Frederick W Alt

Frederick W Alt

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Frederick W Alt

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RAG Chromatin Scanning During V(D)J Recombination and Chromatin Loop Extrusion are Related Processes.

Adv Immunol 2018 27;139:93-135. Epub 2018 Aug 27.

Program in Cellular and Molecular Medicine, Boston Children's Hospital, and Department of Genetics, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA, United States.

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http://dx.doi.org/10.1016/bs.ai.2018.07.001DOI Listing
September 2019

DNA double-strand breaks as drivers of neural genomic change, function, and disease.

DNA Repair (Amst) 2018 11 23;71:158-163. Epub 2018 Aug 23.

Department of Neurological Surgery and Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, CA 94158, United States. Electronic address:

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http://dx.doi.org/10.1016/j.dnarep.2018.08.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340756PMC
November 2018

Neural blastocyst complementation enables mouse forebrain organogenesis.

Nature 2018 11 10;563(7729):126-130. Epub 2018 Oct 10.

Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children's Hospital, Department of Genetics and Department of Pediatrics, Harvard Medical School, Boston, MA, USA.

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http://www.nature.com/articles/s41586-018-0586-0
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http://dx.doi.org/10.1038/s41586-018-0586-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6588192PMC
November 2018

Guiding a mutator in antibody diversification.

Cell Res 2018 10;28(10):963-964

Boston Children's Hospital, Harvard Medical School, HHMI, Boston, MA, 02115, USA.

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http://dx.doi.org/10.1038/s41422-018-0085-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6170500PMC
October 2018

DNA melting initiates the RAG catalytic pathway.

Nat Struct Mol Biol 2018 08 30;25(8):732-742. Epub 2018 Jul 30.

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1038/s41594-018-0098-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6080600PMC
August 2018

CTCF-Binding Elements Mediate Accessibility of RAG Substrates During Chromatin Scanning.

Cell 2018 06 24;174(1):102-116.e14. Epub 2018 May 24.

Howard Hughes Medical Institute; Program in Cellular and Molecular Medicine, Boston Children's Hospital, and Department of Genetics, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00928674183056
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http://dx.doi.org/10.1016/j.cell.2018.04.035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6026039PMC
June 2018

Three classes of recurrent DNA break clusters in brain progenitors identified by 3D proximity-based break joining assay.

Proc Natl Acad Sci U S A 2018 02 5;115(8):1919-1924. Epub 2018 Feb 5.

Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115;

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http://dx.doi.org/10.1073/pnas.1719907115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5828622PMC
February 2018

Histone methyltransferase MMSET promotes AID-mediated DNA breaks at the donor switch region during class switch recombination.

Proc Natl Acad Sci U S A 2017 12 20;114(49):E10560-E10567. Epub 2017 Nov 20.

UMR1126 Institut National de la Santé et de la Recherche Médicale, Université Paris Diderot, Sorbonne Paris Cité, Institut Universitaire d'Hématologie, 75475 Paris, France;

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http://dx.doi.org/10.1073/pnas.1701366114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5724247PMC
December 2017

Mechanism of tandem duplication formation in BRCA1-mutant cells.

Nature 2017 11 22;551(7682):590-595. Epub 2017 Nov 22.

Department of Medicine, Division of Hematology-Oncology and Cancer Research Institute, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/nature24477DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5728692PMC
November 2017

Synthetic lethality between murine DNA repair factors XLF and DNA-PKcs is rescued by inactivation of Ku70.

DNA Repair (Amst) 2017 09 26;57:133-138. Epub 2017 Jul 26.

Institute for Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Laboratory Center, Erling Skjalgssons Gate 1, 7491 Trondheim, Norway; The NNF Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen, Denmark; Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children's Hospital, Department of Genetics, Harvard Medical School, Boston, MA 02115, United States; St. Olavs Hospital, Trondheim University Hospital, Clinic of Medicine, Postboks 3250 Sluppen, 7006 Trondheim, Norway. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15687864173013
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http://dx.doi.org/10.1016/j.dnarep.2017.07.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5584571PMC
September 2017

AID Recognizes Structured DNA for Class Switch Recombination.

Mol Cell 2017 Aug 27;67(3):361-373.e4. Epub 2017 Jul 27.

Program in Cellular and Molecular Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10972765173049
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http://dx.doi.org/10.1016/j.molcel.2017.06.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5771415PMC
August 2017

Human Ig knockin mice to study the development and regulation of HIV-1 broadly neutralizing antibodies.

Immunol Rev 2017 01;275(1):89-107

Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children's Hospital and Department of Genetics, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1111/imr.12505DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5300080PMC
January 2017

An Ectopic CTCF Binding Element Inhibits Tcrd Rearrangement by Limiting Contact between Vδ and Dδ Gene Segments.

J Immunol 2016 10 9;197(8):3188-3197. Epub 2016 Sep 9.

Department of Immunology, Duke University Medical Center, Durham, NC 27710;

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http://dx.doi.org/10.4049/jimmunol.1601124DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5380924PMC
October 2016

PAXX and XLF DNA repair factors are functionally redundant in joining DNA breaks in a G1-arrested progenitor B-cell line.

Proc Natl Acad Sci U S A 2016 09 6;113(38):10619-24. Epub 2016 Sep 6.

Howard Hughes Medical Institute, Boston, MA 02115; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA 02115; Department of Genetics, Harvard Medical School, Boston, MA 02115.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5035843PMC
http://dx.doi.org/10.1073/pnas.1611882113DOI Listing
September 2016

Orientation-specific RAG activity in chromosomal loop domains contributes to Tcrd V(D)J recombination during T cell development.

J Exp Med 2016 08 15;213(9):1921-36. Epub 2016 Aug 15.

Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine Children's Hospital Boston, Department of Genetics, Harvard Medical School, Boston, MA 02115

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http://dx.doi.org/10.1084/jem.20160670DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4995090PMC
August 2016

Highly sensitive and unbiased approach for elucidating antibody repertoires.

Proc Natl Acad Sci U S A 2016 07 27;113(28):7846-51. Epub 2016 Jun 27.

Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA 02115; Department of Genetics, Harvard Medical School, Boston, MA 02115; Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115

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http://dx.doi.org/10.1073/pnas.1608649113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4948367PMC
July 2016

Detecting DNA double-stranded breaks in mammalian genomes by linear amplification-mediated high-throughput genome-wide translocation sequencing.

Nat Protoc 2016 May 31;11(5):853-71. Epub 2016 Mar 31.

Program in Cellular and Molecular Medicine, Boston Children's Hospital, Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/nprot.2016.043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4895203PMC
May 2016

Sequential activation and distinct functions for distal and proximal modules within the IgH 3' regulatory region.

Proc Natl Acad Sci U S A 2016 Feb 1;113(6):1618-23. Epub 2016 Feb 1.

Contrôle de la Réponse Immune B et des Lymphoproliférations, UMR 7276, Centre National de la Recherche Scientifique, Université de Limoges, 87025 Limoges, France;

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http://dx.doi.org/10.1073/pnas.1514090113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4760834PMC
February 2016

Long Neural Genes Harbor Recurrent DNA Break Clusters in Neural Stem/Progenitor Cells.

Cell 2016 Feb;164(4):644-55

Program in Cellular and Molecular Medicine, Boston Children's Hospital, Howard Hughes Medical Institute, Boston, MA 02115, USA; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA; Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2015.12.039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4752721PMC
February 2016

Transcription-associated processes cause DNA double-strand breaks and translocations in neural stem/progenitor cells.

Proc Natl Acad Sci U S A 2016 Feb 12;113(8):2258-63. Epub 2016 Feb 12.

Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA 02115; Department of Genetics, Harvard Medical School, Boston, MA 02115; Department of Pediatrics, Harvard Medical School, Boston, MA 02115

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http://dx.doi.org/10.1073/pnas.1525564113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4776469PMC
February 2016

Sequence-Intrinsic Mechanisms that Target AID Mutational Outcomes on Antibody Genes.

Cell 2015 Nov 12;163(5):1124-1137. Epub 2015 Nov 12.

Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine at Boston Children's Hospital, and Department of Genetics, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2015.10.042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4751889PMC
November 2015

Chromosomal Loop Domains Direct the Recombination of Antigen Receptor Genes.

Cell 2015 Nov 22;163(4):947-59. Epub 2015 Oct 22.

Howard Hughes Medical Institute; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA 02115, USA; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2015.10.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4660266PMC
November 2015

Orientation-specific joining of AID-initiated DNA breaks promotes antibody class switching.

Nature 2015 Sep 26;525(7567):134-139. Epub 2015 Aug 26.

Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children's Hospital, and Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1038/nature14970DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4592165PMC
September 2015

A Rapid Embryonic Stem Cell-Based Mouse Model for B-cell Lymphomas Driven by Epstein-Barr Virus Protein LMP1.

Cancer Immunol Res 2015 Jun 1;3(6):641-9. Epub 2015 May 1.

Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Children's Hospital Boston, Department of Genetics, Harvard Medical School, Boston, Massachusetts.

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http://cancerimmunolres.aacrjournals.org/cgi/doi/10.1158/232
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http://dx.doi.org/10.1158/2326-6066.CIR-15-0058DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4456688PMC
June 2015

An oncogenic role for alternative NF-κB signaling in DLBCL revealed upon deregulated BCL6 expression.

Cell Rep 2015 May 23;11(5):715-26. Epub 2015 Apr 23.

Program of Cellular and Molecular Medicine, Children's Hospital, and Immune Disease Institute, Harvard Medical School, Boston, MA 02115, USA; Max Delbrück Center for Molecular Medicine, Robert-Rössle-Str 10, Berlin 13125, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.03.059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4426003PMC
May 2015

Aberrant TCRδ rearrangement underlies the T-cell lymphocytopenia and t(12;14) translocation associated with ATM deficiency.

Blood 2015 Apr 26;125(17):2665-8. Epub 2015 Feb 26.

Department of Pathology and Cell Biology, Institute for Cancer Genetics, and Herbert Irving Comprehensive Cancer Research Center, Columbia University Medical Center, New York, NY; Division of Hematology, Oncology, and Stem Cell Transplantation, Department of Pediatrics, College for Physicians and Surgeons, Columbia University Medical Center, New York, NY.

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http://dx.doi.org/10.1182/blood-2015-01-622621DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4408291PMC
April 2015

Genome-wide detection of DNA double-stranded breaks induced by engineered nucleases.

Nat Biotechnol 2015 Feb 15;33(2):179-86. Epub 2014 Dec 15.

1] Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, Massachusetts, USA. [2] Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA. [3] Howard Hughes Medical Institute, Boston, Massachusetts, USA.

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http://www.nature.com/articles/nbt.3101
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http://dx.doi.org/10.1038/nbt.3101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4320661PMC
February 2015

CTCF-binding elements 1 and 2 in the Igh intergenic control region cooperatively regulate V(D)J recombination.

Proc Natl Acad Sci U S A 2015 Feb 26;112(6):1815-20. Epub 2015 Jan 26.

Program in Cellular and Molecular Medicine and Department of Genetics, Harvard Medical School, Boston, MA 02115 Howard Hughes Medical Institute, Boston Children's Hospital, Boston, MA 02115; and

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http://dx.doi.org/10.1073/pnas.1424936112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4330762PMC
February 2015

Related Mechanisms of Antibody Somatic Hypermutation and Class Switch Recombination.

Microbiol Spectr 2015 Feb;3(1):MDNA3-0037-2014

Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children's Hospital, and Department of Genetics, Harvard Medical School, Boston, MA 02115.

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http://dx.doi.org/10.1128/microbiolspec.MDNA3-0037-2014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4481323PMC
February 2015

Convergent transcription at intragenic super-enhancers targets AID-initiated genomic instability.

Cell 2014 Dec 4;159(7):1538-48. Epub 2014 Dec 4.

Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children's Hospital, and Department of Genetics, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2014.11.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4322776PMC
December 2014

Mechanisms that can promote peripheral B-cell lymphoma in ATM-deficient mice.

Cancer Immunol Res 2014 Sep 9;2(9):857-66. Epub 2014 Jun 9.

Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children's Hospital; and Department of Genetics, Harvard Medical School, Boston, Massachusetts

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http://dx.doi.org/10.1158/2326-6066.CIR-14-0090DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4156541PMC
September 2014

Developmental propagation of V(D)J recombination-associated DNA breaks and translocations in mature B cells via dicentric chromosomes.

Proc Natl Acad Sci U S A 2014 Jul 30;111(28):10269-74. Epub 2014 Jun 30.

Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children's Hospital, and Department of Genetics, Harvard Medical School, Boston, MA 02115

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http://dx.doi.org/10.1073/pnas.1410112111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4104897PMC
July 2014

Reprint of "Functional overlaps between XLF and the ATM-dependent DNA double strand break response".

DNA Repair (Amst) 2014 May 24;17:52-63. Epub 2014 Apr 24.

Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children's Hospital, Department of Genetics, Harvard Medical School, Boston, MA 02115, United States. Electronic address:

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http://dx.doi.org/10.1016/j.dnarep.2014.04.004DOI Listing
May 2014

Functional overlaps between XLF and the ATM-dependent DNA double strand break response.

DNA Repair (Amst) 2014 Apr 20;16:11-22. Epub 2014 Feb 20.

Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children's Hospital, Department of Genetics, Harvard Medical School, Boston, MA 02115, United States. Electronic address:

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http://dx.doi.org/10.1016/j.dnarep.2014.01.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4017585PMC
April 2014

IgH class switching exploits a general property of two DNA breaks to be joined in cis over long chromosomal distances.

Proc Natl Acad Sci U S A 2014 Feb 3;111(7):2644-9. Epub 2014 Feb 3.

Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children's Hospital, and Department of Genetics, Harvard Medical School, Boston, MA 02115.

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http://dx.doi.org/10.1073/pnas.1324176111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3932927PMC
February 2014

Localized DNA demethylation at recombination intermediates during immunoglobulin heavy chain gene assembly.

PLoS Biol 2013 29;11(1):e1001475. Epub 2013 Jan 29.

Laboratory of Molecular Biology and Immunology, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America.

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http://dx.doi.org/10.1371/journal.pbio.1001475DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3558432PMC
July 2013

Ataxia telangiectasia mutated (ATM) is dispensable for endonuclease I-SceI-induced homologous recombination in mouse embryonic stem cells.

J Biol Chem 2013 Mar 26;288(10):7086-95. Epub 2013 Jan 26.

Department of Medicine, Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M112.445825
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http://dx.doi.org/10.1074/jbc.M112.445825DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3591618PMC
March 2013

Functional redundancy between the XLF and DNA-PKcs DNA repair factors in V(D)J recombination and nonhomologous DNA end joining.

Proc Natl Acad Sci U S A 2013 Feb 23;110(6):2234-9. Epub 2013 Jan 23.

Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children's Hospital, and Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.

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http://www.pnas.org/content/110/6/2234.full.pdf
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http://www.pnas.org/cgi/doi/10.1073/pnas.1222573110
Publisher Site
http://dx.doi.org/10.1073/pnas.1222573110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3568359PMC
February 2013

Conditional inactivation of p53 in mature B cells promotes generation of nongerminal center-derived B-cell lymphomas.

Proc Natl Acad Sci U S A 2013 Feb 4;110(8):2934-9. Epub 2013 Feb 4.

Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA 02115, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.1222570110
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http://dx.doi.org/10.1073/pnas.1222570110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3581964PMC
February 2013

Classical and alternative end-joining pathways for repair of lymphocyte-specific and general DNA double-strand breaks.

Adv Immunol 2012 ;116:1-49

Howard Hughes Medical Institute, Immune Disease Institute, Program in Cellular and Molecular Medicine, Children's Hospital Boston, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1016/B978-0-12-394300-2.00001-6DOI Listing
January 2013

Mechanisms of programmed DNA lesions and genomic instability in the immune system.

Cell 2013 Jan;152(3):417-29

Departments of Genetics and Pediatrics, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.cell.2013.01.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4382911PMC
January 2013

Enteropathogenic Escherichia coli and vaccinia virus do not require the family of WASP-interacting proteins for pathogen-induced actin assembly.

Infect Immun 2012 Dec 10;80(12):4071-7. Epub 2012 Sep 10.

Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1128/IAI.06148-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3497443PMC
December 2012

Localized epigenetic changes induced by DH recombination restricts recombinase to DJH junctions.

Nat Immunol 2012 Dec 28;13(12):1205-12. Epub 2012 Oct 28.

Laboratory of Molecular Biology and Immunology, National Institute on Aging, US National Institutes of Health, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1038/ni.2447DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3685187PMC
December 2012

Reprogramming IgH isotype-switched B cells to functional-grade induced pluripotent stem cells.

Proc Natl Acad Sci U S A 2012 Aug 6;109(34):13745-50. Epub 2012 Aug 6.

Program in Cellular and Molecular Medicine and Immune Disease Institute, Boston Children's Hospital, Boston, MA 02115, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.1210286109
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http://dx.doi.org/10.1073/pnas.1210286109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3427115PMC
August 2012

Spatial organization of the mouse genome and its role in recurrent chromosomal translocations.

Cell 2012 Mar 16;148(5):908-21. Epub 2012 Feb 16.

Howard Hughes Medical Institute, Children's Hospital Boston and Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.cell.2012.02.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3320767PMC
March 2012

Functional redundancy between repair factor XLF and damage response mediator 53BP1 in V(D)J recombination and DNA repair.

Proc Natl Acad Sci U S A 2012 Feb 30;109(7):2455-60. Epub 2012 Jan 30.

Department of Genetics, Harvard Medical School, Children's Hospital, Immune Disease Institute, Howard Hughes Medical Institute, Boston, MA 02115, USA.

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http://dx.doi.org/10.1073/pnas.1121458109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3289340PMC
February 2012

Robust chromosomal DNA repair via alternative end-joining in the absence of X-ray repair cross-complementing protein 1 (XRCC1).

Proc Natl Acad Sci U S A 2012 Feb 30;109(7):2473-8. Epub 2012 Jan 30.

Program in Cellular and Molecular Medicine, Howard Hughes Medical Institute, Children's Hospital Boston and Department of Genetics, Immune Disease Institute, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1073/pnas.1121470109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3289296PMC
February 2012

CTCF-binding elements mediate control of V(D)J recombination.

Nature 2011 Sep 11;477(7365):424-30. Epub 2011 Sep 11.

Howard Hughes Medical Institute, The Children's Hospital, The Immune Disease Institute, Department of Genetics, Harvard Medical School, 300 Longwood Avenue, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/nature10495DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3342812PMC
September 2011

Genome-wide translocation sequencing reveals mechanisms of chromosome breaks and rearrangements in B cells.

Cell 2011 Sep;147(1):107-19

Howard Hughes Medical Institute, Immune Disease Institute, Program in Cellular and Molecular Medicine, Children's Hospital Boston and Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.cell.2011.07.049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3186939PMC
September 2011

Epigenetic tethering of AID to the donor switch region during immunoglobulin class switch recombination.

J Exp Med 2011 Aug 11;208(8):1649-60. Epub 2011 Jul 11.

Institut de Génétique et de Biologie Moléculaire et Cellulaire, Institut National de Santé et de Recherche Médicale Unité 964/Centre National de Recherche Scientifique Unité Mixte de Recherche 7104, Université de Strasbourg, 67404 Illkirch, France.

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http://dx.doi.org/10.1084/jem.20110118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3149220PMC
August 2011

Mechanisms that promote and suppress chromosomal translocations in lymphocytes.

Annu Rev Immunol 2011 ;29:319-50

Howard Hughes Medical Institute, Immune Disease Institute, Program in Cellular and Molecular Medicine, Children's Hospital Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1146/annurev-immunol-031210-101329DOI Listing
June 2011

Ataxia telangiectasia-mutated protein and DNA-dependent protein kinase have complementary V(D)J recombination functions.

Proc Natl Acad Sci U S A 2011 Feb 18;108(5):2028-33. Epub 2011 Jan 18.

Howard Hughes Medical Institute, Children's Hospital, Immune Disease Institute and Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1073/pnas.1019293108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3033273PMC
February 2011

The RNA exosome targets the AID cytidine deaminase to both strands of transcribed duplex DNA substrates.

Cell 2011 Feb 20;144(3):353-63. Epub 2011 Jan 20.

Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Immune Disease Institute, Children's Hospital Boston, Department of Genetics, Harvard Medical School, MA 02115, USA.

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http://dx.doi.org/10.1016/j.cell.2011.01.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3065114PMC
February 2011

PAIRing for distal Igh locus V(D)J recombination.

Immunity 2011 Feb;34(2):139-41

Howard Hughes Medical Institute, The Children's Hospital, The Immune Disease Institute, Department of Genetics, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.immuni.2011.02.010DOI Listing
February 2011

ATM damage response and XLF repair factor are functionally redundant in joining DNA breaks.

Nature 2011 Jan 15;469(7329):250-4. Epub 2010 Dec 15.

Howard Hughes Medical Institute, The Children's Hospital, the Immune Disease Institute and the Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/nature09604DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3058373PMC
January 2011

Neural sirtuin 6 (Sirt6) ablation attenuates somatic growth and causes obesity.

Proc Natl Acad Sci U S A 2010 Dec 22;107(50):21790-4. Epub 2010 Nov 22.

Department of Genetics, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1073/pnas.1016306107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3003110PMC
December 2010

Analysis of mice lacking DNaseI hypersensitive sites at the 5' end of the IgH locus.

PLoS One 2010 Nov 15;5(11):e13992. Epub 2010 Nov 15.

The Howard Hughes Medical Institute, The Children's Hospital, Immune Disease Institute, and Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0013992PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2981565PMC
November 2010

ATM-deficient thymic lymphoma is associated with aberrant tcrd rearrangement and gene amplification.

J Exp Med 2010 Jul 21;207(7):1369-80. Epub 2010 Jun 21.

Howard Hughes Medical Institute, Children's Hospital, Immune Disease Institute, and Harvard Medical School, Boston, MA 02115, USA.

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http://www.jem.org/lookup/doi/10.1084/jem.20100285
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http://dx.doi.org/10.1084/jem.20100285DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2901073PMC
July 2010

Long-range oncogenic activation of Igh-c-myc translocations by the Igh 3' regulatory region.

Nature 2009 Dec;462(7274):803-7

Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/nature08633DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2802177PMC
December 2009