Frederick E Dewey

Frederick E Dewey

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Frederick E Dewey

Frederick E Dewey

Publications by authors named "Frederick E Dewey"

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Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls.

Authors:
Jason Flannick Josep M Mercader Christian Fuchsberger Miriam S Udler Anubha Mahajan Jennifer Wessel Tanya M Teslovich Lizz Caulkins Ryan Koesterer Francisco Barajas-Olmos Thomas W Blackwell Eric Boerwinkle Jennifer A Brody Federico Centeno-Cruz Ling Chen Siying Chen Cecilia Contreras-Cubas Emilio Córdova Adolfo Correa Maria Cortes Ralph A DeFronzo Lawrence Dolan Kimberly L Drews Amanda Elliott James S Floyd Stacey Gabriel Maria Eugenia Garay-Sevilla Humberto García-Ortiz Myron Gross Sohee Han Nancy L Heard-Costa Anne U Jackson Marit E Jørgensen Hyun Min Kang Megan Kelsey Bong-Jo Kim Heikki A Koistinen Johanna Kuusisto Joseph B Leader Allan Linneberg Ching-Ti Liu Jianjun Liu Valeriya Lyssenko Alisa K Manning Anthony Marcketta Juan Manuel Malacara-Hernandez Angélica Martínez-Hernández Karen Matsuo Elizabeth Mayer-Davis Elvia Mendoza-Caamal Karen L Mohlke Alanna C Morrison Anne Ndungu Maggie C Y Ng Colm O'Dushlaine Anthony J Payne Catherine Pihoker Wendy S Post Michael Preuss Bruce M Psaty Ramachandran S Vasan N William Rayner Alexander P Reiner Cristina Revilla-Monsalve Neil R Robertson Nicola Santoro Claudia Schurmann Wing Yee So Xavier Soberón Heather M Stringham Tim M Strom Claudia H T Tam Farook Thameem Brian Tomlinson Jason M Torres Russell P Tracy Rob M van Dam Marijana Vujkovic Shuai Wang Ryan P Welch Daniel R Witte Tien-Yin Wong Gil Atzmon Nir Barzilai John Blangero Lori L Bonnycastle Donald W Bowden John C Chambers Edmund Chan Ching-Yu Cheng Yoon Shin Cho Francis S Collins Paul S de Vries Ravindranath Duggirala Benjamin Glaser Clicerio Gonzalez Ma Elena Gonzalez Leif Groop Jaspal Singh Kooner Soo Heon Kwak Markku Laakso Donna M Lehman Peter Nilsson Timothy D Spector E Shyong Tai Tiinamaija Tuomi Jaakko Tuomilehto James G Wilson Carlos A Aguilar-Salinas Erwin Bottinger Brian Burke David J Carey Juliana C N Chan Josée Dupuis Philippe Frossard Susan R Heckbert Mi Yeong Hwang Young Jin Kim H Lester Kirchner Jong-Young Lee Juyoung Lee Ruth J F Loos Ronald C W Ma Andrew D Morris Christopher J O'Donnell Colin N A Palmer James Pankow Kyong Soo Park Asif Rasheed Danish Saleheen Xueling Sim Kerrin S Small Yik Ying Teo Christopher Haiman Craig L Hanis Brian E Henderson Lorena Orozco Teresa Tusié-Luna Frederick E Dewey Aris Baras Christian Gieger Thomas Meitinger Konstantin Strauch Leslie Lange Niels Grarup Torben Hansen Oluf Pedersen Philip Zeitler Dana Dabelea Goncalo Abecasis Graeme I Bell Nancy J Cox Mark Seielstad Rob Sladek James B Meigs Steve S Rich Jerome I Rotter David Altshuler Noël P Burtt Laura J Scott Andrew P Morris Jose C Florez Mark I McCarthy Michael Boehnke

Nature 2019 06 22;570(7759):71-76. Epub 2019 May 22.

Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA.

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http://www.nature.com/articles/s41586-019-1231-2
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http://dx.doi.org/10.1038/s41586-019-1231-2DOI Listing
June 2019

APPLICATIONS OF GENETICS, GENOMICS AND BIOINFORMATICS IN DRUG DISCOVERY.

Pac Symp Biocomput 2018 ;23:1-7

Genentech Inc. South San Francisco, CA 94080, USA,

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August 2018

Genetic inactivation of ANGPTL4 improves glucose homeostasis and is associated with reduced risk of diabetes.

Nat Commun 2018 06 13;9(1):2252. Epub 2018 Jun 13.

Regeneron Pharmaceuticals, Tarrytown, 10591, NY, USA.

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http://dx.doi.org/10.1038/s41467-018-04611-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5997992PMC
June 2018

A Protein-Truncating HSD17B13 Variant and Protection from Chronic Liver Disease.

N Engl J Med 2018 03;378(12):1096-1106

From the Regeneron Genetics Center (N.S.A.-H., A.H.L., C.S., S. McCarthy, C.O., J.S.P., S.B., N.G., S. Mukherjee, A.E.L., E.D.F., J.P., I.B.B., A.R.S., J.G.R., J.D.O., O.G., T.M.T., A.B., F.E.D.) and Regeneron Pharmaceuticals (X. Cheng, Y.X., P.S., Y.L., D.E., S.Y.K., B.Z., W.O., A.J.M., G.D.Y., J.G.), Tarrytown, NY; the University of Texas Southwestern Medical Center at Dallas, Dallas (J.K., S.S., H.H.H., J.C.C.); and Geisinger Health System, Danville (G.C.W., A.N.S., M.D.S., X. Chu, J.Z.L., U.L.M., D.J.C., C.D.S., T.M.), and Perelman School of Medicine, University of Pennsylvania, Philadelphia (M.D.F., A.S., S.M.D., D.J.R.) - both in Pennsylvania.

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http://dx.doi.org/10.1056/NEJMoa1712191DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6668033PMC
March 2018

Genome-wide Study of Atrial Fibrillation Identifies Seven Risk Loci and Highlights Biological Pathways and Regulatory Elements Involved in Cardiac Development.

Am J Hum Genet 2018 01 28;102(1):103-115. Epub 2017 Dec 28.

Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI 48109, USA; Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109, USA; Center for Statistical Genetics, University of Michigan, Ann Arbor, MI 48109, USA; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health, Norwegian University of Science and Technology, Trondheim 7491, Norway; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ajhg.2017.12.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5777936PMC
January 2018

Genetic and Pharmacologic Inactivation of ANGPTL3 and Cardiovascular Disease.

N Engl J Med 2017 07 24;377(3):211-221. Epub 2017 May 24.

From Regeneron Genetics Center (F.E.D., C.O., C.S., O.G., S.M., C.V.V.H., S.B., L.H., A.L., J.P., N.S., A.J.M., J.D.O., J.G.R., A.R.S., I.B.B., T.M.T., G.D.Y., S.J.M., A. Baras) and Regeneron Pharmaceuticals (V.G., H.M.D., A.Z., W.S., N.S., A.J.M., S.H., A. Bouzelmat, R.Z., B.S., R.P., D.G., G.A.H., W.J.S., P.B., G.D.Y., S.J.M., J.G.) Tarrytown, NY; the Department of Medicine, Division of Translational Medicine and Human Genetics (R.L.D.), and Departments of Surgery (S.D.) and Genetics and Medicine (A.S., D.J.R.), Perelman School of Medicine, University of Pennsylvania, Philadelphia, and Geisinger Health System, Danville (J.B.L., M.F.M., M.D.R., H.L.K., D.H.L., D.J.C.) - both in Pennsylvania; the Division of Endocrinology and Metabolism, Department of Internal Medicine (W.H.H.S., I.-T.L.) and Cardiovascular Center (K.-W.L.), Taichung Veterans General Hospital, Institute of Medical Technology, National Chung-Hsing University (W.H.H.S.), School of Medicine, Chung Shan Medical University (I.-T.L.), and the Department of Medicine, China Medical University (K.-W.L.), Taichung, and School of Medicine, National Yang-Ming University (W.H.H.S., I.-T.L., K.-W.L.), and School of Medicine, National Defense Medical Center (W.H.H.S.), Taipei - all in Taiwan; Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA (X.G., J.I.R., Y.-D.I.C.); the Division of Cardiology, Department of Medicine, Molecular Physiology Institute, School of Medicine, Duke University, Durham, NC (W.E.K., S.H.S.); the Department of Clinical Biochemistry, Rigshospitalet (A.B.W., B.G.N., A.T.-H.), the Copenhagen General Population Study (B.G.N., A.T.-H.) and Department of Clinical Biochemistry (B.G.N.), Herlev and Gentofte Hospital, and the Copenhagen City Heart Study, Frederiksberg Hospital, Copenhagen University Hospital, and Faculty of Health and Medical Sciences, University of Copenhagen (B.G.N., A.T.-H.) - all in Copenhagen; and TNO Metabolic Health Research, Gaubius Laboratory, Leiden, the Netherlands (A.M.H., H.M.G.P.).

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http://dx.doi.org/10.1056/NEJMoa1612790DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5800308PMC
July 2017

Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets.

Authors:
Louise V Wain Nick Shrine María Soler Artigas A Mesut Erzurumluoglu Boris Noyvert Lara Bossini-Castillo Ma'en Obeidat Amanda P Henry Michael A Portelli Robert J Hall Charlotte K Billington Tracy L Rimington Anthony G Fenech Catherine John Tineka Blake Victoria E Jackson Richard J Allen Bram P Prins Archie Campbell David J Porteous Marjo-Riitta Jarvelin Matthias Wielscher Alan L James Jennie Hui Nicholas J Wareham Jing Hua Zhao James F Wilson Peter K Joshi Beate Stubbe Rajesh Rawal Holger Schulz Medea Imboden Nicole M Probst-Hensch Stefan Karrasch Christian Gieger Ian J Deary Sarah E Harris Jonathan Marten Igor Rudan Stefan Enroth Ulf Gyllensten Shona M Kerr Ozren Polasek Mika Kähönen Ida Surakka Veronique Vitart Caroline Hayward Terho Lehtimäki Olli T Raitakari David M Evans A John Henderson Craig E Pennell Carol A Wang Peter D Sly Emily S Wan Robert Busch Brian D Hobbs Augusto A Litonjua David W Sparrow Amund Gulsvik Per S Bakke James D Crapo Terri H Beaty Nadia N Hansel Rasika A Mathias Ingo Ruczinski Kathleen C Barnes Yohan Bossé Philippe Joubert Maarten van den Berge Corry-Anke Brandsma Peter D Paré Don D Sin David C Nickle Ke Hao Omri Gottesman Frederick E Dewey Shannon E Bruse David J Carey H Lester Kirchner Stefan Jonsson Gudmar Thorleifsson Ingileif Jonsdottir Thorarinn Gislason Kari Stefansson Claudia Schurmann Girish Nadkarni Erwin P Bottinger Ruth J F Loos Robin G Walters Zhengming Chen Iona Y Millwood Julien Vaucher Om P Kurmi Liming Li Anna L Hansell Chris Brightling Eleftheria Zeggini Michael H Cho Edwin K Silverman Ian Sayers Gosia Trynka Andrew P Morris David P Strachan Ian P Hall Martin D Tobin

Nat Genet 2017 Mar 6;49(3):416-425. Epub 2017 Feb 6.

Department of Health Sciences, University of Leicester, Leicester, UK.

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http://dx.doi.org/10.1038/ng.3787DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5326681PMC
March 2017

Variants in ANGPTL4 and the Risk of Coronary Artery Disease.

N Engl J Med 2016 12;375(23):2305-2306

Regeneron Genetics Center, Tarrytown, NY

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http://dx.doi.org/10.1056/NEJMc1607380DOI Listing
December 2016

INTEGRATING CLINICAL LABORATORY MEASURES AND ICD-9 CODE DIAGNOSES IN PHENOME-WIDE ASSOCIATION STUDIES.

Pac Symp Biocomput 2016 ;21:168-79

Biomedical and Translational Informatics, Geisinger Health System, Danville, PA, USA3Center for Systems Genomics, The Pennsylvania State University, University Park, PA, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4718547PMC
October 2016

Early somatic mosaicism is a rare cause of long-QT syndrome.

Proc Natl Acad Sci U S A 2016 10 28;113(41):11555-11560. Epub 2016 Sep 28.

Stanford Center for Inherited Cardiovascular Disease, Stanford University School of Medicine, Stanford, CA 94305; Child Health Research Institute, Stanford University School of Medicine, Stanford, CA 94305; Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA 94305;

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http://dx.doi.org/10.1073/pnas.1607187113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5068256PMC
October 2016

Multidimensional structure-function relationships in human β-cardiac myosin from population-scale genetic variation.

Proc Natl Acad Sci U S A 2016 06 31;113(24):6701-6. Epub 2016 May 31.

Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305; Stanford Center for Inherited Cardiovascular Disease, Stanford University, Stanford, CA 94305;

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http://dx.doi.org/10.1073/pnas.1606950113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4914177PMC
June 2016

Inactivating Variants in ANGPTL4 and Risk of Coronary Artery Disease.

N Engl J Med 2016 Mar 2;374(12):1123-33. Epub 2016 Mar 2.

From the Regeneron Genetics Center (F.E.D., C.O., O.G., C.V.V.H., L.H., J.P., A.L., I.B.B., J.D.O., J.G.R., A.J.M., G.D.Y., A.B., J.G., A.R.S.) and Regeneron Pharmaceuticals (V.G., J.T., C.H., D.B., K.-M.V.L., A.J.M., G.D.Y.) - both in Tarrytown, NY; and Geisinger Health System, Danville, PA (J.B.L., M.F.M., M.D.R., H.L.K., D.H.L., D.J.C.).

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http://dx.doi.org/10.1056/NEJMoa1510926DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4900689PMC
March 2016

Sequence to Medical Phenotypes: A Framework for Interpretation of Human Whole Genome DNA Sequence Data.

PLoS Genet 2015 Oct 8;11(10):e1005496. Epub 2015 Oct 8.

Stanford Center for Inherited Cardiovascular Disease, Stanford University, Stanford, California, United States of America; Stanford Cardiovascular Institute, Stanford University, Stanford, California, United States of America; Division of Cardiovascular Medicine, Stanford University, Stanford, California, United States of America; Department of Genetics, Stanford University, Stanford, California, United States of America.

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http://dx.plos.org/10.1371/journal.pgen.1005496
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http://dx.doi.org/10.1371/journal.pgen.1005496DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4598191PMC
October 2015

Molecular diagnosis of long QT syndrome at 10 days of life by rapid whole genome sequencing.

Heart Rhythm 2014 Oct 25;11(10):1707-13. Epub 2014 Jun 25.

Division of Cardiovascular Medicine; Child Health Research Institute; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, California. Electronic address:

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http://dx.doi.org/10.1016/j.hrthm.2014.06.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4379486PMC
October 2014

Systems-based approaches to cardiovascular biomarker discovery.

Circ Cardiovasc Genet 2012 Jun;5(3):360-7

Department of Cardiovascular Diseases, Public Research Centre for Health, Luxembourg, Luxembourg.

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https://www.ahajournals.org/doi/10.1161/CIRCGENETICS.112.962
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http://dx.doi.org/10.1161/CIRCGENETICS.112.962977DOI Listing
June 2012

DNA sequencing: clinical applications of new DNA sequencing technologies.

Circulation 2012 Feb;125(7):931-44

Center for Inherited Cardiovascular Disease, Division of Cardiovascular Medicine, Stanford University School of Medicine, Falk CVRB, 300 Pasteur Dr, Stanford, CA 94305, USA.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.110.972828DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3364518PMC
February 2012

Systems biology of heart failure, challenges and hopes.

Curr Opin Cardiol 2011 Jul;26(4):314-21

Division of Cardiovascular Medicine, Stanford Hospital and Clinics, Stanford, California, USA.

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http://dx.doi.org/10.1097/HCO.0b013e328346597dDOI Listing
July 2011

Gene coexpression network topology of cardiac development, hypertrophy, and failure.

Circ Cardiovasc Genet 2011 Feb 2;4(1):26-35. Epub 2010 Dec 2.

Department of Internal Medicine and the Division of Cardiovascular Medicine, Stanford Hospital and Clinics, and Stanford University School of Medicine, Stanford, CA 94305, USA.

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http://dx.doi.org/10.1161/CIRCGENETICS.110.941757DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3324316PMC
February 2011

Hemoglobin levels predict exercise performance, ST-segment depression, and outcome in patients referred for routine exercise treadmill testing.

Clin Cardiol 2009 Dec;32(12):E22-31

Veterans Affairs Palo Alto Health Care System, Stanford University Administration Health Care System, Palo Alto, California, USA.

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http://dx.doi.org/10.1002/clc.20418DOI Listing
December 2009

Electrocardiographic predictors of atrial fibrillation.

Am Heart J 2009 Oct;158(4):622-8

Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA.

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http://dx.doi.org/10.1016/j.ahj.2009.08.002DOI Listing
October 2009

Statin use and ventricular arrhythmias during clinical treadmill testing.

J Cardiovasc Electrophysiol 2009 Feb 3;20(2):193-9. Epub 2008 Sep 3.

Department of Internal Medicine, Stanford University, Palo Alto, California, USA.

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http://doi.wiley.com/10.1111/j.1540-8167.2008.01284.x
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http://dx.doi.org/10.1111/j.1540-8167.2008.01284.xDOI Listing
February 2009

Added value of a resting ECG neural network that predicts cardiovascular mortality.

Ann Noninvasive Electrocardiol 2009 Jan;14(1):26-34

Stanford University School of Medicine, Cardiovascular Medicine, Stanford, CA, USA.

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http://dx.doi.org/10.1111/j.1542-474X.2008.00270.xDOI Listing
January 2009

Prognostic value of double product reserve.

Eur J Cardiovasc Prev Rehabil 2008 Oct;15(5):541-7

Stanford University Medical Center, Division of Cardiovascular Medicine, 300 Pasteur Dr Falk CVRC, Stanford, CA 94305-5406, USA.

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http://dx.doi.org/10.1097/HJR.0b013e328305deefDOI Listing
October 2008

Age-adjusted modification of the Duke Treadmill Score nomogram.

Am Heart J 2008 Jun 12;155(6):1033-8. Epub 2008 Mar 12.

Division of Cardiovascular Medicine, Stanford University Medical Center, Stanford, CA 94305-5406, USA.

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http://dx.doi.org/10.1016/j.ahj.2008.01.025DOI Listing
June 2008

Does size matter? Clinical applications of scaling cardiac size and function for body size.

Circulation 2008 Apr;117(17):2279-87

Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.

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https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.107.7
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http://dx.doi.org/10.1161/CIRCULATIONAHA.107.736785DOI Listing
April 2008

Ventricular arrhythmias during clinical treadmill testing and prognosis.

Arch Intern Med 2008 Jan;168(2):225-34

Stanford University Medical School, Palo Alto, California, USA.

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http://dx.doi.org/10.1001/archinte.168.2.225DOI Listing
January 2008

Prognostic value of heart rate increase at onset of exercise testing.

Circulation 2007 Jan 22;115(4):468-74. Epub 2007 Jan 22.

Stanford University Medical Center, Stanford University Medical School, Calif, USA.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.106.666388DOI Listing
January 2007

Autonomic nervous system interaction with the cardiovascular system during exercise.

Prog Cardiovasc Dis 2006 Mar-Apr;48(5):342-62

Division of Cardiovascular Medicine, Stanford University Medical Center and Veterans Affairs Health Care System, Palo Alto, CA 94304, USA.

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http://dx.doi.org/10.1016/j.pcad.2005.11.003DOI Listing
May 2006