Publications




Succinate dehydrogenase activity regulates PCB3-quinone-induced metabolic oxidative stress and toxicity in HaCaT human keratinocytes.
Arch Toxicol 2016 Feb 23;90(2):319-32. Epub 2014 Nov 23.
Free Radical and Radiation Biology Division, Department of Radiation Oncology, B180 Medical Laboratories, The University of Iowa, Iowa City, IA, 52242, USA.

Disruption of thioredoxin metabolism enhances the toxicity of transforming growth factor β-activated kinase 1 (TAK1) inhibition in KRAS-mutated colon cancer cells.
Redox Biol 2015 Aug 18;5:319-27. Epub 2015 Jun 18.
Department of Surgery, Division of Surgical Oncology, University of Iowa Hospitals and Clinics, Iowa City, IA, USA; Department of Radiation Oncology, Free Radical and Radiation Biology, University of Iowa Hospitals and Clinics, Iowa City, IA, USA. Electronic address:


Mitochondria, energetics, epigenetics, and cellular responses to stress.
Environ Health Perspect 2014 Dec 15;122(12):1271-8. Epub 2014 Aug 15.
Division of Extramural Research and Training, National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Research Triangle Park, North Carolina, USA.

PCB 126 perturbs hypoxia-induced HIF-1α activity and glucose consumption in human HepG2 cells.
Exp Toxicol Pathol 2014 Oct 7;66(8):377-82. Epub 2014 Jun 7.
Interdisciplinary Graduate Program in Human Toxicology, The University of Iowa, Iowa City, IA, USA; Department of Radiation Oncology, The University of Iowa, Iowa City, IA, USA; Department of Pathology, The University of Iowa, Iowa City, IA, USA. Electronic address:

Systematic dissection of the mechanisms underlying progesterone receptor downregulation in endometrial cancer.
Oncotarget 2014 Oct;5(20):9783-97
Department of Obstetrics and Gynecology, University of Iowa, IA, 52242, USA. Carver College of Medicine and Holden Comprehensive Cancer Center, University of Iowa, IA, 52242, USA.

Hypoxia perturbs aryl hydrocarbon receptor signaling and CYP1A1 expression induced by PCB 126 in human skin and liver-derived cell lines.
Toxicol Appl Pharmacol 2014 Feb 16;274(3):408-16. Epub 2013 Dec 16.
Interdisciplinary Graduate Program in Human Toxicology, The University of Iowa, Iowa City, IA, USA; Department of Radiation Oncology, The University of Iowa, Iowa City, IA, USA; Department of Surgery, The University of Iowa, Iowa City, IA, USA. Electronic address:

NOX4 mediates cytoprotective autophagy induced by the EGFR inhibitor erlotinib in head and neck cancer cells.
Toxicol Appl Pharmacol 2013 Nov 31;272(3):736-45. Epub 2013 Jul 31.
Interdisciplinary Graduate Program in Human Toxicology, The University of Iowa, Iowa City, IA, USA; Department of Pathology, The University of Iowa, Iowa City, IA, USA.

Low-dose radiation-induced enhancement of thymic lymphomagenesis in Lck-Bax mice is dependent on LET and gender.
Radiat Res 2013 Aug 2;180(2):156-65. Epub 2013 Jul 2.
Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, University of Iowa, Iowa City, Iowa 52242, USA.

Genetic and epigenetic inactivation of extracellular superoxide dismutase promotes an invasive phenotype in human lung cancer by disrupting ECM homeostasis.
Mol Cancer Res 2012 Jan 7;10(1):40-51. Epub 2011 Nov 7.
Free Radical and Radiation Biology Program, Department of Radiation Oncology, Carver College of Medicine and The Holden Comprehensive Cancer Center, The University of Iowa, Iowa City, Iowa 52242, USA.

Elevated mitochondrial superoxide disrupts normal T cell development, impairing adaptive immune responses to an influenza challenge.
Free Radic Biol Med 2011 Feb 2;50(3):448-58. Epub 2010 Dec 2.
Free Radical and Radiation Biology Program, Department of Radiation Oncology, Carver College of Medicine, Holden Comprehensive Cancer Center, The University of Iowa, Iowa City, IA 52242, USA.


Transgenic biosynthesis of trypanothione protects Escherichia coli from radiation-induced toxicity.
Radiat Res 2010 Sep;174(3):290-6
Department of Radiation Oncology, Carver College of Medicine, and Holden Comprehensive Cancer Center, The University of Iowa Free Radical and Radiation Biology Program, Montevideo, Uruguay.

Mitochondrial complex II dysfunction can contribute significantly to genomic instability after exposure to ionizing radiation.
Radiat Res 2009 Dec;172(6):737-45
Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, The University of Iowa, Iowa City, Iowa 52242, USA.


A novel nuclear interactor of ARF and MDM2 (NIAM) that maintains chromosomal stability.
J Biol Chem 2007 Jan 16;282(2):1322-33. Epub 2006 Nov 16.
Department of Pharmacology, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, 52242-1109, USA, and the Laboratoire de Genetique Cellulaire et Moleculaire, UPRES EA2622, Centre Hospitalier Universitaire de Poitiers, France.

Cervical keratinocytes containing stably replicating extrachromosomal HPV-16 are refractory to transformation by oncogenic H-Ras.
Virology 2006 Dec 5-20;356(1-2):68-78. Epub 2006 Aug 30.
Department of Microbiology, Holden Comprehensive Cancer Research Center, University of Iowa, 375 Newton Road, 2202 MERF, Iowa City, IA 52242, USA.

Glutathione peroxidase-1 inhibits UVA-induced AP-2alpha expression in human keratinocytes.
Biochem Biophys Res Commun 2006 Dec 7;351(4):1066-71. Epub 2006 Nov 7.
Free Radical and Radiation Biology Program, Department of Radiation Oncology, Carver College of Medicine, and Holden Comprehensive Cancer Center, The University of Iowa, Iowa City, IA 52242, USA.

Epigenetic regulation of maspin expression in human ovarian carcinoma cells.
Gynecol Oncol 2006 Aug 7;102(2):319-24. Epub 2006 Feb 7.
Department of Obstetrics and Gynecology, The University of Iowa Hospitals and Clinics, The Holden Comprehensive Cancer Center, 4630 John Colloton Pavilion, 200 Hawkins Drive, Iowa City, IA 52242, USA.

Mutation of succinate dehydrogenase subunit C results in increased O2.-, oxidative stress, and genomic instability.
Cancer Res 2006 Aug;66(15):7615-20
Free Radical and Radiation Biology Program, B180 Medical Laboratories, Department of Radiation Oncology, Holden Comprehensive Cancer Center, The University of Iowa, Iowa City, IA 52242, USA.

Inhibition of glutamate cysteine ligase activity sensitizes human breast cancer cells to the toxicity of 2-deoxy-D-glucose.
Cancer Res 2006 Feb;66(3):1605-10
Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, Roy J. and Lucille A. Carver College of Medicine, The University of Iowa, Iowa City, IA 52242, USA.

Manganese superoxide dismutase suppresses hypoxic induction of hypoxia-inducible factor-1alpha and vascular endothelial growth factor.
Oncogene 2005 Dec;24(55):8154-66
Department of Radiation Oncology, Free Radical and Radiation Biology Program, Holden Comprehensive Cancer Center, The University of Iowa, Iowa City, IA 52242-1181, USA.


Differential activation of catalase expression and activity by PPAR agonists: implications for astrocyte protection in anti-glioma therapy.
Redox Biol 2013 26;1:70-9. Epub 2013 Jan 26.
Department of Radiation Oncology, Free Radical and Radiation Biology, Holden Comprehensive Cancer Center, The University of Iowa, Iowa City, IA 52242, USA ; Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA.

Maintenance of mitochondrial genomic integrity in the absence of manganese superoxide dismutase in mouse liver hepatocytes.
Redox Biol 2013 5;1:172-7. Epub 2013 Feb 5.
Free Radical and Radiation Biology Program, Department of Radiation Oncology, Carver College of Medicine and the Holden Comprehensive Cancer Center, The University of Iowa, Iowa City, IA 52242, USA.

Mitochondrial calcium uniporter activity is dispensable for MDA-MB-231 breast carcinoma cell survival.
PLoS One 2014 6;9(5):e96866. Epub 2014 May 6.
Department of Internal Medicine, Division of Cardiovascular Medicine, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States of America; Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States of America; Department of Molecular Physiology and Biophysics, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States of America.

Retroviral-infection increases tumorigenic potential of MDA-MB-231 breast carcinoma cells by expanding an aldehyde dehydrogenase (ALDH1) positive stem-cell like population.
Redox Biol 2014 24;2:847-54. Epub 2014 Jun 24.
Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, Carver College of Medicine, University of Iowa, Iowa City, IA 52240, United States.


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