Fumiyoshi Yamashita

Fumiyoshi Yamashita

UNVERIFIED PROFILE

Are you Fumiyoshi Yamashita?   Register this Author

Register author
Fumiyoshi Yamashita

Fumiyoshi Yamashita

Publications by authors named "Fumiyoshi Yamashita"

Are you Fumiyoshi Yamashita?   Register this Author

100Publications

1597Reads

22Profile Views

A model-based comparative meta-analysis of the efficacy of dolutegravir-based and efavirenz-based regimens in HIV-infected patients.

J Infect Chemother 2019 Sep 11;25(9):687-694. Epub 2019 Apr 11.

Department of Drug Delivery Research, Graduate School of Pharmaceutical Sciences, Kyoto University, 46-29 Yoshidashimoadachi-cho, Sakyo-ku, Kyoto, 606-8501, Japan; Department of Applied Pharmaceutics and Pharmacokinetics, Graduate School of Pharmaceutical Sciences, Kyoto University, 46-29 Yoshidashimoadachi-cho, Sakyo-ku, Kyoto, 606-8501, Japan. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jiac.2019.03.015DOI Listing
September 2019

Evaluation of the theranostic potential of perfluorohexane-based acoustic nanodroplets.

Biol Pharm Bull 2019 Sep 25. Epub 2019 Sep 25.

Kyoto University, Institute for Advanced Study (KUIAS), Institute for Integrated Cell-Material Sciences (iCeMS).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1248/bpb.b19-00525DOI Listing
September 2019

Ratiometric co-encapsulation and co-delivery of doxorubicin and paclitaxel by tumor-targeted lipodisks for combination therapy of breast cancer.

Int J Pharm 2019 Apr 12;560:191-204. Epub 2019 Feb 12.

Department of Pharmaceutics, School of Pharmacy, Jiangsu University, Zhenjiang 212013, PR China. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijpharm.2019.02.009DOI Listing
April 2019

Development of mKO2 fusion proteins for real-time imaging and mechanistic investigation of the degradation kinetics of human IκBα in living cells.

Biochim Biophys Acta Mol Cell Res 2019 02 31;1866(2):190-198. Epub 2018 Oct 31.

Department of Drug Delivery Research, Graduate School of Pharmaceutical Sciences, Kyoto University, Yoshidashimoadachi-cho, Sakyo-ku, Kyoto 606-8501, Japan; Institute for Integrated Cell-Material Sciences, Kyoto University, Yoshidaushinomiya-cho, Sakyo-ku, Kyoto 606-8501, Japan. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbamcr.2018.10.018DOI Listing
February 2019

Binding and structure-kinetic relationship analysis of selective TLR4-targeted immunosuppressive self-assembling heparin nanoparticles.

Int J Pharm 2018 Dec 22;552(1-2):76-83. Epub 2018 Sep 22.

Department of Drug Delivery Research, Graduate School of Pharmaceutical Sciences, Kyoto University, Yoshidashimoadachi-cho, Sakyo-ku, Kyoto 606-8501, Japan. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijpharm.2018.09.054DOI Listing
December 2018

Urokinase injection-triggered clearance enhancement of a 4-arm PEG-conjugated Cu-bombesin analog tetramer: A novel approach for the improvement of PET imaging contrast.

Int J Pharm 2018 Jul 7;545(1-2):206-214. Epub 2018 May 7.

RIKEN Center for Life Science Technologies, 6-7-3 Minatojima-minamimachi, Chuo-ku, Kobe, Hyogo 650-0047, Japan. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijpharm.2018.05.014DOI Listing
July 2018

[Dynamic Simulation of Drug-Drug Interactions by Using Multi-level Physiological Modeling & Simulation Platforms].

Yakugaku Zasshi 2018 ;138(3):347-351

Center for Integrative Education of Pharmacy and Pharmaceutical Sciences, Graduate School of Pharmaceutical Sciences, Kyoto University.

View Article

Download full-text PDF

Source
https://www.jstage.jst.go.jp/article/yakushi/138/3/138_17-00
Publisher Site
http://dx.doi.org/10.1248/yakushi.17-00191-2DOI Listing
March 2018

The development of mechanically formed stable nanobubbles intended for sonoporation-mediated gene transfection.

Drug Deliv 2017 Nov;24(1):320-327

a Department of Drug Delivery Researches , Graduate School of Pharmaceutical Sciences, Kyoto University , Kyoto , Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/10717544.2016.1250139DOI Listing
November 2017

An Evolutionary Search Algorithm for Covariate Models in Population Pharmacokinetic Analysis.

J Pharm Sci 2017 09 25;106(9):2407-2411. Epub 2017 Apr 25.

Graduate School of Pharmaceutical Sciences, Kyoto University, Yoshidashimoadachi-cho, Sakyo-ku, Kyoto 606-8501, Japan; Institute for Integrated Cell-Material Sciences, Kyoto University, Yoshida-Ushinomiya-cho, Sakyo-ku, Kyoto 606-8501, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.xphs.2017.04.029DOI Listing
September 2017

Anti-inflammatory Effect of Self-assembling Glycol-Split Glycosaminoglycan-Stearylamine Conjugates in Lipopolysaccharide-Stimulated Macrophages.

Biol Pharm Bull 2017 ;40(4):540-545

Department of Drug Delivery Research, Graduate School of Pharmaceutical Sciences, Kyoto University.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1248/bpb.b16-00928DOI Listing
July 2017

Synthesis and Functional Characterization of Novel Sialyl LewisX Mimic-Decorated Liposomes for E-selectin-Mediated Targeting to Inflamed Endothelial Cells.

Mol Pharm 2017 05 24;14(5):1528-1537. Epub 2017 Feb 24.

Department of Drug Delivery Research, Graduate School of Pharmaceutical Sciences, Kyoto University , 46-29 Yoshidashimoadachi-cho, Sakyo-ku, Kyoto 606-8302, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.molpharmaceut.6b00982DOI Listing
May 2017

Quantitative prediction of ionization effect on human skin permeability.

Int J Pharm 2017 Apr 7;522(1-2):222-233. Epub 2017 Mar 7.

Department of Drug Delivery Research, Graduate School of Pharmaceutical Sciences, Kyoto University, 46-29, Yoshida-shimoadachicho, Sakyo-ku, Kyoto 606-8501 Japan. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijpharm.2017.03.009DOI Listing
April 2017

In Vitro Cellular Gene Delivery Employing a Novel Composite Material of Single-Walled Carbon Nanotubes Associated With Designed Peptides With Pegylation.

J Pharm Sci 2017 03 16;106(3):792-802. Epub 2016 Dec 16.

Institute for Integrated Cell-Material Sciences (iCeMS), Kyoto University, Yoshida Ushinomiya-cho, Sakyo-ku, Kyoto 606-8501, Japan; Department of Drug Delivery Research, Graduate School of Pharmaceutical Sciences, Kyoto University, 46-29 Yoshida Shimoadachi-cho, Sakyo-ku, Kyoto 606-8501, Japan. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.xphs.2016.10.025DOI Listing
March 2017

Sustained Release of Mitomycin C from Its Conjugate with Single-Walled Carbon Nanotubes Associated by Pegylated Peptide.

Biol Pharm Bull 2016 ;39(10):1687-1693

Institute for Integrated Cell-Material Sciences (iCeMS), Kyoto University.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1248/bpb.b16-00434DOI Listing
January 2017

Anti-MUC1 Aptamer/Negatively Charged Amino Acid Dendrimer Conjugates for Targeted Delivery to Human Lung Adenocarcinoma A549 Cells.

Biol Pharm Bull 2016 ;39(10):1734-1738

Department of Drug Delivery Research, Graduate School of Pharmaceutical Sciences, Kyoto University.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1248/bpb.b16-00508DOI Listing
January 2017

Optimization of renal transfection using a renal suction-mediated transfection method in mice.

J Drug Target 2016 22;24(5):450-6. Epub 2015 Sep 22.

a Department of Drug Delivery Research , Graduate School of Pharmaceutical Sciences, Kyoto University , Kyoto , Japan .

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3109/1061186X.2015.1087526DOI Listing
December 2016

Development of Novel Drug and Gene Delivery Carriers Composed of Single-Walled Carbon Nanotubes and Designed Peptides With PEGylation.

J Pharm Sci 2016 09 12;105(9):2815-2824. Epub 2016 May 12.

Institute for Integrated Cell-Material Sciences, (iCeMS), Kyoto University, Kyoto 606-8302, Japan; Department of Drug Delivery Research, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606-8501, Japan. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.xphs.2016.03.031DOI Listing
September 2016

Distribution of Silver Nanoparticles to Breast Milk and Their Biological Effects on Breast-Fed Offspring Mice.

ACS Nano 2016 09 15;10(9):8180-91. Epub 2016 Aug 15.

Section of Behavior Patterns, Center for Genetic Analysis of Behavior, National Institute for Physiological Sciences , 38 Aza-Nishigo-naka, Myodaiji-cho, Okazaki, Aichi 444-8585, Japan.

View Article

Download full-text PDF

Source
http://pubs.acs.org/doi/10.1021/acsnano.6b01782
Publisher Site
http://dx.doi.org/10.1021/acsnano.6b01782DOI Listing
September 2016

Development of PEGylated Cysteine-Modified Lysine Dendrimers with Multiple Reduced Thiols To Prevent Hepatic Ischemia/Reperfusion Injury.

Mol Pharm 2016 08 6;13(8):2867-73. Epub 2016 Jul 6.

Department of Biopharmaceutics, Kyoto Pharmaceutical University , Yamashina-ku, Kyoto 607-8414, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.molpharmaceut.6b00557DOI Listing
August 2016

Development of a Support Vector Machine-Based System to Predict Whether a Compound Is a Substrate of a Given Drug Transporter Using Its Chemical Structure.

J Pharm Sci 2016 07 1;105(7):2222-30. Epub 2016 Jun 1.

Sugiyama Laboratory, RIKEN Innovation Center, RIKEN Cluster for Industry Partnerships, RIKEN, 1-6, Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.xphs.2016.04.023DOI Listing
July 2016

Modeling and Prediction of Solvent Effect on Human Skin Permeability using Support Vector Regression and Random Forest.

Pharm Res 2015 Nov 2;32(11):3604-17. Epub 2015 Jun 2.

Department of Drug Delivery Research, Graduate School of Pharmaceutical Sciences, Kyoto University, 46-29, Yoshida-shimoadachicho, Sakyo-ku, Kyoto, 606-8501, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11095-015-1720-4DOI Listing
November 2015

Multiple Linear Regression Analysis Indicates Association of P-Glycoprotein Substrate or Inhibitor Character with Bitterness Intensity, Measured with a Sensor.

J Pharm Sci 2015 Sep 24;104(9):2789-94. Epub 2014 Dec 24.

Faculty of Pharmacy, Takasaki University of Health and Welfare, Takasaki, Gunma, 370-0033, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jps.24232DOI Listing
September 2015

Inhibition of cancer cell growth by GRP78 siRNA lipoplex via activation of unfolded protein response.

Biol Pharm Bull 2014 ;37(4):648-53

Department of Drug Delivery Research, Graduate School of Pharmaceutical Sciences, Kyoto University.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1248/bpb.b13-00930DOI Listing
June 2015

Long-term in vivo gene expression in mouse kidney using φC31 integrase and electroporation.

J Drug Target 2015 Jun 12;23(5):427-35. Epub 2015 Feb 12.

Department of Drug Delivery Research, Graduate School of Pharmaceutical Sciences, Kyoto University , Kyoto , Japan .

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3109/1061186X.2014.1002788DOI Listing
June 2015

Evaluation of the potential of doxorubicin loaded microbubbles as a theranostic modality using a murine tumor model.

Acta Biomater 2015 Jun 17;19:112-8. Epub 2015 Mar 17.

Kyoto University, Graduate School of Pharmaceutical Sciences, Kyoto, Japan; Kyoto University, Institute for Integrated Cell-Material Science (iCeMS), Kyoto, Japan. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S17427061150012
Publisher Site
http://dx.doi.org/10.1016/j.actbio.2015.03.014DOI Listing
June 2015

Development of fluorous lipid-based nanobubbles for efficiently containing perfluoropropane.

Int J Pharm 2015 Jun 1;487(1-2):64-71. Epub 2015 Apr 1.

Laboratory of Drug and Gene Delivery System, Faculty of Pharma-Sciences, Teikyo University, Japan. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijpharm.2015.03.073DOI Listing
June 2015

Synthesis and evaluation of glyco-coated liposomes as drug carriers for active targeting in drug delivery systems.

Carbohydr Res 2015 Mar 1;405:78-86. Epub 2014 Jul 1.

Department of Applied Bioorganic Chemistry, Gifu University, 1-1 Yanagido, Gifu-shi, Gifu 501-1193, Japan; Institute for Integrated Cell-Material Science (WPI program), Kyoto University, Yoshida-ushinomiya-cho, Sakyo-ku, Kyoto 606-8501, Japan. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.carres.2014.06.028DOI Listing
March 2015

Kidney-selective gene transfection using anionic bubble lipopolyplexes with renal ultrasound irradiation in mice.

Nanomedicine 2014 Nov 20;10(8):1829-38. Epub 2014 Jun 20.

Department of Drug Delivery Research, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan; Institute of Integrated Cell-Material Sciences (iCeMS), Kyoto University, Kyoto, Japan. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S15499634140032
Publisher Site
http://dx.doi.org/10.1016/j.nano.2014.06.009DOI Listing
November 2014

Enhancement of the anti-tumor effect of DNA vaccination using an ultrasound-responsive mannose-modified gene carrier in combination with doxorubicin-encapsulated PEGylated liposomes.

Int J Pharm 2014 Nov 12;475(1-2):401-7. Epub 2014 Sep 12.

Department of Drug Delivery Research, Graduate School of Pharmaceutical Sciences, Kyoto University, 46-29 Yoshida-Shimoadachi-cho, Sakyo-ku, Kyoto 606-8501, Japan; Institute for Integrated Cell-Material Sciences (iCeMS), Kyoto University, Yoshida-Ushinomiya-cho, Sakyo-ku, Kyoto 606-8302, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijpharm.2014.09.005DOI Listing
November 2014

Self-assembling lipid modified glycol-split heparin nanoparticles suppress lipopolysaccharide-induced inflammation through TLR4-NF-κB signaling.

J Control Release 2014 Nov 16;194:332-40. Epub 2014 Sep 16.

Department of Drug Delivery Research, Graduate School of Pharmaceutical Sciences, Kyoto University, Yoshidashimoadachi-cho, Sakyo-ku, Kyoto 606-8501, Japan; Institute for Integrated Cell-Material Sciences, Kyoto University, Yoshidaushinomiya-cho, Sakyo-ku, Kyoto 606-8501, Japan. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S01683659140064
Publisher Site
http://dx.doi.org/10.1016/j.jconrel.2014.09.011DOI Listing
November 2014

Suppression of experimental arthritis with self-assembling glycol-split heparin nanoparticles via inhibition of TLR4-NF-κB signaling.

J Control Release 2014 Nov 19;194:295-300. Epub 2014 Sep 19.

Department of Drug Delivery Research, Graduate School of Pharmaceutical Sciences, Kyoto University, Yoshidashimoadachi-cho, Sakyo-ku, Kyoto 606-8501, Japan; Institute for Integrated Cell-Material Sciences, Kyoto University, Yoshidaushinomiya-cho, Sakyo-ku, Kyoto 606-8501, Japan. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S01683659140064
Publisher Site
http://dx.doi.org/10.1016/j.jconrel.2014.09.015DOI Listing
November 2014

Targeted gene integration using the combination of a sequence-specific DNA-binding protein and phiC31 integrase.

J Biotechnol 2014 Sep 17;186:139-47. Epub 2014 Jul 17.

Department of Drug Delivery Research, Graduate School of Pharmaceutical Sciences, Kyoto University, 46-29 Yoshida Shimoadachi-cho, Sakyo-ku, Kyoto 606-8501, Japan; Institute for Integrated Cell-Material Sciences (iCeMS), Kyoto University, 69 Yoshida Ushinomiya-cho, Sakyo-ku, Kyoto 606-8501, Japan. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jbiotec.2014.07.012DOI Listing
September 2014

In vitro evaluation of inhibitory effect of nuclear factor-kappaB activity by small interfering RNA on pro-tumor characteristics of M2-like macrophages.

Biol Pharm Bull 2014 19;37(1):137-44. Epub 2013 Oct 19.

Department of Drug Delivery Research, Graduate School of Pharmaceutical Sciences, Kyoto University.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1248/bpb.b13-00659DOI Listing
August 2014

Antitumor effect of nuclear factor-κB decoy transfer by mannose-modified bubble lipoplex into macrophages in mouse malignant ascites.

Cancer Sci 2014 Aug 31;105(8):1049-55. Epub 2014 Jul 31.

Department of Drug Delivery Research, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cas.12452DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4317846PMC
August 2014

Preparation of immunostimulatory single-walled carbon nanotube/CpG DNA complexes and evaluation of their potential in cancer immunotherapy.

Int J Pharm 2014 Aug 23;471(1-2):214-23. Epub 2014 May 23.

Department of Drug Delivery Research, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan; Institute for Integrated Cell-Material Sciences (iCeMS), Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijpharm.2014.05.037DOI Listing
August 2014

Tumour-associated macrophages targeted transfection with NF-κB decoy/mannose-modified bubble lipoplexes inhibits tumour growth in tumour-bearing mice.

J Drug Target 2014 Jun 3;22(5):439-49. Epub 2014 Mar 3.

Department of Drug Delivery Research, Graduate School of Pharmaceutical Sciences, Kyoto University , Kyoto , Japan .

View Article

Download full-text PDF

Source
http://www.tandfonline.com/doi/full/10.3109/1061186X.2014.88
Publisher Site
http://dx.doi.org/10.3109/1061186X.2014.880443DOI Listing
June 2014

Sedative effects of inhaled benzylacetone and structural features contributing to its activity.

Biol Pharm Bull 2013 ;36(9):1474-81

Department of Pharmacognosy, Graduate School of Pharmaceutical Sciences, Kyoto University.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1248/bpb.b13-00250DOI Listing
April 2014

Development of anionic bubble lipopolyplexes for efficient and safe gene transfection with ultrasound exposure in mice.

J Control Release 2014 Feb 30;176:24-34. Epub 2013 Dec 30.

Department of Drug Delivery Research, Graduate School of Pharmaceutical Sciences, Kyoto University, 46-29 Yoshidashimoadachi-cho, Sakyo-ku, Kyoto 606-8501, Japan; Institute of Integrated Cell-Material Sciences (iCeMS), Kyoto University, Yoshida-Ushinomiya-cho, Sakyo-ku, Kyoto 606-8302, Japan. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jconrel.2013.12.023DOI Listing
February 2014

Photothermal ablation of tumor cells using a single-walled carbon nanotube-peptide composite.

J Control Release 2014 Jan 6;173:59-66. Epub 2013 Nov 6.

Institute for Integrated Cell-Material Sciences (iCeMS), Kyoto University, Kyoto, Japan; Department of Drug Delivery Research, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jconrel.2013.10.039DOI Listing
January 2014

Bilinear Model for the Size-Dependency of the CYP3A4 Inhibitory Activity of Structurally Diverse Compounds.

Mol Inform 2014 Jan 16;33(1):8-14. Epub 2013 Dec 16.

Graduate School of Pharmaceutical Sciences, Kyoto University, 46-29 Yoshidashimoadachi-cho, Sakyo-ku, Kyoto 606-8501, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/minf.201300132DOI Listing
January 2014

Automated extraction of information on chemical-P-glycoprotein interactions from the literature.

J Chem Inf Model 2013 Oct 24;53(10):2506-10. Epub 2013 Sep 24.

Department of Drug Delivery Research, Graduate School of Pharmaceutical Sciences, and ⊥Institute for Integrated Cell-Material Sciences, Kyoto University , 46-29 Yoshidashimoadachi-cho, Sakyo-ku, Kyoto 606-8501, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/ci4003188DOI Listing
October 2013

Pivotal role of oxidative stress in tumor metastasis under diabetic conditions in mice.

J Control Release 2013 Sep 2;170(2):191-7. Epub 2013 Jun 2.

Department of Drug Delivery Research, Kyoto University, Sakyo-ku, Kyoto, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jconrel.2013.05.028DOI Listing
September 2013

Structure-activity relationship modeling for predicting interactions with pregnane X receptor by recursive partitioning.

Drug Metab Pharmacokinet 2012 27;27(5):506-12. Epub 2012 Mar 27.

Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2133/dmpk.dmpk-11-rg-159DOI Listing
June 2013

Computer-based evolutionary search for a nonlinear conversion function for establishing in vitro-in vivo correlation (IVIVC) of oral drug formulations.

Drug Metab Pharmacokinet 2012 6;27(3):280-5. Epub 2011 Dec 6.

Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2133/dmpk.dmpk-11-rg-075DOI Listing
January 2013

Pharmacokinetic considerations for targeted drug delivery.

Adv Drug Deliv Rev 2013 Jan 29;65(1):139-47. Epub 2012 Dec 29.

Department of Drug Delivery Research, Graduate School of Pharmaceutical Sciences, Kyoto University, Yoshidashimoadachi-cho, Sakyo-ku, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.addr.2012.11.006DOI Listing
January 2013

Bovine serum albumin as a lyoprotectant for preparation of DNA dry powder formulations using the spray-freeze drying method.

Biol Pharm Bull 2012 ;35(7):1178-81

Department of Drug Delivery Research, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1248/bpb.b110731DOI Listing
December 2012

Evaluation of long-term gene expression in mouse liver using PhiC31 integrase and hydrodynamic injection.

Biol Pharm Bull 2012 ;35(7):1182-6

Department of Drug Delivery Research, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606-8501, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1248/bpb.b12-00083DOI Listing
December 2012

Efficient suppression of murine intracellular adhesion molecule-1 using ultrasound-responsive and mannose-modified lipoplexes inhibits acute hepatic inflammation.

Hepatology 2012 Jul 6;56(1):259-69. Epub 2012 Jun 6.

Department of Drug Delivery Research, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/hep.25607DOI Listing
July 2012

Development of bone-targeted catalase derivatives for inhibition of bone metastasis of tumor cells in mice.

J Pharm Sci 2012 Feb 23;101(2):552-7. Epub 2011 Sep 23.

Department of Drug Delivery Research, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jps.22773DOI Listing
February 2012

The involvement of NK cell activation following intranasal administration of CpG DNA lipoplex in the prevention of pulmonary metastasis and peritoneal dissemination in mice.

Clin Exp Metastasis 2012 Jan 4;29(1):63-70. Epub 2011 Nov 4.

Department of Drug Delivery Research, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10585-011-9429-1DOI Listing
January 2012

Formulation and pharmacokinetic evaluation of tetracycline-loaded solid lipid nanoparticles for subcutaneous injection in mice.

Chem Pharm Bull (Tokyo) 2011 ;59(2):260-5

Department of Pharmaceutics, School of Pharmacy, Jiangsu University, Zhenjiang, PR China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1248/cpb.59.260DOI Listing
December 2011

Involvement of activated transcriptional process in efficient gene transfection using unmodified and mannose-modified bubble lipoplexes with ultrasound exposure.

J Control Release 2011 Dec 3;156(3):355-63. Epub 2011 Jul 3.

Department of Drug Delivery Research, Graduate School of Pharmaceutical Sciences, Kyoto University, 46-29 Yoshida-Shimoadachi-cho, Sakyo-ku, Kyoto 606-8501, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jconrel.2011.06.040DOI Listing
December 2011

Development of lysine-histidine dendron modified chitosan for improving transfection efficiency in HEK293 cells.

J Control Release 2011 Dec 23;156(2):195-202. Epub 2011 Jul 23.

Department of Drug Delivery Research, Graduate School of Pharmaceutical Sciences, Kyoto University, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jconrel.2011.07.021DOI Listing
December 2011

Polyamidoamine dendrimer-conjugated quantum dots for efficient labeling of primary cultured mesenchymal stem cells.

Biomaterials 2011 Oct 22;32(28):6676-82. Epub 2011 Jun 22.

Graduate School of Pharmaceutical Sciences, Kyoto University, 46-29 Yoshida-shimoadachi, Sakyo-ku, Kyoto 606-8501, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.biomaterials.2011.05.076DOI Listing
October 2011

Key physiological phenomena governing transgene expression based on tissue pressure-mediated transfection in mice.

Biol Pharm Bull 2010 ;33(9):1627-32

Department of Drug Delivery Research, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1248/bpb.33.1627DOI Listing
July 2011

The elucidation of gene transferring mechanism by ultrasound-responsive unmodified and mannose-modified lipoplexes.

Biomaterials 2011 Jul 9;32(20):4659-69. Epub 2011 Apr 9.

Department of Drug Delivery Research, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.biomaterials.2011.03.013DOI Listing
July 2011

Comparison of piggyBac transposition efficiency between linear and circular donor vectors in mammalian cells.

J Biotechnol 2011 Jul 27;154(4):205-8. Epub 2011 May 27.

Department of Drug Delivery Research, Graduate School of Pharmaceutical Sciences, Kyoto University, 46-29 Yoshida Shimoadachi-cho, Sakyo-ku, Kyoto 606-8501, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jbiotec.2011.05.009DOI Listing
July 2011

Suppression of melanoma growth and metastasis by DNA vaccination using an ultrasound-responsive and mannose-modified gene carrier.

Mol Pharm 2011 Apr 22;8(2):543-54. Epub 2011 Feb 22.

Department of Drug Delivery Research, Graduate School of Pharmaceutical Sciences, Kyoto University, 46-29 Yoshida-shimoadachi-cho, Sakyo-ku, Kyoto 606-8501, Japan.

View Article

Download full-text PDF

Source
http://pubs.acs.org/doi/abs/10.1021/mp100369n
Publisher Site
http://dx.doi.org/10.1021/mp100369nDOI Listing
April 2011

Evaluation of osteoclastogenesis via NFκB decoy/mannosylated cationic liposome-mediated inhibition of pro-inflammatory cytokine production from primary cultured macrophages.

Pharm Res 2011 Apr 21;28(4):742-51. Epub 2011 Jan 21.

Department of Drug Delivery Research Graduate School of Pharmaceutical Sciences, Kyoto University, 46-29, Yoshida-shimoadachi, Sakyo-ku, Kyoto, 606-8501, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11095-011-0366-0DOI Listing
April 2011

Automated information extraction and structure-activity relationship analysis of cytochrome P450 substrates.

J Chem Inf Model 2011 Feb 19;51(2):378-85. Epub 2011 Jan 19.

Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto, Japan.

View Article

Download full-text PDF

Source
http://pubs.acs.org/doi/abs/10.1021/ci100334z
Publisher Site
http://dx.doi.org/10.1021/ci100334zDOI Listing
February 2011

Intratracheally instilled mannosylated cationic liposome/NFκB decoy complexes for effective prevention of LPS-induced lung inflammation.

J Control Release 2011 Jan 24;149(1):42-50. Epub 2009 Dec 24.

Department of Drug Delivery Research, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606-8501, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jconrel.2009.12.016DOI Listing
January 2011

Improvement of insulin resistance by removal of systemic hydrogen peroxide by PEGylated catalase in obese mice.

Mol Pharm 2010 Dec 15;7(6):2069-76. Epub 2010 Nov 15.

Department of Drug Delivery Research and Department of Biopharmaceutics and Drug Metabolism, Graduate School of Pharmaceutical Sciences, and Institute for Integrated Cell-Material Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan.

View Article

Download full-text PDF

Source
http://pubs.acs.org/doi/abs/10.1021/mp100110c
Publisher Site
http://dx.doi.org/10.1021/mp100110cDOI Listing
December 2010

Development of an ultrasound-responsive and mannose-modified gene carrier for DNA vaccine therapy.

Biomaterials 2010 Oct 24;31(30):7813-26. Epub 2010 Jul 24.

Department of Drug Delivery Research, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto, Japan.

View Article

Download full-text PDF

Source
http://repository.kulib.kyoto-u.ac.jp/dspace/bitstream/2433/
Web Search
http://linkinghub.elsevier.com/retrieve/pii/S014296121000838
Publisher Site
http://dx.doi.org/10.1016/j.biomaterials.2010.06.058DOI Listing
October 2010

Anionic amino acid dendrimer-trastuzumab conjugates for specific internalization in HER2-positive cancer cells.

Mol Pharm 2010 Aug;7(4):1318-27

Department of Drug Delivery Research, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606-8501, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/mp100105cDOI Listing
August 2010

Efficient gene transfection by histidine-modified chitosan through enhancement of endosomal escape.

Bioconjug Chem 2010 Jun;21(6):1087-95

Department of Drug Delivery Research, Institute for Innovative NanoBio Drug Discovery and Development, Kyoto University, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/bc1000609DOI Listing
June 2010

piggyBac transposon-mediated long-term gene expression in mice.

Mol Ther 2010 Apr 26;18(4):707-14. Epub 2010 Jan 26.

Department of Drug Delivery Research, Graduate School of Pharmaceutical Sciences, Kyoto University, Yoshida Shimoadachi-cho, Kyoto, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/mt.2009.302DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2862518PMC
April 2010

Intranasal administration of CpG DNA lipoplex prevents pulmonary metastasis in mice.

Cancer Lett 2010 Jan 5;287(1):75-81. Epub 2009 Aug 5.

Department of Drug Delivery Research, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.canlet.2009.05.037DOI Listing
January 2010

Enhanced transfection efficiency into macrophages and dendritic cells by a combination method using mannosylated lipoplexes and bubble liposomes with ultrasound exposure.

Hum Gene Ther 2010 Jan;21(1):65-74

Department of Drug Delivery Research, Graduate School of Pharmaceutical Sciences, Kyoto University , Kyoto 606-8501, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/hum.2009.106DOI Listing
January 2010

[Development and therapeutic application of transposon-based vectors].

Yakugaku Zasshi 2009 Dec;129(12):1433-43

Department of Drug Delivery Research, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1248/yakushi.129.1433DOI Listing
December 2009

Prevention of ischemia/reperfusion injury by hepatic targeting of nitric oxide in mice.

J Control Release 2009 Nov 29;140(1):12-7. Epub 2009 Jul 29.

Department of Drug Delivery Research, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jconrel.2009.07.013DOI Listing
November 2009

Pressure-mediated transfection of murine spleen and liver.

Hum Gene Ther 2009 Oct;20(10):1157-67

Department of Drug Delivery Research, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606-8501, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/hum.2008.213DOI Listing
October 2009

Prevention of pulmonary metastasis from subcutaneous tumors by binary system-based sustained delivery of catalase.

J Control Release 2009 Jul 8;137(2):110-5. Epub 2009 Apr 8.

Department of Drug Delivery Research, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jconrel.2009.04.005DOI Listing
July 2009

Enhanced in vivo antitumor efficacy of fenretinide encapsulated in polymeric micelles.

Int J Pharm 2009 May 31;373(1-2):100-6. Epub 2009 Jan 31.

Department of Drug Delivery Research, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijpharm.2009.01.019DOI Listing
May 2009

Mannosylated cationic liposomes/CpG DNA complex for the treatment of hepatic metastasis after intravenous administration in mice.

J Pharm Sci 2009 Mar;98(3):1193-7

Department of Drug Delivery Research, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jps.21475DOI Listing
March 2009

Immunostimulatory characteristics induced by linear polyethyleneimine-plasmid DNA complexes in cultured macrophages.

Hum Gene Ther 2009 Feb;20(2):137-45

Department of Drug Delivery Research, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan.

View Article

Download full-text PDF

Source
http://www.liebertpub.com/doi/10.1089/hum.2008.013
Publisher Site
http://dx.doi.org/10.1089/hum.2008.013DOI Listing
February 2009

Systematic research of peptide spacers controlling drug release from macromolecular prodrug system, carboxymethyldextran polyalcohol-peptide-drug conjugates.

Bioconjug Chem 2009 Jan;20(1):60-70

Biological Research Laboratories IV and Medicinal Chemistry Research Laboratories II, Daiichi Sankyo Co. Ltd., Kasai R&D Center, Kita-Kasai 1-16-13, Edogawa-Ku, Tokyo 134-8630, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/bc800238fDOI Listing
January 2009

SOD derivatives prevent metastatic tumor growth aggravated by tumor removal.

Clin Exp Metastasis 2008 21;25(5):531-6. Epub 2008 Mar 21.

Department of Drug Delivery Research, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10585-008-9165-3DOI Listing
September 2008

Hydrogen peroxide-mediated nuclear factor kappaB activation in both liver and tumor cells during initial stages of hepatic metastasis.

Cancer Sci 2008 Aug;99(8):1546-52

Department of Drug Delivery Research, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1349-7006.2008.00856.xDOI Listing
August 2008

Block copolymer design for stable encapsulation of N-(4-hydroxyphenyl)retinamide into polymeric micelles in mice.

Int J Pharm 2008 Jun 3;357(1-2):318-22. Epub 2008 Feb 3.

Department of Drug Delivery Research, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606-8501, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijpharm.2008.01.044DOI Listing
June 2008

Use of mannosylated cationic liposomes/ immunostimulatory CpG DNA complex for effective inhibition of peritoneal dissemination in mice.

J Gene Med 2008 Apr;10(4):392-9

Department of Drug Delivery Research, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jgm.1162DOI Listing
April 2008

Efficient peritoneal dissemination treatment obtained by an immunostimulatory phosphorothioate-type CpG DNA/cationic liposome complex in mice.

J Control Release 2008 Mar 31;126(3):274-80. Epub 2008 Jan 31.

Department of Drug Delivery Research, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jconrel.2007.12.007DOI Listing
March 2008

Automated extraction of information from the literature on chemical-CYP3A4 interactions.

J Chem Inf Model 2007 Nov-Dec;47(6):2449-55. Epub 2007 Sep 27.

Department of Drug Delivery Research, Graduate School of Pharmaceutical Sciences, Kyoto University, 46-29 Yoshidashimoadachi-cho, Sakyo-ku, Kyoto 606-8501, Japan.

View Article

Download full-text PDF

Source
http://pubs.acs.org/doi/abs/10.1021/ci700091m
Publisher Site
http://dx.doi.org/10.1021/ci700091mDOI Listing
February 2008

Novel hierarchical classification and visualization method for multiobjective optimization of drug properties: application to structure-activity relationship analysis of cytochrome P450 metabolism.

J Chem Inf Model 2008 Feb 23;48(2):364-9. Epub 2008 Jan 23.

Department of Drug Delivery Research, Graduate School of Pharmaceutical Sciences, Kyoto University, 46-29 Yoshidashimoadachi-cho, Sakyo-ku, Kyoto 606-8501, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/ci700262yDOI Listing
February 2008

Insertion of nuclear factor-kappaB binding sequence into plasmid DNA for increased transgene expression in colon carcinoma cells.

J Biotechnol 2008 Jan 16;133(1):36-41. Epub 2007 Sep 16.

Department of Drug Delivery Research, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan.

View Article

Download full-text PDF

Source
http://linkinghub.elsevier.com/retrieve/pii/S016816560701579
Publisher Site
http://dx.doi.org/10.1016/j.jbiotec.2007.08.047DOI Listing
January 2008

Efficient targeting to alveolar macrophages by intratracheal administration of mannosylated liposomes in rats.

J Control Release 2008 Jan 22;125(2):121-30. Epub 2007 Oct 22.

Department of Drug Delivery Research, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto, 606-8501, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jconrel.2007.10.011DOI Listing
January 2008

Prevention of hepatic ischemia/reperfusion injury by prolonged delivery of nitric oxide to the circulating blood in mice.

Transplantation 2008 Jan;85(2):264-9

Department of Drug Delivery Research, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan.

View Article

Download full-text PDF

Source
https://insights.ovid.com/crossref?an=00007890-200801270-000
Publisher Site
http://dx.doi.org/10.1097/TP.0b013e31815e902bDOI Listing
January 2008

Relationship between drug release of DE-310, macromolecular prodrug of DX-8951f, and cathepsins activity in several tumors.

Biol Pharm Bull 2007 Dec;30(12):2365-70

Biological Research Laboratories IV, Daiichi Sankyo Co., Ltd., Kasai R&D Center, 1-16-13 Kita-Kasai, Edogawa-ku, Tokyo 134-8630, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1248/bpb.30.2365DOI Listing
December 2007

Cationized catalase-loaded hydrogel for growth inhibition of peritoneally disseminated tumor cells.

J Control Release 2007 Sep 24;122(2):151-8. Epub 2007 Jul 24.

Department of Drug Delivery Research, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto, Japan.

View Article

Download full-text PDF

Source
http://linkinghub.elsevier.com/retrieve/pii/S016836590700317
Publisher Site
http://dx.doi.org/10.1016/j.jconrel.2007.07.002DOI Listing
September 2007

Efficient protection by cationized catalase against H2O2 injury in primary cultured alveolar epithelial cells.

J Control Release 2007 Aug 24;121(1-2):74-80. Epub 2007 May 24.

Department of Drug Delivery Research, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jconrel.2007.05.020DOI Listing
August 2007

Development of an antigen-presenting cell-targeted DNA vaccine against melanoma by mannosylated liposomes.

Biomaterials 2007 Jul 5;28(21):3255-62. Epub 2007 Apr 5.

Department of Drug Delivery Research, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.biomaterials.2007.03.028DOI Listing
July 2007

Optimization of tumor-selective targeting by basic fibroblast growth factor-binding peptide grafted PEGylated liposomes.

J Control Release 2007 Jun 9;119(3):262-70. Epub 2007 Feb 9.

Department of Drug Delivery Research, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jconrel.2007.01.018DOI Listing
June 2007