Frederic J de Sauvage

Frederic J de Sauvage

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Frederic J de Sauvage

Frederic J de Sauvage

Publications by authors named "Frederic J de Sauvage"

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The great escape: tumour cell plasticity in resistance to targeted therapy.

Nat Rev Drug Discov 2019 Oct 10. Epub 2019 Oct 10.

Department of Molecular Oncology, Genentech, South San Francisco, CA, USA.

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http://dx.doi.org/10.1038/s41573-019-0044-1DOI Listing
October 2019

Cellular Plasticity in Intestinal Homeostasis and Disease.

Cell Stem Cell 2019 01 27;24(1):54-64. Epub 2018 Dec 27.

Molecular Oncology, Genentech, Inc., South San Francisco, CA 94080, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2018.11.019DOI Listing
January 2019

Publisher Correction: Parasitic helminths induce fetal-like reversion in the intestinal stem cell niche.

Nature 2018 10;562(7727):E22

Program in Craniofacial Biology and Department of Orofacial Sciences, University of California, San Francisco, CA, USA.

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http://dx.doi.org/10.1038/s41586-018-0370-1DOI Listing
October 2018

A cell identity switch allows residual BCC to survive Hedgehog pathway inhibition.

Nature 2018 10 8;562(7727):429-433. Epub 2018 Oct 8.

Department of Molecular Oncology, Genentech, San Francisco, CA, USA.

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http://www.nature.com/articles/s41586-018-0596-y
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http://dx.doi.org/10.1038/s41586-018-0596-yDOI Listing
October 2018

Subtle Changes in the Levels of BCL-2 Proteins Cause Severe Craniofacial Abnormalities.

Cell Rep 2018 09;24(12):3285-3295.e4

The Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC 3052, Australia; Department of Medical Biology, The University of Melbourne, Melbourne, VIC 3052, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.08.048DOI Listing
September 2018

Parasitic helminths induce fetal-like reversion in the intestinal stem cell niche.

Nature 2018 07 27;559(7712):109-113. Epub 2018 Jun 27.

Program in Craniofacial Biology and Department of Orofacial Sciences, University of California, San Francisco, CA, USA.

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http://dx.doi.org/10.1038/s41586-018-0257-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6042247PMC
July 2018

Grking the Smoothened signal.

Sci Signal 2018 02 6;11(516). Epub 2018 Feb 6.

Department of Molecular Oncology, Genentech, 1 DNA Way, South San Francisco, CA 94080, USA.

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http://dx.doi.org/10.1126/scisignal.aar6377DOI Listing
February 2018

Stem cell plasticity enables hair regeneration following Lgr5 cell loss.

Nat Cell Biol 2017 Jun 29;19(6):666-676. Epub 2017 May 29.

Department of Molecular Oncology, Genentech, 1 DNA Way, South San Francisco, California 94080, USA.

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http://dx.doi.org/10.1038/ncb3535DOI Listing
June 2017

Randomized Phase Ib/II Study of Gemcitabine Plus Placebo or Vismodegib, a Hedgehog Pathway Inhibitor, in Patients With Metastatic Pancreatic Cancer.

J Clin Oncol 2015 Dec 2;33(36):4284-92. Epub 2015 Nov 2.

Daniel V.T. Catenacci, Theodore Karrison, James Wallace, Mark Kozloff, Peng Xu, Les Henderson, Ravi Salgia, Walter M. Stadler, Hedy L. Kindler, University of Chicago Medical Center; Patrick Stiff, Loyola University Medical Center, Chicago; Robert Marsh, Northshore University Health System, Evanston; James Wallace, Mark Kozloff, Ingalls Hospital, Harvey; James Wade, Decatur Memorial Hospital, Decatur; Pankaj Kumar, Oncology/Hematology Associates, Peoria, IL; Melissa R. Junttila, Xi Wang, and Frederic J. de Sauvage, Genentech, South San Francisco; Heinz-Josef Lenz, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA; Nathan Bahary, University of Pittsburgh Cancer Institute, Pittsburgh, PA; Margit N. Horiba, University of Maryland Greenebaum Cancer Center, Baltimore, MD; Sreenivasa R. Nattam, Ft Wayne Medical Oncology/Hematology, Ft Wayne, IN; Lakshmi Rajdev, Montefiore Medical Center, Bronx; Deirdre Cohen, New York University Cancer Center, New York, NY; Bethany Sleckman, St John's Mercy Medical Center, St Louis, MO; and Naoko Takebe, National Cancer Institute, National Institutes of Health, Bethesda, MD.

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http://dx.doi.org/10.1200/JCO.2015.62.8719DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4678179PMC
December 2015

Translational value of mouse models in oncology drug development.

Nat Med 2015 May;21(5):431-9

Department of Molecular Oncology at Genentech, Inc., South San Francisco, California, USA.

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http://dx.doi.org/10.1038/nm.3853DOI Listing
May 2015

Regulation of the oncoprotein Smoothened by small molecules.

Nat Chem Biol 2015 Apr;11(4):246-55

Department of Molecular Oncology, Genentech Inc., San Francisco, California, USA.

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http://dx.doi.org/10.1038/nchembio.1776DOI Listing
April 2015

Opposing activities of Notch and Wnt signaling regulate intestinal stem cells and gut homeostasis.

Cell Rep 2015 Apr 26;11(1):33-42. Epub 2015 Mar 26.

Departments of Orofacial Sciences and Pediatrics, Institute of Human Genetics and Program in Craniofacial Biology, UCSF, 513 Parnassus Avenue, San Francisco, CA 94143-0442, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.03.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4394041PMC
April 2015

Efficacy of Hedgehog pathway inhibitors in Basal cell carcinoma.

Mol Cancer Ther 2015 Mar 13;14(3):633-41. Epub 2015 Jan 13.

Department of Molecular Oncology, Genentech Inc., South San Francisco, California.

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http://dx.doi.org/10.1158/1535-7163.MCT-14-0703DOI Listing
March 2015

Discovery and preclinical development of vismodegib.

Expert Opin Drug Discov 2014 Aug 23;9(8):969-84. Epub 2014 May 23.

Translational Oncology, Genentech, Inc. , 1 DNA Way, South San Francisco, CA , USA.

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http://dx.doi.org/10.1517/17460441.2014.920816DOI Listing
August 2014

Induction of ectopic taste buds by SHH reveals the competency and plasticity of adult lingual epithelium.

Development 2014 Aug 3;141(15):2993-3002. Epub 2014 Jul 3.

Department of Cell and Developmental Biology, University of Colorado School of Medicine, Aurora, CO 80045, USA Rocky Mountain Taste and Smell Center, University of Colorado School of Medicine, Aurora, CO 80045, USA Graduate Program in Cell Biology, Stem Cells and Development, University of Colorado School of Medicine, Aurora, CO 80045, USA

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http://dev.biologists.org/content/develop/141/15/2993.full.p
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http://dev.biologists.org/cgi/doi/10.1242/dev.107631
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http://dx.doi.org/10.1242/dev.107631DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4197660PMC
August 2014

Comparative oncogenomics identifies PSMB4 and SHMT2 as potential cancer driver genes.

Cancer Res 2014 Jun 22;74(11):3114-26. Epub 2014 Apr 22.

Authors' Affiliations: Departments of Discovery Oncology, Molecular Biology, Bioinformatics, Pathology, and Molecular Oncology, Genentech Inc., South San Francisco, California

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http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
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http://dx.doi.org/10.1158/0008-5472.CAN-13-2683DOI Listing
June 2014

Intestinal crypt homeostasis revealed at single-stem-cell level by in vivo live imaging.

Nature 2014 Mar 16;507(7492):362-365. Epub 2014 Feb 16.

Hubrecht Institute-KNAW & University Medical Centre Utrecht, Uppsalalaan 8, 3584 CT, Utrecht, the Netherlands.

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http://dx.doi.org/10.1038/nature12972DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3964820PMC
March 2014

Lgr5+ stem cells are indispensable for radiation-induced intestinal regeneration.

Cell Stem Cell 2014 Feb 12;14(2):149-59. Epub 2013 Dec 12.

Molecular Oncology Department, Genentech, South San Francisco, CA 94080, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2013.11.008DOI Listing
February 2014

PTEN loss mitigates the response of medulloblastoma to Hedgehog pathway inhibition.

Cancer Res 2013 Dec 23;73(23):7034-42. Epub 2013 Oct 23.

Authors' Affiliation: Genentech Inc., South San Francisco, California.

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http://dx.doi.org/10.1158/0008-5472.CAN-13-1222DOI Listing
December 2013

Influence of tumour micro-environment heterogeneity on therapeutic response.

Nature 2013 Sep;501(7467):346-54

Department of Molecular Biology, Genentech, 1 DNA Way, South San Francisco, California 94080, USA.

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http://www.nature.com/articles/nature12626
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http://dx.doi.org/10.1038/nature12626DOI Listing
September 2013

A tumor-specific stem cell.

Nat Genet 2013 Jan;45(1):7-9

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http://dx.doi.org/10.1038/ng.2502DOI Listing
January 2013

Signaling: An oxysterol ligand for Smoothened.

Nat Chem Biol 2012 Jan 18;8(2):139-40. Epub 2012 Jan 18.

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http://dx.doi.org/10.1038/nchembio.774DOI Listing
January 2012

A reserve stem cell population in small intestine renders Lgr5-positive cells dispensable.

Nature 2011 Sep 18;478(7368):255-9. Epub 2011 Sep 18.

Department of Molecular Biology, Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA.

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http://dx.doi.org/10.1038/nature10408DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4251967PMC
September 2011

Hedgehog fights back: mechanisms of acquired resistance against Smoothened antagonists.

Cancer Res 2011 Aug 19;71(15):5057-61. Epub 2011 Jul 19.

Department of Molecular Biology, Genentech Inc., South San Francisco, CA, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-11-0923DOI Listing
August 2011

Pharmacokinetic-pharmacodynamic analysis of vismodegib in preclinical models of mutational and ligand-dependent Hedgehog pathway activation.

Clin Cancer Res 2011 Jul 24;17(14):4682-92. Epub 2011 May 24.

Department of Translational Oncology, Genentech Inc, 1 DNA Way, South San Francisco, California 94080, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-11-0975DOI Listing
July 2011

Clinical experience with Hedgehog pathway inhibitors.

J Clin Oncol 2010 Dec 1;28(36):5321-6. Epub 2010 Nov 1.

Genentech Inc, 1 DNA Way, South San Francisco, CA 94080, USA.

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http://dx.doi.org/10.1200/JCO.2010.27.9943DOI Listing
December 2010

Hedgehog pathway antagonist 5E1 binds hedgehog at the pseudo-active site.

J Biol Chem 2010 Aug 26;285(34):26570-80. Epub 2010 May 26.

Department of Protein Engineering, Genentech, Inc., South San Francisco, California 94080, USA.

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http://www.jbc.org/content/285/34/26570.full.pdf
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http://www.jbc.org/cgi/doi/10.1074/jbc.M110.112284
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http://dx.doi.org/10.1074/jbc.M110.112284DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2924095PMC
August 2010

Vive la science! Vive le hérisson!

EMBO Rep 2010 Aug 16;11(8):566-8. Epub 2010 Jul 16.

Department of Biochemistry and Biophysics, Cardiovascular Research Institute, University of California, San Francisco, CA, USA.

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http://dx.doi.org/10.1038/embor.2010.109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2920439PMC
August 2010

Paracrine Hedgehog signaling in cancer.

Cancer Res 2009 Aug 28;69(15):6007-10. Epub 2009 Jul 28.

Department of Molecular Biology, Genentech Inc, South San Francisco, California 94080, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-09-0756DOI Listing
August 2009

The structure of SHH in complex with HHIP reveals a recognition role for the Shh pseudo active site in signaling.

Nat Struct Mol Biol 2009 Jul 28;16(7):691-7. Epub 2009 Jun 28.

Department of Structural Biology, Genentech, Inc., South San Francisco, California, USA.

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http://dx.doi.org/10.1038/nsmb.1632DOI Listing
July 2009

Mechanisms of Hedgehog pathway activation in cancer and implications for therapy.

Trends Pharmacol Sci 2009 Jun 13;30(6):303-12. Epub 2009 May 13.

Department of Molecular Biology, Genentech, 1 DNA Way, South San Francisco, CA 94080, USA.

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http://dx.doi.org/10.1016/j.tips.2009.03.007DOI Listing
June 2009

A paracrine requirement for hedgehog signalling in cancer.

Nature 2008 Sep 27;455(7211):406-10. Epub 2008 Aug 27.

Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA.

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http://dx.doi.org/10.1038/nature07275DOI Listing
September 2008

Kinome siRNA screen identifies regulators of ciliogenesis and hedgehog signal transduction.

Sci Signal 2008 Sep 30;1(39):ra7. Epub 2008 Sep 30.

Department of Molecular Biology, Genentech, South San Francisco, CA 94080, USA.

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http://dx.doi.org/10.1126/scisignal.1162925DOI Listing
September 2008

Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens.

Nat Med 2008 Mar 10;14(3):282-9. Epub 2008 Feb 10.

Department of Immunology, Genentech, 1 DNA Way, South San Francisco, California 94080, USA.

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http://www.nature.com/articles/nm1720
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http://dx.doi.org/10.1038/nm1720DOI Listing
March 2008

Cutting edge: IL-27 is a potent inducer of IL-10 but not FoxP3 in murine T cells.

J Immunol 2008 Mar;180(5):2752-6

Department of Molecular Biology, Genentech, Inc., South San Francisco, CA 94080,USA.

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http://dx.doi.org/10.4049/jimmunol.180.5.2752DOI Listing
March 2008

Regulation of myeloid progenitor cell proliferation/survival by IL-31 receptor and IL-31.

Exp Hematol 2007 Apr;35(4 Suppl 1):78-86

Department of Microbiology and Immunology, and the Walther Oncology Center, Indiana University School of Medicine, Indianapolis, IN 46202-5181, USA.

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http://dx.doi.org/10.1016/j.exphem.2007.01.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2706484PMC
April 2007

IL-31-IL-31R interactions negatively regulate type 2 inflammation in the lung.

J Exp Med 2007 Mar 12;204(3):481-7. Epub 2007 Mar 12.

Department of Pathobiology, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1084/jem.20061791DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2137900PMC
March 2007

Targeting the Hedgehog pathway in cancer.

Nat Rev Drug Discov 2006 Dec;5(12):1026-33

Harvard Stem Cell Institute, Biolabs, Room 150, 16 Divinity Avenue, Cambridge, Massachusetts 02138, USA.

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http://dx.doi.org/10.1038/nrd2086DOI Listing
December 2006

Structure of SAP18: a ubiquitin fold in histone deacetylase complex assembly.

Biochemistry 2006 Oct;45(39):11974-82

Department of Protein Engineering, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080-4990, USA.

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http://dx.doi.org/10.1021/bi060687lDOI Listing
October 2006

The hedgehog signaling pathway in cancer.

Clin Cancer Res 2006 Oct;12(20 Pt 1):5924-8

Department of Molecular Biology, Genentech, Inc., South San Francisco, California 94080, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-06-1736DOI Listing
October 2006

Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17-producing T cells.

Nat Immunol 2006 Sep 13;7(9):929-36. Epub 2006 Aug 13.

Department of Molecular Biology, Genentech, South San Francisco, California 94080, USA.

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http://dx.doi.org/10.1038/ni1375DOI Listing
September 2006

Notch signaling is required for normal prostatic epithelial cell proliferation and differentiation.

Dev Biol 2006 Feb 15;290(1):66-80. Epub 2005 Dec 15.

Department of Molecular Biology, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S001216060500786
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http://dx.doi.org/10.1016/j.ydbio.2005.11.009DOI Listing
February 2006

IL-27 limits IL-2 production during Th1 differentiation.

J Immunol 2006 Jan;176(1):237-47

Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.4049/jimmunol.176.1.237DOI Listing
January 2006

Positive and negative regulation of the IL-27 receptor during lymphoid cell activation.

J Immunol 2005 Jun;174(12):7684-91

Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, and Wistar Institute, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.4049/jimmunol.174.12.7684DOI Listing
June 2005

Compromised humoral and delayed-type hypersensitivity responses in IL-23-deficient mice.

J Immunol 2004 Mar;172(5):2827-33

Department of Molecular Biology, Genentech, South San Francisco, CA 94080, USA.

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http://dx.doi.org/10.4049/jimmunol.172.5.2827DOI Listing
March 2004

IL-27 regulates IL-12 responsiveness of naive CD4+ T cells through Stat1-dependent and -independent mechanisms.

Proc Natl Acad Sci U S A 2003 Dec 1;100(25):15047-52. Epub 2003 Dec 1.

Department of Molecular Biology, Genentech, 1 DNA Way, South San Francisco, CA 94080, USA.

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http://dx.doi.org/10.1073/pnas.2536517100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC299900PMC
December 2003

Inhibition of epithelial ductal branching in the prostate by sonic hedgehog is indirectly mediated by stromal cells.

J Biol Chem 2003 May 7;278(20):18506-13. Epub 2003 Mar 7.

Department of Molecular Oncology, Genentech, Inc., South San Francisco, California 94080, USA.

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http://dx.doi.org/10.1074/jbc.M300968200DOI Listing
May 2003

Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17.

J Biol Chem 2003 Jan 3;278(3):1910-4. Epub 2002 Nov 3.

Department of Molecular Biology, Genentech, South San Francisco, California 94080, USA.

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http://dx.doi.org/10.1074/jbc.M207577200DOI Listing
January 2003

Dissecting the oncogenic potential of Gli2: deletion of an NH(2)-terminal fragment alters skin tumor phenotype.

Cancer Res 2002 Sep;62(18):5308-16

Comprehensive Cancer Center, Department of Dermatology, University of Michigan, 1500 E Medical Center Drive, Ann Arbor, MI 48109, USA.

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http://cancerres.aacrjournals.org/content/62/18/5308.full.pd
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September 2002

A novel type I cytokine receptor is expressed on monocytes, signals proliferation, and activates STAT-3 and STAT-5.

J Biol Chem 2002 May 4;277(19):16831-6. Epub 2002 Mar 4.

Department of Molecular Oncology, Genentech, Inc., South San Francisco, California 94080, USA.

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http://dx.doi.org/10.1074/jbc.M201140200DOI Listing
May 2002