Fredrik Piehl

Fredrik Piehl

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Fredrik Piehl

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Is the treatment of myasthenia gravis improving? Why not ask our patients?

Neurology 2020 Aug 5. Epub 2020 Aug 5.

University at Buffalo.

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http://dx.doi.org/10.1212/WNL.0000000000010578DOI Listing
August 2020

Rituximab, MS, and pregnancy.

Neurol Neuroimmunol Neuroinflamm 2020 Jul 1;7(4). Epub 2020 May 1.

From the Department of Research & Evaluation (J.B.S.), Kaiser Permanente Southern California; Department of Neurology (K.H.), St. Josef Hospital, Bochum, Germany; Department of Clinical Neuroscience (K.F., F.P.), Karolinska Institute; Center for Neurology (K.F.), Academic Specialist Center, Stockholm, Sweden; Department of Obstetrics & Gynecology - Maternal Fetal Medicine (D.J.L.), Stanford University School of Medicine, Stanford, CA; Department of Neurology (F.P.), Karolinska University Hospital, Stockholm, Sweden; and Department of Neurology (A.L.-G.), Los Angeles Medical Center, Southern California Permanente Medical Group, Los Angeles, CA.

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http://dx.doi.org/10.1212/NXI.0000000000000734DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7217660PMC
July 2020

Diagnostic accuracy of intrathecal kappa free light chains compared with OCBs in MS.

Neurol Neuroimmunol Neuroinflamm 2020 Jul 11;7(4). Epub 2020 Jun 11.

From the Department of Neurobiology, Care Sciences and Society (F.D.), Department of Clinical Neuroscience (B.E., F.A.N., T.O., M.K., M.A.H., F.P.), and Department of Laboratory Medicine (M.H.), Karolinska Institutet; Department of Clinical Chemistry (F.D., A.S., M.H.) and Department of Neurology (B.E., T.O., M.K., M.A.H., F.P.), Karolinska University Hospital; and Unit of Medical Statistics (D.O.), Department of Learning, Informatics, Management and Ethics (LIME), Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1212/NXI.0000000000000775DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7309528PMC
July 2020

Infections in patients with multiple sclerosis: A national cohort study in Sweden.

Mult Scler Relat Disord 2020 Jul 23;45:102420. Epub 2020 Jul 23.

Clinical Epidemiology and Biostatistics, School of Medical Sciences, Örebro University Hospital and Örebro University, Fakultetsgatan 1, 701 82 Örebro, Sweden; Clinical Epidemiology Division, Karolinska Institutet, Stockholm, Sweden; Department of Epidemiology and Public Health, University College London, London, United Kingdom.

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http://dx.doi.org/10.1016/j.msard.2020.102420DOI Listing
July 2020

Plasma neurofilament light levels are associated with risk of disability in multiple sclerosis.

Neurology 2020 Jun 20;94(23):e2457-e2467. Epub 2020 May 20.

From the Department of Clinical Neuroscience (A.M., P.S., M.K., F.P., T.O., I.K.), The Karolinska Neuroimmunology & Multiple Sclerosis Centre, Karolinska Institutet; Centre for Molecular Medicine (A.M., P.S., M.K., F.P., T.O., I.K.), Karolinska University Hospital, Stockholm, Sweden; Departments of Medicine, Biomedicine, and Clinical Research (D.L., C.B., Z.M., L.K., J.K.), Neurologic Clinic and Policlinic, University Hospital Basel, University of Basel; Clinical Trial Unit (P.B.), Department of Clinical Research, University Hospital Basel, University of Switzerland; Institution of Neuroscience and Physiology (J.L.), Sahlgrenska Academy, University of Gothenburg, Gothenburg; Institute of Environmental Medicine (L.A.), Karolinska Institutet, Stockholm; and Centre for Occupational and Environmental Medicine (L.A.), Stockholm County Council, Sweden.

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http://dx.doi.org/10.1212/WNL.0000000000009571DOI Listing
June 2020

Inflammation-related plasma and CSF biomarkers for multiple sclerosis.

Proc Natl Acad Sci U S A 2020 Jun 26;117(23):12952-12960. Epub 2020 May 26.

Neuroimmunology Unit, Center of Molecular Medicine, Department of Clinical Neuroscience, Karolinska University Hospital, Karolinska Institutet, SE-171 77 Stockholm, Sweden;

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http://dx.doi.org/10.1073/pnas.1912839117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7293699PMC
June 2020

Enlarged perivascular spaces in multiple sclerosis on magnetic resonance imaging: a systematic review and meta-analysis.

J Neurol 2020 Jun 13. Epub 2020 Jun 13.

Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1007/s00415-020-09971-5DOI Listing
June 2020

Characterization of More Selective Central Nervous System Nrf2-Activating Novel Vinyl Sulfoximine Compounds Compared to Dimethyl Fumarate.

Neurotherapeutics 2020 May 11. Epub 2020 May 11.

Department of Medical Biochemistry and Biophysics, Division of Biochemistry, Karolinska Institutet, 17177, Stockholm, Sweden.

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http://dx.doi.org/10.1007/s13311-020-00855-0DOI Listing
May 2020

MRI-Based Manual versus Automated Corpus Callosum Volumetric Measurements in Multiple Sclerosis.

J Neuroimaging 2020 03 20;30(2):198-204. Epub 2019 Nov 20.

Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden.

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http://dx.doi.org/10.1111/jon.12676DOI Listing
March 2020

Blood neurofilament light levels segregate treatment effects in multiple sclerosis.

Neurology 2020 03 11;94(11):e1201-e1212. Epub 2020 Feb 11.

From the Department of Medicine Solna, Clinical Epidemiology Division (B.D.), The Karolinska Neuroimmunology & Multiple Sclerosis Centre, Department of Clinical Neuroscience (A.M., I.K., T.O., F.P.), and Institute of Environmental Medicine (L.A.), Karolinska Institutet; Centre for Molecular Medicine (A.M., I.K., T.O., F.P.), Karolinska University Hospital, Stockholm, Sweden; Neurologic Clinic and Policlinic, Departments of Medicine, Biomedicine, and Clinical Research (C.B., Z.M., L.K., D.L., J.K.), and Clinical Trial Unit, Department of Clinical Research (P.B.), University Hospital Basel, University of Basel, Switzerland; Sanofi Genzyme (J.A.T.), Stockholm, Sweden; Biogen (T.P., B.C.K.), Cambridge, MA; Department of Neurology, Medical Faculty (B.C.K.), Heinrich-Heine University, Duesseldorf, Germany; and Institution of Neuroscience and Physiology (J.L.), Sahlgrenska Academy, University of Gothenburg, Sweden.

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http://dx.doi.org/10.1212/WNL.0000000000009097DOI Listing
March 2020

Rituximab, MS, and pregnancy.

Neurol Neuroimmunol Neuroinflamm 2020 Jul 1;7(4). Epub 2020 May 1.

From the Department of Research & Evaluation (J.B.S.), Kaiser Permanente Southern California; Department of Neurology (K.H.), St. Josef Hospital, Bochum, Germany; Department of Clinical Neuroscience (K.F., F.P.), Karolinska Institute; Center for Neurology (K.F.), Academic Specialist Center, Stockholm, Sweden; Department of Obstetrics & Gynecology - Maternal Fetal Medicine (D.J.L.), Stanford University School of Medicine, Stanford, CA; Department of Neurology (F.P.), Karolinska University Hospital, Stockholm, Sweden; and Department of Neurology (A.L.-G.), Los Angeles Medical Center, Southern California Permanente Medical Group, Los Angeles, CA.

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http://dx.doi.org/10.1212/NXI.0000000000000734DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7217660PMC
July 2020

Rituximab treatment for multiple sclerosis.

Mult Scler 2020 02 25;26(2):137-152. Epub 2019 Jun 25.

Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden Center for Neurology, Academic Specialist Center, Stockholm Health Services, Stockholm, Sweden.

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http://dx.doi.org/10.1177/1352458519858604DOI Listing
February 2020

Interrupting rituximab treatment in relapsing-remitting multiple sclerosis; no evidence of rebound disease activity.

Mult Scler Relat Disord 2020 Jan 24;37:101468. Epub 2019 Oct 24.

Department of Clinical Neuroscience, Karolinska Institutet, Center for Molecular Medicine, Karolinska University Hospital, Solna, 171 76, Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.msard.2019.101468DOI Listing
January 2020

Confounding effect of blood volume and body mass index on blood neurofilament light chain levels.

Ann Clin Transl Neurol 2020 01 1;7(1):139-143. Epub 2020 Jan 1.

Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1002/acn3.50972DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6952306PMC
January 2020

Incidence of osmotic demyelination syndrome in Sweden: A nationwide study.

Acta Neurol Scand 2019 Nov 19;140(5):342-349. Epub 2019 Aug 19.

Department of Neurology, The National University Hospital of Iceland, Reykjavik, Iceland.

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http://dx.doi.org/10.1111/ane.13150DOI Listing
November 2019

Successful combined treatment with thymectomy, rituximab and tocilizumab for severe thymoma-associated multi autoimmune syndrome.

J Neuroimmunol 2019 11 23;336:577028. Epub 2019 Aug 23.

Department of Neurology, Karolinska University Hospital, Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.jneuroim.2019.577028DOI Listing
November 2019

Retinal nerve fiber layer thickness associates with cognitive impairment and physical disability in multiple sclerosis.

Mult Scler Relat Disord 2019 Nov 26;36:101414. Epub 2019 Sep 26.

Unit of Optometry, Department of Clinical Neuroscience, Karolinska Institutet, Box 8056, S-104 20 Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.msard.2019.101414DOI Listing
November 2019

A Serum Protein Biomarker Panel Improves Outcome Prediction in Human Traumatic Brain Injury.

J Neurotrauma 2019 10 19;36(20):2850-2862. Epub 2019 Jun 19.

Department of Physiology and Pharmacology, Section of Perioperative Medicine and Intensive Care, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1089/neu.2019.6375DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6761606PMC
October 2019

Dynamics of extracellular matrix proteins in cerebrospinal fluid and serum and their relation to clinical outcome in human traumatic brain injury.

Clin Chem Lab Med 2019 Sep;57(10):1565-1573

Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.

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http://dx.doi.org/10.1515/cclm-2019-0034DOI Listing
September 2019

Different epigenetic clocks reflect distinct pathophysiological features of multiple sclerosis.

Epigenomics 2019 09 8;11(12):1429-1439. Epub 2019 Oct 8.

Department of Clinical Neuroscience, Center for Molecular Medicine, Karolinska Institutet, Karolinska University Hospital, 171 76 Stockholm, Sweden.

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http://dx.doi.org/10.2217/epi-2019-0102DOI Listing
September 2019

Increased peripheral levels of TARC/CCL17 in first episode psychosis patients.

Schizophr Res 2019 08 3;210:221-227. Epub 2019 Jan 3.

Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.schres.2018.12.033DOI Listing
August 2019

Comparative effectiveness of dimethyl fumarate as the initial and secondary treatment for MS.

Mult Scler 2019 Aug 8:1352458519866600. Epub 2019 Aug 8.

Department of Clinical Neuroscience, Center for Molecular Medicine (CMM), Karolinska Institutet, Stockholm, Sweden.

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http://journals.sagepub.com/doi/10.1177/1352458519866600
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http://dx.doi.org/10.1177/1352458519866600DOI Listing
August 2019

Randomized phase 2 study of FcRn antagonist efgartigimod in generalized myasthenia gravis.

Neurology 2019 06 22;92(23):e2661-e2673. Epub 2019 May 22.

From the Department of Neurology (J.F.H.), University of North Carolina, Chapel Hill; Krembil Neuroscience Centre (V.B.), University Health Network, Toronto, Canada; Department of Neurology (T.M.B.), University of Virginia, Charlottesville; Department of Neuroimmunology and Neuromuscular Diseases (R.M.), Fondazione Istituto Neurologico Carlo Besta, Milan, Italy; Department of Neurology (B.M.), Wroclaw Medical University; Department of Neurology (A.S.), Jagiellonian University Medical College, Cracow, Poland; Department of Neurology (S.B.), University of Southern California, Keck School of Medicine, Los Angeles County Medical Center; Department of Neurology (F.J.R.D.R.G.), La Paz University Hospital, Neuroscience Area of IdiPAZ Health Research Institute, Autonoma University of Madrid, Spain; Neuroimmunology Unit, Department Clinical Neuroscience (F.P.), Karolinska Institutet, Karolinska University Hospital (Solna), Stockholm, Sweden; USC Neurologia (M.R.), USS Malattie Autoimmuni-Centro Sclerosi Multipla, Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII, Bergamo, Italy; Neurology Department (P.V.D.), University Hospitals Leuven; Laboratory of Neurobiology (P.V.D.), Department of Neuroscience, KU Leuven and Center for Brain & Disease Research, VIB, Leuven, Belgium; Department of Neurology (T.V.), University of South Florida, Morsani College of Medicine, Tampa; Institute of Neurology (A.E.), Fondazione Policlinico Universitario "A. Gemelli" IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy; Neurology Department (M.F.), The Ohio State University, Columbus; Department of Neurology (T.M.), University of California, Irvine; Department of Molecular and Cellular Medicine (E.S.W.), Texas A&M University Health Science Center, College Station; argenx BVBA (T.D., P.U., K.V., A.G., H.d.H., N.L.), Zwijnaarde, Belgium; and Department of Neurology (J.J.G.M.V.), Leiden University Medical Center (LUMC), the Netherlands.

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http://dx.doi.org/10.1212/WNL.0000000000007600DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6556100PMC
June 2019

Diagnostic Value of Cerebrospinal Fluid Neurofilament Light Protein in Neurology: A Systematic Review and Meta-analysis.

JAMA Neurol 2019 Jun 17. Epub 2019 Jun 17.

UCL Institute of Neurology, Queen Square, London, United Kingdom.

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http://dx.doi.org/10.1001/jamaneurol.2019.1534DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6580449PMC
June 2019

Neuronal methylome reveals CREB-associated neuro-axonal impairment in multiple sclerosis.

Clin Epigenetics 2019 05 30;11(1):86. Epub 2019 May 30.

Department of Clinical Neuroscience, Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1186/s13148-019-0678-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6543588PMC
May 2019

Validation of the Swedish Multiple Sclerosis Register: Further Improving a Resource for Pharmacoepidemiologic Evaluations.

Epidemiology 2019 03;30(2):230-233

Clinical Epidemiology Division, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1097/EDE.0000000000000948DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369893PMC
March 2019

miR-31 regulates energy metabolism and is suppressed in T cells from patients with Sjögren's syndrome.

Eur J Immunol 2019 02 22;49(2):313-322. Epub 2018 Oct 22.

Unit of Rheumatology, Department of Medicine, Karolinska Institutet, Center for Molecular Medicine Karolinska University Hospital, Stockholm, Sweden.

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http://dx.doi.org/10.1002/eji.201747416DOI Listing
February 2019

The association between multiple sclerosis and pain medications.

Pain 2019 Feb;160(2):424-432

Centre for Pharmacoepidemiology, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden.

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http://Insights.ovid.com/crossref?an=00006396-900000000-9882
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http://dx.doi.org/10.1097/j.pain.0000000000001429DOI Listing
February 2019

B cell alterations during BAFF inhibition with belimumab in SLE.

EBioMedicine 2019 Feb 26;40:517-527. Epub 2018 Dec 26.

Department of Medicine, Rheumatology Unit, Karolinska Institutet, Karolinska University Hospital, 171 76 Stockholm, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.ebiom.2018.12.035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6412067PMC
February 2019

Morvan's syndrome treated successfully with rituximab and lacosamide.

BMJ Case Rep 2019 Feb 13;12(2). Epub 2019 Feb 13.

Department of Neurology, Karolinska University Hospital, Stockholm, Sweden.

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http://dx.doi.org/10.1136/bcr-2018-226832DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381950PMC
February 2019

Susceptibility to Oxidative Stress Is Determined by Genetic Background in Neuronal Cell Cultures.

eNeuro 2018 Mar-Apr;5(2). Epub 2018 Mar 19.

Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, SE-171 77, Sweden.

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http://dx.doi.org/10.1523/ENEURO.0335-17.2018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5861596PMC
January 2019

Multiple sclerosis.

Nat Rev Dis Primers 2018 11 8;4(1):43. Epub 2018 Nov 8.

Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy.

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http://www.nature.com/articles/s41572-018-0041-4
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http://dx.doi.org/10.1038/s41572-018-0041-4DOI Listing
November 2018

Author Correction: Multiple sclerosis.

Nat Rev Dis Primers 2018 Nov 22;4(1):49. Epub 2018 Nov 22.

Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy.

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http://dx.doi.org/10.1038/s41572-018-0050-3DOI Listing
November 2018

Neurofilaments as biomarkers in neurological disorders.

Nat Rev Neurol 2018 10;14(10):577-589

Neurologic Clinic and Policlinic, Departments of Medicine, Clinical Research, and Biomedicine, University Hospital Basel, University of Basel, Basel, Switzerland.

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http://www.nature.com/articles/s41582-018-0058-z
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http://dx.doi.org/10.1038/s41582-018-0058-zDOI Listing
October 2018

Cerebrospinal fluid levels of sphingolipids associate with disease severity in first episode psychosis patients.

Schizophr Res 2018 09 4;199:438-441. Epub 2018 Apr 4.

Division of Physiological Chemistry II, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, SE-171 77 Stockholm, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.schres.2018.03.029DOI Listing
September 2018

Identification of MS-specific serum miRNAs in an international multicenter study.

Neurol Neuroimmunol Neuroinflamm 2018 Sep 20;5(5):e491. Epub 2018 Aug 20.

Partners Multiple Sclerosis Center (K.R., B.C.H., A.P., M.A.M., R.R., P.K., T.C., H.L.W., R.G.), Brigham and Women's Hospital; Department of Neurology, Harvard Medical School (B.C.H., C.D.-C., B.I.G., T.C., H.L.W, R.G.), Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital; Biostatistics Center (B.C.H.); Massachusetts General Hospital, Boston, MA; Department of Clinical Neuroscience, Neuroimmunology Unit (M.J., F.P., T.O., M.K.), Karolinska Institute, Stockholm, Sweden; Department of Neurology (S.H., J.O.), School of Medicine, University of California, San Francisco; and Nehme and Therese Tohme Multiple Sclerosis Center (S.J.K.), Faculty of Medicine, American University of Beirut Medical Center, Lebanon.

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http://dx.doi.org/10.1212/NXI.0000000000000491DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6117192PMC
September 2018

Rituximab in multiple sclerosis: Frequency and clinical relevance of anti-drug antibodies.

Mult Scler 2018 08 1;24(9):1224-1233. Epub 2017 Aug 1.

Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden / Center for Molecular Medicine, Karolinska University Hospital Solna, Stockholm, Sweden.

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http://dx.doi.org/10.1177/1352458517720044DOI Listing
August 2018

Rituximab is an acceptable alternative to ocrelizumab for treating multiple sclerosis - Yes.

Mult Scler 2018 08 22;24(9):1157-1159. Epub 2018 Feb 22.

Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden/Department of Neurology, Karolinska University Hospital, Stockholm, Sweden.

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http://dx.doi.org/10.1177/1352458518757930DOI Listing
August 2018

Plasma neurofilament light chain levels in patients with MS switching from injectable therapies to fingolimod.

Mult Scler 2018 07 19;24(8):1046-1054. Epub 2017 Jun 19.

Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden/Department of Neurology, Karolinska University Hospital Solna, Stockholm, Sweden.

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http://dx.doi.org/10.1177/1352458517715132DOI Listing
July 2018

Comparative effectiveness of rituximab relative to IFN-β or glatiramer acetate in relapsing-remitting MS from the Swedish MS registry.

Mult Scler 2018 07 26;24(8):1087-1095. Epub 2017 Jun 26.

Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1177/1352458517713668DOI Listing
July 2018

Polygenic link between blood lipids and amyotrophic lateral sclerosis.

Neurobiol Aging 2018 07 27;67:202.e1-202.e6. Epub 2018 Mar 27.

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.neurobiolaging.2018.03.022DOI Listing
July 2018

Cerebrospinal fluid mtDNA concentration is elevated in multiple sclerosis disease and responds to treatment.

Mult Scler 2018 04 15;24(4):472-480. Epub 2017 Mar 15.

Neurochemistry Laboratory and Biobank, Department of Clinical Chemistry, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1177/1352458517699874DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5987988PMC
April 2018

Novel genetic loci associated HLA-B*08:01 positive myasthenia gravis.

J Autoimmun 2018 03 14;88:43-49. Epub 2017 Oct 14.

Department of Laboratory Medicine, Karolinska Institutet at Karolinska University Hospital Huddinge, SE-14186, Stockholm, Sweden; BGI-Shenzhen, Shenzhen, China, China National GeneBank-Shenzhen, 518083, Shenzhen, China.

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http://dx.doi.org/10.1016/j.jaut.2017.10.002DOI Listing
March 2018

Depression and fatigue in multiple sclerosis: Relation to exposure to violence and cerebrospinal fluid immunomarkers.

Psychoneuroendocrinology 2018 03 4;89:53-58. Epub 2018 Jan 4.

Division of Psychiatry, Department of Clinical Neuroscience, Karolinska Institutet, SE-171 77 Stockholm, Sweden; Department of Clinical Sciences, Umeå University, SE-901 87, Umeå, Sweden.

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http://dx.doi.org/10.1016/j.psyneuen.2018.01.002DOI Listing
March 2018

Persistence with dimethyl fumarate in relapsing-remitting multiple sclerosis: a population-based cohort study.

Eur J Clin Pharmacol 2018 Feb 11;74(2):219-226. Epub 2017 Nov 11.

Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1007/s00228-017-2366-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5765201PMC
February 2018

Successful combined targeting of B- and plasma cells in treatment refractory anti-NMDAR encephalitis.

J Neuroimmunol 2017 11 25;312:15-18. Epub 2017 Aug 25.

Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden; Department of Neurology, Karolinska University Hospital, Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.jneuroim.2017.08.011DOI Listing
November 2017

Monitoring disease activity in multiple sclerosis using serum neurofilament light protein.

Neurology 2017 Nov 27;89(22):2230-2237. Epub 2017 Oct 27.

From the Department of Clinical Neuroscience (L.N., M.A., C.M., J.L.) and Department of Psychiatry and Neurochemistry (H.Z., K.B.), Institute of Neuroscience and Physiology at Sahlgrenska Academy, University of Gothenburg; Clinical Neurochemistry Laboratory (H.Z., K.B.), Sahlgrenska University Hospital, Mölndal, Sweden; Department of Molecular Neuroscience (H.Z.), UCL Institute of Neurology, London, UK; Department of Pharmacology and Clinical Neuroscience (P.S.), Umeå University; University Department of Clinical Neuroscience (M.K., T.O., F.P.), Neuroimmunology Unit, and Department of Clinical Sciences (A.S.), Danderyd Hospital, Karolinska Institutet, Stockholm; and Department of Neurology (M.G.), Faculty of Medicine and Health, Örebro University, Sweden.

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http://dx.doi.org/10.1212/WNL.0000000000004683DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5705244PMC
November 2017

Neurodegenerative and psychiatric diseases among families with amyotrophic lateral sclerosis.

Neurology 2017 Aug 12;89(6):578-585. Epub 2017 Jul 12.

From the Departments of Medical Epidemiology and Biostatistics (E.L., D.M., H.L., W.Y., C.A., P.L., F.F.) and Clinical Neuroscience (C.I., F.P.), Karolinska Institutet, Solna; Department of Medical Sciences (H.L.), Örebro University; and Astrid Lindgren Children's Hospital, Lung and Allergy Unit (C.A.), Karolinska University Hospital, Solna, Sweden.

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http://dx.doi.org/10.1212/WNL.0000000000004179DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5562958PMC
August 2017

A minimal unified model of disease trajectories captures hallmarks of multiple sclerosis.

Math Biosci 2017 07 29;289:1-8. Epub 2017 Mar 29.

Unit of Computational Medicine, Center for Molecular Medicine, Department of Medicine, Solna, Karolinska Institutet 17176, Sweden; Biological and Environmental Sciences and Engineering Division, Computer, Electrical and Mathematical Sciences and Engineering Division, King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Saudi Arabia. Electronic address:

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http://dx.doi.org/10.1016/j.mbs.2017.03.006DOI Listing
July 2017

Beneficial effect of tocilizumab in myasthenia gravis refractory to rituximab.

Neuromuscul Disord 2017 Jun 16;27(6):565-568. Epub 2017 Mar 16.

Karolinska University Hospital, Department of Neurology, Stockholm, Sweden; Karolinska Institutet, Department of Clinical Neuroscience, Stockholm, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.nmd.2017.03.007DOI Listing
June 2017

Cerebrospinal fluid biomarkers as a measure of disease activity and treatment efficacy in relapsing-remitting multiple sclerosis.

J Neurochem 2017 04 29;141(2):296-304. Epub 2016 Nov 29.

Department of Clinical Neuroscience, Institute of Neuroscience and Physiology at Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

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http://dx.doi.org/10.1111/jnc.13881DOI Listing
April 2017

Effects of C2ta genetic polymorphisms on MHC class II expression and autoimmune diseases.

Immunology 2017 04 22;150(4):408-417. Epub 2016 Dec 22.

Medical Inflammation Research, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1111/imm.12692DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5343355PMC
April 2017

Multiple Sclerosis-A Tuning Fork Still Required.

Authors:
Fredrik Piehl

JAMA Neurol 2017 03;74(3):264-265

Department of Clinical Neuroscience, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden2Department of Neurology, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden.

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http://dx.doi.org/10.1001/jamaneurol.2016.5126DOI Listing
March 2017

Cross Talk in HEK293 Cells Between Nrf2, HIF, and NF-κB Activities upon Challenges with Redox Therapeutics Characterized with Single-Cell Resolution.

Antioxid Redox Signal 2017 02 11;26(6):229-246. Epub 2015 Nov 11.

1 Division of Biochemistry, Department of Medical Biochemistry and Biophysics, Karolinska Institutet , Stockholm, Sweden .

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http://dx.doi.org/10.1089/ars.2015.6419DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5704776PMC
February 2017

Cerebrospinal fluid biomarkers of inflammation and degeneration as measures of fingolimod efficacy in multiple sclerosis.

Mult Scler 2017 01 11;23(1):62-71. Epub 2016 Jul 11.

Department of Clinical Neuroscience and Rehabilitation, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

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http://dx.doi.org/10.1177/1352458516639384DOI Listing
January 2017

Successful autologous haematopoietic stem cell transplantation for refractory myasthenia gravis - a case report.

Neuromuscul Disord 2017 Jan 28;27(1):90-93. Epub 2016 Sep 28.

Department of Medical Sciences, Division of Haematology, University Hospital, Uppsala, Sweden.

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http://dx.doi.org/10.1016/j.nmd.2016.09.020DOI Listing
January 2017

Reply.

Ann Neurol 2016 11 27;80(5):791-792. Epub 2016 Sep 27.

Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden.

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http://dx.doi.org/10.1002/ana.24767DOI Listing
November 2016

Rituximab in multiple sclerosis: A retrospective observational study on safety and efficacy.

Neurology 2016 Nov 19;87(20):2074-2081. Epub 2016 Oct 19.

From the Department of Pharmacology and Clinical Neuroscience (J.S., R.S., P.I.-J., M.V., P.S., A.S.), Umeå University; Departments of Clinical Neuroscience (R.S., P.A., A.B., K.F., F.P.) and Clinical Sciences, Danderyd Hospital (A.S.), Karolinska Institutet, Stockholm; and Department of Clinical Neuroscience (L.N., C.M., M.A., J.L.), Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Sweden.

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http://dx.doi.org/10.1212/WNL.0000000000003331DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5109942PMC
November 2016

Cognitive function did not improve after initiation of natalizumab treatment in relapsing-remitting multiple sclerosis. A prospective one-year dual control group study.

Mult Scler Relat Disord 2016 Nov 24;10:36-43. Epub 2016 Aug 24.

Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.msard.2016.08.011DOI Listing
November 2016

T-cell activation and HLA-regulated response to smoking in the deep airways of patients with multiple sclerosis.

Clin Immunol 2016 08 23;169:114-120. Epub 2016 Jun 23.

Respiratory Medicine Unit, Department of Medicine and Center for Molecular Medicine, Karolinska Institutet, Karolinska University Hospital, SE-171 76 Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.clim.2016.06.006DOI Listing
August 2016

Chronic inflammatory demyelinating polyradiculoneuropathy occurring after autologous haematopoietic stem cell transplantation for multiple sclerosis.

Mult Scler J Exp Transl Clin 2016 Jan-Dec;2:2055217316658304. Epub 2016 Jul 12.

Department of Neurology, Drammen Hospital, Vestre Viken HF, Norway.

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http://dx.doi.org/10.1177/2055217316658304DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5433337PMC
July 2016

Rituximab versus fingolimod after natalizumab in multiple sclerosis patients.

Ann Neurol 2016 Jun 20;79(6):950-8. Epub 2016 Apr 20.

Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden.

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http://dx.doi.org/10.1002/ana.24651DOI Listing
June 2016

Circulating miR-150 in CSF is a novel candidate biomarker for multiple sclerosis.

Neurol Neuroimmunol Neuroinflamm 2016 Jun 20;3(3):e219. Epub 2016 Apr 20.

Department of Clinical Neuroscience, Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1212/NXI.0000000000000219DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4841644PMC
June 2016

Complement Receptor 2 is increased in cerebrospinal fluid of multiple sclerosis patients and regulates C3 function.

Clin Immunol 2016 05 13;166-167:89-95. Epub 2016 Apr 13.

Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Sweden; Linnæus Center of Biomaterials Chemistry, Linnæus University, Kalmar, Sweden.

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http://dx.doi.org/10.1016/j.clim.2016.04.003DOI Listing
May 2016

High-intensity resistance training in multiple sclerosis - An exploratory study of effects on immune markers in blood and cerebrospinal fluid, and on mood, fatigue, health-related quality of life, muscle strength, walking and cognition.

J Neurol Sci 2016 Mar 3;362:251-7. Epub 2016 Feb 3.

Department of Clinical Neurosciences, K8, Karolinska Institutet, CMM L8:04, S-171 76 Stockholm, Sweden; Department of Neurology, R3:04, Karolinska University Hospital, S-171 76 Stockholm, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.jns.2016.01.063DOI Listing
March 2016

Rituximab in paediatric onset multiple sclerosis: a case series.

J Neurol 2016 Feb 24;263(2):322-326. Epub 2015 Nov 24.

Department of Pharmacology and Clinical Neuroscience, Section of Neurology, Umeå University, 90187, Umeå, Sweden.

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http://dx.doi.org/10.1007/s00415-015-7979-xDOI Listing
February 2016

Lipocalin-2 is increased in progressive multiple sclerosis and inhibits remyelination.

Neurol Neuroimmunol Neuroinflamm 2016 Feb 7;3(1):e191. Epub 2016 Jan 7.

Neuroimmunology Unit (F.A.N., M.K., S.A., T.O., F.P.), Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden; Institute of Infection, Immunity and Inflammation (C.E., C.L.), University of Glasgow, UK; Department of Pharmacology and Clinical Neuroscience (J.B., A.M.D., A.S.) and Neurosurgery (T.B.), Umeå University, Sweden; and Danish Multiple Sclerosis Center (J.R.C., F.S.), Department of Neurology, Rigshospitalet, University of Copenhagen, Denmark.

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http://dx.doi.org/10.1212/NXI.0000000000000191DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4708925PMC
February 2016

Cerebrospinal fluid kynurenines in multiple sclerosis; relation to disease course and neurocognitive symptoms.

Brain Behav Immun 2016 Jan 17;51:47-55. Epub 2015 Jul 17.

Department of Clinical Neuroscience, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.bbi.2015.07.016DOI Listing
January 2016

Hexosylceramides as intrathecal markers of worsening disability in multiple sclerosis.

Mult Scler 2015 Sep 5;21(10):1271-9. Epub 2014 Dec 5.

Department of Medical Biochemistry and Biophysics, Division of Physiological Chemistry II, Karolinska Institutet, Stockholm, Sweden

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http://dx.doi.org/10.1177/1352458514561908DOI Listing
September 2015

MicroRNAs as promising novel biomarkers and potential drug targets for inflammatory neurological diseases.

J Neurol Sci 2015 Sep 14;356(1-2):3-4. Epub 2015 Jun 14.

Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.jns.2015.06.023DOI Listing
September 2015

P300 amplitude and response speed relate to preserved cognitive function in relapsing-remitting multiple sclerosis.

Clin Neurophysiol 2015 Apr 20;126(4):689-97. Epub 2014 Aug 20.

Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S13882457140042
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http://dx.doi.org/10.1016/j.clinph.2014.07.024DOI Listing
April 2015

[A recently acknowledged state with great variation in severity. NMDAR encephalitis frequently misinterpreted as psychiatric illness].

Lakartidningen 2015 Mar 24;112. Epub 2015 Mar 24.

Karolinska Universitetssjukhuset Solna - Neurologiska kliniken Stockholm, Sweden.

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March 2015

Risk factors for amyotrophic lateral sclerosis.

Clin Epidemiol 2015 12;7:181-93. Epub 2015 Feb 12.

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.2147/CLEP.S37505DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4334292PMC
February 2015

Variability in C-type lectin receptors regulates neuropathic pain-like behavior after peripheral nerve injury.

Mol Pain 2014 Dec 10;10:78. Epub 2014 Dec 10.

Department of Clinical Neuroscience, Neuroimmunology Unit, CMM L8:05, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1186/1744-8069-10-78DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4271486PMC
December 2014

Multiple sclerosis-associated IL2RA polymorphism controls GM-CSF production in human TH cells.

Nat Commun 2014 Oct 3;5:5056. Epub 2014 Oct 3.

Institute of Experimental Immunology, University of Zurich, Winterthurerstrasse 190, Zurich 8052, Switzerland.

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http://dx.doi.org/10.1038/ncomms6056DOI Listing
October 2014