Listing
May 2021

Knowledge framework and emerging trends in intracranial aneurysm magnetic resonance angiography: a scientometric analysis from 2004 to 2020.

Quant Imaging Med Surg 2021 May;11(5):1854-1869

Department of Epidemiology, School of Public Health (Guangdong Provincial Key Laboratory of Tropical Disease Research), Southern Medical University, Guangzhou, China.

Background: As magnetic resonance angiography (MRA) has been increasingly used in the follow-up of intracranial aneurysms (IAs) as a non-invasive technique, the knowledge framework and areas of research interest in intracranial aneurysms magnetic resonance angiography (IAMRA) change approximately every 10 years. However, few studies have quantitatively analyzed the published literature in this field. In the present study, we used scientometrics to survey the knowledge field, development trends, and research focus of IAMRA with the aim of providing a reference for further study.

Methods: We collected articles on IAMRA published from 2004 (Jan 1, 2004) to 2020 (May 24, 2020). Web of Science Core Collection databases (WoSCCd) including the Science Citation Index Expanded were searched. An experienced staff member from the Department of Radiology at Southern Medical University, assisted in screening articles for relevant articles. We used ArcGIS (a mapping and location analytics platform) to perform geographic visualization. Excel 2016 was used to analyze the literature data, including number of publications, impact factor (IF), and publication year. CiteSpace V was used to conduct a series of literature feature clustering, including author co-citation analysis, reference co-citation analysis (RCA), and burst keywords analysis.

Results: A total of 1,272 articles on IAMRA published between 2004 and 2020 were included. Of 257 journals, (IF 2018: 3.256) published the most IAMRA articles (109 publications, 8.57%), followed by (IF 2018: 4.131, 51 publications, 4.16%), and (IF 2018: 2.504, 51 publications, 4.01%). Of 56 countries, the USA published the most, with 347 articles [27.28%, IF: 3.14 (average IF of all journals in the country)], followed by Japan (242 articles, 19.03%, IF: 2.38), Germany (135 articles, 10.61%, IF: 3.21), and China (101 articles, 7.94%, IF: 2.86). A total of 1387 institutions published articles, with the Mayo Clinic publishing the most (33 articles, 2.59%), followed by Shanghai Jiao Tong University (25 article, 1.97%), Seoul National University (23 articles, 1.81%), and University Medical Center Utrecht (19 articles, 1.49%). Of 399 authors, Rinkel ranked first with 19 articles, followed by Li MH (18 articles), Uchino A (15 articles), and Saito N (13 articles). Cluster RCA showed that the first cluster was "#0 growth", followed by "#1 Guglielmi detachable coils". Timeline views showed that the time span of "#0 growth" was the closest to today. The modularity value was 0.6971, and the mean silhouette value was 0.5477. According to the burst keyword analysis, "risk factors associated to rupture" was the topic with the strongest burst since 2017. Studies conducted in several countries suggested that age is inversely related to the risk of rupture, which implies the importance of MRA follow-up for patients of different age.

Conclusions: From 2004 to 2020, the number of published IAMRA-related articles gradually increased. The USA and Western Europe lead in the field, with a concentration of cutting-edge talents and high-level scientific research institutions. A synthesis of the clustering results of RCA and burst keyword analysis indicated that unruptured IA growth, stent-assisted coil embolization, and risk factors associated to rupture were the current hotspots in IAMRA research.
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http://dx.doi.org/10.21037/qims-20-729DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8047370PMC
May 2021

A Case of Foreign Body Granuloma Caused by Acupoint Catgut Embedding Therapy for Obesity.

Ann Dermatol 2020 Dec 11;32(6):529-530. Epub 2020 Nov 11.

Department of Dermatology, Peking University First Hospital, Beijing, China.

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http://dx.doi.org/10.5021/ad.2020.32.6.529DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7875237PMC
December 2020

Association between dietary diversity and cognitive impairment among the oldest-old: Findings from a nationwide cohort study.

Clin Nutr 2021 Apr 2;40(4):1452-1462. Epub 2021 Mar 2.

Department of Epidemiology, School of Public Health (Guangdong Provincial Key Laboratory of Tropical Disease Research), Southern Medical University, Guangzhou, Guangdong, China. Electronic address:

Background & Aims: Dietary diversity is widely recommended in national and international guidelines; however, whether the beneficial effects on cognitive function still apply in the oldest-old (80+) has rarely been studied. This study aimed to evaluate the associations of dietary diversity with cognitive function among the oldest-old in a large prospective cohort in China.

Methods: We conducted a long-term prospective analysis on 11,970 participants aged 80+ (6581 octogenarians, 3730 nonagenarians, and 1659 centenarians). We constructed the baseline dietary diversity score (DDS) based on eight food items of a food frequency questionnaire. Mini-mental state examination (MMSE) was used to classify the participants as having cognitive impairment or not and was also used as a continuous metric. Non-linear associations of DDS with cognitive impairment was evaluated by cox models with penalized splines. We used mixed-effect models for longitudinal data with repeated measurements of MMSE (for up to seven time during the follow-up between 1998 and 2014).

Results: We documented 4778 cognitive impairment during 46,738 person-years of follow-up. Each one unit increase in DDS was associated with a 4% lower risk of cognitive impairment (adjusted hazard ratio (HR): 0.96; 95% confidential interval (CI): 0.94-0.98). Compared to participants with DDS of 0 score, those with a DDS of 1-2, 3-4, and higher than 5 scores had a lower cognitive impairment risk, the HRs were 0.86 (0.79-0.95), 0.82 (0.74-0.91), and 0.72 (0.64-0.82) respectively, and a significant trend emerged (p < 0.001). Compared with DDS of zero score, a DDS of 1-2,3-4, ≥5 was related to slower MMSE decline (β = 0.128, 0.162, 0.301, respectively, p < 0.01).

Conclusions: Even after the age of 80, dietary diversity may offer a simple and straightforward mean of identifying and screening individuals at high risk for cognitive impairment. Recommendation of dietary diversity may be advocated to attenuate cognitive decline and decrease the risk of cognitive impairment in the oldest-old, especially in a low income or middle-income countries.
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http://dx.doi.org/10.1016/j.clnu.2021.02.041DOI Listing
April 2021

Condylomata acuminata in einem Fall von Morbus Hailey-Hailey mit einer neuartigen Mutation.

J Dtsch Dermatol Ges 2021 Mar;19(3):454-456

Department of Dermatology, Peking University First Hospital, Beijing, China.

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http://dx.doi.org/10.1111/ddg.14299_gDOI Listing
March 2021

A risk-based approach for the safety analysis of eight trace elements in Chinese flowering cabbage (Brassica parachinensis L.) in China.

J Sci Food Agric 2021 Mar 11. Epub 2021 Mar 11.

Institute of Quality Standard and Monitoring Technology for Agro-Products of Guangdong Academy of Agricultural Sciences, Guangzhou, China.

Background: Most countries set regulatory values for the total trace element (TE) concentrations in soil, although there is growing interest in using a risk-based approach to evaluate the bioavailable TE using dilute salt extractants or other soil parameters, including pH and organic carbon The present study compares the current regulatory system (based on total TEs and pH) and a risk-based approach using 0.01 mol L CaCl to estimate the bioavailable fraction.

Results: In total, 150 paired samples of Chinese flowering cabbages (Brassica parachinensis) and their growth soils were collected, and the total and extractable concentrations of chromium (Cr), cadmium (Cd), lead (Pb), nickel (Ni), copper (Cu), zinc (Zn), arsenic (As) and mercury (Hg), as well as soil pH and organic matter content, were measured. No more than 3.33% of the edible parts exceeded Chinese food safety standards, even when growing in soils exceeding the current regulatory thresholds by over 50%. The total soil Cd (1.5 mg kg ), as well as the extractable concentrations of Cd (0.1 mg kg ), Ni (0.03 mg kg ) and Zn (0.1 mg kg ), are the key factors affecting the TE concentrations in B. parachinensis.

Conclusion: Our findings suggest that the current soil regulatory guidelines for safe production of B. parachinensis are overly strict and conservative. A risk-based approach based on the extractable TE concentrations would provide a better indication for plant uptake of soil TEs and avoid the waste of farmlands that can still produce safe vegetables. Future research should focus on providing crop-specific available TE concentration guidelines to promote effective utilization of farmlands. © 2021 Society of Chemical Industry.
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http://dx.doi.org/10.1002/jsfa.11209DOI Listing
March 2021

Establishment of human embryonic stem cell WAe009-A-48 carrying a long QT syndrome mutation in SCN5A.

Stem Cell Res 2021 03 25;51:102194. Epub 2021 Jan 25.

Translational Medicine Collaborative Innovation Center, The Second Clinical Medical College (Shenzhen People's Hospital), Jinan University, 518020 Shenzhen, China; Post-doctoral Scientific Research Station of Basic Medicine, Jinan University, Guangzhou 510632, China; Guangdong Engineering Technology Research Center of Stem Cell and Cell Therapy, 518020 Shenzhen, China; Shenzhen Key Laboratory of Stem Cell Research and Clinical Transformation, 518020 Shenzhen, China. Electronic address:

The long QT syndrome type 3 (LQT3) is currently the 3rd most prevalent of the 15 known types of LQT syndrome. Cardiac events in LQT3 are less frequent than LQT1 and LQT2, but more likely to be fatal. LQT3 is caused by mutation in gene SCN5A, which codes for the Nav1.5 Na+ channel. Herein, we have generated a human embryonic stem cell line (WAe009-A-48) carrying a LQTS related mutation in SCN5A (WAe009-A-48). The WAe009-A-48 line maintained stem cell like morphology, pluripotency, normal karyotype and could differentiate into all three germ layers in vivo.
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http://dx.doi.org/10.1016/j.scr.2021.102194DOI Listing
March 2021

IFI16 promotes human embryonic stem cell trilineage specification through interaction with p53.

NPJ Regen Med 2020 Oct 29;5(1):18. Epub 2020 Oct 29.

Translational Medicine Collaborative Innovation Center, The Second Clinical Medical College (Shenzhen People's Hospital), Jinan University, 518020, Shenzhen, China.

Transcriptional regulation plays an essential role in the self-renewal and differentiation of human embryonic stem cells (hESCs). However, how external signals disrupt the self-renewal regulatory network and further drive hESC differentiation remains largely unknown. Here, we found the immune regulative protein, gamma-interferon-inducible protein 16 (IFI16) was involved in the regulation of both self-renewal and differentiation gene expression during hESC trilineage specification through interaction with p53. IFI16 expression levels were upregulated through JNK activation. IFI16 knockdown delayed the downregulation of self-renewal gene expression and suppressed the upregulation of differentiation gene expression, while IFI16 overexpression accelerated trilineage specification. Furthermore, IFI16 stabilized p53-binding in the genome through IFI16-p53 interaction and differentially regulated self-renewal and differentiation gene expression. Together, our results suggest a particular role of IFI16 in differential gene expression regulation during trilineage specification of hESCs in a manner that is dependent on the genome-wide profile of p53-binding directed by IFI16-p53 interaction.
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http://dx.doi.org/10.1038/s41536-020-00104-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7596047PMC
October 2020

Preparation and Performance of Dual-functional Magnetic Phase-change Microcapsules.

Chem Asian J 2021 Jan 11;16(1):102-109. Epub 2020 Dec 11.

School of Chemical Engineering and Technology, Hainan University, Haikou, Hainan, 570228, P. R. China.

The fabrication of desired anti-magnetic materials for irradiation shielding remains a challenge to date. In this work, a new type of dual-functional magnetic shielding phase change microcapsules with paraffin as the core, melamine-formaldehyde (MF) resin as the shell and doped with magnetic particles in the shell were successfully prepared by in situ polymerization. The magnetic particles were dispersed in the shell layer by coating a hydrophilic emulsifier on the surface. These microcapsules were specifically applied to the field of magnetic shielding by the screen printing method. The effect of magnetic particles on the performance of phase-change microcapsules was examined by differential scanning calorimetry and thermogravimetric analyses. The magnetic type and magnetic strength of the microcapsules were studied by the vibrating sample magnetometer. Moreover, the effects of different magnetic particles (Fe O , CrO ) on the performance of phase change microcapsules and the magnetic strength of microcapsules were compared. The results showed that these two kinds of magnetic particles can greatly improve the phase change latent heat, thermal stability, and thermal conductivity of the microcapsules. Finally, the great magnetic shielding role of these microcapsules was demonstrated in both static and pulsed magnetic fields through the screen printing of magnetic shielding ink on wallpaper. Incorporating 0.5 g Fe O inside of microcapsules, specifically, the magnetic intensity was effectively reduced by ∼250 Oe within a short distance in the static field. We expect that these magnetic microcapsules hold great potential for the shielding of irradiations via the screen printing on various substrates.
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http://dx.doi.org/10.1002/asia.202001280DOI Listing
January 2021

Uniaxial Dynamic Compressive Behaviors of Hydraulic Asphalt Concrete under the Coupling Effect between Temperature and Strain Rate.

Materials (Basel) 2020 Nov 25;13(23). Epub 2020 Nov 25.

College of Civil Engineering, Yancheng Institute of Technology, Yancheng 224051, China.

To investigate the compressive dynamic properties of hydraulic asphalt concrete under various temperatures, four temperatures and four strain rates have been set to perform the uniaxial compression experiments using hydraulic servo machine in this paper. The influence of temperature and strain rate on the failure modes, stress-strain curves and mechanical characteristic parameters of hydraulic asphalt concrete is analyzed and the results reveal that the failure modes and stress-strain curves have significant temperature effect. When the temperature is between -20 °C and 0 °C, the failure mode is dominated by brittle failure of asphalt binder, and hydraulic asphalt concrete shows obvious strain softening. With the addition of temperature, the failure modes of specimens are transferred from brittle failure to ductile failure since the asphalt changes from elastic-brittleness to viscoelasticity. Influenced by temperature effect, the compressive stress-strain curves of hydraulic asphalt concrete show strain hardening while the peak stress of hydraulic asphalt concrete is obviously decreased, and the variation coefficient of peak stress has a power relation with temperature. With successive increases in strain rate, the stress-strain curves of hydraulic asphalt concrete gradually are transferred from strain hardening to strain softening. The peak stress and stiffness modulus of specimens under compression gradually increase, and the dynamic increase factor of peak stress is linearly related with the logarithm value of strain rate after dimensionless treatment. In terms of the quantitative analysis of the experimental data, two relationship models of the coupling effect between temperature and strain rate are proposed. The proposed models have good applicability to the quantitative analysis of the experimental results in the manuscript. This paper offers important insights into the application and development of hydraulic asphalt concrete in hydraulic engineering.
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http://dx.doi.org/10.3390/ma13235348DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7728374PMC
November 2020

Publications in Integrative and Complementary Medicine: A Ten-Year Bibliometric Survey in the Field of ICM.

Evid Based Complement Alternat Med 2020 6;2020:4821950. Epub 2020 Oct 6.

School of Science, China Pharmaceutical University, Nanjing, China.

Background: This article aims to analyze the research status of integrative complementary medicine (ICM) and features of highly cited papers in the field to provide reference of the future development of ICM.

Methods: Publications in the field of ICM from 2009 to 2018 were retrieved from the Web of Science Core Collection. The top 20 countries/territories, institutions, journals, keywords of highly cited and noncited papers, and characteristics of essential science indicator (ESI) papers, as well as open access (OA) and non-OA papers, were analyzed.

Results: Mainland China had the largest number of ICM publications. The top 20 journals published a total of 31667 papers in 2009-2018, which represented 92.9% of all publications. Keywords of highly cited and noncited papers point to different research directions. 48 ESI highly cited/hot papers were identified, most of which are related to phytochemistry. Furthermore, the average citation rate (percentage of publications that have been cited one or more times) of OA papers was lower than that of total papers and non-OA papers.

Conclusions: China leads in number of publications; however, publication quality in ICM field requires improvement. A few journals accounted for more than half of number of publications and citations, which are important for the development of ICM. Many of the keywords in ICM noncited publications pointed towards broad meaning that poorly reflect the exact research content. Most highly cited ICM studies focused on the identification and evaluation of plant active components. OA may not be an effective approach to increase paper citations in the field of ICM.
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http://dx.doi.org/10.1155/2020/4821950DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7559521PMC
October 2020

Features and Risk Factors for Paraneoplastic Autoimmune Multiorgan Syndrome in 145 Chinese Patients.

Acta Derm Venereol 2020 Nov;100(18):adv00312

Department of Dermatology, Peking University First Hospital, 100034 Beijing, China.

Paraneoplastic autoimmune multiorgan syndrome is a complex and deadly disease. We retrospectively reviewed the clinical features and risk factors for paraneoplastic autoimmune multiorgan syndrome in 145 Chinese patients. The most common neoplasm was Castleman disease (56%), and patients with Castleman disease tended to be younger (≤ 42 years old: 83% vs. 29%) and to have a greater proportions of lichen planus-like lesions (47% vs. 27%) and bronchiolitis obliterans (49% vs. 29%), compared to other neoplasm-associated patients. Among all 145 patients in the study, the survival rates were 84% at 1 year, 65% at 3 years, and 54% at 5 years. Kaplan-Meier curve analysis revealed that mortality was associated with older age (> 42 years), neoplasm type, labial lesions, and larger skin lesion area (> 17.5% of the body surface area). However, only older age and larger skin lesion area were independent factors associated with mortality in multivariate analysis. We suggest that patients with Castleman disease and paraneoplastic autoimmune multiorgan syndrome have many unique characteristics and the underlying risk factors for death require further exploration.
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http://dx.doi.org/10.2340/00015555-3673DOI Listing
November 2020

Development of Rapid Curing SiO Aerogel Composite-Based Quasi-Solid-State Dye-Sensitized Solar Cells through Screen-Printing Technology.

ACS Appl Mater Interfaces 2020 Oct 14;12(43):48794-48803. Epub 2020 Oct 14.

Key Laboratory of Advanced Materials of Tropical Island Resources, Ministry of Education, School of Chemical Engineering and Technology, Hainan University, Haikou, Hainan 570228, P. R. China.

Grätzel's dye-sensitized solar cells (DSSCs) can readily convert sunlight into electricity, attracting considerable attention of global scientists. The fabrication efficiency of DSSCs was greatly limited by the slow fabrication (∼3.5-24 h) of quasi-solid (QS) electrolytes to date. In this study, novel composites of SiO aerogel with graphene (GR), multi-walled carbon nanotubes, or polyaniline were proposed in the fabrication of QS-state electrolytes. The morphology of these composites was characterized. The gels with SiO aerogels as QS electrolytes of DSSCs can be rapidly cured in ∼3 s. Using the screen-printing technology, these QS electrolytes can be readily utilized to construct the QS-DSSC to provide high efficiency and great stability. The photovoltaic parameters and interfacial charge-transfer resistances of the QS-DSSC incorporated with our synthetic composites were investigated in detail. Specifically, the SiO aerogel composed of GR ([email protected]) as a gel can greatly improve the performance of QS-DSSCs up to 8.25%. It is likely that these SiO aerogel composite electrolytes could provide a rapid curing process in the preparation of QS-state DSSCs, which might be useful to promote the development of DSSCs for future industrialization.
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http://dx.doi.org/10.1021/acsami.0c14551DOI Listing
October 2020

Features and associated factors of bacterial skin infections in hospitalized patients with pemphigus: a single-center retrospective study.

Ann Clin Microbiol Antimicrob 2020 Oct 8;19(1):46. Epub 2020 Oct 8.

Department of Dermatology, Peking University First Hospital, 8 Xishiku Street, Xicheng District, Beijing, 100034, China.

Background: Infections were the primary cause of death (34.3-55.5%) in patients with pemphigus. Skin was usually the origin of infections. The study aimed to explore features and associated factors of bacterial skin infections (BSIs) in inpatients with pemphigus.

Methods: One hundred and seventy-seven inpatients with pemphigus hospitalizing from November 2014 to April 2019 were continuously recruited through Peking University First Hospital's inpatient records inpatients with pemphigus hospitalizing from November 2014 to April 2019 were continuously recruited through Peking University First Hospital's inpatient records. Then, we retrieved the clinical and laboratory data to explore the characteristics and associated factors of BSIs.

Results: Of patients enrolled, pemphigus vulgaris (PV, n = 142) and pemphigus foliaceus (PF, n = 9) were most common, followed by pemphigus erythematosus (PE, n = 25) and pemphigus vegetans (Pveg, n = 1). Eighty-seven of 177 (49.2%) inpatients developed BSIs, and they had a longer length of stay compared with inpatients without BSIs (median: 18.9 vs. 14.1 days, p = 0.008). Staphylococcus aureus was the most common bacteria (71.3%, 62/87) and highly resistant to penicillin (91.9%, 57/62). Higher levels of anti-Dsg1 autoantibodies (> 124.2 U/mL) (p < 0.001, odds ratio [OR] = 3.564, 95% confidence interval [CI]: 1.784-7.123) and anti-Dsg3 autoantibodies (> 169.5 U/mL) (p = 0.03, OR = 2.074, 95% CI: 1.084-3.969) were underlying risk factors of BSIs when analyzed by binary regression analysis. As for Gram's stain of bacteria, females had a lower rate of Gram-positive infections (p = 0.03). Patients using oral antibiotics (p = 0.05) had a higher rate of Gram-negative infections. Inpatients who were hospitalized in other hospitals within 2 weeks before the current admission had a higher rate of Gram-negative and co-infections (p = 0.03).

Conclusions: Inpatients with pemphigus had a high incidence of BSIs. Some factors were associated with the susceptibility of BSIs and bacterial species.
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http://dx.doi.org/10.1186/s12941-020-00388-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7545872PMC
October 2020

Condylomata acuminata in a case of Hailey-Hailey disease with a novel mutation.

J Dtsch Dermatol Ges 2021 03 8;19(3):454-455. Epub 2020 Oct 8.

Department of Dermatology, Peking University First Hospital, Beijing, China.

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http://dx.doi.org/10.1111/ddg.14299DOI Listing
March 2021

Optimization of Factor Combinations for Stem Cell Differentiations on a Design-of-Experiment Microfluidic Chip.

Anal Chem 2020 10 5;92(20):14228-14235. Epub 2020 Oct 5.

Department of Biology, Southern University of Science and Technology, 1088 Xueyuan Avenue, Nanshan District, Shenzhen, 518055 Guangdong, China.

Directed differentiation of stem cells plays a vital role in cell replacement therapy. Many activators and inhibitors targeting different signaling pathways have been identified to contribute to each step of differentiation. Most studies relied on empirically optimizing the combinations of the aforementioned factors for each step to optimize the efficiency of differentiation, which are time-consuming and nonsystematic. Design-of-experiment (DOE) is a powerful strategy to identify the critical combinations from multiple factors systematically. However, it is prohibitively complicated for typical laboratories, given a large number of potential combinations. Here, we develop a multilayer polymethyl methacrylate-based, reusable microfluidic chip to directly facilitate the DOE in the differentiation of stem cells. The chip consists of an inlet layer and multiple disperse layers. Different solutions are injected simultaneously to the chip through the inlet layer. Subsequently, the channels in the disperse layers split and recombine the flow streams to generate solution combinations based on hard-wired DOE designs. We demonstrated that it is in quantitative agreement with the designs using fluorescent dyes. Moreover, we constructed a human-induced pluripotent stem reporter cell line to improve the consistency of the cellular state measurements and use the chip to identify critical factors for cell differentiation to definitive endoderm (DE). We found that the differentiation efficiencies under various factor combinations are significantly different, and CHIR99201 and GDF8 are the most critical factors for differentiation to DE. Our method is potentially applicable to the optimization of factor combinations for multi-step stem cell differentiation and combinatorial drug screening.
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http://dx.doi.org/10.1021/acs.analchem.0c03488DOI Listing
October 2020

Do health insurances reduce catastrophic health expenditure in China? A systematic evidence synthesis.

PLoS One 2020 24;15(9):e0239461. Epub 2020 Sep 24.

Department of Health Policy and Management, West China school of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, China.

Objective: To examine the association of health insurances on catastrophic health expenditure (CHE), and compares that among different health insurances in the last two decades in China.

Methods: The systematic review was conducted according to the Cochrane Handbook and reported according to PRISMA. We searched English and Chinese literature databases including PubMed, EM base, web of science, CNKI, Wan fang, VIP and CBM (Sino Med) for empirical studies on the association between health insurance and CHE from January 2000 to June 2020. Study selection, data extraction and quality appraisal were conducted by two reviewers. The secular trend of CHE rate and comparisons between population with different health insurances were conducted using meta-analysis, subgroup analysis and meta-regression.

Results: A total of 4874 citations were obtained, and finally 30 eligible studies with 633917 participants were included. The overall CHE rate was 13.6% (95% CI: 13.1% - 14.0%) from Jan 2000 to June 2020, 12.8% (95% CI: 12.2% - 13.3%) for people with health insurance compared with 16.2% (95% CI:15.4% - 16.9%) for people without health insurance. For types of insurance, the CHE rate was 13.0% (95% CI: 12.4% - 13.6%) for people with new rural cooperative medical scheme (NCMS), 11.9% (95% CI: 9.3% - 14.5%) for urban employees health insurance (UEBMI), 12.0% (95% CI: 8.3% - 15.6%) for urban residents health insurance (URBMI), and 18.0% (95% CI: - 4.5% - 31.5%) for commercial insurance. However, the CHE rate in China has increased in the past 20 years, even adjusted for other factors. The CHE rate of people with NCMS has increased significantly more than people with UEBMI and URBMI.

Conclusion: In the past 20 years, the basic health insurance plan has reduce the rate of CHE to a certain extent, but due to the rapid increase in medical costs and the release of health needs in recent years, it masks the role of health insurance. More efforts are needed to control unreasonable medical demand and rising costs.
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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0239461PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7514005PMC
November 2020

BIOCHIP mosaic for the diagnosis of autoimmune bullous diseases in Chinese patients.

Eur J Dermatol 2020 Aug;30(4):338-344

Department of Dermatology, Peking University First Hospital, and National Clinical Research Center for Skin and Immune Diseases, and Beijing Key Laboratory of Molecular Diagnosis on Dermatoses, Beijing, China.

Background: Autoimmune blistering diseases (AIBDs) are a group of fatal diseases with specific autoantibodies. BIOCHIP mosaic is a novel and all-in-one measure used for the rapid diagnosis of AIBDs.

Objectives: To evaluate the diagnostic accuracy based on BIOCHIP mosaic (FA1501-1005-60) in Chinese patients with AIBDs.

Materials And Methods: Seventy-seven patients with AIBDs and 20 controls were enrolled. The BIOCHIP mosaic was performed using both serum and plasma samples.

Results: Based on BIOCHIP mosaic, the data from paired plasma and serum samples demonstrated a high degree of concordance (Cohen's kappa = 0.896-1.000) for autoantibodies against Dsg1, Dsg3, BP180-NC16A-4X, BP230gC, prickle-cell desmosomes, and pemphigoid antigens. Moreover, BIOCHIP mosaic also demonstrated a high degree of consistency for the detection rate of anti-Dsg1, Dsg3, plakins, BP180-NC16A-4X and non-collagenous domain of type VII collagen autoantibodies for the diagnosis of pemphigus foliaceus (77.3%), pemphigus vulgaris (88.6%), paraneoplastic pemphigus (100.0%), bullous pemphigoid (92.8%) and epidermolysis bullosa acquisita (99.0%), respectively.

Conclusion: Using BIOCHIP mosaic, serum and plasma samples may be used interchangeably at 1/10 dilution. Overall, the BIOCHIP mosaic was shown to be a useful and accurate tool for the diagnosis of AIBDs.
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http://dx.doi.org/10.1684/ejd.2020.3839DOI Listing
August 2020

Corrigendum to "Detailed process analysis for glomerular capillary formation by immunofluorescence on ultra-thick sections" [Gene Expr. Patterns 35 (2020) 119096].

Gene Expr Patterns 2020 Dec 18;38:119143. Epub 2020 Sep 18.

Department of Nephrology, Institute of Nephrology of Chongqing and Kidney Center of PLA, Xinqiao Hospital, Army Medical University, Chongqing, 400037, China. Electronic address:

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http://dx.doi.org/10.1016/j.gep.2020.119143DOI Listing
December 2020

Incidence, clinical course and risk factor for recurrent PCR positivity in discharged COVID-19 patients in Guangzhou, China: A prospective cohort study.

PLoS Negl Trop Dis 2020 08 31;14(8):e0008648. Epub 2020 Aug 31.

Department of Epidemiology, School of Public Health (Guangdong Provincial Key Laboratory of Tropical Disease Research), Southern Medical University, Guangzhou, Guangdong, China.

The phenomenon of COVID-19 patients tested positive for SARS-CoV-2 after discharge (redetectable as positive, RP) emerged globally. The data of incidence rate and risk factors for RP event and the clinical features of RP patients may provide recommendations for virus containment and cases management for COVID-19. We prospectively collected and analyzed the epidemiological, clinical and virological data from 285 adult patients with COVID-19 and acquired their definite clinical outcome (getting PCR positive or not during post-discharge surveillance). By March 10, 27 (9.5%) discharged patients had tested positive for SARS-CoV-2 in their nasopharyngeal swab after a median duration of 7·0 days (IQR 5·0-8·0). Compared to first admission, RP patients generally had milder clinical symptoms, lower viral load, shorter length of stay and improved pulmonary conditions at readmission (p<0.05). Elder RP patients (≥ 60 years old) were more likely to be symptomatic compared to younger patients (7/8, 87.5% vs. 3/19, 18.8%, p = 0.001) at readmission. Age, sex, epidemiological history, clinical symptoms and underlying diseases were similar between RP and non-RP patients (p>0.05). A prolonged duration of viral shedding (>10 days) during the first hospitalization [adjusted odds ratio [aOR]: 5.82, 95% confidence interval [CI]: 2.50-13.57 for N gene; aOR: 9.64, 95% CI: 3.91-23.73 for ORF gene] and higher Ct value (ORF) in the third week of the first hospitalization (aOR: 0.69; 95% CI: 0.50-0.95) were associated with RP events. In conclusion, RP events occurred in nearly 10% of COVID-19 patients shortly after the negative tests, were not associated with worsening symptoms and unlikely reflect reinfection. Patients' lack of efficiency in virus clearance was a risk factor for RP result. It is noteworthy that elder RP patients (≥ 60 years old) were more susceptible to clinical symptoms at readmission.
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http://dx.doi.org/10.1371/journal.pntd.0008648DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7505432PMC
August 2020

Treatment with catalpol protects against cisplatin-induced renal injury through Nrf2 and NF-κB signaling pathways.

Exp Ther Med 2020 Oct 29;20(4):3025-3032. Epub 2020 Jul 29.

Department of Nephrology, The key Laboratory for the Prevention and Treatment of Chronic Kidney Disease of Chongqing, Kidney Center of PLA, Xinqiao Hospital, Army Medical University (Third Military Medical University), Chongqing 400037, P.R. China.

Cisplatin (CP) is one of the most widely used chemotherapy drugs for cancer treatment, but it often leads to nephrotoxicity. It is well known that catalpol exhibits antioxidant and anti-inflammatory functions, thus the present study aimed to investigate the potential protective effects of catalpol on CP-induced kidney injury in rats, in addition to determining the underlying mechanisms. Sprague-Dawley rats were treated with 25, 50 or 100 mg/kg catalpol for two days, injected with 20 mg/kg cisplatin and catalpol on day 3 and sacrificed on day 4. The histological analysis of isolated kidney tissues was performed using hematoxylin and eosin staining, cleaved caspase-3 expression levels were analyzed using western blotting and the expression levels of inflammatory cytokines in the tissues, including tumor necrosis factor α (TNF-α), interleukin (IL)-1β, IL-6, IL-8, IL-10 and inducible nitric oxide synthase (iNOS) were evaluated using ELISAs. Furthermore, the mRNA and protein expression levels of nuclear factor erythroid 2-related factor 2 (Nrf2), heme oxygenase 1 (HO-1), kelch-like ECH-associated protein 1 (Keap1), NF-κB and inhibitory κB (IκB) were determined using reverse transcription-quantitative PCR and western blotting, respectively. The results revealed that the treatment with catalpol prevented the histopathological injury and renal dysfunction caused by CP. In addition, catalpol significantly suppressed the CP-induced apoptosis of tubular cells, inhibited the CP-induced upregulation of TNF-α, IL-1β, IL-6, IL-8 and iNOS and promoted the production of the anti-inflammatory cytokine IL-10. Additionally, the mRNA and protein expression levels of Nrf2, HO-1 and IκB in the kidney tissues were increased, whereas the expression levels of Keap1 and NF-κB were significantly decreased following the treatment with catalpol. In conclusion, these results suggested that catalpol may inhibit CP-induced renal injury and suppress the associated inflammatory response through activating the Nrf2 and inhibiting the NF-κB signaling pathways, respectively.
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http://dx.doi.org/10.3892/etm.2020.9077DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7444339PMC
October 2020

Systematic Evaluation of the Diagnostic and Prognostic Significance of Competitive Endogenous RNA Networks in Prostate Cancer.

Front Genet 2020 30;11:785. Epub 2020 Jul 30.

College of Life Science, Northwest A&F University, Yangling, China.

Long non-coding RNA (lncRNA)-mediated competitive endogenous RNA (ceRNA) networks act as essential mechanisms in tumor initiation and progression, but their diagnostic and prognostic significance in prostate cancer (PCa) remains poorly understood. Presently, using the RNA expression data derived from multiple independent PCa-related studies, we constructed a high confidence and PCa-specific core ceRNA network by employing three lncRNA-gene inference approaches and key node filter strategies and then established a logistic model and risk score formula to evaluate its diagnostic and prognostic values, respectively. The core ceRNA network consists of 10 nodes, all of which are significantly associated with clinical outcomes. Combination of expression of the 10 ceRNAs with a logistic model achieved AUC of ROC and PR curve up to ∼96 and 99% in excluding normal prostate samples, respectively. Additionally, a risk score formula constructed with the ceRNAs exhibited significant association with disease-free survival. More importantly, utilizing the expression of RNAs in the core ceRNA network as a molecular signature, the TCGA-PRAD cohort was divided into four novel clinically relevant subgroups with distinct expression patterns, highlighting a feasible way for improving patient stratification in the future. Overall, we constructed a PCa-specific core ceRNA network, which provides diagnostic and prognostic value.
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http://dx.doi.org/10.3389/fgene.2020.00785DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7406720PMC
July 2020

The role of an active surveillance strategy of targeting household and neighborhood  contacts related to leprosy cases released from treatment in a low-endemic area of China.

PLoS Negl Trop Dis 2020 08 14;14(8):e0008563. Epub 2020 Aug 14.

Shandong Provincial Hospital for Skin Diseases & Shandong Provincial Institute of Dermatology and Venereology, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, China.

Objective: Early diagnosis remains the primary goal for leprosy management programs. This study aims to determine whether active surveillance of patients with leprosy and their contact individuals increased identification of latent leprosy cases in the low-endemic areas.

Methods: This cross-sectional survey was carried out between October 2014 and August 2016 in 21 counties throughout Shandong Province. The survey was conducted among patients with leprosy released from treatment (RFT) and their contacts from both household and neighbors.

Results: A total of 2,210 RFT patients and 9,742 contacts comprising 7877 household contacts (HHCs), including 5,844 genetic related family members (GRFMs) and 2033 non-genetic related family members and 1,865 contacts living in neighboring houses (neighbor contacts, NCs), were recruited. Among identified individuals, one relapsed and 13 were newly diagnosed, giving a detection rate of 0.12%, corresponding to 120 times the passive case detection rate. Detection rates were similar for HHCs and NCs (0.114% vs. 0.214%, P = 0.287). Analysis of the family history of leprosy patients revealed clustering of newly diagnosed cases and association with residential coordinates of previously-diagnosed multibacillary leprosy cases.

Conclusion: Active case-finding programs are feasible and contributes to early case detection by tracking HHCs and NCs in low-endemic areas.
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http://dx.doi.org/10.1371/journal.pntd.0008563DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7485864PMC
August 2020

Prevalence of genital Chlamydia trachomatis infection in the general population: a meta-analysis.

BMC Infect Dis 2020 Aug 8;20(1):589. Epub 2020 Aug 8.

Shandong Provincial Hospital for Skin Disease, Shandong First Medical University, Jinan, China.

Background: Estimating prevalence of Chlamydia trachomatis (CT) worldwide is necessary in designing control programs and allocating health resources. We performed a meta-analysis to calculate the prevalence of CT in the general population.

Methods: The Pubmed and Embase databases were searched for eligible population-based studies from its inception through June 5, 2019. Q test and I statistic were used to calculate the heterogeneity between studies. Random effects models were used to pool the prevalence of CT. Meta regression was performed to explore the possible sources of heterogeneity. Publication bias was evaluated using a funnel plot and "trim and fill" method.

Results: Twenty nine studies that reported prevalence of CT infection from 24 countries were identified, including a total population of 89,886 persons. The pooled prevalence of CT among the general population was 2.9% (95% CI, 2.4-3.5%), and females had a higher CT prevalence (3.1, 95% CI, 2.5-3.8%) than males (2.6, 95% CI, 2.0-3.2%) (χ = 10.38, P <  0.01). Prevalence of CT was highest in region of America (4.5, 95% CI, 3.1-5.9%), especially in Latin America (6.7, 95% CI, 5.0-8.4%), followed by females in region of Africa (3.8, 95% CI, 0.7-6.9%), while South-East Asia had a lowest CT prevalence 0.8% (95% CI, 0.3-1.3%).

Conclusions: This study provided the updated prevalence of CT among general population worldwide. General population from Latin America, especially females, and women in Africa should be given priority by WHO when design and delivery CT control programs.
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http://dx.doi.org/10.1186/s12879-020-05307-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7414538PMC
August 2020

Author Correction: ABCG2-overexpressing H460/MX20 cell xenografts in athymic nude mice maintained original biochemical and cytological characteristics.

Sci Rep 2020 Jul 22;10(1):12467. Epub 2020 Jul 22.

Collaborative Innovation Center for Cancer Medicine, State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, China.

An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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http://dx.doi.org/10.1038/s41598-020-68768-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7376156PMC
July 2020

Recovery of pneumonia in 27 discharged COVID-19 patients with positive virus detection.

Quant Imaging Med Surg 2020 Jul;10(7):1572-1575

Department of Epidemiology, School of Public Health (Guangdong Provincial Key Laboratory of Tropical Disease Research), Southern Medical University, Guangzhou, China.

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http://dx.doi.org/10.21037/qims-20-656DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7358416PMC
July 2020
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