Frederick W Miller

Frederick W Miller

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Frederick W Miller

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Identification of distinctive interferon gene signatures in different types of myositis.

Neurology 2019 Sep 21;93(12):e1193-e1204. Epub 2019 Aug 21.

From the National Institute of Arthritis and Musculoskeletal and Skin Diseases (I.P.-F, M.C.-D, A.D., K.P., P.P., F.W.M., A.L.M.), NIH, Bethesda; Johns Hopkins University School of Medicine (I.P.-F., M.C.-D., J.P., J.A., L.C.-S., T.E.L., A.M.C., A.L.M.), Baltimore, MD; Clinic Hospital and the University of Barcelona (J.C.M., J.M.G.-J.); Vall d'Hebron Hospital and Autonomous University of Barcelona (A.S.-O.); and Faculty of Health Sciences (I.P.-F.), Universitat Oberta de Catalunya, Barcelona, Spain.

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http://dx.doi.org/10.1212/WNL.0000000000008128DOI Listing
September 2019

Endothelial Activation Markers as Disease Activity and Damage Measures in Juvenile Dermatomyositis.

J Rheumatol 2019 Aug 1. Epub 2019 Aug 1.

From the Environmental Autoimmunity Group, Clinical Research Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Bethesda, MD, USA. The source of support in the form of grants or industrial supports: This work was supported by in part by the Intramural Research Program of the National Institute of Environmental Health Sciences (project ES101074, Takayuki Kishi, Lisa Rider, and Frederick Miller). Takayuki Kishi was supported by a research fellowship of the Cure JM Foundation and by Tokyo Women's Medical University. Address correspondence to: Dr. Lisa G. Rider, M.D. Deputy Chief, Environmental Autoimmunity Group, Clinical Research Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Building 10, CRC Rm 6-5700, MSC 1301 10 Center Drive, Bethesda, MD 20892-1301 E-mail:

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http://dx.doi.org/10.3899/jrheum.181275DOI Listing
August 2019

Anti-Ro52 autoantibodies are associated with interstitial lung disease and more severe disease in patients with juvenile myositis.

Ann Rheum Dis 2019 Jul 24;78(7):988-995. Epub 2019 Apr 24.

Environmental Autoimmunity Group, National Institute of EnvironmentalHealth Sciences, National Institutes of Health (NIH), Bethesda, MD, United States.

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http://dx.doi.org/10.1136/annrheumdis-2018-215004DOI Listing
July 2019

Response to: 'response to: 'Anti-Ro52 autoantibodies are associated with interstitial lung disease and more severe disease in patients with juvenile myositis' by Sabbagh S by Yang .

Ann Rheum Dis 2019 Jun 17. Epub 2019 Jun 17.

Muscle Disease Unit, Laboratory of Muscle Stem Cells and Gene Expression, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland, USA

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http://dx.doi.org/10.1136/annrheumdis-2019-215693DOI Listing
June 2019

Long-term outcomes in Juvenile Myositis patients.

Semin Arthritis Rheum 2019 Jun 28. Epub 2019 Jun 28.

Division of Rheumatology, Department of Medicine, George Washington University, Washington, DC, United States; Environmental Autoimmunity Group, National Institute of Environmental Health Sciences, National Institutes of Health, Bethesda, MD, United States. Electronic address:

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http://dx.doi.org/10.1016/j.semarthrit.2019.06.014DOI Listing
June 2019

Medications received by patients with juvenile dermatomyositis.

Semin Arthritis Rheum 2018 12 28;48(3):513-522. Epub 2018 Mar 28.

Environmental Autoimmunity Group, Clinical Research Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Building 10, Rm 4-2352, MSC 1301, 10 Center Drive, Bethesda, MD 20892-1301. Electronic address:

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http://dx.doi.org/10.1016/j.semarthrit.2018.03.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6162169PMC
December 2018

Prescription medication use and antinuclear antibodies in the United States, 1999-2004.

J Autoimmun 2018 08 18;92:93-103. Epub 2018 May 18.

Clinical Research Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jaut.2018.05.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6054905PMC
August 2018

Anti-NT5C1A autoantibodies are associated with more severe disease in patients with juvenile myositis.

Ann Rheum Dis 2018 05 23;77(5):714-719. Epub 2018 Jan 23.

Muscle Disease Unit, Laboratory of Muscle Stem Cells and Gene Regulation, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health (NIH), Bethesda, Maryland, USA.

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http://dx.doi.org/10.1136/annrheumdis-2017-212436DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5898976PMC
May 2018

Risk factors and disease mechanisms in myositis.

Nat Rev Rheumatol 2018 04;14(5):255-268

Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, Binghamton University, Binghamton, NY, USA.

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http://dx.doi.org/10.1038/nrrheum.2018.48DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6745704PMC
April 2018

Antinuclear antibodies and mortality in the National Health and Nutrition Examination Survey (1999-2004).

PLoS One 2017 9;12(10):e0185977. Epub 2017 Oct 9.

Clinical Research Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Bethesda, Maryland, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0185977PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5633179PMC
October 2017

Association of Anti-3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase Autoantibodies With DRB1*07:01 and Severe Myositis in Juvenile Myositis Patients.

Arthritis Care Res (Hoboken) 2017 07;69(7):1088-1094

Laboratory of Muscle Stem Cells and Gene Expression, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland.

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http://doi.wiley.com/10.1002/acr.23113
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http://dx.doi.org/10.1002/acr.23113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5487292PMC
July 2017

Muscle myeloid type I interferon gene expression may predict therapeutic responses to rituximab in myositis patients.

Rheumatology (Oxford) 2016 09 23;55(9):1673-80. Epub 2016 May 23.

Environmental Autoimmunity Group, National Institute of Environmental Health Sciences, National Institutes of Health, Bethesda, MD, USA

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http://dx.doi.org/10.1093/rheumatology/kew213DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5854096PMC
September 2016

Gene Expression Profiles from Disease Discordant Twins Suggest Shared Antiviral Pathways and Viral Exposures among Multiple Systemic Autoimmune Diseases.

PLoS One 2015 10;10(11):e0142486. Epub 2015 Nov 10.

Environmental Autoimmunity Group, Clinical Research Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Bethesda, Maryland, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0142486PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4640563PMC
June 2016

Magnetic resonance measurement of muscle T2, fat-corrected T2 and fat fraction in the assessment of idiopathic inflammatory myopathies.

Rheumatology (Oxford) 2016 Mar 27;55(3):441-9. Epub 2015 Sep 27.

Environmental Autoimmunity Group, Clinical Research Branch, National Institute of Environmental Health Sciences and

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http://dx.doi.org/10.1093/rheumatology/kev344DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4757924PMC
March 2016

Chimeric cells of maternal origin do not appear to be pathogenic in the juvenile idiopathic inflammatory myopathies or muscular dystrophy.

Arthritis Res Ther 2015 Sep 4;17:238. Epub 2015 Sep 4.

National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Environmental Autoimmunity Group, Program of Clinical Research, 9000 Rockville Pike, Bethesda, MD, 20892, USA.

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http://dx.doi.org/10.1186/s13075-015-0732-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4558637PMC
September 2015

Novel assessment tools to evaluate clinical and laboratory responses in a subset of patients enrolled in the Rituximab in Myositis trial.

Clin Exp Rheumatol 2014 Sep-Oct;32(5):689-96. Epub 2014 Jul 28.

Environmental Autoimmunity Group, Program of Clinical Research, NIEHS, NIH, Department of Health and Human Services (DHHS), Bethesda, MD, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4644185PMC
December 2014

Myositis registries and biorepositories: powerful tools to advance clinical, epidemiologic and pathogenic research.

Curr Opin Rheumatol 2014 Nov;26(6):724-41

aEnvironmental Autoimmunity Group, Program of Clinical Research, National Institute of Environmental Health Sciences, National Institutes of Health (NIH), DHHS, Bethesda, Maryland, USA bDivision of Immunology, 3rd Department of Internal Medicine, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5081267PMC
http://dx.doi.org/10.1097/BOR.0000000000000119DOI Listing
November 2014

Expert panel workshop consensus statement on the role of the environment in the development of autoimmune disease.

Int J Mol Sci 2014 Aug 15;15(8):14269-97. Epub 2014 Aug 15.

Division of Extramural Research and Training, NIEHS, NIH, Research Triangle Park, NC 27709, USA.

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http://dx.doi.org/10.3390/ijms150814269DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4159850PMC
August 2014

Idiopathic inflammatory myopathies and the anti-synthetase syndrome: a comprehensive review.

Autoimmun Rev 2014 Apr-May;13(4-5):367-71. Epub 2014 Jan 11.

Department of Medicine, University of Calgary, Calgary, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15689972140003
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http://dx.doi.org/10.1016/j.autrev.2014.01.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3970575PMC
May 2014

The myositis autoantibody phenotypes of the juvenile idiopathic inflammatory myopathies.

Medicine (Baltimore) 2013 Jul;92(4):223-43

Environmental Autoimmunity Group, Program of Clinical Research, National Institute of Environmental Health Sciences, National Institutes of Health, DHHS, Bethesda, Maryland 20892-1301, USA.

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http://dx.doi.org/10.1097/MD.0b013e31829d08f9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3721421PMC
July 2013

Childhood socioeconomic factors and perinatal characteristics influence development of rheumatoid arthritis in adulthood.

Ann Rheum Dis 2013 Mar 14;72(3):350-6. Epub 2012 May 14.

Epidemiology Branch, Division of Intramural Research, National Institute of Environmental Health Sciences, Durham, NC 27599, USA.

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http://ard.bmj.com/lookup/doi/10.1136/annrheumdis-2011-20108
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http://dx.doi.org/10.1136/annrheumdis-2011-201083DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5029277PMC
March 2013

The clinical phenotypes of the juvenile idiopathic inflammatory myopathies.

Medicine (Baltimore) 2013 Jan;92(1):25-41

Environmental Autoimmunity Group, Program of Clinical Research, National Institute of Environmental Health Sciences, National Institutes of Health, DHHS, Bethesda, Maryland 20892-1301, USA.

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http://pdfs.journals.lww.com/md-journal/2013/01000/The_Clini
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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1097/MD.0b013e31827f264dDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4580479PMC
January 2013

Plasma proteomic profiles from disease-discordant monozygotic twins suggest that molecular pathways are shared in multiple systemic autoimmune diseases.

Arthritis Res Ther 2011 1;13(6):R181. Epub 2011 Nov 1.

Environmental Autoimmunity Group, National Institute of Environmental Health Sciences, National Institutes of Health, DHHS, 9000 Rockville Pike, Bethesda, MD 20892, USA.

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http://arthritis-research.biomedcentral.com/articles/10.1186
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http://dx.doi.org/10.1186/ar3506DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3315681PMC
December 2012

Epidemiology of environmental exposures and human autoimmune diseases: findings from a National Institute of Environmental Health Sciences Expert Panel Workshop.

J Autoimmun 2012 Dec 25;39(4):259-71. Epub 2012 Jun 25.

Environmental Autoimmunity Group, National Institute of Environmental Health Sciences, National Institutes of Health Clinical Research Center, Bethesda, MD 20892-1301, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S08968411120005
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http://dx.doi.org/10.1016/j.jaut.2012.05.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3496812PMC
December 2012

Criteria for environmentally associated autoimmune diseases.

J Autoimmun 2012 Dec 6;39(4):253-8. Epub 2012 Jul 6.

Environmental Autoimmunity Group, National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health Clinical Research Center, Bethesda, MD 20892-1301, USA.

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http://dx.doi.org/10.1016/j.jaut.2012.05.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3468712PMC
December 2012

Laboratory Test Abnormalities are Common in Polymyositis and Dermatomyositis and Differ Among Clinical and Demographic Groups.

Open Rheumatol J 2012 1;6:54-63. Epub 2012 Jun 1.

Environmental Autoimmunity Group, Program of Clinical Research, National Institute of Environmental Health Sciences, National Institutes of Health, HHS, Bethesda, Maryland, USA.

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http://dx.doi.org/10.2174/1874312901206010054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3377888PMC
August 2012

New approaches to the assessment and treatment of the idiopathic inflammatory myopathies.

Ann Rheum Dis 2012 Apr;71 Suppl 2:i82-5

Environmental Autoimmunity Group, Program of Clinical Research, National Institute of Environmental Health Sciences, National Institutes of Health Clinical Research Centre, NIH 10, 10 Centre Drive, MSC 1301 Bethesda, MD 20892-1301, USA.

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http://dx.doi.org/10.1136/annrheumdis-2011-200587DOI Listing
April 2012

State of the art: what we know about infectious agents and myositis.

Curr Opin Rheumatol 2011 Nov;23(6):585-94

National Institutes of Health Clinical Research Center, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1097/BOR.0b013e32834b5457DOI Listing
November 2011

Mass spectrometric determination of IgG subclass-specific glycosylation profiles in siblings discordant for myositis syndromes.

J Proteome Res 2011 Jul 8;10(7):2969-78. Epub 2011 Jun 8.

Laboratory of Structural Biology, NIH/DHHS, Research Triangle Park, North Carolina 27709, USA.

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http://pubs.acs.org/doi/abs/10.1021/pr200397h
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http://dx.doi.org/10.1021/pr200397hDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3137520PMC
July 2011

Environmental agents and autoimmune diseases.

Adv Exp Med Biol 2011 ;711:61-81

National Institute of Environmental Health Sciences, National Institutes of Health, HHS, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1007/978-1-4419-8216-2_6DOI Listing
June 2011

Gene expression profiles from discordant monozygotic twins suggest that molecular pathways are shared among multiple systemic autoimmune diseases.

Arthritis Res Ther 2011 Apr 26;13(2):R69. Epub 2011 Apr 26.

Environmental Autoimmunity Group, National Institute of Environmental Health Sciences, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1186/ar3330DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3132064PMC
April 2011

Deciphering the clinical presentations, pathogenesis, and treatment of the idiopathic inflammatory myopathies.

JAMA 2011 Jan;305(2):183-90

Environmental Autoimmunity Group, Program of Clinical Research, National Institute of Environmental Health Sciences, National Institutes of Health, US Department of Health and Human Services, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1001/jama.2010.1977DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4047218PMC
January 2011

Environmental factors preceding illness onset differ in phenotypes of the juvenile idiopathic inflammatory myopathies.

Rheumatology (Oxford) 2010 Dec 27;49(12):2381-90. Epub 2010 Aug 27.

Environmental Autoimmunity Group, National Institute of Environmental Sciences, National Institutes of Health, DHHS, Clinical Research Center Room 4-2352, 10 Center Drive, MSC 1301, Bethesda, MD 20892-1301, USA.

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http://dx.doi.org/10.1093/rheumatology/keq277DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2981509PMC
December 2010

Microstructure and mineral composition of dystrophic calcification associated with the idiopathic inflammatory myopathies.

Arthritis Res Ther 2009 26;11(5):R159. Epub 2009 Oct 26.

Paffenbarger Research Center, American Dental Association Foundation, National Institute of Standards and Technology, 100 Bureau Drive, Stop 8546, Gaithersburg, MD 20899, USA.

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http://arthritis-research.biomedcentral.com/articles/10.1186
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http://dx.doi.org/10.1186/ar2841DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2787294PMC
February 2010

Metabolic abnormalities and cardiovascular risk factors in children with myositis.

J Pediatr 2009 Dec 29;155(6):882-7. Epub 2009 Jul 29.

National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892-1301, USA.

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http://dx.doi.org/10.1016/j.jpeds.2009.06.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2809424PMC
December 2009

Genetic risk and protective factors for the idiopathic inflammatory myopathies.

Curr Rheumatol Rep 2009 Aug;11(4):287-94

National Institute of Environmental Health Sciences, National Institutes of Health, Room 1W101, Bethesda, MD 20892, USA.

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August 2009

Photoessay of the cutaneous manifestations of the idiopathic inflammatory myopathies.

Dermatol Online J 2009 Feb 15;15(2). Epub 2009 Feb 15.

Division of Dermatology, Department of Medicine, Georgetown University Hospital, Washington, DC.

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February 2009

Review of the classification and assessment of the cutaneous manifestations of the idiopathic inflammatory myopathies.

Dermatol Online J 2009 Feb 15;15(2). Epub 2009 Feb 15.

Division of Dermatology, Department of Medicine, Georgetown University Hospital, Washington, DC.

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February 2009

UV radiation regulates Mi-2 through protein translation and stability.

J Biol Chem 2008 Dec 15;283(50):34976-82. Epub 2008 Oct 15.

Laboratory of Molecular Carcinogenesis, NIEHS, National Intitutes of Health, Research Triangle Park, NC 27709, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M805383200
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http://dx.doi.org/10.1074/jbc.M805383200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2596409PMC
December 2008

Alternative scoring of the Cutaneous Assessment Tool in juvenile dermatomyositis: results using abbreviated formats.

Arthritis Rheum 2008 Mar;59(3):352-6

Izaak Walton Killam Health Centre and Dalhousie University, Halifax, Nova Scotia, Canada.

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http://dx.doi.org/10.1002/art.23313DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2598766PMC
March 2008

Seasonal birth patterns in myositis subgroups suggest an etiologic role of early environmental exposures.

Arthritis Rheum 2007 Aug;56(8):2719-28

Environmental Autoimmunity Group, National Institute of Environmental Health Sciences, NIH/DHHS, 10 Center Drive, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1002/art.22751DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2151046PMC
August 2007

Late-onset gastrointestinal pain in juvenile dermatomyositis as a manifestation of ischemic ulceration from chronic endarteropathy.

Arthritis Rheum 2007 Jun;57(5):881-4

Environmental Autoimmunity Group, National Institute of Environmental Health Sciences, Bethesda, Maryland 20892-1301, USA.

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http://dx.doi.org/10.1002/art.22782DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2099313PMC
June 2007

Mechanisms of disease: Environmental factors in the pathogenesis of rheumatic disease.

Nat Clin Pract Rheumatol 2007 Mar;3(3):172-80

Environmental Autoimmunity Group, National Institute of Environmental Health Sciences, NIH, Bethesda, MD 20892-1301, USA.

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http://www.nature.com/articles/ncprheum0435
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http://dx.doi.org/10.1038/ncprheum0435DOI Listing
March 2007

Developing international consensus on measures of improvement for patients with myositis.

Stat Methods Med Res 2007 Feb;16(1):51-64

FDA Center for Biologics Evaluation and Research, USA.

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http://dx.doi.org/10.1177/0962280206070652DOI Listing
February 2007

Is occupational exposure to mineral oil a risk factor for rheumatoid arthritis?

Nat Clin Pract Rheumatol 2006 Mar;2(3):130-1

Environmental Autoimmunity Group, National Institutes of Health, DHHS, Clinical Research Center, Bethesda, MD 20892-1301, USA.

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http://dx.doi.org/10.1038/ncprheum0137DOI Listing
March 2006

Endothelial cell activation and neovascularization are prominent in dermatomyositis.

J Autoimmune Dis 2006 Feb 20;3. Epub 2006 Feb 20.

Children's National Medical Center, Research Center for Genetic Medicine, 111 Michigan Ave NW, Washington, DC 20010, USA.

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http://dx.doi.org/10.1186/1740-2557-3-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1397829PMC
February 2006