Publications by authors named "Frederico C Pereira"

31 Publications

Repeated Administration of Clinically Relevant Doses of the Prescription Opioids Tramadol and Tapentadol Causes Lung, Cardiac, and Brain Toxicity in Wistar Rats.

Pharmaceuticals (Basel) 2021 Jan 27;14(2). Epub 2021 Jan 27.

IINFACTS-Institute of Research and Advanced Training in Health Sciences and Technologies, Department of Sciences, University Institute of Health Sciences (IUCS), CESPU, CRL, 4585-116 Gandra, Portugal.

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January 2021

Circulating Extracellular Vesicles: The Missing Link between Physical Exercise and Depression Management?

Int J Mol Sci 2021 Jan 7;22(2). Epub 2021 Jan 7.

Institute of Pharmacology and Experimental Therapeutics/IBILI, Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, Portugal.

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January 2021

Pharmacotherapeutic strategies for methamphetamine use disorder: mind the subgroups.

Expert Opin Pharmacother 2019 Dec 31;20(18):2273-2293. Epub 2019 Oct 31.

Institute of Pharmacology and Experimental Therapeutics/iCBR, Faculty of Medicine, University of Coimbra, Coimbra, Portugal.

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December 2019

Heartfelt exercise: Physical exercise gets the cardiovascular system into shape.

Rev Port Cardiol 2019 05 18;38(5):347-348. Epub 2019 Jun 18.

Institute of Pharmacology and Experimental Therapeutics/IBILI, Faculty of Medicine, University of Coimbra, Coimbra, Portugal; CNC.IBILI-University of Coimbra, Coimbra, Portugal. Electronic address:

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May 2019

Efficacy Analysis of Capsaicin 8% Patch in Neuropathic Peripheral Pain Treatment.

Pharmacology 2018 27;101(5-6):290-297. Epub 2018 Mar 27.

Department of Physical Medicine and Rehabilitation, Northwestern University, Sensory Motor Performance Program, Rehabilitation Institute of Chicago, Chicago, Illinois, USA.

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September 2018

Glucose and Lipid Dysmetabolism in a Rat Model of Prediabetes Induced by a High-Sucrose Diet.

Nutrients 2017 Jun 21;9(6). Epub 2017 Jun 21.

Center of Neuroscience and Cell Biology (CNC) and CNC.IBILI Research Consortium, University of Coimbra, 3004-504 Coimbra, Portugal.

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June 2017

The effects of physical exercise on nonmotor symptoms and on neuroimmune RAGE network in experimental parkinsonism.

J Appl Physiol (1985) 2017 Jul 6;123(1):161-171. Epub 2017 Apr 6.

Laboratory of Pharmacology and Experimental Therapeutics, Institute for Biomedical Imaging and Life Sciences, Faculty of Medicine, University of Coimbra, Coimbra, Portugal;

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July 2017

Mitochondrial Metabolism Regulates Microtubule Acetylome and Autophagy Trough Sirtuin-2: Impact for Parkinson's Disease.

Mol Neurobiol 2018 02 6;55(2):1440-1462. Epub 2017 Feb 6.

CNC - Center for Neuroscience and Cell Biology, University of Coimbra, Largo Marquês de Pombal, 3004-517, Coimbra, Portugal.

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February 2018

Parkinson's disease-associated GPR37 receptor regulates cocaine-mediated synaptic depression in corticostriatal synapses.

Neurosci Lett 2017 01 19;638:162-166. Epub 2016 Dec 19.

Unitat de Farmacologia, Departament Patologia i Terapèutica Experimental, Facultat de Medicina, IDIBELL, Universitat de Barcelona, L'Hospitalet de Llobregat, Spain; Institut de Neurosciències, Universitat de Barcelona, Barcelona, Spain. Electronic address:

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January 2017

Methamphetamine Induces Anhedonic-Like Behavior and Impairs Frontal Cortical Energetics in Mice.

CNS Neurosci Ther 2017 Feb 19;23(2):119-126. Epub 2016 Oct 19.

Laboratory of Pharmacology and Experimental Therapeutics/Biomedical Imaging and Life Sciences (IBILI), Faculty of Medicine, University of Coimbra, Coimbra, Portugal.

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February 2017

Monophosphoryl Lipid-A: A Promising Tool for Alzheimer's Disease Toll.

J Alzheimers Dis 2016 04;52(4):1189-202

Laboratório de Farmacologia e Terapêutica Experimental/IBILI, Faculdade de Medicina da Universidade de Coimbra, Portugal.

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April 2016

Presymptomatic MPTP Mice Show Neurotrophic S100B/mRAGE Striatal Levels.

CNS Neurosci Ther 2016 May 4;22(5):396-403. Epub 2016 Feb 4.

Laboratory of Pharmacology and Experimental Therapeutics/IBILI, Faculty of Medicine, University of Coimbra, Coimbra, Portugal.

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May 2016

Decreased synaptic plasticity in the medial prefrontal cortex underlies short-term memory deficits in 6-OHDA-lesioned rats.

Behav Brain Res 2016 Mar 18;301:43-54. Epub 2015 Dec 18.

Departamento de Farmacologia, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, Florianópolis 88049-900, SC, Brazil; Centro de Neurociências Aplicadas (CeNAp), Hospital Universitário (HU), Universidade Federal de Santa Catarina, Florianópolis, SC, Brazil. Electronic address:

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March 2016

Impaired adrenal medullary function in a mouse model of depression induced by unpredictable chronic stress.

Eur Neuropsychopharmacol 2015 Oct 2;25(10):1753-66. Epub 2015 Jul 2.

CNC - Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal; Faculty of Pharmacy, University of Coimbra, Coimbra, Portugal. Electronic address:

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October 2015

A single neurotoxic dose of methamphetamine induces a long-lasting depressive-like behaviour in mice.

Neurotox Res 2014 Apr 26;25(3):295-304. Epub 2013 Sep 26.

Laboratory of Pharmacology and Experimental Therapeutics, IBILI, Faculty of Medicine, University of Coimbra, Subunit 1 - Polo 3, Azinhaga de Santa Comba, Celas, 3000-548, Coimbra, Portugal.

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April 2014

Early cardiac changes in a rat model of prediabetes: brain natriuretic peptide overexpression seems to be the best marker.

Cardiovasc Diabetol 2013 Mar 7;12:44. Epub 2013 Mar 7.

Laboratory of Pharmacology and Experimental Therapeutics, IBILI, Faculty of Medicine, University of Coimbra, Coimbra, Portugal.

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March 2013

Dexamethasone effect on postoperative pain and tramadol requirement after thyroidectomy.

Pharmacology 2013 6;91(3-4):153-7. Epub 2013 Feb 6.

Department of Anaesthesiology, Centro Hospitalar Tondela-Viseu, E.P.E, Viseu, Portugal.

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December 2013

Disruption of striatal glutamatergic/GABAergic homeostasis following acute methamphetamine in mice.

Neurotoxicol Teratol 2012 Sep-Oct;34(5):522-9. Epub 2012 Aug 2.

Pharmacology and Experimental Therapeutics/Biomedical Institute for Research on Light and Image (IBILI), University of Coimbra, Portugal.

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February 2013

Buprenorphine modulates methamphetamine-induced dopamine dynamics in the rat caudate nucleus.

Neurotox Res 2011 Jan 22;19(1):94-101. Epub 2009 Dec 22.

Institute of Pharmacology and Therapeutics, Biomedical Institute for Research in Light and Image, Faculty of Medicine, University of Coimbra, Subunit 1-Polo 3, Azinhaga de Santa Comba, Celas, 3000-354 Coimbra, Portugal.

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January 2011

Influence of chronic exercise on the amphetamine-induced dopamine release and neurodegeneration in the striatum of the rat.

Ann N Y Acad Sci 2008 Oct;1139:222-31

Department of Pharmacology, Biomedical Institute for Research on Light and Image (IBILI), Faculty of Medicine, University of Coimbra, Coimbra, Portugal.

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October 2008

Acute increase of the glutamate-glutamine cycling in discrete brain areas after administration of a single dose of amphetamine.

Ann N Y Acad Sci 2008 Oct;1139:212-21

Institute of Pharmacology and Therapeutics and Biomedical Institute for Research in Light and Image (IBILI), Faculty of Medicine, University of Coimbra, Coimbra, Portugal.

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October 2008

A single exposure to morphine induces long-lasting hyporeactivity of rat caudate putamen dopaminergic nerve terminals.

Ann N Y Acad Sci 2004 Oct;1025:414-23

Instituto de Farmacologia e Terapêutica, Medical School, University of Coimbra, Coimbra, Portugal.

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October 2004