Frederic Vellieux, B.Sc., Ph.D., HdR - 1st Faculty of Medicine, Charles University - Dr

Frederic Vellieux

B.Sc., Ph.D., HdR

1st Faculty of Medicine, Charles University

Dr

Vestec, Central Bohemia | Czech Republic

Main Specialties: Chemistry, Pharmacology

Additional Specialties: Structural Biology

ORCID logohttps://orcid.org/0000-0002-1922-5707

Frederic Vellieux, B.Sc., Ph.D., HdR - 1st Faculty of Medicine, Charles University - Dr

Frederic Vellieux

B.Sc., Ph.D., HdR

Introduction

Primary Affiliation: 1st Faculty of Medicine, Charles University - Vestec, Central Bohemia , Czech Republic

Specialties:

Additional Specialties:

Research Interests:


View Frederic Vellieux’s Resume / CV

Education

Oct 2006
Université de Grenoble
Habilitation
Physics
Jun 1990
Rijksuniversiteit Groningen
Ph.D. (doktoraat)
Protein Crystallography
Jun 1984
Birkbeck, University of London
B. Sc. 1st class hons
Chemistry

Publications

19Publications

22Reads

25Profile Views

Synthesis, Conformational Analysis and Crystal Structure of New Thioxo, Oxo, Seleno Diastereomeric Cyclophosphamides Containing 1,3,2-dioxaphosphorinane

Current Organic Chemistry 2019, DOI : 10.2174/1385272823666190213142748

Current Organic Chemistry

Abstract: Thioxo, Oxo, Seleno and diastereomeric cyclophosphamides containing 1,3,2-dioxaphosphorinane are prepared by a one-step chemical reaction. Their structural determination is carried out by means of Nuclear Magnetic Resonance NMR (31P, 1 H, 13C) and High-Resolution Mass Spectroscopy (HRMS). The conformational study of diastereomeric products is described. Density Functional Theory (DFT) calculations allowed the identification of preferred conformations. Experimental and calculated 31P, 13C, 1H NMR chemical shifts are compared. The molecular structure of the 2-Benzylamino-5-methyl-5-propyl-2-oxo-1,3,2-dioxaphosphorinane (3d) has been determined by means of crystal X-ray diffraction methods.

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February 2019
61 Reads

Noncrystallographic symmetry averaging in phase refinement and extension.

Methods Enzymol 1997 ;277:18-53

Institut de Biologie Structurale, Jean-Pierre Ebel CEA CNRS, Grenoble 01, France.

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May 2008
1 Read
2.088 Impact Factor

Crystallization and preliminary crystallographic investigation of glycosomal pyruvate phosphate dikinase from Trypanosoma brucei.

Acta Crystallogr D Biol Crystallogr 2000 Dec;56(Pt 12):1688-90

Laboratoire de Biophysique Moléculaire, Institut de Biologie Structurale J.-P. Ebel CEA CNRS, 41 Rue Jules Horowitz, 38027 Grenoble CEDEX 01, France.

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December 2000
1 Read
7.232 Impact Factor

Crystallographic studies of the interaction between the ferredoxin-NADP+ reductase and ferredoxin from the cyanobacterium Anabaena: looking for the elusive ferredoxin molecule.

Acta Crystallogr D Biol Crystallogr 2000 Nov;56(Pt 11):1408-12

LCCP, Institut de Biologie Structurale J. P. Ebel, CEA-CNRS, 41 Rue Jules Horowitz, F38027 Grenoble, France.

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November 2000
1 Read
7.232 Impact Factor

PBR: a heavy-atom refinement and phasing procedure to reduce phase bias when heavy-atom derivatives contain common sites.

Acta Crystallogr D Biol Crystallogr 1999 Feb;55(Pt 2):469-72

Laboratoire de Cristallographie et de Cristallogenèse des Protéines, Institut de Biologie Structurale J.-P. Ebel CEA--CNRS, 41 Avenue des Martyrs, 38027 Grenoble CEDEX 01, France.

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http://dx.doi.org/10.1107/s0907444998011366DOI Listing
February 1999
1 Read
7.232 Impact Factor

A comparison of two algorithms for electron-density map improvement by introduction of atomicity: skeletonization, and map sorting followed by refinement.

Authors:
F M Vellieux

Acta Crystallogr D Biol Crystallogr 1998 Jan;54(Pt 1):81-5

Institut de Biologie Structurale J.-P. Ebel CEA CNRS, 41 Avenue des Martyrs, 38027 Grenoble CEDEX 01, France.

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http://dx.doi.org/10.1107/s0907444997008081DOI Listing
January 1998
1 Read
7.232 Impact Factor

A connected set algorithm for the identification of spatially contiguous regions in crystallographic envelopes.

Acta Crystallogr D Biol Crystallogr 1997 Jul;53(Pt 4):434-7

Howard Hughes Medical Institute and Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75235-9050, USA.

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http://dx.doi.org/10.1107/S0907444997001431DOI Listing
July 1997
1 Read
7.232 Impact Factor

Crystal structures of a ferredoxin: NADP+ reductase and of a complex with NADP+.

Biochem Soc Trans 1996 Feb;24(1):10S

IBS/LCCP 41, Grenoble, France.

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February 1996
1 Read
3.194 Impact Factor

Refined 3.2 A structure of glycosomal holo glyceraldehyde phosphate dehydrogenase from Trypanosoma brucei brucei.

Acta Crystallogr D Biol Crystallogr 1995 Jul;51(Pt 4):575-89

BIOSON Research Institute, University of Groningen, The Netherlands.

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http://dx.doi.org/10.1107/S0907444995003015DOI Listing
July 1995
1 Read
7.232 Impact Factor

Structure of glycosomal glyceraldehyde-3-phosphate dehydrogenase from Trypanosoma brucei determined from Laue data.

Proc Natl Acad Sci U S A 1993 Mar;90(6):2355-9

Department of Chemistry, BIOSON Research Institute, University of Groningen, The Netherlands.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC46085PMC
http://dx.doi.org/10.1073/pnas.90.6.2355DOI Listing
March 1993
1 Read
9.809 Impact Factor

Three-dimensional structure of the quinoprotein methylamine dehydrogenase from Paracoccus denitrificans determined by molecular replacement at 2.8 A resolution.

Proteins 1992 Oct;14(2):288-99

Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, Missouri 63110.

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http://dx.doi.org/10.1002/prot.340140214DOI Listing
October 1992
1 Read
2.627 Impact Factor

Crystal structure of an electron-transfer complex between methylamine dehydrogenase and amicyanin.

Biochemistry 1992 Jun;31(21):4959-64

Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, Missouri 63110.

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June 1992
2 Reads
3.015 Impact Factor

Crystallographic investigations of the tryptophan-derived cofactor in the quinoprotein methylamine dehydrogenase.

FEBS Lett 1991 Aug;287(1-2):163-6

Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, MO 63110.

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August 1991
2 Reads
3.169 Impact Factor

The cytosolic and glycosomal glyceraldehyde-3-phosphate dehydrogenase from Trypanosoma brucei. Kinetic properties and comparison with homologous enzymes.

Eur J Biochem 1991 Jun;198(2):429-35

International Institute of Cellular and Molecular Pathology, Research Unit for Tropical Diseases, Brussels, Belgium.

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June 1991
1 Read

Structure determination of quinoprotein methylamine dehydrogenase from Thiobacillus versutus.

Acta Crystallogr B 1990 Dec;46 ( Pt 6):806-23

Department of Chemistry, University of Groningen, The Netherlands.

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http://dx.doi.org/10.1107/s010876819000636xDOI Listing
December 1990
1 Read
2.184 Impact Factor

Structure of quinoprotein methylamine dehydrogenase at 2.25 A resolution.

EMBO J 1989 Aug;8(8):2171-8

Laboratory of Chemical Physics, University of Groningen, Nijenborgh, The Netherlands.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC401144PMC
August 1989
1 Read
10.434 Impact Factor