Publications by authors named "Frederick S Varn"

24Publications

Whole transcriptome signature for prognostic prediction (WTSPP): application of whole transcriptome signature for prognostic prediction in cancer.

Lab Invest 2020 Oct 6;100(10):1356-1366. Epub 2020 Mar 6.

Department of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, NH, 03755, USA.

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http://dx.doi.org/10.1038/s41374-020-0413-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7483260PMC
October 2020

Longitudinal molecular trajectories of diffuse glioma in adults.

Nature 2019 12 20;576(7785):112-120. Epub 2019 Nov 20.

The Jackson Laboratory for Genomic Medicine, Farmington, CT, USA.

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http://dx.doi.org/10.1038/s41586-019-1775-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6897368PMC
December 2019

Single-cell RNA sequencing reveals the impact of chromosomal instability on glioblastoma cancer stem cells.

BMC Med Genomics 2019 05 31;12(1):79. Epub 2019 May 31.

Department of Biochemistry and Cell Biology, HB7200, Geisel School of Medicine at Dartmouth, Hanover, NH, 03755, USA.

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http://dx.doi.org/10.1186/s12920-019-0532-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6545015PMC
May 2019

A B cell-derived gene expression signature associates with an immunologically active tumor microenvironment and response to immune checkpoint blockade therapy.

Oncoimmunology 2019 19;8(1):e1513440. Epub 2018 Sep 19.

Department of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, NH, USA.

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https://www.tandfonline.com/doi/full/10.1080/2162402X.2018.1
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http://dx.doi.org/10.1080/2162402X.2018.1513440DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287894PMC
September 2018

Genomic Characterization of Six Virus-Associated Cancers Identifies Changes in the Tumor Immune Microenvironment and Altered Genetic Programs.

Cancer Res 2018 11 25;78(22):6413-6423. Epub 2018 Sep 25.

Department of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire.

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http://cancerres.aacrjournals.org/lookup/doi/10.1158/0008-54
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http://dx.doi.org/10.1158/0008-5472.CAN-18-1342DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6239894PMC
November 2018

Cytokine sensitivity screening highlights BMP4 pathway signaling as a therapeutic opportunity in ER breast cancer.

FASEB J 2019 02 30;33(2):1644-1657. Epub 2018 Aug 30.

Department of Molecular and Systems Biology, Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire, USA.

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https://www.fasebj.org/doi/10.1096/fj.201801241R
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http://dx.doi.org/10.1096/fj.201801241RDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338642PMC
February 2019

Computational immune profiling in lung adenocarcinoma reveals reproducible prognostic associations with implications for immunotherapy.

Oncoimmunology 2018 15;7(6):e1431084. Epub 2018 Mar 15.

Department of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, NH, USA.

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http://dx.doi.org/10.1080/2162402X.2018.1431084DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5980421PMC
March 2018

A P53-Deficiency Gene Signature Predicts Recurrence Risk of Patients with Early-Stage Lung Adenocarcinoma.

Cancer Epidemiol Biomarkers Prev 2018 01 15;27(1):86-95. Epub 2017 Nov 15.

Department of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire.

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http://dx.doi.org/10.1158/1055-9965.EPI-17-0478DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5839302PMC
January 2018

The E2F4 prognostic signature predicts pathological response to neoadjuvant chemotherapy in breast cancer patients.

BMC Cancer 2017 05 2;17(1):306. Epub 2017 May 2.

Department of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, NH, 03755, USA.

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http://dx.doi.org/10.1186/s12885-017-3297-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5414335PMC
May 2017

Immunoregulatory functions of VISTA.

Immunol Rev 2017 03;276(1):66-79

Department of Microbiology and Immunology, Norris Cotton Cancer Center Geisel School of Medicine at Dartmouth, Lebanon, NH, USA.

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http://dx.doi.org/10.1111/imr.12525DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5702497PMC
March 2017

Systematic Pan-Cancer Analysis Reveals Immune Cell Interactions in the Tumor Microenvironment.

Cancer Res 2017 03 26;77(6):1271-1282. Epub 2017 Jan 26.

Department of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire.

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http://dx.doi.org/10.1158/0008-5472.CAN-16-2490DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5798883PMC
March 2017

In silico frameworks for systematic pre-clinical screening of potential anti-leukemia therapeutics.

Expert Opin Drug Discov 2016 Dec 11;11(12):1213-1222. Epub 2016 Oct 11.

a Department of Molecular and Systems Biology , Geisel School of Medicine at Dartmouth , Hanover , NH , USA.

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http://dx.doi.org/10.1080/17460441.2016.1243524DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5180445PMC
December 2016

Application of pharmacologically induced transcriptomic profiles to interrogate PI3K-Akt-mTOR pathway activity associated with cancer patient prognosis.

Oncotarget 2016 Dec;7(51):84142-84154

Department of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, 03755 USA.

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http://dx.doi.org/10.18632/oncotarget.11776DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5356650PMC
December 2016

Adaptive immunity programmes in breast cancer.

Immunology 2017 Jan 20;150(1):25-34. Epub 2016 Sep 20.

Department of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, NH, USA.

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http://dx.doi.org/10.1111/imm.12664DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5341497PMC
January 2017

Integrative Genomic Analyses Yield Cell-Cycle Regulatory Programs with Prognostic Value.

Mol Cancer Res 2016 Apr 8;14(4):332-43. Epub 2016 Feb 8.

Department of Genetics, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire.

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http://dx.doi.org/10.1158/1541-7786.MCR-15-0368DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5033644PMC
April 2016

Integrative analysis of breast cancer reveals prognostic haematopoietic activity and patient-specific immune response profiles.

Nat Commun 2016 Jan 4;7:10248. Epub 2016 Jan 4.

Department of Genetics, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire 03755, USA.

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http://dx.doi.org/10.1038/ncomms10248DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4725766PMC
January 2016

Systematic analysis of hematopoietic gene expression profiles for prognostic prediction in acute myeloid leukemia.

Sci Rep 2015 Nov 24;5:16987. Epub 2015 Nov 24.

Department of Genetics, Geisel School of Medicine at Dartmouth, 1 Rope Ferry Road, Hanover, New Hampshire 03755, USA.

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http://dx.doi.org/10.1038/srep16987DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4657053PMC
November 2015

E2F4 Program Is Predictive of Progression and Intravesical Immunotherapy Efficacy in Bladder Cancer.

Mol Cancer Res 2015 Sep 1;13(9):1316-24. Epub 2015 Jun 1.

Department of Pharmacology and Toxicology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire.

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http://dx.doi.org/10.1158/1541-7786.MCR-15-0120DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4734892PMC
September 2015

Regulators associated with clinical outcomes revealed by DNA methylation data in breast cancer.

PLoS Comput Biol 2015 May 21;11(5):e1004269. Epub 2015 May 21.

Department of Genetics, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, United States of America; Institute for Quantitative Biomedical Sciences, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire, United States of America; Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire, United States of America.

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https://dx.plos.org/10.1371/journal.pcbi.1004269
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http://dx.doi.org/10.1371/journal.pcbi.1004269DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4440643PMC
May 2015

Integrative analysis of survival-associated gene sets in breast cancer.

BMC Med Genomics 2015 Mar 12;8:11. Epub 2015 Mar 12.

Department of Genetics, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, 03755, USA.

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http://dx.doi.org/10.1186/s12920-015-0086-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4359519PMC
March 2015