Frederick S Buckner

Frederick S Buckner

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Frederick S Buckner

Frederick S Buckner

Publications by authors named "Frederick S Buckner"

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Methionyl-tRNA synthetase inhibitor has potent in vivo activity in a novel Giardia lamblia luciferase murine infection model.

J Antimicrob Chemother 2020 Feb 3. Epub 2020 Feb 3.

Department of Medicine, Division of Allergy and Infectious Diseases, Center for Emerging and Reemerging Infectious Diseases (CERID), University of Washington, Seattle, WA 98109, USA.

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http://dx.doi.org/10.1093/jac/dkz567DOI Listing
February 2020

Phenotypic Drug Discovery for Human African Trypanosomiasis: A Powerful Approach.

Trop Med Infect Dis 2020 Feb 5;5(1). Epub 2020 Feb 5.

Department of Chemistry, University of Washington, Seattle, WA 98195, USA.

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http://dx.doi.org/10.3390/tropicalmed5010023DOI Listing
February 2020

Bioactivity of Farnesyltransferase Inhibitors Against and .

Front Cell Infect Microbiol 2019 29;9:180. Epub 2019 May 29.

Center for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA, United States.

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http://dx.doi.org/10.3389/fcimb.2019.00180DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6548881PMC
January 2020

A new chemotype with promise against Trypanosoma cruzi.

Bioorg Med Chem Lett 2020 Jan 31;30(1):126778. Epub 2019 Oct 31.

College of Pharmacy, University of Nebraska Medical Center, 986025 Nebraska Medical Center, Omaha, NE, United States. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2019.126778DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6892603PMC
January 2020

A 71-year-old man with recurrent pulmonary mycobacterial avium complex infections and lymphopenia.

Allergy Asthma Proc 2020 Jan;41(1):66-69

From the Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, Washington.

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http://dx.doi.org/10.2500/aap.2020.41.190003DOI Listing
January 2020

Brucella melitensis Methionyl-tRNA-Synthetase (MetRS), a Potential Drug Target for Brucellosis.

PLoS One 2016 8;11(8):e0160350. Epub 2016 Aug 8.

Center for Emerging and Re-emerging Infectious Diseases (CERID), Department of Medicine, Division of Allergy and Infectious Diseases, University of Washington, Seattle, Washington, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0160350PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4976878PMC
August 2017

1-Benzyl-3-aryl-2-thiohydantoin Derivatives as New Anti- Agents: SAR and in Vivo Efficacy.

ACS Med Chem Lett 2017 Aug 10;8(8):886-891. Epub 2017 Jul 10.

Department of Chemistry, University of Washington, Seattle, Washington 98195, United States.

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http://pubs.acs.org/doi/10.1021/acsmedchemlett.7b00230
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http://dx.doi.org/10.1021/acsmedchemlett.7b00230DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5554913PMC
August 2017

New Class of Antitrypanosomal Agents Based on Imidazopyridines.

ACS Med Chem Lett 2017 Jul 27;8(7):766-770. Epub 2017 Jun 27.

Departments of Chemistry, Medicine, and Biochemistry, University of Washington, Seattle, Washington 98195, United States.

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http://dx.doi.org/10.1021/acsmedchemlett.7b00202DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5512129PMC
July 2017

Urea Derivatives of 2-Aryl-benzothiazol-5-amines: A New Class of Potential Drugs for Human African Trypanosomiasis.

J Med Chem 2017 02 19;60(3):957-971. Epub 2016 Dec 19.

Department of Pathology and Laboratory Medicine, University of North Carolina , Chapel Hill, North Carolina 27599, United States.

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http://dx.doi.org/10.1021/acs.jmedchem.6b01163DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5362113PMC
February 2017

Inhibitors of methionyl-tRNA synthetase have potent activity against Giardia intestinalis trophozoites.

Antimicrob Agents Chemother 2015 Nov 31;59(11):7128-31. Epub 2015 Aug 31.

Department of Medicine, University of Washington, Seattle, Washington, USA

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http://dx.doi.org/10.1128/AAC.01573-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4604383PMC
November 2015

Recent developments in drug discovery for leishmaniasis and human African trypanosomiasis.

Chem Rev 2014 Nov 3;114(22):11305-47. Epub 2014 Nov 3.

Genomics Institute of the Novartis Research Foundation , 10675 John Jay Hopkins Drive, San Diego, California 92121, United States.

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http://dx.doi.org/10.1021/cr500365fDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4633805PMC
November 2014

Synergy testing of FDA-approved drugs identifies potent drug combinations against Trypanosoma cruzi.

PLoS Negl Trop Dis 2014 Jul 17;8(7):e2977. Epub 2014 Jul 17.

Department of Medicine, University of Washington, Seattle, Washington, United States of America.

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http://dx.doi.org/10.1371/journal.pntd.0002977DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4102417PMC
July 2014

Recent highlights in anti-protozoan drug development and resistance research.

Int J Parasitol Drugs Drug Resist 2012 Dec 12;2:230-5. Epub 2012 Jun 12.

Discovery Biology, Griffith University, Nathan, Queensland 4111, Australia.

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http://dx.doi.org/10.1016/j.ijpddr.2012.05.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3862445PMC
December 2012

Recent Developments in Sterol 14-demethylase Inhibitors for Chagas Disease.

Int J Parasitol Drugs Drug Resist 2012 Dec;2:236-242

Department of Medicine, University of Washington, Seattle, WA 98195, USA.

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http://dx.doi.org/10.1016/j.ijpddr.2011.12.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3531554PMC
December 2012

Structure of the prolyl-tRNA synthetase from the eukaryotic pathogen Giardia lamblia.

Acta Crystallogr D Biol Crystallogr 2012 Sep 18;68(Pt 9):1194-200. Epub 2012 Aug 18.

Medical Structural Genomics of Pathogenic Protozoa, http://msgpp.org, USA.

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http://dx.doi.org/10.1107/S0907444912024699DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3489102PMC
September 2012

An essential farnesylated kinesin in Trypanosoma brucei.

PLoS One 2011 2;6(11):e26508. Epub 2011 Nov 2.

Department of Medicine, Division of Allergy and Infectious Diseases, University of Washington, Seattle, Washington, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0026508PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3206815PMC
March 2012

Experimental chemotherapy and approaches to drug discovery for Trypanosoma cruzi infection.

Adv Parasitol 2011 ;75:89-119

Department of Medicine, University of Washington, Seattle, Washington, USA.

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http://dx.doi.org/10.1016/B978-0-12-385863-4.00005-8DOI Listing
December 2011

Advances in Chagas disease drug development: 2009-2010.

Curr Opin Infect Dis 2010 Dec;23(6):609-16

Department of Medicine, Division of Allergy & Infectious Diseases, University of Washington, Seattle, Washington, 98195, USA.

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http://dx.doi.org/10.1097/QCO.0b013e3283402956DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3603362PMC
December 2010

Delusional parasitosis: six-year experience with 23 consecutive cases at an academic medical center.

Int J Infect Dis 2010 Apr 15;14(4):e317-21. Epub 2009 Aug 15.

Tropical Diseases Unit, Division of Infectious Diseases, University Health Network-Toronto General Hospital, Ontario, Canada.

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http://dx.doi.org/10.1016/j.ijid.2009.05.018DOI Listing
April 2010

Isoquinoline-based analogs of the cancer drug clinical candidate tipifarnib as anti-Trypanosoma cruzi agents.

Bioorg Med Chem Lett 2009 Dec 13;19(23):6582-4. Epub 2009 Oct 13.

Department of Chemistry, University of Washington, Seattle, WA 98195, USA.

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http://dx.doi.org/10.1016/j.bmcl.2009.10.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2783978PMC
December 2009

Heterologous expression of L. major proteins in S. cerevisiae: a test of solubility, purity, and gene recoding.

J Struct Funct Genomics 2009 Sep 22;10(3):233-47. Epub 2009 Aug 22.

Center for Pediatric Biomedical Research, University of Rochester Medical School, Rochester, NY 14642, USA.

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http://dx.doi.org/10.1007/s10969-009-9068-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6703162PMC
September 2009

Altered sterol profile induced in Leishmania amazonensis by a natural dihydroxymethoxylated chalcone.

J Antimicrob Chemother 2009 Mar 28;63(3):469-72. Epub 2009 Jan 28.

Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.

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https://academic.oup.com/jac/article-lookup/doi/10.1093/jac/
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http://dx.doi.org/10.1093/jac/dkn546DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2640159PMC
March 2009

Rational modification of a candidate cancer drug for use against Chagas disease.

J Med Chem 2009 Mar;52(6):1639-47

Department of Chemistry, University of Washington, Seattle, Washington 98195-7185, USA.

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http://dx.doi.org/10.1021/jm801313tDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2715367PMC
March 2009

Glycogen synthase kinase 3 is a potential drug target for African trypanosomiasis therapy.

Antimicrob Agents Chemother 2008 Oct 21;52(10):3710-7. Epub 2008 Jul 21.

Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, WA 98195-7185, USA.

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http://dx.doi.org/10.1128/AAC.00364-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2565902PMC
October 2008

Sterol 14-demethylase inhibitors for Trypanosoma cruzi infections.

Adv Exp Med Biol 2008 ;625:61-80

Department of Medicine, University of Washington, Seattle, Washington, USA.

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http://dx.doi.org/10.1007/978-0-387-77570-8_6DOI Listing
April 2008

Protein geranylgeranyltransferase-I of Trypanosoma cruzi.

Mol Biochem Parasitol 2008 Jan 2;157(1):32-43. Epub 2007 Oct 2.

Department of Chemistry, University of Washington, Seattle, WA 98195, USA.

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http://dx.doi.org/10.1016/j.molbiopara.2007.09.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2246023PMC
January 2008

Confirmation of Chagas' cardiomyopathy following heart transplantation.

Heart Vessels 2006 Sep 29;21(5):325-7. Epub 2006 Sep 29.

Division of Cardiology, Department of Medicine, University of Washington, 1914 N 34th Street, Suite 105, Seattle, WA 98103, USA.

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http://dx.doi.org/10.1007/s00380-005-0899-4DOI Listing
September 2006

Thematic review series: lipid posttranslational modifications. Fighting parasitic disease by blocking protein farnesylation.

J Lipid Res 2006 Feb 7;47(2):233-40. Epub 2005 Dec 7.

Department of Pathobiology, University of Washington, Seattle, WA, USA.

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http://dx.doi.org/10.1194/jlr.R500016-JLR200DOI Listing
February 2006

Upregulation of sterol C14-demethylase expression in Trypanosoma cruzi treated with sterol biosynthesis inhibitors.

Mol Biochem Parasitol 2005 Nov;144(1):68-75

Department of Medicine, University of Washington, Seattle, WA 98195, USA.

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http://dx.doi.org/10.1016/j.molbiopara.2005.08.002DOI Listing
November 2005

Differential drug binding by the highly conserved Plasmodium falciparum thymidylate synthase.

Mol Biochem Parasitol 2005 Sep;143(1):121-4

Department of Chemistry, University of Washington, Box 351700, Seattle, WA 98195-1700, USA.

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http://dx.doi.org/10.1016/j.molbiopara.2005.02.016DOI Listing
September 2005

Leishmania inactivation in human pheresis platelets by a psoralen (amotosalen HCl) and long-wavelength ultraviolet irradiation.

Transfusion 2005 Sep;45(9):1459-63

Departments of Pathobiology and Medicine, University of Washington, 1959 NE Pacific Street, Seattle, WA 98195, USA.

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http://doi.wiley.com/10.1111/j.1537-2995.2005.00552.x
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http://dx.doi.org/10.1111/j.1537-2995.2005.00552.xDOI Listing
September 2005

Protein farnesyl transferase inhibitors for the treatment of malaria and African trypanosomiasis.

Curr Opin Investig Drugs 2005 Aug;6(8):791-7

Department of Medicine, University of Washington, Seattle, WA 98125-7185, USA.

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August 2005

Colorimetric assay for screening compounds against Leishmania amastigotes grown in macrophages.

Am J Trop Med Hyg 2005 May;72(5):600-5

Department of Medicine, University of Washington, Seattle, Washington 98195-7185, USA.

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May 2005

Cloning and analysis of Trypanosoma cruzi lanosterol 14alpha-demethylase.

Mol Biochem Parasitol 2003 Dec;132(2):75-81

Department of Medicine, University of Washington, Box 357185, Seattle, WA 98195-7185, USA.

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http://dx.doi.org/10.1016/j.molbiopara.2003.07.004DOI Listing
December 2003

Oxidosqualene cyclase inhibitors as antimicrobial agents.

J Med Chem 2003 Sep;46(20):4240-3

Department of Medicinal Chemistry, University of Utah, 419 Wakara Way, Suite 205, Salt Lake City, Utah 84108-1257, USA.

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http://dx.doi.org/10.1021/jm034126tDOI Listing
September 2003

Leishmania major activates IL-1 alpha expression in macrophages through a MyD88-dependent pathway.

Microbes Infect 2002 Jul;4(8):763-71

Division of Infectious Diseases, Department of Medicine, University of Washington, Seattle, WA 98195, USA.

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http://dx.doi.org/10.1016/s1286-4579(02)01596-4DOI Listing
July 2002