Publications by authors named "Fritz Krombach"

92Publications

Plasminogen Activator Inhibitor-1 Promotes Neutrophil Infiltration and Tissue Injury on Ischemia-Reperfusion.

Arterioscler Thromb Vasc Biol 2018 04 25;38(4):829-842. Epub 2018 Jan 25.

From the Walter Brendel Centre of Experimental Medicine (M.P., G.Z., M.H., B.U., J.S., L.M., M.F., D.F., M.L., A.K., F.K., C.A.R.), Department of Otorhinolaryngology (G.Z., M.H., B.U., C.A.R.), Head and Neck Surgery (M.P.), Pharmaceutical Biology, Department of Pharmacy, Center for Drug Research (S.Z.), Department of Surgery (D.F., M.L., A.K.), and Department of Radiation Oncology (K.L.), Ludwig-Maximilians-Universität München, Munich, Germany; Department of Psychiatry and Psychotherapy, University Clinic, Friedrich-Alexander-University of Erlangen-Nuremberg, Germany (M.P); Institute of Pharmaceutical Biology, Goethe University Frankfurt, Germany (R.F.); and Institute of Basic Medical Sciences, University of Oslo, Norway (S.K.).

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April 2018

The surface chemistry determines the spatio-temporal interaction dynamics of quantum dots in atherosclerotic lesions.

Nanomedicine (Lond) 2018 03 15;13(6):623-638. Epub 2018 Jan 15.

Walter Brendel Centre of Experimental Medicine, Klinikum der Universität München, Munich, Germany.

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March 2018

Early pulmonary response is critical for extra-pulmonary carbon nanoparticle mediated effects: comparison of inhalation versus intra-arterial infusion exposures in mice.

Part Fibre Toxicol 2017 06 20;14(1):19. Epub 2017 Jun 20.

Institute of Lung Biology and Disease, Comprehensive Pneumology Center, Helmholtz Zentrum München, German Research Center for Environmental Health, D85764, Neuherberg, Germany.

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June 2017

Dexamethasone-conjugated DNA nanotubes as anti-inflammatory agents in vivo.

Biomaterials 2017 Jul 17;134:78-90. Epub 2017 Apr 17.

Walter Brendel Centre of Experimental Medicine, Ludwig-Maximilians-Universität München, Marchioninistraße 15, 81377 Munich, Germany; Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-Universität München, Feodor-Lynen-Straße 17, 81377 Munich, Germany. Electronic address:

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July 2017

The Endothelial Glycocalyx Controls Interactions of Quantum Dots with the Endothelium and Their Translocation across the Blood-Tissue Border.

ACS Nano 2017 02 7;11(2):1498-1508. Epub 2017 Feb 7.

Walter Brendel Centre of Experimental Medicine, Klinikum der Universität München, Ludwig-Maximilians-Universität München , 81377 Munich, Germany.

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February 2017

The glycocalyx regulates the uptake of nanoparticles by human endothelial cells in vitro.

Nanomedicine (Lond) 2017 Feb 12;12(3):207-217. Epub 2017 Jan 12.

Walter Brendel Centre of Experimental Medicine, Ludwig-Maximilians-Universität München, Marchioninistr. 15, 81377 Munich, Germany.

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February 2017

Platelets Guide Leukocytes to Their Sites of Extravasation.

PLoS Biol 2016 05 6;14(5):e1002459. Epub 2016 May 6.

Department of Otorhinolaryngology, Head and Neck Surgery, Klinikum der Universität München, Munich, Germany.

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May 2016

Multiphoton Microscopy of Nonfluorescent Nanoparticles In Vitro and In Vivo.

Small 2016 Jun 27;12(24):3245-57. Epub 2016 Apr 27.

Walter-Brendel-Zentrum für Experimentelle Medizin, Ludwig-Maximilians-Universität München, 81377, München, Germany.

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June 2016

Influence of Surface Modifications on the Spatiotemporal Microdistribution of Quantum Dots In Vivo.

Small 2016 05 29;12(19):2641-51. Epub 2016 Mar 29.

Walter Brendel Centre of Experimental Medicine, Ludwig-Maximilians-Universität München, Marchioninistr, 15, 81377, Munich, Germany.

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May 2016

Intercellular Transport of Nanomaterials is Mediated by Membrane Nanotubes In Vivo.

Small 2016 Apr 8;12(14):1882-90. Epub 2016 Feb 8.

Walter Brendel Centre of Experimental Medicine, Ludwig-Maximilians-Universität München, Munich, Germany.

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April 2016

DNA nanotubes as intracellular delivery vehicles in vivo.

Biomaterials 2015 19;53:453-63. Epub 2015 Mar 19.

Walter Brendel Centre of Experimental Medicine, Ludwig-Maximilians-Universität München, Marchioninistr. 15, 81377 Munich, Germany. Electronic address:

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January 2016

Spatiotemporal expression dynamics of selectins govern the sequential extravasation of neutrophils and monocytes in the acute inflammatory response.

Arterioscler Thromb Vasc Biol 2015 Apr 26;35(4):899-910. Epub 2015 Feb 26.

From the Department of Otorhinolaryngology, Head and Neck Surgery (G.Z., C.A.R.), Department of Radiation Oncology (K.L.), Walter Brendel Centre of Experimental Medicine (G.Z., B.U., M.E.T.H., A.R.M.K., M.R., F.K., C.A.R.), Klinikum der Universität München, Munich, Germany.

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April 2015

Proinflammatory and cytotoxic response to nanoparticles in precision-cut lung slices.

Beilstein J Nanotechnol 2014 18;5:2440-9. Epub 2014 Dec 18.

Walter Brendel Centre of Experimental Medicine, Ludwig-Maximilians-Universität München, Marchioninistr. 15, 81377 Munich, Germany.

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February 2015

Effects of acute systemic administration of TiO2, ZnO, SiO2, and Ag nanoparticles on hemodynamics, hemostasis and leukocyte recruitment.

Nanotoxicology 2015 11;9(8):963-71. Epub 2015 Feb 11.

a Walter Brendel Centre of Experimental Medicine, Klinikum der Universität München , Munich , Germany.

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April 2017

Tissue plasminogen activator promotes postischemic neutrophil recruitment via its proteolytic and nonproteolytic properties.

Arterioscler Thromb Vasc Biol 2014 Jul 24;34(7):1495-504. Epub 2014 Apr 24.

From the Walter Brendel Centre of Experimental Medicine (B.U., G.Z., D.P.-W., M.P., M.R., M.F., M. Hessenauer, M. Holzer, F.K., C.A.R.), Department of Otorhinolaryngology, Head and Neck Surgery (G.Z., M. Hessenauer, M. Holzer, C.A.R.), Department of Surgery, Klinikum der Universität München (A.K.), and Department of Pharmacy (R.F., S.Z.), Ludwig-Maximilians-Universität München, Munich, Germany; and Institute of Pharmaceutical Biology, Biocenter, Goethe-University Frankfurt/Main, Frankfurt am Main, Germany (R.F.).

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July 2014

Carbon-based nanomaterials accelerate arteriolar thrombus formation in the murine microcirculation independently of their shape.

J Appl Toxicol 2014 Nov 14;34(11):1167-76. Epub 2014 Feb 14.

Walter Brendel Centre of Experimental Medicine, Ludwig-Maximilians-Universität München, 81377, Munich, Germany.

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November 2014

Cytotoxic and proinflammatory effects of PVP-coated silver nanoparticles after intratracheal instillation in rats.

Beilstein J Nanotechnol 2013 Dec 19;4:933-40. Epub 2013 Dec 19.

Institute of Lung Biology and Disease, Helmholtz Center Munich, Neuherberg/Munich, Germany ; Current address: Berufsgenossenschaft Holz und Metall, Am Knie 8, 81241 München, Germany.

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December 2013

Targeting platelet migration in the postischemic liver by blocking protease-activated receptor 4.

Transplantation 2014 Jan;97(2):154-60

1 Department of Surgery-Grosshadern, Klinikum der Universität München, Ludwig-Maximilians-Universität München, Munich, Germany. 2 Walter Brendel Centre of Experimental Medicine, Klinikum der Universität München, Ludwig-Maximilians-Universität München, Munich, Germany. 3 Institute of Laboratory Medicine, Klinikum der Universität München, Ludwig-Maximilians-Universität München, Munich, Germany. 4 Institute of Pathology, Klinikum der Universität München, Ludwig-Maximilians-Universität München, Munich, Germany. 5 Address correspondence to: Andrej Khandoga, M.D., Ph.D., Department of Surgery - Grosshadern Klinikum der Universität München Marchioninistr. 15 81377 Munich, Germany.

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January 2014

At the interface of fibrinolysis and inflammation: the role of urokinase-type plasminogen activator in the leukocyte extravasation cascade.

Trends Cardiovasc Med 2012 Oct 10;22(7):192-6. Epub 2012 Oct 10.

Department of Otorhinolaryngology, Head and Neck Surgery, Klinikum der Universität München, Ludwig-Maximilians-Universität München, D-81366 Munich, Germany.

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October 2012

C-C motif chemokine CCL3 and canonical neutrophil attractants promote neutrophil extravasation through common and distinct mechanisms.

Blood 2012 Jul 6;120(4):880-90. Epub 2012 Jun 6.

Klinikum der Universität München, Walter Brendel Centre of Experimental Medicine, Campus Grosshadern, Ludwig-Maximilians-Universität München, Marchioninistrasse 15, Munich, Germany.

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July 2012

Surface chemistry of quantum dots determines their behavior in postischemic tissue.

ACS Nano 2012 Feb 24;6(2):1370-9. Epub 2012 Jan 24.

Walter Brendel Centre of Experimental Medicine, Ludwig-Maximilians-Universität München, Munich, Germany.

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February 2012

Label-free 3D visualization of cellular and tissue structures in intact muscle with second and third harmonic generation microscopy.

PLoS One 2011 28;6(11):e28237. Epub 2011 Nov 28.

Walter-Brendel-Zentrum für Experimentelle Medizin, Ludwig-Maximilians-Universität München, München, Germany.

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April 2012

A novel approach to prevent endothelial hyperpermeability: the Crataegus extract WS® 1442 targets the cAMP/Rap1 pathway.

J Mol Cell Cardiol 2012 Jan 31;52(1):196-205. Epub 2011 Oct 31.

Department of Pharmacy, Center for Drug Research, Pharmaceutical Biology, University of Munich, Butenandtstr. 5-13, 81377 Munich, Germany.

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January 2012

Inhibitor of apoptosis proteins as novel targets in inflammatory processes.

Arterioscler Thromb Vasc Biol 2011 Oct 4;31(10):2240-50. Epub 2011 Aug 4.

Munich Center for System-Based Drug Research, Department of Pharmacy, University of Munich, Germany.

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October 2011

Plasmin inhibitors prevent leukocyte accumulation and remodeling events in the postischemic microvasculature.

PLoS One 2011 Feb 22;6(2):e17229. Epub 2011 Feb 22.

Walter Brendel Centre of Experimental Medicine, Ludwig-Maximilians-Universität München, Munich, Germany.

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February 2011

Signal improvement in multiphoton microscopy by reflection with simple mirrors near the sample.

J Biomed Opt 2010 Mar-Apr;15(2):026017

Ludwig-Maximilians-Universitat Munchen, Walter-Brendel-Zentrum fur Experimentelle Medizin, Marchioninistrasse 27, Munchen, D-81377 Germany.

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September 2010

Single-walled carbon nanotubes activate platelets and accelerate thrombus formation in the microcirculation.

Toxicology 2010 Mar 19;269(2-3):148-54. Epub 2009 Aug 19.

Walter Brendel Centre of Experimental Medicine, Ludwig-Maximilians-Universität München, Marchioninistrasse 27, D-81377 Munich, Germany.

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March 2010

In vivo imaging and quantitative analysis of leukocyte directional migration and polarization in inflamed tissue.

PLoS One 2009 4;4(3):e4693. Epub 2009 Mar 4.

Walter Brendel Centre of Experimental Medicine, Ludwig-Maximilians-Universität München, Munich, Germany.

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April 2009

Leukocyte transmigration in inflamed liver: A role for endothelial cell-selective adhesion molecule.

J Hepatol 2009 Apr 7;50(4):755-65. Epub 2009 Feb 7.

Department of Surgery, Ludwig-Maximilians-Universität München, Marchioninistr. 15, D-81377 Munich, Germany.

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April 2009

Optimized dispersion of nanoparticles for biological in vitro and in vivo studies.

Part Fibre Toxicol 2008 Nov 6;5:14. Epub 2008 Nov 6.

Walter Brendel Centre of Experimental Medicine, Ludwig-Maximilians-Universität München, Munich, Germany.

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November 2008

Reciprocal activation between CD4+ T cells and Kupffer cells during hepatic ischemia-reperfusion.

Transplantation 2008 Sep;86(5):710-8

Institute for Surgical Research, Klinikum der Universität München, Ludwig-Maximilians-Universität München, Munich, Germany.

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September 2008

Atrial natriuretic peptide protects against histamine-induced endothelial barrier dysfunction in vivo.

Mol Pharmacol 2008 Jul 15;74(1):1-8. Epub 2008 Apr 15.

Department of Pharmacy, Pharmaceutical Biology, University of Munich, Butenandtstr. 5-13, 81377 Munich, Germany.

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July 2008

Gelatinases mediate neutrophil recruitment in vivo: evidence for stimulus specificity and a critical role in collagen IV remodeling.

J Leukoc Biol 2008 Apr 3;83(4):864-74. Epub 2008 Jan 3.

Institute for Surgical review, University of Munich, Marchioninistr. 27, D-81377 Munich, Germany.

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April 2008

A CD99-related antigen on endothelial cells mediates neutrophil but not lymphocyte extravasation in vivo.

Blood 2007 Jun 7;109(12):5327-36. Epub 2007 Mar 7.

Institute of Cell Biology, Zentrum für Molekularbiologie der Entzündung (ZMBE), Interdisziplinäres Klinisches Forschungszentrum Münster, University of Münster, Münster, Germany.

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June 2007

The role of JAM-A and PECAM-1 in modulating leukocyte infiltration in inflamed and ischemic tissues.

J Leukoc Biol 2006 Oct 20;80(4):714-8. Epub 2006 Jul 20.

National Heart and Lung Institute, Imperial College London, UK.

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October 2006

ESAM supports neutrophil extravasation, activation of Rho, and VEGF-induced vascular permeability.

J Exp Med 2006 Jul 3;203(7):1671-7. Epub 2006 Jul 3.

Max-Planck-Institute for Molecular Biomedicine and Institute of Cell Biology, University of Münster, D-48149 Münster, Germany.

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July 2006

Matrix metalloproteinase-9 promotes neutrophil and T cell recruitment and migration in the postischemic liver.

J Leukoc Biol 2006 Jun 21;79(6):1295-305. Epub 2006 Mar 21.

Institute for Surgical Research, University of Munich, Marchioninistr. 27, D-81377 Munich, Germany.

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June 2006

CD4+ T cells contribute to postischemic liver injury in mice by interacting with sinusoidal endothelium and platelets.

Hepatology 2006 Feb;43(2):306-15

Institute for Surgical Research, Ludwig-Maximilians-University of Munich, Germany.

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February 2006

Hyperoxia-induced reactive oxygen species formation in pulmonary capillary endothelial cells in situ.

Am J Respir Cell Mol Biol 2006 Apr 15;34(4):453-63. Epub 2005 Dec 15.

Institute of Physiology Charité - Universitätsmedizin Berlin, Campus Benjamin Franklin, Arnimallee 22, 14195 Berlin, Germany.

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April 2006

Chemokine receptors Ccr1, Ccr2, and Ccr5 mediate neutrophil migration to postischemic tissue.

J Leukoc Biol 2006 Jan 7;79(1):114-22. Epub 2005 Nov 7.

Institute for Surgical Research, Arbeitsgruppe Klinische Biochemie, University of Munich, Germany.

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January 2006

Peripheral expansion of circulating T-helper 1 cells predicts coronary endothelial dysfunction after cardiac transplantation.

J Heart Lung Transplant 2005 Jul;24(7):833-40

Department of Cardiology, University Hospital Grosshadern, Ludwig-Maximilians-University, Munich, Germany.

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July 2005

ROS-mediated TNF-alpha and MIP-2 gene expression in alveolar macrophages exposed to pine dust.

Part Fibre Toxicol 2004 Dec 13;1(1). Epub 2004 Dec 13.

Institute for Surgical Research, University of Munich, Munich, Germany.

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December 2004

Cardiovascular effects of fine and ultrafine particles.

J Aerosol Med 2005 ;18(1):1-22

Institute for Inhalation Biology, GSF-National Research Center for Environment and Health, Neuherberg/Munich, Germany.

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May 2005

Proinflammatory role of inducible nitric oxide synthase in acute hyperoxic lung injury.

Respir Res 2004 Sep 15;5:11. Epub 2004 Sep 15.

Institute for Surgical Research, University of Munich, Marchioninistr, 15, 81366 Munich, Germany.

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September 2004

The fate of autoreactive, GFP+ T cells in rat models of uveitis analyzed by intravital fluorescence microscopy and FACS.

Int Immunol 2004 Nov 6;16(11):1573-82. Epub 2004 Sep 6.

Section of Immunobiology, Department of Ophthalmology, Ludwig-Maximilians-University, Munich, Germany.

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November 2004

Platelet-endothelial cell interactions during hepatic ischemia-reperfusion in vivo: a systematic analysis.

Microvasc Res 2003 Mar;65(2):71-7

Institute for Surgical Research, University of Munich, 81377, Munich, Germany.

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March 2003

Microcirculation of the urinary bladder in a rat model of ischemia-reperfusion-induced cystitis.

Urology 2002 Dec;60(6):1136-40

Institute for Surgical Research, University of Munich, Klinikum Grosshadern, Munich, Germany.

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December 2002

Poly(ADP-ribose) polymerase triggers the microvascular mechanisms of hepatic ischemia-reperfusion injury.

Am J Physiol Gastrointest Liver Physiol 2002 Sep;283(3):G553-60

Institute for Surgical Research, University of Munich, D-81377 Munich, Germany.

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September 2002

Dual role of inducible nitric oxide synthase in acute asbestos-induced lung injury.

Free Radic Biol Med 2002 Aug;33(4):491-501

Institute for Surgical Research, University of Munich, Munich, Germany.

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August 2002

New method: the intravital videomicroscopic characteristics of the microcirculation of the urinary bladder in rats.

Urol Res 2002 Jul 17;30(3):148-52. Epub 2002 May 17.

Institute of Surgical Research, University of Munich, Klinikum Grosshadern, Munich, Germanny.

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July 2002

Response of alveolar macrophages to inhaled particulates.

Eur Surg Res 2002 Jan-Apr;34(1-2):47-52

Institute for Surgical Research, University of Munich, Germany.

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August 2002

Revascularization of transplanted adipose tissue: a study in the dorsal skinfold chamber of hamsters.

Ann Plast Surg 2002 Jan;48(1):53-9

Institute for Surgical Research, Ludwig-Maximilians-Universität München, Universitätsklinikum Grosshadern, Munich, Germany.

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January 2002