Frederick R Simeons

Frederick R C Simeons

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Frederick R Simeons

Frederick R C Simeons

Publications by authors named "Frederick R C Simeons"

13Publications

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1PubMed Central Citations

Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis.

Proc Natl Acad Sci U S A 2019 04 20;116(14):7015-7020. Epub 2019 Mar 20.

Wellcome Centre for Anti-Infectives Research, Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, University of Dundee, DD1 5EH Dundee, United Kingdom;

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http://www.pnas.org/lookup/doi/10.1073/pnas.1814685116
Publisher Site
http://dx.doi.org/10.1073/pnas.1814685116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452685PMC
April 2019

A Molecular Hybridization Approach for the Design of Potent, Highly Selective, and Brain-Penetrant N-Myristoyltransferase Inhibitors.

J Med Chem 2018 09 12;61(18):8374-8389. Epub 2018 Sep 12.

Drug Discovery Unit, Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, School of Life Sciences , University of Dundee , Dundee , DD1 5EH , United Kingdom.

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http://dx.doi.org/10.1021/acs.jmedchem.8b00884DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6167002PMC
September 2018

Chemical Validation of Methionyl-tRNA Synthetase as a Druggable Target in Leishmania donovani.

ACS Infect Dis 2017 10 2;3(10):718-727. Epub 2017 Oct 2.

Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee , Dow Street, Dundee DD1 5EH, United Kingdom.

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http://dx.doi.org/10.1021/acsinfecdis.7b00047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5663395PMC
October 2017

The R enantiomer of the antitubercular drug PA-824 as a potential oral treatment for visceral Leishmaniasis.

Antimicrob Agents Chemother 2013 Oct 15;57(10):4699-706. Epub 2013 Jul 15.

Division of Biological Chemistry and Drug Discovery, Wellcome Trust Biocentre, College of Life Sciences, University of Dundee, Dundee, Scotland, United Kingdom.

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http://dx.doi.org/10.1128/AAC.00722-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3811480PMC
October 2013

The anti-trypanosome drug fexinidazole shows potential for treating visceral leishmaniasis.

Sci Transl Med 2012 Feb;4(119):119re1

Division of Biological Chemistry and Drug Discovery, Wellcome Trust Biocentre, College of Life Sciences, University of Dundee, Dundee, Scotland, UK.

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http://dx.doi.org/10.1126/scitranslmed.3003326DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3457684PMC
February 2012