Frederick J Livesey

Frederick J Livesey

UNVERIFIED PROFILE

Are you Frederick J Livesey?   Register this Author

Register author
Frederick J Livesey

Frederick J Livesey

Publications by authors named "Frederick J Livesey"

Are you Frederick J Livesey?   Register this Author

54Publications

779Reads

30Profile Views

Microtubules Deform the Nuclear Membrane and Disrupt Nucleocytoplasmic Transport in Tau-Mediated Frontotemporal Dementia.

Cell Rep 2019 01;26(3):582-593.e5

Gurdon Institute, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QN, UK; Alzheimer's Research UK Stem Cell Research Centre, University of Cambridge, CB2 1QN, UK; UCL Great Ormond Street Institute of Child Health, 30 Guilford Street, London, WC1N 1EH, UK. Electronic address:

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S22111247183204
Publisher Site
http://dx.doi.org/10.1016/j.celrep.2018.12.085DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335264PMC
January 2019

Altered γ-Secretase Processing of APP Disrupts Lysosome and Autophagosome Function in Monogenic Alzheimer's Disease.

Cell Rep 2018 12;25(13):3647-3660.e2

Gurdon Institute and ARUK Stem Cell Research Centre, University of Cambridge, Cambridge CB2 1QN, UK; UCL Great Ormond Street Institute of Child Health, Guildford Street, London WC1N 1EH, UK. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.celrep.2018.11.095DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6315085PMC
December 2018

Chromatin Accessibility Impacts Transcriptional Reprogramming in Oocytes.

Cell Rep 2018 07;24(2):304-311

Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge, Cambridge CB2 1QN, United Kingdom. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.celrep.2018.06.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6057489PMC
July 2018

Extracellular Forms of Aβ and Tau from iPSC Models of Alzheimer's Disease Disrupt Synaptic Plasticity.

Cell Rep 2018 05;23(7):1932-1938

Department of Pharmacology & Therapeutics and Institute of Neuroscience, Trinity College, Dublin 2, Ireland. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.celrep.2018.04.040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5972225PMC
May 2018

Functional Studies of Missense TREM2 Mutations in Human Stem Cell-Derived Microglia.

Stem Cell Reports 2018 04 29;10(4):1294-1307. Epub 2018 Mar 29.

The Gurdon Institute, ARUK Stem Cell Research Centre and Department of Biochemistry, University of Cambridge, Cambridge CB2 1QN, UK. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.stemcr.2018.03.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5998752PMC
April 2018

Extracellular Monomeric and Aggregated Tau Efficiently Enter Human Neurons through Overlapping but Distinct Pathways.

Cell Rep 2018 03;22(13):3612-3624

Talisman Therapeutics, Babraham Research Campus, Cambridge CB22 3AT, UK; Gurdon Institute and Department of Biochemistry, University of Cambridge, Cambridge CB2 1QN, UK. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.celrep.2018.03.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5896171PMC
March 2018

Filopodyan: An open-source pipeline for the analysis of filopodia.

J Cell Biol 2017 10 31;216(10):3405-3422. Epub 2017 Jul 31.

Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge, Cambridge, England, UK

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1083/jcb.201705113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5626553PMC
October 2017

Guided self-organization and cortical plate formation in human brain organoids.

Nat Biotechnol 2017 Jul 31;35(7):659-666. Epub 2017 May 31.

IMBA-Institute of Molecular Biotechnology of the Austrian Academy of Science, Vienna, Austria.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nbt.3906DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5824977PMC
July 2017

Phenotypic Screening Identifies Modulators of Amyloid Precursor Protein Processing in Human Stem Cell Models of Alzheimer's Disease.

Stem Cell Reports 2017 04 9;8(4):870-882. Epub 2017 Mar 9.

The Gurdon Institute and Department of Biochemistry, University of Cambridge, Cambridge CB2 1QN, UK. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.stemcr.2017.02.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5390098PMC
April 2017

Automated Synthesis and Analysis of Switching Gene Regulatory Networks.

Biosystems 2016 Aug 10;146:26-34. Epub 2016 May 10.

Microsoft Research, UK; Bar-Ilan University, Israel. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.biosystems.2016.03.012DOI Listing
August 2016

Cortical Differentiation of Human Pluripotent Cells for In Vitro Modeling of Alzheimer's Disease.

Methods Mol Biol 2016 ;1303:267-78

Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/978-1-4939-2627-5_16DOI Listing
April 2016

2D and 3D Stem Cell Models of Primate Cortical Development Identify Species-Specific Differences in Progenitor Behavior Contributing to Brain Size.

Cell Stem Cell 2016 Apr 31;18(4):467-80. Epub 2016 Mar 31.

Gurdon Institute and Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.stem.2016.03.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4826446PMC
April 2016

Development and function of human cerebral cortex neural networks from pluripotent stem cells in vitro.

Development 2015 Sep;142(18):3178-87

Wellcome Trust/CRUK Gurdon Institute and Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1242/dev.123851DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4582178PMC
September 2015

G&T-seq: parallel sequencing of single-cell genomes and transcriptomes.

Nat Methods 2015 Jun 27;12(6):519-22. Epub 2015 Apr 27.

1] Sanger Institute-EBI Single-Cell Genomics Centre, Wellcome Trust Sanger Institute, Hinxton, UK. [2] Department of Human Genetics, University of Leuven, Leuven, Belgium.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nmeth.3370DOI Listing
June 2015

APP metabolism regulates tau proteostasis in human cerebral cortex neurons.

Cell Rep 2015 May 23;11(5):689-96. Epub 2015 Apr 23.

The Gurdon Institute, Cambridge Stem Cell Institute and Department of Biochemistry, University of Cambridge, Cambridge CB2 1QN, UK. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.celrep.2015.03.068DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4431668PMC
May 2015

Reconstructing the neuronal milieu intérieur.

Proc Natl Acad Sci U S A 2015 May 11;112(20):6250-1. Epub 2015 May 11.

Gurdon Institute, University of Cambridge, Cambridge CB2 1QN, United Kingdom

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1506303112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4443355PMC
May 2015

On human development: lessons from stem cell systems.

Development 2015 Jan;142(1):17-20

Gurdon Institute, University of Cambridge, Cambridge CB2 1QR, UK.

View Article

Download full-text PDF

Source
http://dev.biologists.org/cgi/doi/10.1242/dev.114868
Publisher Site
http://dx.doi.org/10.1242/dev.114868DOI Listing
January 2015

Imatinib treatment and Aβ42 in humans.

Alzheimers Dement 2014 Oct 10;10(5 Suppl):S374-80. Epub 2013 Dec 10.

Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jalz.2013.08.283DOI Listing
October 2014

Human stem cell models of dementia.

Hum Mol Genet 2014 Sep 16;23(R1):R35-9. Epub 2014 Jun 16.

Gurdon Institute, Cambridge Stem Cell Institute & Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/hmg/ddu302DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4170721PMC
September 2014

Stem cell models of Alzheimer's disease and related neurological disorders.

Alzheimers Res Ther 2012 6;4(6):44. Epub 2012 Nov 6.

Gurdon Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/alzrt147DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3580453PMC
June 2014

The phosphorylation status of Ascl1 is a key determinant of neuronal differentiation and maturation in vivo and in vitro.

Development 2014 Jun 12;141(11):2216-24. Epub 2014 May 12.

University of Cambridge, Department of Oncology, Hutchison/MRC Research Centre, Hills Road, Cambridge CB2 0XZ, UK

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1242/dev.106377DOI Listing
June 2014

Dicer is required for neural stem cell multipotency and lineage progression during cerebral cortex development.

Neural Dev 2013 Jul 29;8:14. Epub 2013 Jul 29.

Gurdon Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/1749-8104-8-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3737057PMC
July 2013

Chromatin regulation by BAF170 controls cerebral cortical size and thickness.

Dev Cell 2013 May 2;25(3):256-69. Epub 2013 May 2.

Research Group of Molecular Developmental Neurobiology, Department of Molecular Cell Biology, Max-Planck-Institute for Biophysical Chemistry, 37077 Göttingen, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.devcel.2013.04.005DOI Listing
May 2013

Ikaros promotes early-born neuronal fates in the cerebral cortex.

Proc Natl Acad Sci U S A 2013 Feb 4;110(8):E716-25. Epub 2013 Feb 4.

Gurdon Institute and Department of Biochemistry, University of Cambridge, Cambridge CB2 1QN, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.1215707110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3581915PMC
February 2013

Directed differentiation of human pluripotent stem cells to cerebral cortex neurons and neural networks.

Nat Protoc 2012 Oct 13;7(10):1836-46. Epub 2012 Sep 13.

Gurdon Institute, University of Cambridge, Cambridge, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nprot.2012.116DOI Listing
October 2012

A potential link between obesity and neural stem cell dysfunction.

Nat Cell Biol 2012 Oct;14(10):987-9

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ncb2599DOI Listing
October 2012

A human stem cell model of early Alzheimer's disease pathology in Down syndrome.

Sci Transl Med 2012 Mar 15;4(124):124ra29. Epub 2012 Feb 15.

Gurdon Institute, Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1126/scitranslmed.3003771DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4129935PMC
March 2012

Human cerebral cortex development from pluripotent stem cells to functional excitatory synapses.

Nat Neurosci 2012 Feb 5;15(3):477-86, S1. Epub 2012 Feb 5.

Gurdon Institute, University of Cambridge, Cambridge, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nn.3041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3882590PMC
February 2012

Neural stem cell biology in vertebrates and invertebrates: more alike than different?

Neuron 2011 May;70(4):719-29

The Gurdon Institute and Department of Physiology, Development and Neuroscience, University of Cambridge, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuron.2011.05.016DOI Listing
May 2011

Gradients in the brain: the control of the development of form and function in the cerebral cortex.

Cold Spring Harb Perspect Biol 2009 Aug;1(2):a002519

Gurdon Institute and Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QN.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1101/cshperspect.a002519DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2742095PMC
August 2009

PMC42, a breast progenitor cancer cell line, has normal-like mRNA and microRNA transcriptomes.

Breast Cancer Res 2008 27;10(3):R54. Epub 2008 Jun 27.

Department of Oncology, Breast Cancer Functional Genomics Laboratory, Cancer Research UK Cambridge Research Institute, University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/bcr2109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2481505PMC
November 2008

Modelling and measuring single cell RNA expression levels find considerable transcriptional differences among phenotypically identical cells.

BMC Genomics 2008 Jun 3;9:268. Epub 2008 Jun 3.

Gurdon Institute and Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge, CB2 1 QN, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/1471-2164-9-268DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2429916PMC
June 2008

A role for the transcriptional repressor REST in maintaining the phenotype of neurosecretory-deficient PC12 cells.

J Neurochem 2006 Dec 25;99(5):1435-44. Epub 2006 Oct 25.

Department of Biochemistry, University of Cambridge, Cambridge, UK.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/j.1471-4159.2006.04190.x
Publisher Site
http://dx.doi.org/10.1111/j.1471-4159.2006.04190.xDOI Listing
December 2006

A role for Dicer in immune regulation.

J Exp Med 2006 Oct 23;203(11):2519-27. Epub 2006 Oct 23.

Lymphocyte Development Group, MRC Clinical Sciences Centre, Imperial College London, London W12 0NN, England, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1084/jem.20061692DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118134PMC
October 2006

Electrophysiological and gene expression profiling of neuronal cell types in mammalian neocortex.

J Physiol 2006 Sep 13;575(Pt 2):361-5. Epub 2006 Jul 13.

Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge, CB2 3EG, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1113/jphysiol.2006.113712DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1819463PMC
September 2006

Comparative evaluation of linear and exponential amplification techniques for expression profiling at the single-cell level.

Genome Biol 2006 7;7(3):R18. Epub 2006 Mar 7.

Gurdon Institute and Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QN, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/gb-2006-7-3-r18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1557751PMC
July 2006

Genomic characterisation of a Fgf-regulated gradient-based neocortical protomap.

Development 2005 Sep 3;132(17):3947-61. Epub 2005 Aug 3.

Wellcome Trust/CR UK Gurdon Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1242/dev.01968DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4729368PMC
September 2005

A dynamic switch in the replication timing of key regulator genes in embryonic stem cells upon neural induction.

Cell Cycle 2004 Dec 4;3(12):1645-50. Epub 2004 Dec 4.

Lymphocyte Development Group, MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, London, UK.

View Article

Download full-text PDF

Source
December 2004

Molecular organization of the ferret visual thalamus.

J Neurosci 2004 Nov;24(44):9962-70

Howard Hughes Medical Institute and Department of Neurobiology, Duke University Medical Center, Durham, North Carolina 27710, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1523/JNEUROSCI.2165-04.2004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6730254PMC
November 2004

Prox1 function controls progenitor cell proliferation and horizontal cell genesis in the mammalian retina.

Nat Genet 2003 May;34(1):53-8

Department of Developmental Neurobiology, St. Jude Children's Research Hospital Memphis, Tennessee 38105, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ng1144DOI Listing
May 2003