Fuchu He

Fuchu He

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Open-pFind Enhances the Identification of Missing Proteins from Human Testis Tissue.

J Proteome Res 2019 Dec 7;18(12):4189-4196. Epub 2019 Nov 7.

State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing) , Beijing Institute of Lifeomics , Beijing 102206 , China.

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http://dx.doi.org/10.1021/acs.jproteome.9b00376DOI Listing
December 2019

The Role of Kupffer Cells as Mediators of Adipose Tissue Lipolysis.

J Immunol 2019 Nov 4;203(10):2689-2700. Epub 2019 Oct 4.

State Key Laboratory of Proteomics, National Center for Protein Sciences, Beijing, Beijing Proteome Research Center, Beijing Institute of Lifeomics, 102206 Beijing, China

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http://dx.doi.org/10.4049/jimmunol.1900366DOI Listing
November 2019

Phosphoproteomics Enables Molecular Subtyping and Nomination of Kinase Candidates for Individual Patients of Diffuse-Type Gastric Cancer.

iScience 2019 Nov 6;22:44-57. Epub 2019 Nov 6.

State Key Laboratory of Proteomics, Joint Laboratory of Gastrointestinal Oncology, Beijing Proteome Research Center, National Center for Protein Sciences (The PHOENIX Center, Beijing), Beijing Institute of Lifeomics, Beijing 102206, China; State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Institute of Biomedical Sciences, Fudan University, Shanghai 200433, China. Electronic address:

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http://dx.doi.org/10.1016/j.isci.2019.11.003DOI Listing
November 2019

Proteomics Links Ubiquitin Chain Topology Change to Transcription Factor Activation.

Mol Cell 2019 Oct 20;76(1):126-137.e7. Epub 2019 Aug 20.

State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Research Unit of Proteomics & Research and Development of New Drug of Chinese Academy of Medical Sciences, Institute of Lifeomics, Beijing 102206, P.R. China; Key Laboratory of Combinatorial Biosynthesis and Drug Discovery of Ministry of Education, School of Pharmaceutical Sciences, School of Medicine, Wuhan University, Wuhan 430072, P.R. China; Guizhou University School of Medicine, Guiyang 550025, P.R. China. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2019.07.001DOI Listing
October 2019

[Mouse liver proteome database].

Sheng Wu Gong Cheng Xue Bao 2019 Sep;35(9):1715-1722

National Center for Protein Sciences·Beijing, Beijing 102206, China.

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http://dx.doi.org/10.13345/j.cjb.190166DOI Listing
September 2019

UVGD 1.0: a gene-centric database bridging ultraviolet radiation and molecular biology effects in organisms.

Int J Radiat Biol 2019 08 13;95(8):1172-1177. Epub 2019 May 13.

a State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences-Beijing (PHOENIX Center), Beijing Institute of Lifeomics , Beijing , China.

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http://dx.doi.org/10.1080/09553002.2019.1609127DOI Listing
August 2019

Trans-acting nonsynonymous variant of FOXA1 predisposes to hepatocellular carcinoma through modulating FOXA1-ERα transcriptional program and may have undergone natural selection.

Carcinogenesis 2019 Aug 11. Epub 2019 Aug 11.

State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences; Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai, China.

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http://dx.doi.org/10.1093/carcin/bgz136DOI Listing
August 2019

LSECtin on tumor-associated macrophages enhances breast cancer stemness via interaction with its receptor BTN3A3.

Cell Res 2019 May 11;29(5):365-378. Epub 2019 Mar 11.

State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences·Beijing, Beijing Institute of Lifeomics, Beijing, China.

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http://dx.doi.org/10.1038/s41422-019-0155-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6796923PMC
May 2019

KeggExp: a web server for visual integration of KEGG pathways and expression profile data.

Bioinformatics 2019 Apr;35(8):1430-1432

State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing, P.R. China.

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https://academic.oup.com/bioinformatics/advance-article/doi/
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http://dx.doi.org/10.1093/bioinformatics/bty798DOI Listing
April 2019

Association of MCP-1 promoter polymorphism with susceptibility to nasopharyngeal carcinoma.

J Cell Biochem 2019 Apr 28;120(4):6661-6670. Epub 2018 Oct 28.

Department of Genomics & Proteomics, State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing, China.

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http://doi.wiley.com/10.1002/jcb.27962
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http://dx.doi.org/10.1002/jcb.27962DOI Listing
April 2019

OsteoporosAtlas: a human osteoporosis-related gene database.

PeerJ 2019 26;7:e6778. Epub 2019 Apr 26.

State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences, Beijing Institute of Lifeomics, Beijing, China.

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https://peerj.com/articles/6778
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http://dx.doi.org/10.7717/peerj.6778DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6487800PMC
April 2019

The Host Restriction Factor Interferon-Inducible Transmembrane Protein 3 Inhibits Vaccinia Virus Infection.

Front Immunol 2018 16;9:228. Epub 2018 Feb 16.

State Key Laboratory of Proteomics, Beijing Proteome Research Center, Institute of Radiation Medicine, Beijing, China.

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http://dx.doi.org/10.3389/fimmu.2018.00228DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5820317PMC
March 2019

PANDA: A comprehensive and flexible tool for quantitative proteomics data analysis.

Bioinformatics 2019 Mar;35(5):898-900

State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Lifeomics, National Center for Protein Sciences (Beijing), Beijing, Peoples Republic of China.

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http://dx.doi.org/10.1093/bioinformatics/bty727DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394390PMC
March 2019

Neutrophils promote the development of reparative macrophages mediated by ROS to orchestrate liver repair.

Nat Commun 2019 03 6;10(1):1076. Epub 2019 Mar 6.

State Key Laboratory of Proteomics, National Center for Protein Sciences, Beijing. Beijing Proteome Research Center, Beijing Institute of Lifeomics, 102206, Beijing, China.

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http://dx.doi.org/10.1038/s41467-019-09046-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6403250PMC
March 2019

The deubiquitylating enzyme USP15 regulates homologous recombination repair and cancer cell response to PARP inhibitors.

Nat Commun 2019 03 15;10(1):1224. Epub 2019 Mar 15.

State Key Laboratory of Proteomics, National Center for Protein Sciences (Beijing), Beijing Proteome Research Center, Beijing Institute of Lifeomics, Beijing, 102206, China.

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http://dx.doi.org/10.1038/s41467-019-09232-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420636PMC
March 2019

Artificial MicroRNA-Mediated Tgfbr2 and Pdgfrb Co-Silencing Ameliorates Carbon Tetrachloride-Induced Hepatic Fibrosis in Mice.

Hum Gene Ther 2019 02 13;30(2):179-196. Epub 2018 Nov 13.

1 The Fifth People's Hospital of Shanghai, State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Institutes of Biomedical Sciences of Shanghai Medical College, Fudan University, Shanghai, P.R. China.

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http://dx.doi.org/10.1089/hum.2018.047DOI Listing
February 2019

Selection of aptamers against Lactoferrin based on silver enhanced and fluorescence-activated cell sorting.

Talanta 2019 Feb 19;193:110-117. Epub 2018 Sep 19.

State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, Jiangsu 210046, China; State Key Laboratory of Proteomics, National Center for Protein Sciences Beijing, Beijing Institute of Radiation Medicine, Beijing 102206, China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00399140183097
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http://dx.doi.org/10.1016/j.talanta.2018.09.063DOI Listing
February 2019

PPICurator: A Tool for Extracting Comprehensive Protein-Protein Interaction Information.

Proteomics 2019 02 7;19(4):e1800291. Epub 2019 Jan 7.

State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Life Omics, Beijing, 102206, P. R. China.

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http://doi.wiley.com/10.1002/pmic.201800291
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http://dx.doi.org/10.1002/pmic.201800291DOI Listing
February 2019

Molecular subtyping of cancer and nomination of kinase candidates for inhibition with phosphoproteomics: Reanalysis of CPTAC ovarian cancer.

EBioMedicine 2019 Feb 26;40:305-317. Epub 2018 Dec 26.

Department of Biomedical Informatics, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China; Institute of Systems Biomedicine, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S23523964183061
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http://dx.doi.org/10.1016/j.ebiom.2018.12.039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6412074PMC
February 2019

Proteomic analysis reveals a protective role of specific macrophage subsets in liver repair.

Sci Rep 2019 Feb 27;9(1):2953. Epub 2019 Feb 27.

State Key Laboratory of Proteomics, National Center for Protein Sciences, Beijing, Beijing Proteome Research Center, Beijing Institute of Lifeomics, Beijing, 102206, P. R. China.

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http://www.nature.com/articles/s41598-019-39007-6
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http://dx.doi.org/10.1038/s41598-019-39007-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393665PMC
February 2019

iProX: an integrated proteome resource.

Nucleic Acids Res 2019 Jan;47(D1):D1211-D1217

State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Life Omics, Beijing 102206, China.

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http://fdslive.oup.com/www.oup.com/pdf/production_in_progres
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http://dx.doi.org/10.1093/nar/gky869DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323926PMC
January 2019

LFAQ: Toward Unbiased Label-Free Absolute Protein Quantification by Predicting Peptide Quantitative Factors.

Anal Chem 2019 Jan 21;91(2):1335-1343. Epub 2018 Dec 21.

State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing) , Beijing Institute of Lifeomics , Beijing 102206 , China.

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http://dx.doi.org/10.1021/acs.analchem.8b03267DOI Listing
January 2019

Author Correction: Dynamic ubiquitylation of Sox2 regulates proteostasis and governs neural progenitor cell differentiation.

Nat Commun 2019 01 8;10(1):173. Epub 2019 Jan 8.

State Key Laboratory of Proteomics, National Center of Protein Sciences (Beijing), Beijing Institute of Lifeomics, 100850, Beijing, China.

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http://dx.doi.org/10.1038/s41467-018-07984-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325103PMC
January 2019

CKIP-1 limits foam cell formation and inhibits atherosclerosis by promoting degradation of Oct-1 by REGγ.

Nat Commun 2019 01 25;10(1):425. Epub 2019 Jan 25.

State Key Laboratory of Proteomics, National Center of Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing, 100850, China.

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http://dx.doi.org/10.1038/s41467-018-07895-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347643PMC
January 2019

Targeting Endothelial Erk1/2-Akt Axis as a Regeneration Strategy to Bypass Fibrosis during Chronic Liver Injury in Mice.

Mol Ther 2018 12 24;26(12):2779-2797. Epub 2018 Aug 24.

Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing 100730, China; State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing 102206, China. Electronic address:

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http://dx.doi.org/10.1016/j.ymthe.2018.08.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277559PMC
December 2018

Digging for Missing Proteins Using Low-Molecular-Weight Protein Enrichment and a "Mirror Protease" Strategy.

J Proteome Res 2018 12 16;17(12):4178-4185. Epub 2018 Oct 16.

State Key Laboratory of Proteomics, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics , Beijing Proteome Research Center , Beijing 102206 , China.

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http://pubs.acs.org/doi/10.1021/acs.jproteome.8b00398
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http://dx.doi.org/10.1021/acs.jproteome.8b00398DOI Listing
December 2018

Multiproteases Combined with High-pH Reverse-Phase Separation Strategy Verified Fourteen Missing Proteins in Human Testis Tissue.

J Proteome Res 2018 12 16;17(12):4171-4177. Epub 2018 Oct 16.

Hebei Province Key Lab of Research and Application on Microbial Diversity, College of Life Sciences , Hebei University , Baoding , Hebei 071002 , China.

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http://dx.doi.org/10.1021/acs.jproteome.8b00397DOI Listing
December 2018

Revealing the metabolic characteristics of human embryonic stem cells by genome-scale metabolic modeling.

FEBS Lett 2018 11 2;592(22):3670-3682. Epub 2018 Nov 2.

School of Life Sciences, Tsinghua University, Beijing, China.

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http://dx.doi.org/10.1002/1873-3468.13255DOI Listing
November 2018

Dynamic ubiquitylation of Sox2 regulates proteostasis and governs neural progenitor cell differentiation.

Nat Commun 2018 11 7;9(1):4648. Epub 2018 Nov 7.

State Key Laboratory of Proteomics, National Center of Protein Sciences (Beijing), Beijing Institute of Lifeomics, 100850, Beijing, China.

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http://www.nature.com/articles/s41467-018-07025-z
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http://dx.doi.org/10.1038/s41467-018-07025-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6220269PMC
November 2018

A two-level model for the role of complex and young genes in the formation of organism complexity and new insights into the relationship between evolution and development.

Evodevo 2018 12;9:22. Epub 2018 Nov 12.

State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing, 102206 The People's Republic of China.

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http://dx.doi.org/10.1186/s13227-018-0111-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6231269PMC
November 2018

PANDA-view: an easy-to-use tool for statistical analysis and visualization of quantitative proteomics data.

Bioinformatics 2018 10;34(20):3594-3596

State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Lifeomics, National Center for Protein Sciences (Beijing), Beijing, People's Republic of China.

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https://academic.oup.com/bioinformatics/article/34/20/3594/5
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http://dx.doi.org/10.1093/bioinformatics/bty408DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6184437PMC
October 2018

C-type lectin receptor LSECtin-mediated apoptotic cell clearance by macrophages directs intestinal repair in experimental colitis.

Proc Natl Acad Sci U S A 2018 10 9;115(43):11054-11059. Epub 2018 Oct 9.

State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences, Beijing Institute of Lifeomics, 102206 Beijing, China;

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http://www.pnas.org/lookup/doi/10.1073/pnas.1804094115
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http://dx.doi.org/10.1073/pnas.1804094115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6205441PMC
October 2018

Germline Duplication of SNORA18L5 Increases Risk for HBV-related Hepatocellular Carcinoma by Altering Localization of Ribosomal Proteins and Decreasing Levels of p53.

Gastroenterology 2018 08 24;155(2):542-556. Epub 2018 Apr 24.

State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing, P. R. China; National Engineering Research Center for Protein Drugs, Beijing, P. R. China; National Center for Protein Sciences at Beijing, Beijing, P. R. China. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2018.04.020DOI Listing
August 2018

KRAB-containing zinc finger protein ZNF496 inhibits breast cancer cell proliferation by selectively repressing ERα activity.

Biochim Biophys Acta Gene Regul Mech 2018 Jul 20. Epub 2018 Jul 20.

State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing 102206, China. Electronic address:

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http://dx.doi.org/10.1016/j.bbagrm.2018.07.003DOI Listing
July 2018

In Vivo Phosphoproteome Analysis Reveals Kinome Reprogramming in Hepatocellular Carcinoma.

Mol Cell Proteomics 2018 06 22;17(6):1067-1083. Epub 2018 Feb 22.

From the ‡State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing 102206, China;

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http://dx.doi.org/10.1074/mcp.RA117.000421DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5986249PMC
June 2018

Dysregulated Response of Follicular Helper T Cells to Hepatitis B Surface Antigen Promotes HBV Persistence in Mice and Associates With Outcomes of Patients.

Gastroenterology 2018 06 12;154(8):2222-2236. Epub 2018 Mar 12.

State Key Laboratory of Proteomics, National Center for Protein Sciences, Beijing, Beijing Proteome Research Center, Beijing Institute of Lifeomics, Beijing, P.R. China; Department of Biochemistry and Molecular Biology, Anhui Medical University, Hefei, Anhui Province, P.R. China. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2018.03.021DOI Listing
June 2018

Mutually exclusive acetylation and ubiquitylation of the splicing factor SRSF5 control tumor growth.

Nat Commun 2018 06 25;9(1):2464. Epub 2018 Jun 25.

State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center of Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing, 100850, China.

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http://www.nature.com/articles/s41467-018-04815-3
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http://dx.doi.org/10.1038/s41467-018-04815-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6018636PMC
June 2018

KRAB-type zinc-finger proteins PITA and PISA specifically regulate p53-dependent glycolysis and mitochondrial respiration.

Cell Res 2018 May 21;28(5):572-592. Epub 2018 Feb 21.

State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center of Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing, China.

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http://www.nature.com/articles/s41422-018-0008-8
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http://dx.doi.org/10.1038/s41422-018-0008-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5951852PMC
May 2018

Author Correction: A proteomic landscape of diffuse-type gastric cancer.

Nat Commun 2018 05 8;9(1):1850. Epub 2018 May 8.

The Joint Laboratory of Translational Medicine, National Center for Protein Sciences (Beijing) and Peking University Cancer Hospital, State Key Laboratory of Proteomics, Institute of Lifeomics, 102206, Beijing, China.

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http://dx.doi.org/10.1038/s41467-018-04166-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5940851PMC
May 2018

A proteomics landscape of circadian clock in mouse liver.

Nat Commun 2018 04 19;9(1):1553. Epub 2018 Apr 19.

State Key Laboratory of Genetic Engineering, Human Phenome Institute, Institutes of Biomedical Sciences, School of Life Sciences, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.

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http://www.nature.com/articles/s41467-018-03898-2
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http://dx.doi.org/10.1038/s41467-018-03898-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5908788PMC
April 2018

Regulation of Tak1 alternative splicing by splice-switching oligonucleotides.

Biochem Biophys Res Commun 2018 03 21;497(4):1018-1024. Epub 2018 Feb 21.

State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing 102206, China. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2018.02.160DOI Listing
March 2018

A proteomic landscape of diffuse-type gastric cancer.

Nat Commun 2018 03 8;9(1):1012. Epub 2018 Mar 8.

The Joint Laboratory of Translational Medicine, National Center for Protein Sciences (Beijing) and Peking University Cancer Hospital, State Key Laboratory of Proteomics, Institute of Lifeomics, Beijing, 102206, China.

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http://dx.doi.org/10.1038/s41467-018-03121-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5843664PMC
March 2018

TiO with Tandem Fractionation (TAFT): An Approach for Rapid, Deep, Reproducible, and High-Throughput Phosphoproteome Analysis.

J Proteome Res 2018 01 15;17(1):710-721. Epub 2017 Nov 15.

State Key Laboratory of Proteomics, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics , Beijing 102206, China.

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http://dx.doi.org/10.1021/acs.jproteome.7b00520DOI Listing
January 2018

Cell-type-resolved alternative splicing patterns in mouse liver.

DNA Res 2018 Jan 8. Epub 2018 Jan 8.

State Key Laboratory of Proteomics, National Center for Protein Sciences Beijing, Beijing Proteome Research Center, Beijing Institute of Lifeomics, Beijing 102206, China.

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http://dx.doi.org/10.1093/dnares/dsx055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6014294PMC
January 2018

AllerGAtlas 1.0: a human allergy-related genes database.

Database (Oxford) 2018 01;2018

School of Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China.

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http://dx.doi.org/10.1093/database/bay010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5824776PMC
January 2018

Identification of Missing Proteins in the Phosphoproteome of Kidney Cancer.

J Proteome Res 2017 12 12;16(12):4364-4373. Epub 2017 Sep 12.

Key Laboratory of Combinatorial Biosynthesis and Drug Discovery of the Ministry of Education, School of Pharmaceutical Sciences, Wuhan University , Wuhan 430072, China.

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http://dx.doi.org/10.1021/acs.jproteome.7b00332DOI Listing
December 2017

Prioritizing Popular Proteins in Liver Cancer: Remodelling One-Carbon Metabolism.

J Proteome Res 2017 12 2;16(12):4506-4514. Epub 2017 Oct 2.

Functional Proteomics Laboratory, Centro Nacional de Biotecnología-CSIC , Proteored-ISCIII, CIBERehd. 28049 Madrid, Spain.

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http://dx.doi.org/10.1021/acs.jproteome.7b00390DOI Listing
December 2017

Multi-Protease Strategy Identifies Three PE2 Missing Proteins in Human Testis Tissue.

J Proteome Res 2017 12 13;16(12):4352-4363. Epub 2017 Oct 13.

State Key Laboratory of Proteomics, National Center for Protein Sciences Beijing, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine , Beijing 102206, China.

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http://dx.doi.org/10.1021/acs.jproteome.7b00340DOI Listing
December 2017

In-depth proteomic analysis of tissue interstitial fluid for hepatocellular carcinoma serum biomarker discovery.

Br J Cancer 2017 Nov 12;117(11):1676-1684. Epub 2017 Oct 12.

State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences Beijing, Beijing Institute of Radiation Medicine, Beijing 102206, China.

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http://dx.doi.org/10.1038/bjc.2017.344DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5729441PMC
November 2017

Proteomic Analysis Reveals Dab2 Mediated Receptor Endocytosis Promotes Liver Sinusoidal Endothelial Cell Dedifferentiation.

Sci Rep 2017 10 18;7(1):13456. Epub 2017 Oct 18.

Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing, China.

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http://dx.doi.org/10.1038/s41598-017-13917-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5647404PMC
October 2017

Discovery of NKCC1 as a potential therapeutic target to inhibit hepatocellular carcinoma cell growth and metastasis.

Oncotarget 2017 Sep 12;8(39):66328-66342. Epub 2017 Aug 12.

State Key Laboratory of Proteomics, National Center for Protein Sciences Beijing, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing 102206, P. R. China.

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http://dx.doi.org/10.18632/oncotarget.20240DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5630415PMC
September 2017

An integrated bioinformatics platform for investigating the human E3 ubiquitin ligase-substrate interaction network.

Nat Commun 2017 08 24;8(1):347. Epub 2017 Aug 24.

State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, National Center for Protein Sciences (The PHOENIX Center, Beijing), Beijing, 102206, China.

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http://dx.doi.org/10.1038/s41467-017-00299-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5570908PMC
August 2017

High-coverage proteomics reveals methionine auxotrophy in Deinococcus radiodurans.

Proteomics 2017 Jul;17(13-14)

State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences, Beijing Institute of Radiation Medicine, Beijing, P. R. China.

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http://dx.doi.org/10.1002/pmic.201700072DOI Listing
July 2017

Casein Kinase 2 Interacting Protein-1 regulates M1 and M2 inflammatory macrophage polarization.

Cell Signal 2017 05 14;33:107-121. Epub 2017 Feb 14.

State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Collaborative Innovation Center for Cancer Medicine, Beijing, China. Electronic address:

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http://dx.doi.org/10.1016/j.cellsig.2017.02.015DOI Listing
May 2017

Proteome-wide Mapping of Endogenous SUMOylation Sites in Mouse Testis.

Mol Cell Proteomics 2017 05 13;16(5):717-727. Epub 2017 Mar 13.

From the ‡State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, Institutes of Biomedical Sciences, School of Life Sciences, Fudan University, Shanghai 200032, China;

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http://dx.doi.org/10.1074/mcp.M116.062125DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5417816PMC
May 2017

Proof-of-Concept Workflow for Establishing Reference Intervals of Human Urine Proteome for Monitoring Physiological and Pathological Changes.

EBioMedicine 2017 Apr 22;18:300-310. Epub 2017 Mar 22.

State Key Laboratory of Proteomics, National Center for Protein Sciences (The PHOENIX Center, Beijing), Beijing Proteome Research Center, Beijing 102206, China; Joint Center for Translational Medicine, Tianjin Baodi Hospital, Tianjin 301800, China; Alkek Center for Molecular Discovery, Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ebiom.2017.03.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5405183PMC
April 2017

Quantitative Proteomic analysis on Activated Hepatic Stellate Cells reversion Reveal STAT1 as a key regulator between Liver Fibrosis and recovery.

Sci Rep 2017 03 21;7:44910. Epub 2017 Mar 21.

State Key Laboratory of Proteomics, National Center for Protein Sciences Beijing, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing 102206, China.

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http://dx.doi.org/10.1038/srep44910DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5359621PMC
March 2017

Inflammasome-Derived Exosomes Activate NF-κB Signaling in Macrophages.

J Proteome Res 2017 01 12;16(1):170-178. Epub 2016 Oct 12.

Anhui Medical University , Hefei, Anhui 230032, China.

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http://dx.doi.org/10.1021/acs.jproteome.6b00599DOI Listing
January 2017

Comprehensive Proteomics Analysis Reveals Metabolic Reprogramming of Tumor-Associated Macrophages Stimulated by the Tumor Microenvironment.

J Proteome Res 2017 01 3;16(1):288-297. Epub 2016 Nov 3.

State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Engineering Research Center for Protein Drugs, National Center for Protein Sciences (Beijing), Beijing Institute of Radiation Medicine , Beijing 102206, P. R. China.

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http://dx.doi.org/10.1021/acs.jproteome.6b00604DOI Listing
January 2017

HisgAtlas 1.0: a human immunosuppression gene database.

Database (Oxford) 2017 Jan;2017

State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences, Beijing Institute of Lifeomics, Beijing 102206, China.

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http://dx.doi.org/10.1093/database/bax094DOI Listing
January 2017

Functional constraints on adaptive evolution of protein ubiquitination sites.

Sci Rep 2017 01 5;7:39949. Epub 2017 Jan 5.

State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, 27 Taiping Road, Beijing 100850, China.

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http://dx.doi.org/10.1038/srep39949DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5215434PMC
January 2017

Transcription Factor Response Elements on Tip: A Sensitive Approach for Large-Scale Endogenous Transcription Factor Quantitative Identification.

Anal Chem 2016 12 30;88(24):11990-11994. Epub 2016 Nov 30.

State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, National Center for Protein Sciences (The PHOENIX Center, Beijing) , Beijing 102206, China.

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http://dx.doi.org/10.1021/acs.analchem.6b03150DOI Listing
December 2016

Searching Missing Proteins Based on the Optimization of Membrane Protein Enrichment and Digestion Process.

J Proteome Res 2016 11 12;15(11):4020-4029. Epub 2016 Aug 12.

State Key Laboratory of Proteomics, National Engineering Research Center for Protein Drugs, Beijing Proteome Research Center, National Center for Protein Sciences Beijing, Beijing Institute of Radiation Medicine , Beijing 102206, P. R. China.

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http://dx.doi.org/10.1021/acs.jproteome.6b00389DOI Listing
November 2016

Deep Coverage Proteomics Identifies More Low-Abundance Missing Proteins in Human Testis Tissue with Q-Exactive HF Mass Spectrometer.

J Proteome Res 2016 11 29;15(11):3988-3997. Epub 2016 Aug 29.

State Key Laboratory of Proteomics, National Center for Protein Sciences Beijing, Beijing Proteome Research Center, National Engineering Research Center for Protein Drugs, Beijing Institute of Radiation Medicine , Beijing 102206, China.

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http://dx.doi.org/10.1021/acs.jproteome.6b00390DOI Listing
November 2016

A Cell-type-resolved Liver Proteome.

Mol Cell Proteomics 2016 10 25;15(10):3190-3202. Epub 2016 Aug 25.

From the ‡State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing 100039, China; §National Center for Protein Sciences (The PHOENIX center, Beijing), Beijing 102206, China; **State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Institute of Biomedical Sciences, Fudan University, Shanghai 200433, China

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http://dx.doi.org/10.1074/mcp.M116.060145DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5054343PMC
October 2016

Itch promotes the neddylation of JunB and regulates JunB-dependent transcription.

Cell Signal 2016 09 28;28(9):1186-95. Epub 2016 May 28.

State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Collaborative Innovation Center for Cancer Medicine, Beijing 100850, China; Institute of Cancer Stem Cell, Dalian Medical University, Dalian, Liaoning Province, 116044, China. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S08986568163011
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http://dx.doi.org/10.1016/j.cellsig.2016.05.016DOI Listing
September 2016

Mapping and analyzing the human liver proteome: progress and potential.

Expert Rev Proteomics 2016 09 2;13(9):833-43. Epub 2016 Aug 2.

a Department of Systems Biology for Medicine, School of Basic Medical Sciences , Fudan University , Shanghai , China.

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http://dx.doi.org/10.1080/14789450.2016.1213132DOI Listing
September 2016

An extended genome-wide association study identifies novel susceptibility loci for nasopharyngeal carcinoma.

Hum Mol Genet 2016 08 19;25(16):3626-3634. Epub 2016 Jul 19.

Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine

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http://dx.doi.org/10.1093/hmg/ddw200DOI Listing
August 2016

ICM: a web server for integrated clustering of multi-dimensional biomedical data.

Nucleic Acids Res 2016 07 30;44(W1):W154-9. Epub 2016 Apr 30.

Beijing Institute of Radiation Medicine, Beijing 100850, P. R. China

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http://dx.doi.org/10.1093/nar/gkw378DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4987925PMC
July 2016

Involvement of LSECtin in the hepatic natural killer cell response.

Biochem Biophys Res Commun 2016 07 14;476(1):49-55. Epub 2016 May 14.

State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing, 102206, China. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2016.05.072DOI Listing
July 2016

Quantitative and In-Depth Survey of the Isotopic Abundance Distribution Errors in Shotgun Proteomics.

Anal Chem 2016 07 20;88(13):6844-51. Epub 2016 Jun 20.

State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Engineering Research Center for Protein Drugs, National Center for Protein Sciences (Beijing), Beijing Institute of Radiation Medicine , Beijing, 102206, P.R. China.

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http://dx.doi.org/10.1021/acs.analchem.6b01409DOI Listing
July 2016

NEDL2 regulates enteric nervous system and kidney development in its Nedd8 ligase activity-dependent manner.

Oncotarget 2016 May;7(21):31440-53

State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Collaborative Innovation Center for Cancer Medicine, Beijing 100850, China.

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http://dx.doi.org/10.18632/oncotarget.8951DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5058769PMC
May 2016

Quantitative Proteomics Analysis of Tissue Interstitial Fluid for Identification of Novel Serum Candidate Diagnostic Marker for Hepatocellular Carcinoma.

Sci Rep 2016 05 24;6:26499. Epub 2016 May 24.

State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences Beijing, Beijing Institute of Radiation Medicine, Beijing 102206, China.

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http://dx.doi.org/10.1038/srep26499DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4877711PMC
May 2016

The Myeloid LSECtin Is a DAP12-Coupled Receptor That Is Crucial for Inflammatory Response Induced by Ebola Virus Glycoprotein.

PLoS Pathog 2016 Mar 4;12(3):e1005487. Epub 2016 Mar 4.

State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing, China.

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http://dx.doi.org/10.1371/journal.ppat.1005487DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4778874PMC
March 2016

The relationships among host transcriptional responses reveal distinct signatures underlying viral infection-disease associations.

Mol Biosyst 2016 Feb;12(2):653-65

Department of Biotechnology, Beijing Institute of Radiation Medicine, Beijing, China.

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http://dx.doi.org/10.1039/c5mb00657kDOI Listing
February 2016

BATMAN-TCM: a Bioinformatics Analysis Tool for Molecular mechANism of Traditional Chinese Medicine.

Sci Rep 2016 Feb 16;6:21146. Epub 2016 Feb 16.

State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing 100850, China.

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http://dx.doi.org/10.1038/srep21146DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4754750PMC
February 2016

Common variations in TERT-CLPTM1L locus are reproducibly associated with the risk of nasopharyngeal carcinoma in Chinese populations.

Oncotarget 2016 Jan;7(1):759-70

State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Beijing, China.

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http://dx.doi.org/10.18632/oncotarget.6397DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4808031PMC
January 2016

Mining the human plasma proteome with three-dimensional strategies by high-resolution Quadrupole Orbitrap Mass Spectrometry.

Anal Chim Acta 2016 Jan 25;904:65-75. Epub 2015 Nov 25.

State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, No. 33 Life Science Park Road, Changping District, Beijing 102206, PR China. Electronic address:

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http://dx.doi.org/10.1016/j.aca.2015.11.001DOI Listing
January 2016

Evolutionary Characteristics of Missing Proteins: Insights into the Evolution of Human Chromosomes Related to Missing-Protein-Encoding Genes.

J Proteome Res 2015 Dec 12;14(12):4985-94. Epub 2015 Nov 12.

State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Radiation Medicine , Beijing 102206, P. R. China.

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http://dx.doi.org/10.1021/acs.jproteome.5b00450DOI Listing
December 2015

Argonaute 2 and nasopharyngeal carcinoma: a genetic association study and functional analysis.

BMC Cancer 2015 Nov 6;15:862. Epub 2015 Nov 6.

State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, No. 27, Taiping Road, Haidian District, Beijing, 100850, P.R. China.

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http://dx.doi.org/10.1186/s12885-015-1895-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4636795PMC
November 2015

Special Enrichment Strategies Greatly Increase the Efficiency of Missing Proteins Identification from Regular Proteome Samples.

J Proteome Res 2015 Sep 15;14(9):3680-92. Epub 2015 Jul 15.

State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Engineering Research Center for Protein Drugs, National Center for Protein Sciences, Beijing Institute of Radiation Medicine , Beijing 102206, China.

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http://dx.doi.org/10.1021/acs.jproteome.5b00481DOI Listing
September 2015

Deubiquitylase OTUD3 regulates PTEN stability and suppresses tumorigenesis.

Nat Cell Biol 2015 Sep 17;17(9):1169-81. Epub 2015 Aug 17.

State Key Laboratory of Proteomics, Beijing Proteome Research Center, Beijing Institute of Radiation Medicine, Collaborative Innovation Center for Cancer Medicine, Beijing 100850, China.

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http://dx.doi.org/10.1038/ncb3218DOI Listing
September 2015

Tissue-Based Proteogenomics Reveals that Human Testis Endows Plentiful Missing Proteins.

J Proteome Res 2015 Sep;14(9):3583-94

CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences , Beijing 100101, China.

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http://dx.doi.org/10.1021/acs.jproteome.5b00435DOI Listing
September 2015

Network fingerprint: a knowledge-based characterization of biomedical networks.

Sci Rep 2015 Aug 26;5:13286. Epub 2015 Aug 26.

Beijing Institute of Radiation Medicine, 27 Taiping Road, Beijing 100850, China.

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http://dx.doi.org/10.1038/srep13286DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4549786PMC
August 2015

Biased random walk model for the prioritization of drug resistance associated proteins.

Sci Rep 2015 Jun 3;5:10857. Epub 2015 Jun 3.

State Key Laboratory of Cancer Biology and Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi'an, P. R. China.

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http://dx.doi.org/10.1038/srep10857DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4454201PMC
June 2015