Fung-Lung Chung

Fung-Lung Chung

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Fung-Lung Chung

Fung-Lung Chung

Publications by authors named "Fung-Lung Chung"

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Monoclonal Antibodies for the Detection of a Specific Cyclic DNA Adduct Derived from ω-6 Polyunsaturated Fatty Acids.

Chem Res Toxicol 2018 08 30;31(8):772-783. Epub 2018 Jul 30.

Department of Oncology, Department of Biochemistry and Molecular and Cellular Biology, Lombardi Comprehensive Cancer Center , Georgetown University Medical Center , Washington , DC 20057 , United States.

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http://pubs.acs.org/doi/10.1021/acs.chemrestox.8b00111
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http://dx.doi.org/10.1021/acs.chemrestox.8b00111DOI Listing
August 2018

Oxidative stress and hepatocarcinogenesis.

Hepatoma Res 2018 1;4. Epub 2018 Aug 1.

Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC 20007, USA.

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http://hrjournal.net/article/view/2719
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http://dx.doi.org/10.20517/2394-5079.2018.29DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370311PMC
August 2018

Detection of a lipid peroxidation-induced DNA adduct across liver disease stages.

Hepatobiliary Surg Nutr 2018 Apr;7(2):85-97

Department of Biochemistry & Molecular Biology, Georgetown University Medical Center, Washington, DC, USA.

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http://hbsn.amegroups.com/article/view/16119/19166
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http://dx.doi.org/10.21037/hbsn.2017.06.01DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5934137PMC
April 2018

Isothiocyanates suppress the invasion and metastasis of tumors by targeting FAK/MMP-9 activity.

Oncotarget 2017 Sep 12;8(38):63949-63962. Epub 2017 Jul 12.

Research Institute of Biomedical Engineering and Department of Medicine, Catholic University of Daegu School of Medicine, Daegu 705-718, Republic of Korea.

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http://dx.doi.org/10.18632/oncotarget.19213DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5609975PMC
September 2017

Aldo-keto reductase 1B10 protects human colon cells from DNA damage induced by electrophilic carbonyl compounds.

Mol Carcinog 2017 01 10;56(1):118-129. Epub 2016 Mar 10.

Department of Medical Microbiology, Immunology and Cell Biology, Simmons Cancer Institute, Southern Illinois University School of Medicine, Springfield, Illinois.

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http://dx.doi.org/10.1002/mc.22477DOI Listing
January 2017

Repair kinetics of acrolein- and (E)-4-hydroxy-2-nonenal-derived DNA adducts in human colon cell extracts.

Mutat Res 2013 Nov-Dec;751-752:15-23. Epub 2013 Oct 8.

Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC 20057, USA.

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http://dx.doi.org/10.1016/j.mrfmmm.2013.09.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4188536PMC
February 2014

Effect of CpG methylation at different sequence context on acrolein- and BPDE-DNA binding and mutagenesis.

Carcinogenesis 2013 Jan 6;34(1):220-7. Epub 2012 Oct 6.

Department of Environmental Medicine, Pathology and Medicine, New York University School of Medicine, Tuxedo Park, New York 10987, USA.

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http://dx.doi.org/10.1093/carcin/bgs323DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3534198PMC
January 2013

Regioselective formation of acrolein-derived cyclic 1,N(2)-propanodeoxyguanosine adducts mediated by amino acids, proteins, and cell lysates.

Chem Res Toxicol 2012 Sep 14;25(9):1921-8. Epub 2012 Aug 14.

Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical School, 3800 Reservoir Road NW, Washington, DC 20057, USA.

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http://dx.doi.org/10.1021/tx3002252DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3535281PMC
September 2012

Proteomic analysis of covalent modifications of tubulins by isothiocyanates.

J Nutr 2012 Jul 30;142(7):1377S-81S. Epub 2012 May 30.

Laboratory of Proteomics and Analytical Technologies, Advanced Technology Program, SAIC-Frederick, Inc., National Cancer Institute at Frederick, Frederick, MD, USA.

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http://dx.doi.org/10.3945/jn.111.152041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3374673PMC
July 2012

Effect of carcinogenic acrolein on DNA repair and mutagenic susceptibility.

J Biol Chem 2012 Apr 24;287(15):12379-86. Epub 2012 Jan 24.

Department of Environmental Medicine, New York University School of Medicine, New York, New York 10987, USA.

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http://dx.doi.org/10.1074/jbc.M111.329623DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3320987PMC
April 2012

Phenethyl isothiocyanate sensitizes human cervical cancer cells to apoptosis induced by cisplatin.

Mol Nutr Food Res 2011 Oct 19;55(10):1572-81. Epub 2011 May 19.

Lombardi Comprehensive Cancer Center, Georgetown University, 3800Reservoir Road NW, Washington, DC 20057, USA.

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http://dx.doi.org/10.1002/mnfr.201000560DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3561716PMC
October 2011

Proteins as binding targets of isothiocyanates in cancer prevention.

Carcinogenesis 2011 Oct 10;32(10):1405-13. Epub 2011 Jun 10.

Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC 20057, USA.

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http://dx.doi.org/10.1093/carcin/bgr111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3179418PMC
October 2011

Identification of potential protein targets of isothiocyanates by proteomics.

Chem Res Toxicol 2011 Oct 26;24(10):1735-43. Epub 2011 Aug 26.

Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, 3800 Reservoir Road, Washington, D.C. 20057, United States.

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http://dx.doi.org/10.1021/tx2002806DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3493163PMC
October 2011

Sulforaphane prevents microcystin-LR-induced oxidative damage and apoptosis in BALB/c mice.

Toxicol Appl Pharmacol 2011 Aug 27;255(1):9-17. Epub 2011 May 27.

State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, CAS, People's Republic of China.

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http://dx.doi.org/10.1016/j.taap.2011.05.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3577421PMC
August 2011

Detoxification: a novel function of BRCA1 in tumor suppression?

Toxicol Sci 2011 Jul 19;122(1):26-37. Epub 2011 Apr 19.

Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC 20057, USA.

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http://dx.doi.org/10.1093/toxsci/kfr089DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3143468PMC
July 2011

Proteomic identification of binding targets of isothiocyanates: A perspective on techniques.

J Proteomics 2011 Jun 30;74(7):1036-44. Epub 2011 Apr 30.

Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC 20057, USA.

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http://dx.doi.org/10.1016/j.jprot.2011.04.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3107917PMC
June 2011

Isothiocyanates inhibit proteasome activity and proliferation of multiple myeloma cells.

Carcinogenesis 2011 Feb 25;32(2):216-23. Epub 2010 Nov 25.

Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC 20057, USA.

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http://dx.doi.org/10.1093/carcin/bgq242DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3026846PMC
February 2011

Selective depletion of mutant p53 by cancer chemopreventive isothiocyanates and their structure-activity relationships.

J Med Chem 2011 Feb 11;54(3):809-16. Epub 2011 Jan 11.

Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, 3800 Reservoir Road, LL 128A, Box 571465, Washington, DC 20057, USA.

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http://dx.doi.org/10.1021/jm101199tDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3139710PMC
February 2011

Metabolism of isothiocyanates in individuals with positive and null GSTT1 and M1 genotypes after drinking watercress juice.

Clin Nutr 2010 Dec 24;29(6):813-8. Epub 2010 Jul 24.

Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, District of Columbia, Washington, DC 20057, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S026156141000112
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http://dx.doi.org/10.1016/j.clnu.2010.06.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2987275PMC
December 2010

Sulforaphane activates heat shock response and enhances proteasome activity through up-regulation of Hsp27.

J Biol Chem 2010 Nov 10;285(46):35528-36. Epub 2010 Sep 10.

Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC 20057, USA.

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http://dx.doi.org/10.1074/jbc.M110.152686DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2975177PMC
November 2010

Sulforaphane protects Microcystin-LR-induced toxicity through activation of the Nrf2-mediated defensive response.

Toxicol Appl Pharmacol 2010 Sep 21;247(2):129-37. Epub 2010 Jun 21.

State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, CAS, People's Republic of China.

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http://dx.doi.org/10.1016/j.taap.2010.06.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3577422PMC
September 2010

Sensitization of non-small cell lung cancer cells to cisplatin by naturally occurring isothiocyanates.

Chem Res Toxicol 2010 Aug;23(8):1307-9

Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, 3800 Reservoir Road, Washington DC 20057, USA.

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http://dx.doi.org/10.1021/tx100187fDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2924773PMC
August 2010

Aggresome-like structure induced by isothiocyanates is novel proteasome-dependent degradation machinery.

Biochem Biophys Res Commun 2009 Oct 12;388(2):456-62. Epub 2009 Aug 12.

Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC 20057, USA.

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http://dx.doi.org/10.1016/j.bbrc.2009.08.047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2748326PMC
October 2009

Cancer preventive isothiocyanates induce selective degradation of cellular alpha- and beta-tubulins by proteasomes.

J Biol Chem 2009 Jun 1;284(25):17039-51. Epub 2009 Apr 1.

Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, D C 20057, USA.

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http://dx.doi.org/10.1074/jbc.M901789200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2719342PMC
June 2009

Acrolein-derived DNA adduct formation in human colon cancer cells: its role in apoptosis induction by docosahexaenoic acid.

Chem Res Toxicol 2009 May;22(5):798-806

Lombardi Comprehensive Cancer Center, Georgetown University, 3800 Reservoir Road NW, Washington, DC 20057, USA.

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http://dx.doi.org/10.1021/tx800355kDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2683896PMC
May 2009

Binding to protein by isothiocyanates: a potential mechanism for apoptosis induction in human non small lung cancer cells.

Nutr Cancer 2008 ;60 Suppl 1:12-20

Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA.

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http://dx.doi.org/10.1080/01635580802381287DOI Listing
February 2009

Covalent binding to tubulin by isothiocyanates. A mechanism of cell growth arrest and apoptosis.

J Biol Chem 2008 Aug 3;283(32):22136-46. Epub 2008 Jun 3.

Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC 20057, USA.

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http://dx.doi.org/10.1074/jbc.M802330200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2494917PMC
August 2008

Urinary total isothiocyanates and colorectal cancer: a prospective study of men in Shanghai, China.

Cancer Epidemiol Biomarkers Prev 2008 Jun;17(6):1354-9

The Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, USA.

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http://dx.doi.org/10.1158/1055-9965.EPI-07-2841DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2474764PMC
June 2008

The role of protein binding in induction of apoptosis by phenethyl isothiocyanate and sulforaphane in human non-small lung cancer cells.

Cancer Res 2007 Jul;67(13):6409-16

Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, District of Columbia 20057, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-07-0340DOI Listing
July 2007

Simultaneous determination of sulforaphane and its major metabolites from biological matrices with liquid chromatography-tandem mass spectroscopy.

J Chromatogr B Analyt Technol Biomed Life Sci 2006 Aug;840(2):99-107

Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 160 Frelinghuysen Road, Piscataway, 08854, USA.

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http://dx.doi.org/10.1016/j.jchromb.2006.04.046DOI Listing
August 2006

A solid-phase extraction/high-performance liquid chromatography-based (32)P-postlabeling method for detection of cyclic 1,N(2)-propanodeoxyguanosine adducts derived from enals.

Anal Biochem 2006 Jan 27;348(1):15-23. Epub 2005 Oct 27.

Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC 20057, USA.

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http://dx.doi.org/10.1016/j.ab.2005.10.011DOI Listing
January 2006

N-acetylcysteine conjugate of phenethyl isothiocyanate enhances apoptosis in growth-stimulated human lung cells.

Cancer Res 2005 Sep;65(18):8538-47

Division of Carcinogenesis, American Health Foundation Cancer Center, Institute for Cancer Prevention, Valhalla, New York, USA.

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http://cancerres.aacrjournals.org/lookup/doi/10.1158/0008-54
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http://dx.doi.org/10.1158/0008-5472.CAN-05-0236DOI Listing
September 2005

Molecular and cellular effects of green tea on oral cells of smokers: a pilot study.

Mol Nutr Food Res 2005 Jan;49(1):43-51

University of Illinois, College of Dentistry, Chicago, IL 60612-7211, USA.

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http://dx.doi.org/10.1002/mnfr.200400031DOI Listing
January 2005

Glutathione depletion enhances the formation of endogenous cyclic DNA adducts derived from t-4-hydroxy-2-nonenal in rat liver.

Chem Res Toxicol 2005 Jan;18(1):24-7

American Health Foundation Cancer Center, Institute for Cancer Prevention, Valhalla, New York 10595, USA.

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http://dx.doi.org/10.1021/tx049728+DOI Listing
January 2005

A novel mechanism of chemoprotection by sulforaphane: inhibition of histone deacetylase.

Cancer Res 2004 Aug;64(16):5767-74

Linus Pauling Institute, Oregon State University, Corvallis, Oregon 97331, USA.

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http://cancerres.aacrjournals.org/lookup/doi/10.1158/0008-54
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http://dx.doi.org/10.1158/0008-5472.CAN-04-1326DOI Listing
August 2004

Targeting cell cycle machinery as a molecular mechanism of sulforaphane in prostate cancer prevention.

Int J Oncol 2004 Jan;24(1):187-92

Division of Medical Oncology, Mount Sinai Medical Center, New York, NY 10029, USA.

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January 2004

Urinary isothiocyanate excretion, brassica consumption, and gene polymorphisms among women living in Shanghai, China.

Cancer Epidemiol Biomarkers Prev 2003 Dec;12(12):1536-9

Vanderbilt University Medical Center, Nashville, Tennessee 37232-8300, USA.

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December 2003

Evidence of alterations in base excision repair of oxidative DNA damage during spontaneous hepatocarcinogenesis in Long Evans Cinnamon rats.

Cancer Res 2003 Nov;63(22):7704-7

DNA Repair Laboratory, Mechanism of Carcinogenesis Program, American Health Foundation Cancer Center, Institute For Cancer Prevention, 1 Dana Road, Valhalla, NY 10595, USA.

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November 2003

Effects of garage employment and tobacco smoking on breathing-zone concentrations of carbonyl compounds.

AIHA J (Fairfax, Va) 2003 May-Jun;64(3):388-93

Environmental and Occupational Health Sciences Institute, UMDNJ-Robert Wood Johnson Medical School, 170 Frelinghuysen Road, Piscataway, NJ 08854, USA.

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October 2003

Tea and cancer prevention: studies in animals and humans.

J Nutr 2003 Oct;133(10):3268S-3274S

American Health Foundation Cancer Center, Institute for Cancer Prevention, Valhalla, NY 10595, USA.

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http://dx.doi.org/10.1093/jn/133.10.3268SDOI Listing
October 2003

Formation of trans-4-hydroxy-2-nonenal- and other enal-derived cyclic DNA adducts from omega-3 and omega-6 polyunsaturated fatty acids and their roles in DNA repair and human p53 gene mutation.

Mutat Res 2003 Oct;531(1-2):25-36

Division of Carcinogenesis and Molecular Epidemiology, Institute for Cancer Prevention, American Health Foundation Cancer Center, Valhalla, NY 10595, USA.

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http://dx.doi.org/10.1016/j.mrfmmm.2003.07.001DOI Listing
October 2003

Urinary isothiocyanate levels, brassica, and human breast cancer.

Cancer Res 2003 Jul;63(14):3980-6

Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee 37232-8300, USA.

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July 2003

Inhibitory effects of 2-mercaptoethane sulfonate and 6-phenylhexyl isothiocyanate on urinary bladder tumorigenesis in rats induced by N-butyl-N-(4-hydroxybutyl)nitrosamine.

Cancer Lett 2003 Apr;193(1):11-6

Division of Carcinogenesis and Molecular Epidemiology, American Health Foundation, 1 Dana Road, Valhalla, NY 10595, USA.

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http://dx.doi.org/10.1016/s0304-3835(02)00097-6DOI Listing
April 2003

The major lipid peroxidation product, trans-4-hydroxy-2-nonenal, preferentially forms DNA adducts at codon 249 of human p53 gene, a unique mutational hotspot in hepatocellular carcinoma.

Carcinogenesis 2002 Nov;23(11):1781-9

Department of Environmental Medicine, Pathology and Medicine, New York University School of Medicine, Tuxedo, NY 10987, USA.

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http://dx.doi.org/10.1093/carcin/23.11.1781DOI Listing
November 2002

Mechanisms of chronic disease causation by nutritional factors and tobacco products and their prevention by tea polyphenols.

Food Chem Toxicol 2002 Aug;40(8):1145-54

American Health Foundation, One Dana Road, Valhalla, NY 10595, USA.

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http://dx.doi.org/10.1016/s0278-6915(02)00044-3DOI Listing
August 2002

Deoxyguanosine adducts of tert-4-hydroxy-2-nonenal as markers of endogenous DNA lesions.

Methods Enzymol 2002 ;353:523-36

Division of Carcinogenesis and Molecular Epidemiology, American Health Foundation, Valhalla, New York 10595, USA.

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http://dx.doi.org/10.1016/s0076-6879(02)53074-3DOI Listing
August 2002

Isothiocyanates as cancer chemopreventive agents: their biological activities and metabolism in rodents and humans.

Curr Drug Metab 2002 Jun;3(3):233-55

Division of Carcinogenesis and Molecular Epidemiology, American Health Foundation, Valhalla, NY 10595, USA.

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June 2002

Formation of cyclic deoxyguanosine adducts from omega-3 and omega-6 polyunsaturated fatty acids under oxidative conditions.

Chem Res Toxicol 2002 Mar;15(3):367-72

Division of Carcinogenesis and Molecular Epidemiology, American Health Foundation, Valhalla, New York 10595, USA.

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http://dx.doi.org/10.1021/tx010136qDOI Listing
March 2002