Publications by authors named "Frederic R Leroux"

32Publications

Deprotonative Functionalization of the Difluoromethyl Group.

Org Lett 2020 11 22;22(21):8741-8745. Epub 2020 Oct 22.

Université de Strasbourg, Université de Haute-Alsace, CNRS, UMR 7042-LIMA, ECPM, 25 Rue Becquerel, Strasbourg 67087, France.

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http://dx.doi.org/10.1021/acs.orglett.0c03380DOI Listing
November 2020

Synthesis and Use of Trifluoromethylthiolated Ketenimines.

Chemistry 2020 Nov 14;26(65):14852-14855. Epub 2020 Oct 14.

Université de Strasbourg, Université de Haute-Alsace, CNRS, UMR 7042-LIMA, ECPM, 25 Rue Becquerel, Strasbourg, 67087, France.

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http://dx.doi.org/10.1002/chem.202002723DOI Listing
November 2020

Access towards enantiopure α,α-difluoromethyl alcohols by means of sulfoxides as traceless chiral auxiliaries.

Chem Commun (Camb) 2018 Sep;54(74):10423-10426

Université de Strasbourg, Université de Haute-Alsace, CNRS, UMR 7042-LIMA, ECPM, 25 Rue Becquerel, Strasbourg 67087, France.

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http://dx.doi.org/10.1039/c8cc05571hDOI Listing
September 2018

Stereoselectivity Switch in the Trapping of Polar Organometallics with Andersen's Reagent-Access to Highly Stereoenriched Transformable Biphenyls.

J Org Chem 2018 Aug 13;83(15):7751-7761. Epub 2018 Jun 13.

Université de Strasbourg , Université de Haute-Alsace, CNRS, LIMA UMR 7042, ECPM , 25 rue Becquerel , F-67000 Strasbourg , France.

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http://dx.doi.org/10.1021/acs.joc.8b00648DOI Listing
August 2018

Synthesis of Mono- and Bis(fluoroalkyl)pyrimidines from FARs, Fluorinated Acetoacetates, and Malononitrile Provides Easy Access to Novel High-Value Pyrimidine Scaffolds.

Chemistry 2018 Jan 23;24(6):1311-1316. Epub 2017 Nov 23.

Laboratoire de Chimie Moléculaire, Université de Strasbourg, CNRS, UMR 7509, 25, rue Becquerel, 67087, Strasbourg, France.

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http://dx.doi.org/10.1002/chem.201703982DOI Listing
January 2018

Fluoroalkyl Amino Reagents for the Introduction of the Fluoro(trifluoromethoxy)methyl Group onto Arenes and Heterocycles.

Org Lett 2017 09 1;19(18):4960-4963. Epub 2017 Sep 1.

University of Strasbourg , CNRS, LCM UMR 7509, 25 Rue Becquerel, 67000 Strasbourg, France.

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http://dx.doi.org/10.1021/acs.orglett.7b02444DOI Listing
September 2017

Asymmetric α-Sulfonyl- and α-Phosphoryl-Oxylation of Ketones by a Chiral Hypervalent Iodine(III).

J Org Chem 2017 11 31;82(22):11877-11883. Epub 2017 Jul 31.

Institut de Chimie des Substances Naturelles , CNRS UPR 2301, Université Paris-Sud, Université Paris-Saclay, 1, av. de la Terrasse, 91198 Gif-sur-Yvette Cedex, France.

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http://dx.doi.org/10.1021/acs.joc.7b01597DOI Listing
November 2017

A Major Advance in the Synthesis of Fluoroalkyl Pyrazoles: Tuneable Regioselectivity and Broad Substitution Patterns.

Chemistry 2016 Aug 30;22(32):11239-44. Epub 2016 Jun 30.

CNRS & University of Strasbourg (ECPM), UMR CNRS 7509, LCR Bayer-CNRS C2OF, 25 Rue Becquerel, 67087, Strasbourg, France.

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http://dx.doi.org/10.1002/chem.201601621DOI Listing
August 2016

Lithium/Element Exchange as an Efficient Tool for Accessing Atropo-enriched Biaryls via Arynes.

Chimia (Aarau) 2016 ;70(1-2):43-7

CNRS/University of Strasbourg UMR CNRS 7509 - Laboratoire de Chimie, Moléculaire, ECPM, 25 Rue Becquerel, 67087 Strasbourg Cedex 2, France.

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http://dx.doi.org/10.2533/chimia.2016.43DOI Listing
April 2016

This special issue is dedicated to French faculty members. Introduction.

Chimia (Aarau) 2016 ;70(1-2):6-7

Laboratory of Molecular Chemistry (LCM), University of Strasbourg, UMR CNRS 7509, France.

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April 2016

In Situ Generated Fluorinated Iminium Salts for Difluoromethylation and Difluoroacetylation.

Org Lett 2015 Sep 3;17(18):4510-3. Epub 2015 Sep 3.

CNRS-University of Strasbourg (ECPM) , UMR CNRS 7509, LCR Bayer-CNRS C2OF, 25 Rue Becquerel, 67087 Strasbourg, France.

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http://dx.doi.org/10.1021/acs.orglett.5b02184DOI Listing
September 2015

Determination of the absolute configuration of phosphinic analogues of glutamate.

Org Biomol Chem 2015 Jan 24;13(4):1106-12. Epub 2014 Nov 24.

Laboratoire de Chimie & Biochimie Pharmacologiques et Toxicologiques, UMR CNRS 8601, Université Paris Descartes, Sorbonne Paris Cité, 45, rue des Saints-Pères 75270, Paris cedex 06, France.

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http://dx.doi.org/10.1039/c4ob01960aDOI Listing
January 2015

Trifluoromethyl ethers and -thioethers as tools for medicinal chemistry and drug discovery.

Curr Top Med Chem 2014 ;14(7):941-51

CNRS-Universite de Strasbourg, UMR7509, SynCat, ECPM, 25 Rue Becquerel, 67087 Strasbourg Cedex 02, France.

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http://dx.doi.org/10.2174/1568026614666140202210016DOI Listing
November 2014

Palladium-catalyzed intramolecular direct arylation of 2-bromo-diaryl sulfoxides via C-H bond activation.

Org Lett 2013 May 2;15(10):2490-3. Epub 2013 May 2.

Laboratoire de Synthèse et Catalyse Asymétrique (SynCat), Université de Strasbourg (ECPM) , UMR CNRS 7509, 25 rue Becquerel, 67087 Strasbourg Cedex 02, France.

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http://dx.doi.org/10.1021/ol400966qDOI Listing
May 2013

Transition-metal-free atropo-selective synthesis of biaryl compounds based on arynes.

Chemistry 2012 Nov 27;18(45):14232-6. Epub 2012 Sep 27.

Laboratoire de Chimie Moléculaire (UMR7509/CNRS/ECPM), Université de Strasbourg, 25 Rue Becquerel, 67087 Strasbourg, France.

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http://dx.doi.org/10.1002/chem.201202739DOI Listing
November 2012

Stereoselective synthesis of P-chirogenic dibenzophosphole-boranes via aryne intermediates.

J Org Chem 2012 Jul 3;77(14):6117-27. Epub 2012 Jul 3.

Laboratoire de Chimie Moléculaire (UMR CNRS 7509), Université de Strasbourg, ECPM, 25 rue Becquerel, 67087 Strasbourg, France.

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http://dx.doi.org/10.1021/jo3009098DOI Listing
July 2012

Stereoselective synthesis of o-bromo (or iodo)aryl P-chirogenic phosphines based on aryne chemistry.

J Org Chem 2012 Jul 27;77(13):5759-69. Epub 2012 Jun 27.

Institut de Chimie Moléculaire de l'Université de Bourgogne (ICMUB-StereochIM-UMR CNRS 6302), 9 avenue A. Savary BP47870, 21078 Dijon Cedex, France.

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http://dx.doi.org/10.1021/jo300910wDOI Listing
July 2012

Construction of the biaryl-part of vancomycin aglycon via atropo-diastereoselective Suzuki-Miyaura coupling.

Org Biomol Chem 2012 May 13;10(20):4095-102. Epub 2012 Apr 13.

CNRS/Université de Strasbourg (ECPM), UMR 7509, 25 Rue Becquerel, F-67087 Strasbourg, France.

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http://xlink.rsc.org/?DOI=c2ob25373a
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http://dx.doi.org/10.1039/c2ob25373aDOI Listing
May 2012

Bromine-lithium exchange: An efficient tool in the modular construction of biaryl ligands.

Beilstein J Org Chem 2011 14;7:1278-87. Epub 2011 Sep 14.

Laboratoire de stéréochimie, UMR 7509, CNRS-Université de Strasbourg, ECPM, 25 rue Becquerel, F-67087 Strasbourg Cedex 02, France.

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http://dx.doi.org/10.3762/bjoc.7.148DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3182437PMC
November 2011

Catalytic palladium phosphination: modular synthesis of C1-symmetric biaryl-based diphosphines.

Chemistry 2011 Sep 18;17(39):11008-16. Epub 2011 Aug 18.

Laboratoire de stéréochimie, UMR CNRS 7509, CNRS/University of Strasbourg, ECPM, 25 Rue Becquerel, 67087 Strasbourg Cedex 02, France.

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http://dx.doi.org/10.1002/chem.201101529DOI Listing
September 2011

Highly efficient one-pot access to functionalized arylboronic acids via noncryogenic bromine/magnesium exchanges.

Org Lett 2011 Sep 11;13(17):4479-81. Epub 2011 Aug 11.

Laboratoire de Stéréochimie (UMR CNRS 7509), CNRS/Université de Strasbourg (ECPM), 25 Rue Becquerel, F-67087 Strasbourg, France.

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http://pubs.acs.org/doi/abs/10.1021/ol2016252
Publisher Site
http://dx.doi.org/10.1021/ol2016252DOI Listing
September 2011

[1,2,3]Triazolo[1,5-a]pyridyl phosphines reflecting the influence of phosphorus lone pair orientation on spectroscopic properties.

Dalton Trans 2011 Feb 23;40(6):1387-95. Epub 2010 Dec 23.

Laboratoire de stéréochimie (UMR7509), CNRS-Université de Strasbourg (ECPM), 25 rue Becquerel, 67087, Strasbourg, France.

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http://dx.doi.org/10.1039/c0dt01183eDOI Listing
February 2011

Efficient synthesis of quaternary and P-stereogenic phosphonium triflates.

Org Lett 2010 Apr;12(7):1568-71

Institut de Chimie Moléculaire de l'Université de Bourgogne (ICMUB), UMR CNRS 5260, 9 Avenue Alain Savary, BP 47870, 21078 Dijon cedex, France.

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http://dx.doi.org/10.1021/ol100304cDOI Listing
April 2010

Axial chirality control during Suzuki-Miyaura cross-coupling reactions: the tert-butylsulfinyl group as an efficient chiral auxiliary.

Org Lett 2009 Nov;11(22):5130-3

Laboratoire de Stéréochimie (UMR CNRS 7509), Université de Strasbourg (ECPM), 25 rue Becquerel, 67087 Strasbourg Cedex 2, France.

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http://dx.doi.org/10.1021/ol9020755DOI Listing
November 2009

The [1,2,3]triazolo[1,5-a]pyridine ring: a sensitive sensor for the electronic profile of phosphorus substituents.

Dalton Trans 2009 Jul 8(26):5068-70. Epub 2009 May 8.

CNRS and University of Strasbourg (ECPM), UMR 7509, 25 rue Becquerel, 67087, Strasbourg, France.

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http://dx.doi.org/10.1039/b906034kDOI Listing
July 2009

Trifluoromethyl ethers--synthesis and properties of an unusual substituent.

Beilstein J Org Chem 2008 29;4:13. Epub 2008 Apr 29.

Laboratoire de Stéréochimie, Université Louis Pasteur (ECPM), CNRS, 25 rue Becquerel, F - 67087 Strasbourg Cedex 2, France.

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http://dx.doi.org/10.3762/bjoc.4.13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2486484PMC
May 2010

Inhibitors of steroidal cytochrome p450 enzymes as targets for drug development.

Recent Pat Anticancer Drug Discov 2007 Jan;2(1):31-58

European Patent Office (EPO), Bayerstrasse 34, D - 80335 Munich, Germany.

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http://dx.doi.org/10.2174/157489207779561453DOI Listing
January 2007

alpha-fluorinated ethers as "exotic" entity in medicinal chemistry.

Mini Rev Med Chem 2007 Oct;7(10):1027-34

aBayer CropScience AG, BCS-R-I Chemistry Insecticides, Building 6240, Alfred-Nobel-Strasse 50, D-40789 Monheim, Germany.

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http://dx.doi.org/10.2174/138955707782110150DOI Listing
October 2007