Frederick E Domann

Frederick E Domann

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Frederick E Domann

Frederick E Domann

Publications by authors named "Frederick E Domann"

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100Publications

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Extracellular superoxide dismutase (SOD3) regulates oxidative stress at the vitreoretinal interface.

Free Radic Biol Med 2018 Aug 22;124:408-419. Epub 2018 Jun 22.

Byers Eye Institute, Department of Ophthalmology, Stanford University, Palo Alto, CA, United States; Omics Laboratory, Stanford University, Palo Alto, CA, United States; Palo Alto Veterans Administration, Palo Alto, CA, United States. Electronic address:

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August 2018

Limitations of oxygen delivery to cells in culture: An underappreciated problem in basic and translational research.

Free Radic Biol Med 2017 Dec 13;113:311-322. Epub 2017 Oct 13.

Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, NE, USA. Electronic address:

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December 2017

Allele-specific interaction between glutathione peroxidase 1 and manganese superoxide dismutase affects the levels of Bcl-2, Sirt3 and E-cadherin.

Free Radic Res 2017 Jun 4;51(6):582-590. Epub 2017 Jul 4.

a Department of Pathology, College of Medicine , University of Illinois at Chicago , Chicago , IL , USA.

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June 2017

Succinate dehydrogenase activity regulates PCB3-quinone-induced metabolic oxidative stress and toxicity in HaCaT human keratinocytes.

Arch Toxicol 2016 Feb 23;90(2):319-32. Epub 2014 Nov 23.

Free Radical and Radiation Biology Division, Department of Radiation Oncology, B180 Medical Laboratories, The University of Iowa, Iowa City, IA, 52242, USA.

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February 2016

SOD2 targeted gene editing by CRISPR/Cas9 yields Human cells devoid of MnSOD.

Free Radic Biol Med 2015 Dec 21;89:379-86. Epub 2015 Jul 21.

Department of Radiation Oncology, B180 Medical Laboratories, The University of Iowa, Iowa City, IA 52242. Electronic address:

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December 2015

Back to the future: transgenerational transmission of xenobiotic-induced epigenetic remodeling.

Epigenetics 2015 16;10(4):259-73. Epub 2015 Mar 16.

a Endocrine Division ; Hospital Sant Joan de Déu ; Esplugues de Llobregat , Barcelona , Spain.

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November 2015

SIRT6 minor allele genotype is associated with >5-year decrease in lifespan in an aged cohort.

PLoS One 2014 26;9(12):e115616. Epub 2014 Dec 26.

Free Radical & Radiation Biology Program, Department of Radiation Oncology, The University of Iowa, Iowa City, Iowa, United States of America.

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August 2015

Disruption of thioredoxin metabolism enhances the toxicity of transforming growth factor β-activated kinase 1 (TAK1) inhibition in KRAS-mutated colon cancer cells.

Redox Biol 2015 Aug 18;5:319-27. Epub 2015 Jun 18.

Department of Surgery, Division of Surgical Oncology, University of Iowa Hospitals and Clinics, Iowa City, IA, USA; Department of Radiation Oncology, Free Radical and Radiation Biology, University of Iowa Hospitals and Clinics, Iowa City, IA, USA. Electronic address:

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August 2015

Absence of manganese superoxide dismutase delays p53-induced tumor formation.

Redox Biol 2014 13;2:220-3. Epub 2014 Jan 13.

Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, The University of Iowa, Iowa City, IA 52242, USA.

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June 2015

Mitochondrial calcium uniporter activity is dispensable for MDA-MB-231 breast carcinoma cell survival.

PLoS One 2014 6;9(5):e96866. Epub 2014 May 6.

Department of Internal Medicine, Division of Cardiovascular Medicine, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States of America; Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States of America; Department of Molecular Physiology and Biophysics, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States of America.

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June 2015

Differential activation of catalase expression and activity by PPAR agonists: implications for astrocyte protection in anti-glioma therapy.

Redox Biol 2013 26;1:70-9. Epub 2013 Jan 26.

Department of Radiation Oncology, Free Radical and Radiation Biology, Holden Comprehensive Cancer Center, The University of Iowa, Iowa City, IA 52242, USA ; Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA.

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May 2015

Maintenance of mitochondrial genomic integrity in the absence of manganese superoxide dismutase in mouse liver hepatocytes.

Redox Biol 2013 5;1:172-7. Epub 2013 Feb 5.

Free Radical and Radiation Biology Program, Department of Radiation Oncology, Carver College of Medicine and the Holden Comprehensive Cancer Center, The University of Iowa, Iowa City, IA 52242, USA.

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May 2015

Ligand-independent activation of aryl hydrocarbon receptor signaling in PCB3-quinone treated HaCaT human keratinocytes.

Toxicol Lett 2015 Mar 7;233(3):258-66. Epub 2015 Feb 7.

Free Radical and Radiation Biology Division, Department of Radiation Oncology, The University of Iowa, B180 Medical Laboratories, Iowa City, IA 52242, USA. Electronic address:

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March 2015

Corrigendum to "Cucurbitacin B Causes Increased Radiation Sensitivity of Human Breast Cancer Cells via G2/M Cell Cycle Arrest".

J Oncol 2015 2;2015:486850. Epub 2015 Feb 2.

Free Radical and Radiation Biology Program, Department of Radiation Oncology, University of Iowa, Iowa City, IA 52242, USA.

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March 2015

Retroviral-infection increases tumorigenic potential of MDA-MB-231 breast carcinoma cells by expanding an aldehyde dehydrogenase (ALDH1) positive stem-cell like population.

Redox Biol 2014 24;2:847-54. Epub 2014 Jun 24.

Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, Carver College of Medicine, University of Iowa, Iowa City, IA 52240, United States.

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January 2015

Mitochondria, energetics, epigenetics, and cellular responses to stress.

Environ Health Perspect 2014 Dec 15;122(12):1271-8. Epub 2014 Aug 15.

Division of Extramural Research and Training, National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Research Triangle Park, North Carolina, USA.

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December 2014

Aberrant CpG methylation of the TFAP2A gene constitutes a mechanism for loss of TFAP2A expression in human metastatic melanoma.

Epigenetics 2014 Dec;9(12):1641-7

a Interdisciplinary Graduate Program in Molecular and Cellular Biology; Graduate College ; The University of Iowa ; Iowa City , IA USA ;

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December 2014

Prolyl-4-hydroxylase 3 (PHD3) expression is downregulated during epithelial-to-mesenchymal transition.

PLoS One 2013 18;8(12):e83021. Epub 2013 Dec 18.

Molecular and Cellular Biology Program, The University of Iowa, Iowa City, Iowa, United States of America ; Department of Radiation Oncology, The University of Iowa, Iowa City, Iowa, United States of America.

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October 2014

PCB 126 perturbs hypoxia-induced HIF-1α activity and glucose consumption in human HepG2 cells.

Exp Toxicol Pathol 2014 Oct 7;66(8):377-82. Epub 2014 Jun 7.

Interdisciplinary Graduate Program in Human Toxicology, The University of Iowa, Iowa City, IA, USA; Department of Radiation Oncology, The University of Iowa, Iowa City, IA, USA; Department of Pathology, The University of Iowa, Iowa City, IA, USA. Electronic address:

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October 2014

Systematic dissection of the mechanisms underlying progesterone receptor downregulation in endometrial cancer.

Oncotarget 2014 Oct;5(20):9783-97

Department of Obstetrics and Gynecology, University of Iowa, IA, 52242, USA. Carver College of Medicine and Holden Comprehensive Cancer Center, University of Iowa, IA, 52242, USA.

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October 2014

Epigenetic determinants of CYP1A1 induction by the aryl hydrocarbon receptor agonist 3,3',4,4',5-pentachlorobiphenyl (PCB 126).

Int J Mol Sci 2014 Aug 11;15(8):13916-31. Epub 2014 Aug 11.

Interdisciplinary Graduate Program in Human Toxicology, the University of Iowa, Iowa City, IA 52242, USA.

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August 2014

Regulatory crosstalk and interference between the xenobiotic and hypoxia sensing pathways at the AhR-ARNT-HIF1α signaling node.

Chem Biol Interact 2014 Jul 10;218:82-8. Epub 2014 May 10.

Interdisciplinary Graduate Program in Human Toxicology, The University of Iowa, Iowa City, IA, USA; Department of Radiation Oncology, The University of Iowa, Iowa City, IA, USA. Electronic address:

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July 2014

Regulation of CuZnSOD and its redox signaling potential: implications for amyotrophic lateral sclerosis.

Antioxid Redox Signal 2014 Apr 1;20(10):1590-8. Epub 2013 Aug 1.

1 Department of Radiation Oncology, Kaiser Permanente Los Angeles Medical Center , Los Angeles, California.

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April 2014

Human Melanoma cells over-express extracellular matrix 1 (ECM1) which is regulated by TFAP2C.

PLoS One 2013 2;8(9):e73953. Epub 2013 Sep 2.

Department of Surgery, University of Iowa, Iowa City, Iowa, United States of America.

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April 2014

Locally targeted delivery of a micron-size radiation therapy source using temperature-sensitive hydrogel.

Int J Radiat Oncol Biol Phys 2014 Apr 1;88(5):1142-7. Epub 2014 Feb 1.

Department of Biomedical Engineering, The University of Iowa, Iowa City, Iowa.

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April 2014

Hypoxia perturbs aryl hydrocarbon receptor signaling and CYP1A1 expression induced by PCB 126 in human skin and liver-derived cell lines.

Toxicol Appl Pharmacol 2014 Feb 16;274(3):408-16. Epub 2013 Dec 16.

Interdisciplinary Graduate Program in Human Toxicology, The University of Iowa, Iowa City, IA, USA; Department of Radiation Oncology, The University of Iowa, Iowa City, IA, USA; Department of Surgery, The University of Iowa, Iowa City, IA, USA. Electronic address:

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February 2014

NOX4 mediates cytoprotective autophagy induced by the EGFR inhibitor erlotinib in head and neck cancer cells.

Toxicol Appl Pharmacol 2013 Nov 31;272(3):736-45. Epub 2013 Jul 31.

Interdisciplinary Graduate Program in Human Toxicology, The University of Iowa, Iowa City, IA, USA; Department of Pathology, The University of Iowa, Iowa City, IA, USA.

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November 2013

Prolyl-hydroxylase 3: Evolving Roles for an Ancient Signaling Protein.

Hypoxia (Auckl) 2013 Oct;2013(1):13-17

Molecular and Cellular Biology Program, The University of Iowa, Iowa City, Iowa, USA ; Department of Radiation Oncology, The University of Iowa, Iowa City, Iowa, USA.

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October 2013

Low-dose radiation-induced enhancement of thymic lymphomagenesis in Lck-Bax mice is dependent on LET and gender.

Radiat Res 2013 Aug 2;180(2):156-65. Epub 2013 Jul 2.

Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, University of Iowa, Iowa City, Iowa 52242, USA.

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August 2013

Rational design of a secreted enzymatically inactive mutant of extracellular superoxide dismutase.

Redox Rep 2012 ;17(6):239-45

Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, The University of Iowa, Iowa City, IA 52242, USA.

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July 2013

Regulation of SOD2 in cancer by histone modifications and CpG methylation: closing the loop between redox biology and epigenetics.

Antioxid Redox Signal 2013 May 18;18(15):1946-55. Epub 2012 Oct 18.

Free Radical and Radiation Biology Program, Department of Radiation Oncology, and Holden Comprehensive Cancer Center, The University of Iowa, Iowa City, Iowa 52242-1181, USA.

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May 2013

Aberrant free radical biology is a unifying theme in the etiology and pathogenesis of major human diseases.

Int J Mol Sci 2013 Apr 17;14(4):8491-5. Epub 2013 Apr 17.

Departments of Radiation Oncology, Surgery, and Pathology; Carver College of Medicine, the University of Iowa, Iowa City, IA 52242, USA.

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April 2013

Manganese superoxide dismutase depletion in murine hematopoietic stem cells perturbs iron homeostasis, globin switching, and epigenetic control in erythrocyte precursor cells.

Free Radic Biol Med 2013 Mar 5;56:17-27. Epub 2012 Dec 5.

Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, Iowa City, IA 52242, USA.

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March 2013

Redox regulation of the epigenetic landscape in cancer: a role for metabolic reprogramming in remodeling the epigenome.

Free Radic Biol Med 2012 Dec 26;53(11):2178-87. Epub 2012 Sep 26.

Department of Radiation Oncology, Kaiser Permanente Los Angeles Medical Center, Los Angeles, CA 90027, USA.

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December 2012

Manganese superoxide dismutase is dispensable for post-natal development and lactation in the murine mammary gland.

Free Radic Res 2012 Nov 5;46(11):1361-8. Epub 2012 Sep 5.

Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, The University of Iowa, Iowa City, IA 52240, USA.

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November 2012

Cucurbitacin B inhibits human breast cancer cell proliferation through disruption of microtubule polymerization and nucleophosmin/B23 translocation.

BMC Complement Altern Med 2012 Oct 12;12:185. Epub 2012 Oct 12.

School of Allied Health Science and Public Health, Walailak University, Bangkok, Thailand.

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October 2012

Cucurbitacin B Causes Increased Radiation Sensitivity of Human Breast Cancer Cells via G2/M Cell Cycle Arrest.

J Oncol 2012 28;2012:601682. Epub 2012 May 28.

Faculty of Medical Technology, Mahidol University, Bangkok, Thailand.

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August 2012

Genomic instability induced by mutant succinate dehydrogenase subunit D (SDHD) is mediated by O2(-•) and H2O2.

Free Radic Biol Med 2012 Jan 19;52(1):160-6. Epub 2011 Oct 19.

Department of Radiation Oncology, Holden Comprehensive Cancer Center, The University of Iowa, Iowa City, IA 52242, USA.

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January 2012

Genetic and epigenetic inactivation of extracellular superoxide dismutase promotes an invasive phenotype in human lung cancer by disrupting ECM homeostasis.

Mol Cancer Res 2012 Jan 7;10(1):40-51. Epub 2011 Nov 7.

Free Radical and Radiation Biology Program, Department of Radiation Oncology, Carver College of Medicine and The Holden Comprehensive Cancer Center, The University of Iowa, Iowa City, Iowa 52242, USA.

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January 2012

AP-2alpha Inhibits c-MYC Induced Oxidative Stress and Apoptosis in HaCaT Human Keratinocytes.

J Oncol 2009 24;2009:780874. Epub 2009 Dec 24.

Free Radical & Radiation Biology Graduate Program, Radiation Oncology Department, Roy J. and Lucille A. Carver College of Medicine, The University of Iowa, Iowa City, IA 52242, USA.

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July 2011

The redox basis of epigenetic modifications: from mechanisms to functional consequences.

Antioxid Redox Signal 2011 Jul 5;15(2):551-89. Epub 2011 Feb 5.

Free Radical and Radiation Biology Program, Department of Radiation Oncology, Carver College of Medicine, The University of Iowa, Iowa City, Iowa 52242-1181, USA.

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July 2011

Elevated mitochondrial superoxide disrupts normal T cell development, impairing adaptive immune responses to an influenza challenge.

Free Radic Biol Med 2011 Feb 2;50(3):448-58. Epub 2010 Dec 2.

Free Radical and Radiation Biology Program, Department of Radiation Oncology, Carver College of Medicine, Holden Comprehensive Cancer Center, The University of Iowa, Iowa City, IA 52242, USA.

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February 2011

Aberrant promoter CpG methylation is a mechanism for impaired PHD3 expression in a diverse set of malignant cells.

PLoS One 2011 Jan 28;6(1):e14617. Epub 2011 Jan 28.

Molecular and Cellular Biology Program, The University of Iowa, Iowa City, Iowa, United States of America.

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January 2011

Identification of primary gene targets of TFAP2C in hormone responsive breast carcinoma cells.

Genes Chromosomes Cancer 2010 Oct;49(10):948-62

Department of Surgery, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA.

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October 2010

ZEB1 coordinately regulates laminin-332 and {beta}4 integrin expression altering the invasive phenotype of prostate cancer cells.

J Biol Chem 2010 Oct 21;285(44):33940-8. Epub 2010 Aug 21.

Departments of Molecular Physiology and Biophysics, Roy J and Lucille ACarver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA.

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October 2010

Transgenic biosynthesis of trypanothione protects Escherichia coli from radiation-induced toxicity.

Radiat Res 2010 Sep;174(3):290-6

Department of Radiation Oncology, Carver College of Medicine, and Holden Comprehensive Cancer Center, The University of Iowa Free Radical and Radiation Biology Program, Montevideo, Uruguay.

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September 2010

Mitochondrial complex II dysfunction can contribute significantly to genomic instability after exposure to ionizing radiation.

Radiat Res 2009 Dec;172(6):737-45

Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, The University of Iowa, Iowa City, Iowa 52242, USA.

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December 2009

Overexpression of extracellular superoxide dismutase attenuates heparanase expression and inhibits breast carcinoma cell growth and invasion.

Cancer Res 2009 Aug 14;69(15):6355-63. Epub 2009 Jul 14.

Department of Radiation Oncology, Roy J and Lucille A Carver College of Medicine, Holden Comprehensive Cancer Center, University of Iowa, Iowa City, Iowa 52242, USA.

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August 2009

Metabolic defects provide a spark for the epigenetic switch in cancer.

Free Radic Biol Med 2009 Jul 10;47(2):115-27. Epub 2009 Apr 10.

Department of Radiation Oncology, Free Radical and Radiation Biology Program, University of Iowa, Iowa City, IA 52242, USA.

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July 2009

Interaction of TFAP2C with the estrogen receptor-alpha promoter is controlled by chromatin structure.

Clin Cancer Res 2009 Jun 19;15(11):3672-9. Epub 2009 May 19.

Departments of Surgery, Radiation Oncology, and Biochemistry, University of Iowa, Iowa City, Iowa, USA.

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June 2009

Epigenetic silencing of SOD2 by histone modifications in human breast cancer cells.

Free Radic Biol Med 2008 Dec 18;45(11):1573-80. Epub 2008 Sep 18.

Free Radical and Radiation Biology Program, Department of Radiation Oncology, University of Iowa, Iowa City, IA 52242, USA.

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December 2008

DNA methylation changes in ovarian cancer are cumulative with disease progression and identify tumor stage.

BMC Med Genomics 2008 Sep 30;1:47. Epub 2008 Sep 30.

Department of Medical Pharmacology, College of Medicine, University of Arizona, Tucson AZ 85724 USA.

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September 2008

Regulation of 14-3-3sigma expression in human thyroid carcinoma is epigenetically regulated by aberrant cytosine methylation.

Cancer Lett 2008 Aug 25;267(1):165-74. Epub 2008 Apr 25.

Department of Surgery, Division of Surgical Oncology, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, 4641 JCP, Iowa city, IA 52242, USA.

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August 2008

Epigenetic regulation of manganese superoxide dismutase expression in human breast cancer cells.

Epigenetics 2006 Oct-Dec;1(4):163-71. Epub 2006 Sep 13.

Department of Radiation Oncology, Free Radical and Radiation Biology Program, University of Iowa, Iowa City, Iowa 52242, USA.

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January 2008

A role for epigenetics in hearing: Establishment and maintenance of auditory specific gene expression patterns.

Hear Res 2007 Nov 19;233(1-2):1-13. Epub 2007 Jul 19.

Department of Otolaryngology - Head and Neck Surgery, University of Iowa, Iowa City, IA 52242-1181, United States.

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November 2007

Increased iodine uptake in thyroid carcinoma after treatment with sodium butyrate and decitabine (5-Aza-dC).

Otolaryngol Head Neck Surg 2007 Nov;137(5):722-8

Department of Otolaryngology-Head and Neck Surgery, University of Iowa, Iowa City, IA, USA.

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November 2007

Relative non-steroidal anti-inflammatory drug (NSAID) antiproliferative activity is mediated through p21-induced G1 arrest and E2F inhibition.

Mol Carcinog 2007 Oct;46(10):857-64

Department of Otolaryngology--Head and Neck Surgery, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA.

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October 2007

AP-2 participates in the transcriptional control of the amyloid precursor protein (APP) gene in oral squamous cell carcinoma.

Exp Mol Pathol 2007 Oct 26;83(2):277-82. Epub 2007 Jun 26.

Department of Otolaryngology - Head and Neck Surgery, University of Iowa, Iowa City, IA 52242-1181, USA.

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October 2007

An epigenetic perspective on the free radical theory of development.

Free Radic Biol Med 2007 Oct 10;43(7):1023-36. Epub 2007 Jul 10.

Department of Radiation Oncology, Free Radical and Radiation Biology Program, University of Iowa, Iowa City, IA 52242, USA.

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October 2007

Superoxide signaling mediates N-acetyl-L-cysteine-induced G1 arrest: regulatory role of cyclin D1 and manganese superoxide dismutase.

Cancer Res 2007 Jul;67(13):6392-9

Department of Microbiology and Immunology, State University of New York at Buffalo School of Medicine, Buffalo, New York, USA.

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July 2007

Celecoxib toxicity is cell cycle phase specific.

Cancer Res 2007 Apr;67(8):3801-8

Department of Otolaryngology-Head and Neck Surgery, University of Iowa Hospital and Clinics, 200 Hawkins Drive, Iowa City, IA 52242, USA.

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April 2007

Cervical keratinocytes containing stably replicating extrachromosomal HPV-16 are refractory to transformation by oncogenic H-Ras.

Virology 2006 Dec 5-20;356(1-2):68-78. Epub 2006 Aug 30.

Department of Microbiology, Holden Comprehensive Cancer Research Center, University of Iowa, 375 Newton Road, 2202 MERF, Iowa City, IA 52242, USA.

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January 2007

Rapid and direct quantitative RT-PCR method to measure promoter activity.

Biotechnol Prog 2006 Sep-Oct;22(5):1461-3

Free Radical and Radiation Program, Radiation Oncology Department, B180 ML, The University of Iowa, Iowa City, Iowa 52242, USA.

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January 2007

A novel nuclear interactor of ARF and MDM2 (NIAM) that maintains chromosomal stability.

J Biol Chem 2007 Jan 16;282(2):1322-33. Epub 2006 Nov 16.

Department of Pharmacology, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, 52242-1109, USA, and the Laboratoire de Genetique Cellulaire et Moleculaire, UPRES EA2622, Centre Hospitalier Universitaire de Poitiers, France.

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January 2007

Glutathione peroxidase-1 inhibits UVA-induced AP-2alpha expression in human keratinocytes.

Biochem Biophys Res Commun 2006 Dec 7;351(4):1066-71. Epub 2006 Nov 7.

Free Radical and Radiation Biology Program, Department of Radiation Oncology, Carver College of Medicine, and Holden Comprehensive Cancer Center, The University of Iowa, Iowa City, IA 52242, USA.

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December 2006

RIZ1 is epigenetically inactivated by promoter hypermethylation in thyroid carcinoma.

Cancer 2006 Dec;107(12):2752-9

Department of Surgery, Division of Surgical Oncology, University of Iowa, Iowa City, Iowa, USA.

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December 2006

Apoptosis induced by selenomethionine and methioninase is superoxide mediated and p53 dependent in human prostate cancer cells.

Mol Cancer Ther 2006 Dec;5(12):3275-84

Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, K4/868, Clinical Science Center, Box 8550, 600 Highland Avenue, Madison, WI 53792, USA.

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December 2006

Inactivation of primary antioxidant enzymes in mouse keratinocytes by photodynamically generated singlet oxygen.

Antioxid Redox Signal 2006 Jul-Aug;8(7-8):1307-14

Free Radical and Radiation Biology Graduate Program, Department of Radiation Oncology, The University of Iowa, Iowa City, 52242, USA.

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October 2006

Epigenetic regulation of maspin expression in human ovarian carcinoma cells.

Gynecol Oncol 2006 Aug 7;102(2):319-24. Epub 2006 Feb 7.

Department of Obstetrics and Gynecology, The University of Iowa Hospitals and Clinics, The Holden Comprehensive Cancer Center, 4630 John Colloton Pavilion, 200 Hawkins Drive, Iowa City, IA 52242, USA.

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August 2006

Mutation of succinate dehydrogenase subunit C results in increased O2.-, oxidative stress, and genomic instability.

Cancer Res 2006 Aug;66(15):7615-20

Free Radical and Radiation Biology Program, B180 Medical Laboratories, Department of Radiation Oncology, Holden Comprehensive Cancer Center, The University of Iowa, Iowa City, IA 52242, USA.

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August 2006

Intrinsic radiation resistance in human chondrosarcoma cells.

Biochem Biophys Res Commun 2006 Jul 5;346(2):379-85. Epub 2006 Jun 5.

Department of Orthopaedics and Rehabilitation, University of Iowa, Iowa City, 52242, USA.

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July 2006

AP-2gamma induces p21 expression, arrests cell cycle, and inhibits the tumor growth of human carcinoma cells.

Neoplasia 2006 Jul;8(7):568-77

Free Radical and Radiation Biology Program, Department of Radiation Oncology, The University of Iowa, Iowa City, IA 52242, USA.

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July 2006

Epigenetic silencing of DSC3 is a common event in human breast cancer.

Breast Cancer Res 2005 16;7(5):R669-80. Epub 2005 Jun 16.

Department of Pharmacology, Arizona Cancer Center, University of Arizona, Tucson, AZ, USA.

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February 2006

Inhibition of glutamate cysteine ligase activity sensitizes human breast cancer cells to the toxicity of 2-deoxy-D-glucose.

Cancer Res 2006 Feb;66(3):1605-10

Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, Roy J. and Lucille A. Carver College of Medicine, The University of Iowa, Iowa City, IA 52242, USA.

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February 2006

Expression of p53 enhances selenite-induced superoxide production and apoptosis in human prostate cancer cells.

Cancer Res 2006 Feb;66(4):2296-304

Department of Pathology and Laboratory Medicine, University of Wisconsin Medical School, Madison 53792, USA.

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February 2006

Manganese superoxide dismutase suppresses hypoxic induction of hypoxia-inducible factor-1alpha and vascular endothelial growth factor.

Oncogene 2005 Dec;24(55):8154-66

Department of Radiation Oncology, Free Radical and Radiation Biology Program, Holden Comprehensive Cancer Center, The University of Iowa, Iowa City, IA 52242-1181, USA.

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December 2005

Epigenetic regulation of the cell type-specific gene 14-3-3sigma.

Neoplasia 2005 Sep;7(9):799-808

Pharmacology and Toxicology, University of Arizona, Arizona Cancer Center, Tucson, AZ 85724, USA.

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September 2005

Tissue-specific changes in H19 methylation and expression in mice with hyperhomocysteinemia.

J Biol Chem 2005 Jul 17;280(27):25506-11. Epub 2005 May 17.

Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, Iowa 52242, USA.

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July 2005

Noninvasive radiological imaging of pulmonary gene transfer and expression using the human sodium iodide symporter.

Eur J Nucl Med Mol Imaging 2005 May 14;32(5):534-40. Epub 2004 Dec 14.

Free Radical and Radiation Biology Program, Department of Radiation Oncology, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, B 180 Med Labs, Iowa City, IA 52242, USA.

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May 2005

Aberrant methylation of the maspin promoter is an early event in human breast cancer.

Neoplasia 2004 Jul-Aug;6(4):380-9

Bone Marrow Transplant Program, Arizona Cancer Center, and Department of Pharmacology and Toxicology, The University of Arizona, Tucson, AZ 85724, USA.

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April 2005

The acetyltransferase p300/CBP-associated factor is a p53 target gene in breast tumor cells.

Neoplasia 2004 May-Jun;6(3):187-94

Bone Marrow Transplant Program, Arizona Cancer Center and Department of Pharmacology and Toxicology, University of Arizona, Tucson, AZ 85724, USA.

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December 2004

Human pancreatic carcinoma cells activate maspin expression through loss of epigenetic control.

Neoplasia 2003 Sep-Oct;5(5):427-36

Department of Radiation Oncology, Free Radical and Radiation Biology Program, University of Iowa, Iowa City, IA 52242, USA.

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July 2004

Flipping the epigenetic switch.

Am J Pathol 2004 Jun;164(6):1883-6

Department of Radiation Oncology, Carver College of Medicine and Holden Cancer Center, The University of Iowa, Iowa City, Iowa 52242, USA.

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June 2004

Genetically targeted radiotherapy of head and neck squamous cell carcinoma using the sodium-iodide symporter (NIS).

Head Neck 2004 Mar;26(3):265-71

Department of Otolaryngology-Head and Neck Surgery, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA.

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March 2004

Multimodality noninvasive imaging of gene transfer using the human sodium iodide symporter.

J Nucl Med 2004 Mar;45(3):445-9

Free Radical and Radiation Biology Program, Department of Radiation Oncology, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, USA.

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March 2004

Characterization of p53 gene mutations in a Brazilian population with oral squamous cell carcinomas.

Int J Oncol 2004 Feb;24(2):295-303

Faculdade de Odontologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.

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February 2004