Frederick R Maxfield

Frederick R Maxfield

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Frederick R Maxfield

Publications by authors named "Frederick R Maxfield"

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TLR4 (Toll-Like Receptor 4)-Dependent Signaling Drives Extracellular Catabolism of LDL (Low-Density Lipoprotein) Aggregates.

Arterioscler Thromb Vasc Biol 2020 Jan 10;40(1):86-102. Epub 2019 Oct 10.

From the Department of Biochemistry, Weill Cornell Medical College, New York, NY (R.K.S., A.S.H., A.A., V.C.B.-L., I.G., H.F.C., F.R.M.).

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http://dx.doi.org/10.1161/ATVBAHA.119.313200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6928397PMC
January 2020

Digestive exophagy: Phagocyte digestion of objects too large for phagocytosis.

Traffic 2020 Jan 2;21(1):6-12. Epub 2019 Dec 2.

Department of Biochemistry, Weill Cornell Medicine, New York, New York.

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http://dx.doi.org/10.1111/tra.12712DOI Listing
January 2020

Stable reduction of STARD4 alters cholesterol regulation and lipid homeostasis.

Biochim Biophys Acta Mol Cell Biol Lipids 2020 Jan 7;1865(4):158609. Epub 2020 Jan 7.

Department of Biochemistry, Weill Cornell Medical College, 1300 York Ave, New York, NY 10065, USA; Weill Cornell Medical College, Rockefeller University, Memorial Sloan-Kettering Cancer Center Tri-Institutional Chemical Biology Program, New York, NY 10065, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bbalip.2020.158609DOI Listing
January 2020

High-density lipoprotein or cyclodextrin extraction of cholesterol from aggregated LDL reduces foam cell formation.

J Cell Sci 2019 Dec 2;132(23). Epub 2019 Dec 2.

Department of Biochemistry, Weill Cornell Medical College, New York, NY 10065, USA

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http://dx.doi.org/10.1242/jcs.237271DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6918773PMC
December 2019

Dynamic Actin Reorganization and Vav/Cdc42-Dependent Actin Polymerization Promote Macrophage Aggregated LDL (Low-Density Lipoprotein) Uptake and Catabolism.

Arterioscler Thromb Vasc Biol 2019 02;39(2):137-149

From the Department of Biochemistry, Weill Cornell Medical College, New York (R.K.S., A.S.H., P.B., F.R.M.).

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http://dx.doi.org/10.1161/ATVBAHA.118.312087DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344252PMC
February 2019

Comment on 'Orthogonal lipid sensors identify transbilayer asymmetry of plasma membrane cholesterol'.

Elife 2018 11 13;7. Epub 2018 Nov 13.

Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ontario, Canada.

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http://dx.doi.org/10.7554/eLife.38493DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257810PMC
November 2018

Progranulin in the hematopoietic compartment protects mice from atherosclerosis.

Atherosclerosis 2018 10 30;277:145-154. Epub 2018 Aug 30.

Department of Genetics and Complex Diseases, Harvard T. H. Chan School of Public Health, Boston, MA, 02115, USA; Department of Cell Biology, Harvard Medical School, Boston, MA, 02115, USA; Bluefield Project to Cure FTD, San Francisco, CA, 94107, USA; Broad Institute, Cambridge, MA, 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.atherosclerosis.2018.08.042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6432779PMC
October 2018

Membrane order in the plasma membrane and endocytic recycling compartment.

PLoS One 2017 10;12(11):e0188041. Epub 2017 Nov 10.

Department of Biochemistry, Weill Cornell Medical College, New York, NY, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0188041PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5681288PMC
December 2017

Mitochondrial Fission Promotes the Continued Clearance of Apoptotic Cells by Macrophages.

Cell 2017 Oct 21;171(2):331-345.e22. Epub 2017 Sep 21.

Department of Medicine, Columbia University, New York, NY 10032, USA; Department of Pathology and Cell Biology, Columbia University, New York, NY 10032, USA; Department of Physiology, Columbia University, New York, NY 10032, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2017.08.041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5679712PMC
October 2017

Metabolically Activated Adipose Tissue Macrophages Perform Detrimental and Beneficial Functions during Diet-Induced Obesity.

Cell Rep 2017 Sep;20(13):3149-3161

Committee on Molecular Metabolism and Nutrition, The University of Chicago, Chicago, IL 60637, USA; Ben May Department for Cancer Research, The University of Chicago, Chicago, IL 60637, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.08.096DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5646237PMC
September 2017

Histone deacetylase inhibitors correct the cholesterol storage defect in most Niemann-Pick C1 mutant cells.

J Lipid Res 2017 04 13;58(4):695-708. Epub 2017 Feb 13.

Department of Biochemistry, Weill Cornell Medical College, New York, NY 10065; and Department of Chemical Physiology and Cell and Molecular Biology,

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http://dx.doi.org/10.1194/jlr.M072140DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5392745PMC
April 2017

Role of STARD4 in sterol transport between the endocytic recycling compartment and the plasma membrane.

Mol Biol Cell 2017 Apr 16;28(8):1111-1122. Epub 2017 Feb 16.

Department of Biochemistry, Weill Cornell Medical College, New York, NY 10065

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http://dx.doi.org/10.1091/mbc.E16-07-0499DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5391187PMC
April 2017

Role of STARD4 and NPC1 in intracellular sterol transport.

Biochem Cell Biol 2016 Dec 28;94(6):499-506. Epub 2016 Jan 28.

Department of Biochemistry, Weill Cornell Medical College, 1300 York Avenue, New York, NY 10065, USA.

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http://dx.doi.org/10.1139/bcb-2015-0154DOI Listing
December 2016

The endocytic pathway in microglia during health, aging and Alzheimer's disease.

Ageing Res Rev 2016 12 12;32:89-103. Epub 2016 Jul 12.

Department of Biochemistry, Weill Cornell Medical College, 1300 York Avenue, New York, NY 10065, United States. Electronic address:

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http://dx.doi.org/10.1016/j.arr.2016.07.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5127718PMC
December 2016

Degradation of aggregated LDL occurs in complex extracellular sub-compartments of the lysosomal synapse.

J Cell Sci 2016 Mar 22;129(5):1072-82. Epub 2016 Jan 22.

Department of Biochemistry, Weill Cornell Medical College, New York, NY 10065, USA.

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http://dx.doi.org/10.1242/jcs.181743DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4813320PMC
March 2016

Cholesterol trafficking and distribution.

Essays Biochem 2015 ;57:43-55

*Department of Biochemistry, Weill Cornell Medical College, 1300 York Ave, New York, NY 10065, U.S.A.

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http://essays.biochemistry.org/content/ppebio/57/43.full.pdf
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http://essays.biochemistry.org/lookup/doi/10.1042/bse0570043
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http://dx.doi.org/10.1042/bse0570043DOI Listing
October 2015

Monocyte-Derived Dendritic Cells Upregulate Extracellular Catabolism of Aggregated Low-Density Lipoprotein on Maturation, Leading to Foam Cell Formation.

Arterioscler Thromb Vasc Biol 2015 Oct 20;35(10):2092-103. Epub 2015 Aug 20.

From the Department of Biochemistry, Weill Cornell Medical College, New York, NY (A.S.H., R.K.S., I.G., H.H., E.C.-Z., H.F.C., F.R.M.); and Department of Dermatology, Harvard Skin Disease Research Center, Bringham and Women's Hospital, Boston, MA (N.A.).

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http://dx.doi.org/10.1161/ATVBAHA.115.305843DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4583358PMC
October 2015

STARD4 Membrane Interactions and Sterol Binding.

Biochemistry 2015 Aug 22;54(30):4623-36. Epub 2015 Jul 22.

†Department of Biochemistry, Weill Cornell Medical College, 1300 York Avenue, New York, New York 10065, United States.

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http://dx.doi.org/10.1021/acs.biochem.5b00618DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4527246PMC
August 2015

Role of endosomes and lysosomes in human disease.

Cold Spring Harb Perspect Biol 2014 May 1;6(5):a016931. Epub 2014 May 1.

Department of Biochemistry, Weill Cornell Medical College, New York, New York 10065.

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http://dx.doi.org/10.1101/cshperspect.a016931DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3996470PMC
May 2014

Beta cyclodextrins bind, stabilize, and remove lipofuscin bisretinoids from retinal pigment epithelium.

Proc Natl Acad Sci U S A 2014 Apr 24;111(14):E1402-8. Epub 2014 Mar 24.

Margaret Dyson Vision Research Institute, Department of Biochemistry, and Department of Physiology, Weill Cornell Medical College of Cornell University, New York, NY 10065.

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http://dx.doi.org/10.1073/pnas.1400530111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3986126PMC
April 2014

Treatment of Niemann--pick type C disease by histone deacetylase inhibitors.

Neurotherapeutics 2013 Oct;10(4):688-97

Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN, 46556 5670, USA.

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http://dx.doi.org/10.1007/s13311-013-0217-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3805865PMC
October 2013

Plasmin promotes foam cell formation by increasing macrophage catabolism of aggregated low-density lipoprotein.

Arterioscler Thromb Vasc Biol 2013 Aug 23;33(8):1768-78. Epub 2013 May 23.

Department of Biochemistry, Weill Cornell Medical College, New York, NY 10065, USA.

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http://dx.doi.org/10.1161/ATVBAHA.112.301109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3716867PMC
August 2013

Efficiency of immunotoxin cytotoxicity is modulated by the intracellular itinerary.

PLoS One 2012 9;7(10):e47320. Epub 2012 Oct 9.

Department of Biochemistry, Weill Cornell Medical College, New York, New York, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0047320PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3467225PMC
May 2013

Quantitative analysis of monocyte subpopulations in murine atherosclerotic plaques by multiphoton microscopy.

PLoS One 2012 14;7(9):e44823. Epub 2012 Sep 14.

Department of Biochemistry, Weill Cornell Medical College, New York, New York, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0044823PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3443108PMC
February 2013

STARD4 knockdown in HepG2 cells disrupts cholesterol trafficking associated with the plasma membrane, ER, and ERC.

J Lipid Res 2012 Dec 2;53(12):2716-25. Epub 2012 Oct 2.

The Laboratory of Biochemical Genetics and Metabolism, The Rockefeller University, New York, NY 10065, USA.

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http://www.jlr.org/lookup/doi/10.1194/jlr.M032227
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http://dx.doi.org/10.1194/jlr.M032227DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3494245PMC
December 2012

Analysis of cholesterol trafficking with fluorescent probes.

Methods Cell Biol 2012 ;108:367-93

Department of Biochemistry, Weill Cornell Medical College, New York, USA.

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https://linkinghub.elsevier.com/retrieve/pii/B97801238648710
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http://dx.doi.org/10.1016/B978-0-12-386487-1.00017-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3626500PMC
May 2012

STARD4 abundance regulates sterol transport and sensing.

Mol Biol Cell 2011 Nov 7;22(21):4004-15. Epub 2011 Sep 7.

Department of Biochemistry, Weill Cornell Medical College, New York, NY 10065, USA.

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http://dx.doi.org/10.1091/mbc.E11-04-0372DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3204063PMC
November 2011

Degradation of Alzheimer's amyloid fibrils by microglia requires delivery of ClC-7 to lysosomes.

Mol Biol Cell 2011 May 25;22(10):1664-76. Epub 2011 Mar 25.

Department of Biochemistry and Weill Cornell Medical College, New York, NY 10065, USA.

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http://dx.doi.org/10.1091/mbc.E10-09-0745DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3093319PMC
May 2011

Niemann-Pick type C disease: molecular mechanisms and potential therapeutic approaches.

J Neurochem 2011 Mar 7;116(5):789-95. Epub 2011 Jan 7.

Department of Biochemistry, Weill Cornell Medical College, New York, New York 10065, USA.

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http://dx.doi.org/10.1111/j.1471-4159.2010.06976.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3008286PMC
March 2011

Deletion of ABCA1 and ABCG1 impairs macrophage migration because of increased Rac1 signaling.

Circ Res 2011 Jan 9;108(2):194-200. Epub 2010 Dec 9.

Division of Molecular Medicine, Department of Medicine, Columbia University, 630 W 168th Street, New York, NY 10032, USA.

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http://dx.doi.org/10.1161/CIRCRESAHA.110.228619DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3097897PMC
January 2011

Cholesterol pathways affected by small molecules that decrease sterol levels in Niemann-Pick type C mutant cells.

PLoS One 2010 Sep 21;5(9):e12788. Epub 2010 Sep 21.

Department of Biochemistry, Weill Cornell Medical College, New York, New York, USA.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0012788PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2943465PMC
September 2010

Cholesterol, the central lipid of mammalian cells.

Curr Opin Cell Biol 2010 Aug 2;22(4):422-9. Epub 2010 Jun 2.

Department of Biochemistry, Weill Cornell Medical College, New York, NY 10065, USA.

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http://dx.doi.org/10.1016/j.ceb.2010.05.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2910236PMC
August 2010

Endocytosis of beta-cyclodextrins is responsible for cholesterol reduction in Niemann-Pick type C mutant cells.

Proc Natl Acad Sci U S A 2010 Mar 8;107(12):5477-82. Epub 2010 Mar 8.

Department of Biochemistry, Weill Cornell Medical College, New York, NY 10065, USA.

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http://dx.doi.org/10.1073/pnas.0914309107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2851804PMC
March 2010

Chemical screen to reduce sterol accumulation in Niemann-Pick C disease cells identifies novel lysosomal acid lipase inhibitors.

Biochim Biophys Acta 2009 Dec 20;1791(12):1155-65. Epub 2009 Aug 20.

Department of Biochemistry, Weill Cornell Medical College, 1300 York Avenue, New York, NY 10065, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S138819810900174
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http://dx.doi.org/10.1016/j.bbalip.2009.08.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2783675PMC
December 2009

Macrophages create an acidic extracellular hydrolytic compartment to digest aggregated lipoproteins.

Mol Biol Cell 2009 Dec 7;20(23):4932-40. Epub 2009 Oct 7.

Department of Biochemistry, Weill Cornell Medical College, New York, NY 10065, USA.

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http://dx.doi.org/10.1091/mbc.e09-07-0559DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2785736PMC
December 2009

Aggregated LDL in contact with macrophages induces local increases in free cholesterol levels that regulate local actin polymerization.

Arterioscler Thromb Vasc Biol 2009 Oct 25;29(10):1615-21. Epub 2009 Jun 25.

Department of Biochemistry, Weill Cornell Medical College, New York, NY 10065, USA.

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http://dx.doi.org/10.1161/ATVBAHA.109.191882DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2755184PMC
October 2009

Intracellular sterol dynamics.

Biochim Biophys Acta 2009 Jul 12;1791(7):636-45. Epub 2009 Mar 12.

Department of Biochemistry, Weill Cornell Medical College, 1300 York Avenue, New York, NY 10065, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S138819810900073
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http://dx.doi.org/10.1016/j.bbalip.2009.03.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2696574PMC
July 2009

(-)-Epigallocatechin gallate causes internalization of the epidermal growth factor receptor in human colon cancer cells.

Carcinogenesis 2008 Oct 26;29(10):1986-93. Epub 2008 Jun 26.

Herbert Irving Comprehensive Cancer Center and Department of Medicine, Columbia University Medical Center, HHSC-1509, 701 West 168th Street, New York, NY 10032-2704, USA.

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https://academic.oup.com/carcin/article-lookup/doi/10.1093/c
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http://dx.doi.org/10.1093/carcin/bgn128DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2556969PMC
October 2008

Degradation of fibrillar forms of Alzheimer's amyloid beta-peptide by macrophages.

Neurobiol Aging 2008 May 11;29(5):707-15. Epub 2007 Jan 11.

Department of Biochemistry, Weill Medical College of Cornell University, New York, NY 10021, United States.

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http://dx.doi.org/10.1016/j.neurobiolaging.2006.12.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2424018PMC
May 2008

Presecretory oxidation, aggregation, and autophagic destruction of apoprotein-B: a pathway for late-stage quality control.

Proc Natl Acad Sci U S A 2008 Apr 7;105(15):5862-7. Epub 2008 Apr 7.

Departments of Medicine, Leon H. Charney Division of Cardiology, and Cell Biology and the Marc and Ruti Bell Vascular Biology and Disease Program, New York University School of Medicine, New York, NY 10016, USA.

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http://dx.doi.org/10.1073/pnas.0707460104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2311371PMC
April 2008

SMS overexpression and knockdown: impact on cellular sphingomyelin and diacylglycerol metabolism, and cell apoptosis.

J Lipid Res 2008 Feb 2;49(2):376-85. Epub 2007 Nov 2.

Department of Anatomy and Cell Biology, State University of New York Downstate Medical Center, Brooklyn, NY 11203, USA.

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http://www.jlr.org/lookup/doi/10.1194/jlr.M700401-JLR200
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http://dx.doi.org/10.1194/jlr.M700401-JLR200DOI Listing
February 2008

Elevated cholesterol levels in the plasma membranes of macrophages inhibit migration by disrupting RhoA regulation.

Arterioscler Thromb Vasc Biol 2007 Jul 10;27(7):1596-602. Epub 2007 May 10.

Department of Biochemistry, Weill Medical College of Cornell University, New York, NY 10021, USA.

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https://www.ahajournals.org/doi/10.1161/ATVBAHA.107.145086
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http://dx.doi.org/10.1161/ATVBAHA.107.145086DOI Listing
July 2007

The inhibitory effect of (-)-epigallocatechin gallate on activation of the epidermal growth factor receptor is associated with altered lipid order in HT29 colon cancer cells.

Cancer Res 2007 Jul;67(13):6493-501

Herbert Irving Comprehensive Cancer Center and Department of Medicine, Columbia University Medical Center, New Yourk, NY 10032-2704, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-07-0411DOI Listing
July 2007

Activation of microglia acidifies lysosomes and leads to degradation of Alzheimer amyloid fibrils.

Mol Biol Cell 2007 Apr 21;18(4):1490-6. Epub 2007 Feb 21.

Department of Biochemistry, Weill Medical College of Cornell University, New York, NY 10021, USA.

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http://www.molbiolcell.org/doi/10.1091/mbc.e06-10-0975
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http://dx.doi.org/10.1091/mbc.e06-10-0975DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1838985PMC
April 2007

Role of an acidic cluster/dileucine motif in cation-independent mannose 6-phosphate receptor traffic.

Traffic 2007 Apr 23;8(4):402-13. Epub 2007 Feb 23.

Department of Biochemistry, Weill Medical College of Cornell University, New York, NY 10021, USA.

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http://dx.doi.org/10.1111/j.1600-0854.2007.00541.xDOI Listing
April 2007

Sterol, protein and lipid trafficking in Chinese hamster ovary cells with Niemann-Pick type C1 defect.

Traffic 2007 Feb 7;8(2):130-41. Epub 2006 Dec 7.

Department of Biochemistry, Weill Medical College of Cornell University, New York, NY 10021, USA.

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http://dx.doi.org/10.1111/j.1600-0854.2006.00513.xDOI Listing
February 2007

Modeling the structure of the StART domains of MLN64 and StAR proteins in complex with cholesterol.

J Lipid Res 2006 Dec 21;47(12):2614-30. Epub 2006 Sep 21.

Department of Physiology and Biophysics, Weill Medical College of Cornell University, New York, NY 10021, USA.

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http://www.jlr.org/lookup/doi/10.1194/jlr.M600232-JLR200
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http://dx.doi.org/10.1194/jlr.M600232-JLR200DOI Listing
December 2006

Parallel analysis of v-Src mutant protein function using reverse transfection cell arrays.

Comb Chem High Throughput Screen 2006 Nov;9(9):711-8

Science and Technology Division, Corning Incorporated, Corning, NY 14831, USA.

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http://dx.doi.org/10.2174/138620706778700116DOI Listing
November 2006

Intracellular sterol transport and distribution.

Curr Opin Cell Biol 2006 Aug 27;18(4):379-85. Epub 2006 Jun 27.

Department of Biochemistry, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA.

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http://dx.doi.org/10.1016/j.ceb.2006.06.012DOI Listing
August 2006

Automated microscopy screening for compounds that partially revert cholesterol accumulation in Niemann-Pick C cells.

J Lipid Res 2006 Feb 15;47(2):284-301. Epub 2005 Nov 15.

Department of Biochemistry, Weill Medical College of Cornell University, New York, NY 10021, USA.

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http://dx.doi.org/10.1194/jlr.M500388-JLR200DOI Listing
February 2006

Elevated plasma membrane cholesterol content alters macrophage signaling and function.

Arterioscler Thromb Vasc Biol 2006 Feb 23;26(2):372-8. Epub 2005 Nov 23.

Department of Biochemistry, Weill Medical College of Cornell University, New York, NY 10021, USA.

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https://www.ahajournals.org/doi/10.1161/01.ATV.0000197848.67
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http://dx.doi.org/10.1161/01.ATV.0000197848.67999.e1DOI Listing
February 2006

Endocytic recycling compartments altered in cisplatin-resistant cancer cells.

Cancer Res 2006 Feb;66(4):2346-53

Laboratory of Cell Biology, National Cancer Institute, NIH, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-05-3436DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1382193PMC
February 2006

Role of cholesterol and lipid organization in disease.

Nature 2005 Dec;438(7068):612-21

Department of Biochemistry, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA.

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http://dx.doi.org/10.1038/nature04399DOI Listing
December 2005

Direct observation of rapid internalization and intracellular transport of sterol by macrophage foam cells.

Traffic 2005 May;6(5):396-412

Department of Biochemistry, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA.

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http://doi.wiley.com/10.1111/j.1600-0854.2005.00285.x
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http://dx.doi.org/10.1111/j.1600-0854.2005.00285.xDOI Listing
May 2005

Membrane domains.

Annu Rev Cell Dev Biol 2004 ;20:839-66

Department of Biochemistry, Weill Medical College of Cornell University, New York, NY 10021, USA.

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http://dx.doi.org/10.1146/annurev.cellbio.20.010403.095451DOI Listing
February 2005

Lipid and cholesterol trafficking in NPC.

Biochim Biophys Acta 2004 Oct;1685(1-3):28-37

Department of Biochemistry, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA.

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October 2004

Fluorescence imaging in living animals. Focus on "Uptake and trafficking of fluorescent conjugates of folic acid in intact kidney determined using intravital two-photon microscopy".

Am J Physiol Cell Physiol 2004 Aug;287(2):C257-9

Dept. of Biochemistry, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA.

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http://www.physiology.org/doi/10.1152/ajpcell.00235.2004
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August 2004

Role of cytoplasmic domain serines in intracellular trafficking of furin.

Mol Biol Cell 2004 Jun 9;15(6):2884-94. Epub 2004 Apr 9.

Department of Biochemistry, Weill Medical College of Cornell University, New York, New York 10021, USA.

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http://dx.doi.org/10.1091/mbc.e03-09-0653DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC420111PMC
June 2004

Effects of cholesterol depletion and increased lipid unsaturation on the properties of endocytic membranes.

J Biol Chem 2004 Apr 20;279(14):14171-8. Epub 2004 Jan 20.

Department of Biochemistry, Weill Medical College of Cornell University, New York, New York 10021, USA.

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April 2004

Oxalic acid alters intracellular calcium in endothelial cells.

Atherosclerosis 2004 Apr;173(2):321-8

Leon H. Charney Division of Cardiology, New York University School of Medicine, New York, NY, USA.

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April 2004

Different transport routes for high density lipoprotein and its associated free sterol in polarized hepatic cells.

J Lipid Res 2004 Mar 16;45(3):427-37. Epub 2003 Dec 16.

Department of Biochemistry, Weill Medical College of Cornell University, New York, NY 10021, USA.

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http://www.jlr.org/lookup/doi/10.1194/jlr.M300440-JLR200
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March 2004

Ratio imaging instrumentation.

Methods Cell Biol 2003 ;72:389-413

Department of Medicine, Indiana University Medical Center, Indianapolis, Indiana 46202-5116, USA.

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http://dx.doi.org/10.1016/s0091-679x(03)72019-6DOI Listing
March 2004

Endocytosed cation-independent mannose 6-phosphate receptor traffics via the endocytic recycling compartment en route to the trans-Golgi network and a subpopulation of late endosomes.

Mol Biol Cell 2004 Feb 31;15(2):721-33. Epub 2003 Oct 31.

Department of Biochemistry, Weill Medical College of Cornell University, New York, New York 10021, USA.

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http://dx.doi.org/10.1091/mbc.e03-07-0497DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC329388PMC
February 2004

Endocytic recycling.

Nat Rev Mol Cell Biol 2004 Feb;5(2):121-32

Department of Biochemistry, Weill Medical College of Cornell University, 1300 York Avenue, New York, New York 10021, USA.

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February 2004

The cytoplasmic domain of the low density lipoprotein (LDL) receptor-related protein, but not that of the LDL receptor, triggers phagocytosis.

J Biol Chem 2003 Nov 26;278(45):44799-807. Epub 2003 Aug 26.

Department of Medicine, Columbia University, New York, New York 10032, USA.

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November 2003

Membrane lipid organization is critical for human neutrophil polarization.

J Biol Chem 2003 Mar 8;278(12):10831-41. Epub 2003 Jan 8.

Department of Biochemistry, Weill Medical College of Cornell University, New York, New York 10021, USA.

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March 2003

Stearoyl-CoA desaturase inhibits ATP-binding cassette transporter A1-mediated cholesterol efflux and modulates membrane domain structure.

J Biol Chem 2003 Feb 12;278(8):5813-20. Epub 2002 Dec 12.

Division of Molecular Medicine, Department of Medicine, Columbia University, New York, New York 10032, USA.

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February 2003

Targeted recycling of PECAM from endothelial surface-connected compartments during diapedesis.

Nature 2003 Feb;421(6924):748-53

Department of Pathology and Laboratory Medicine, Weill Medical College, 1300 York Avenue, New York, New York 10021, USA.

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February 2003

Optical microscopy-based migration assay for human neutrophils.

Curr Protoc Cell Biol 2003 Feb;Chapter 12:Unit 12.6

Weill Medical College of Cornell University, New York, New York, USA.

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http://dx.doi.org/10.1002/0471143030.cb1206s17DOI Listing
February 2003

Microtubule asymmetry during neutrophil polarization and migration.

Mol Biol Cell 2002 Dec;13(12):4470-83

Department of Biochemistry, Weill Medical College of Cornell University, New York, New York 10021, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC138647PMC
December 2002

Intracellular cholesterol transport.

J Clin Invest 2002 Oct;110(7):891-8

Department of Biochemistry, Weill Medical College of Cornell University, New York, New York 10021, USA.

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http://dx.doi.org/10.1172/JCI16500DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC151159PMC
October 2002

Rapid nonvesicular transport of sterol between the plasma membrane domains of polarized hepatic cells.

J Biol Chem 2002 Aug 5;277(33):30325-36. Epub 2002 Jun 5.

Department of Biochemistry, Weill Medical College of Cornell University, New York, New York 10021, USA.

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August 2002

Plasma membrane microdomains.

Curr Opin Cell Biol 2002 Aug;14(4):483-7

Department of Biochemistry, Weill Medical College of Cornell University, New York, NY 10021, USA.

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http://dx.doi.org/10.1016/s0955-0674(02)00351-4DOI Listing
August 2002

Vesicular and non-vesicular sterol transport in living cells. The endocytic recycling compartment is a major sterol storage organelle.

J Biol Chem 2002 Jan 26;277(1):609-17. Epub 2001 Oct 26.

Department of Biochemistry, Weill Medical College of Cornell University, New York, New York 10021, USA.

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January 2002