Frederic Checler

Frederic Checler

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Frederic Checler

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Targeting γ-secretase triggers the selective enrichment of oligomeric APP-CTFs in brain extracellular vesicles from Alzheimer cell and mouse models.

Transl Neurodegener 2019 5;8:35. Epub 2019 Dec 5.

1Institut de Pharmacologie Moléculaire et Cellulaire, CNRS-UMR7275, team labeled «Fondation pour la Recherche Médicale» et «Laboratoire d'excellence Distalz», Université de Nice-Sophia-Antipolis, Sophia-Antipolis, France.

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http://dx.doi.org/10.1186/s40035-019-0176-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6894230PMC
December 2019

Nuclear TP53: An unraveled function as transcriptional repressor of PINK1.

Autophagy 2018 11;14(6):1099-1101. Epub 2018 May 11.

a Université Côte d'Azur, INSERM, CNRS/UMR7275, IPMC , Sophia-Antipolis , Valbonne , France.

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http://dx.doi.org/10.1080/15548627.2018.1450022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6103405PMC
June 2019

Chronic fornix deep brain stimulation in a transgenic Alzheimer's rat model reduces amyloid burden, inflammation, and neuronal loss.

Brain Struct Funct 2019 Jan 19;224(1):363-372. Epub 2018 Oct 19.

Université Côte d'Azur, INSERM, CNRS/UMR7275, IPMC, Team Labeled "Laboratory of Excellence (LABEX) Distalz", 660 route des Lucioles, 06560, Sophia-Antipolis, Valbonne, France.

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http://dx.doi.org/10.1007/s00429-018-1779-xDOI Listing
January 2019

The Transcription Factor Function of Parkin: Breaking the Dogma.

Front Neurosci 2018 15;12:965. Epub 2019 Jan 15.

Université Côte d'Azur, Institut National de la Santé et de la Recherche Médicale, Centre National de la Recherche Scientifique, IPMC, Team Labeled "Laboratory of Excellence (LABEX) DistAlz", Valbonne, France.

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http://dx.doi.org/10.3389/fnins.2018.00965DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341214PMC
January 2019

Intraneuronal accumulation of C99 contributes to synaptic alterations, apathy-like behavior, and spatial learning deficits in 3×TgAD and 2×TgAD mice.

Neurobiol Aging 2018 11 12;71:21-31. Epub 2018 Jul 12.

Université Côte d'Azur, INSERM, CNRS, IPMC, UMR7275, Team labeled « Laboratory of Excellence (Labex) DISTALZ», Sophia-Antipolis, Valbonne, France. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2018.06.038DOI Listing
November 2018

Neurolysin: From Initial Detection to Latest Advances.

Neurochem Res 2018 Nov 29;43(11):2017-2024. Epub 2018 Aug 29.

Department of Pharmacology, Biomedical Science Institute, University of São Paulo, Av. Prof. Lineu Prestes 1524, Sala 317, São Paulo, SP, 05508-000, Brazil.

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http://dx.doi.org/10.1007/s11064-018-2624-6DOI Listing
November 2018

Are N- and C-terminally truncated Aβ species key pathological triggers in Alzheimer's disease?

J Biol Chem 2018 10 24;293(40):15419-15428. Epub 2018 Aug 24.

From the Université Côte d'Azur, INSERM, CNRS, IPMC, Team labeled "Laboratory of Excellence (LABEX) Distalz," 660 Route des Lucioles, Sophia-Antipolis, 06560 Valbonne, France

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http://dx.doi.org/10.1074/jbc.R118.003999DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6177599PMC
October 2018

Nuclear p53-mediated repression of autophagy involves PINK1 transcriptional down-regulation.

Cell Death Differ 2018 05 19;25(5):873-884. Epub 2018 Jan 19.

Université Côte d'Azur, INSERM, CNRS, IPMC, team labeled "Laboratory of Excellence (LABEX) Distalz", 660 route des Lucioles, 06560, Sophia-Antipolis, Valbonne, France.

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http://dx.doi.org/10.1038/s41418-017-0016-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5943347PMC
May 2018

β-Amyloid Precursor Protein Intracellular Domain Controls Mitochondrial Function by Modulating Phosphatase and Tensin Homolog-Induced Kinase 1 Transcription in Cells and in Alzheimer Mice Models.

Biol Psychiatry 2018 03 3;83(5):416-427. Epub 2017 May 3.

Institut de Pharmacologie Moléculaire et Cellulaire, Université Côte d'Azur, Centre National de la Recherche Scientifique (CNRS), Institut National de la Santé et de la Recherche Médicale (INSERM), Valbonne, France. Electronic address:

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http://dx.doi.org/10.1016/j.biopsych.2017.04.011DOI Listing
March 2018

Post-translational remodeling of ryanodine receptor induces calcium leak leading to Alzheimer's disease-like pathologies and cognitive deficits.

Acta Neuropathol 2017 11 19;134(5):749-767. Epub 2017 Jun 19.

Department of Physiology and Cellular Biophysics, Clyde and Helen Wu Center for Molecular Cardiology, Columbia University College of Physicians and Surgeons, New York, NY, 10032, USA.

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http://dx.doi.org/10.1007/s00401-017-1733-7DOI Listing
November 2017

Amyloid β production is regulated by β2-adrenergic signaling-mediated post-translational modifications of the ryanodine receptor.

J Biol Chem 2017 06 5;292(24):10153-10168. Epub 2017 May 5.

From the Université Côte d'Azur, CNRS, IPMC, France, "Labex Distalz," 660 route des Lucioles, 06560 Sophia-Antipolis, Valbonne, France,

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http://dx.doi.org/10.1074/jbc.M116.743070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5473221PMC
June 2017

α-synuclein and p53 functional interplay in physiopathological contexts.

Oncotarget 2017 Feb;8(6):9001-9002

Université Côte d'Azur, INSERM, CNRS, IPMC, team labeled "Laboratory of Excellence (LABEX) Distalz", Sophia-Antipolis, Valbonne, France.

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http://dx.doi.org/10.18632/oncotarget.14385DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354703PMC
February 2017

The transcription factor XBP1 in memory and cognition: Implications in Alzheimer disease.

Mol Med 2017 Feb 4;22:905-917. Epub 2017 Jan 4.

Université Côte d'Azur, INSERM, CNRS, IPMC, team labeled "Fondation pour la Recherche Médicale" and "Laboratory of Excellence (LABEX) Distalz", 660 route des Lucioles, 06560, Sophia-Antipolis, Valbonne, France.

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http://dx.doi.org/10.2119/molmed.2016.00229DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5319207PMC
February 2017

Aβ42 oligomers modulate β-secretase through an XBP-1s-dependent pathway involving HRD1.

Sci Rep 2016 11 17;6:37436. Epub 2016 Nov 17.

Université Côte d'Azur, INSERM, CNRS, IPMC, France, Laboratory of excellence DistALZ, 660 route des Lucioles, 06560, Sophia-Antipolis, Valbonne, France.

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http://dx.doi.org/10.1038/srep37436DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5112606PMC
November 2016

Intraneuronal aggregation of the β-CTF fragment of APP (C99) induces Aβ-independent lysosomal-autophagic pathology.

Acta Neuropathol 2016 08 30;132(2):257-276. Epub 2016 Apr 30.

Université de Nice-Sophia-Antipolis, Institut de Pharmacologie Moléculaire et Cellulaire, CNRS-UMR7275, Team Labelised Fondation pour la Recherche Médicale et Laboratoire d'excellence Distalz, Sophia-Antipolis, France.

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http://dx.doi.org/10.1007/s00401-016-1577-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4947121PMC
August 2016

Presenilin 1 and Presenilin 2 Target γ-Secretase Complexes to Distinct Cellular Compartments.

J Biol Chem 2016 Jun 8;291(24):12821-37. Epub 2016 Apr 8.

From the Université de Nice Sophia-Antipolis, Institut de Pharmacologie Moléculaire et Cellulaire CNRS UMR7275, Laboratoire d'Excellence Distalz, Sophia-Antipolis, 06560 Valbonne, France

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http://dx.doi.org/10.1074/jbc.M115.708297DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4933450PMC
June 2016

Direct α-synuclein promoter transactivation by the tumor suppressor p53.

Mol Neurodegener 2016 Feb 2;11:13. Epub 2016 Feb 2.

Institut de Pharmacologie Moléculaire et Cellulaire, UMR7275 CNRS/UNSA, team labeled "Fondation pour la Recherche Médicale" and "Laboratory of Excellence (LABEX) Distalz", 660 route des Lucioles, 06560, Sophia-Antipolis, Valbonne, France.

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http://dx.doi.org/10.1186/s13024-016-0079-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4736712PMC
February 2016

Ryanodine receptors: dual contribution to Alzheimer disease?

Channels (Austin) 2014 ;8(3):168

University of Nice Sophia Antipolis; IPMC; Sophia Antipolis, France; CNRS; IPMC; Sophia Antipolis, France.

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http://dx.doi.org/10.4161/chan.29000DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5210168PMC
June 2015

Melatonin stimulates the nonamyloidogenic processing of βAPP through the positive transcriptional regulation of ADAM10 and ADAM17.

J Pineal Res 2015 Mar 27;58(2):151-65. Epub 2014 Dec 27.

The Research Center for Neuroscience, Mahidol University, Nakhon Pathom, Thailand; Institute of Molecular Biosciences, Mahidol University, Nakhon Pathom, Thailand.

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http://dx.doi.org/10.1111/jpi.12200DOI Listing
March 2015

Eph receptors: new players in Alzheimer's disease pathogenesis.

Neurobiol Dis 2015 Jan 1;73:137-49. Epub 2014 Sep 1.

Institut de Pharmacologie Moléculaire et Cellulaire, UMR7275 CNRS/UNS, "Labex Distalz", 660 route des Lucioles, 06560, Sophia-Antipolis, Valbonne, France.. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2014.08.028DOI Listing
January 2015

Visualization of specific γ-secretase complexes using bimolecular fluorescence complementation.

J Alzheimers Dis 2014 ;40(1):161-76

Université de Nice Sophia-Antipolis, Institut de Pharmacologie Moléculaire et Cellulaire, Equipe labellisée Fondation pour la Recherche Médicale et Laboratoire d'Excellence Distalz, Sophia-Antipolis, Valbonne, France.

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http://dx.doi.org/10.3233/JAD-131268DOI Listing
October 2014

The transcription factor X-box binding protein-1 in neurodegenerative diseases.

Mol Neurodegener 2014 Sep 12;9:35. Epub 2014 Sep 12.

Institut de Pharmacologie Moléculaire et Cellulaire, UMR7275 CNRS-UNS, Sophia Antipolis, Nice, Valbonne F-06560, France.

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http://dx.doi.org/10.1186/1750-1326-9-35DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4166022PMC
September 2014

Study on Aβ34 biology and detection in transgenic mice brains.

Neurobiol Aging 2014 Jul 11;35(7):1570-81. Epub 2014 Jan 11.

Institut de Pharmacologie Moléculaire et Cellulaire, UMR7275 CNRS/UNS, Team "Fondation pour la Recherche Médicale" and "Labex Distalz", Valbonne, France. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2014.01.011DOI Listing
July 2014

Ryanodine receptors: physiological function and deregulation in Alzheimer disease.

Mol Neurodegener 2014 Jun 5;9:21. Epub 2014 Jun 5.

Université de Nice Sophia Antipolis, IPMC, Sophia Antipolis, Nice, F-06560 Valbonne, France.

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http://dx.doi.org/10.1186/1750-1326-9-21DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4063224PMC
June 2014

p53 in neurodegenerative diseases and brain cancers.

Pharmacol Ther 2014 Apr 25;142(1):99-113. Epub 2013 Nov 25.

Institut de Pharmacologie Moléculaire et Cellulaire, UMR7275 CNRS/UNS, "Labex Distalz", 660 route des Lucioles, 06560, Sophia-Antipolis, Valbonne, France. Electronic address:

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http://dx.doi.org/10.1016/j.pharmthera.2013.11.009DOI Listing
April 2014

Experimental stroke: neurolysin back on stage.

J Neurochem 2014 Apr 5;129(1):1-3. Epub 2014 Jan 5.

IPMC, CNRS/UNS, Laboratory of Excellence 'DISTALZ', Valbonne, France.

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http://dx.doi.org/10.1111/jnc.12635DOI Listing
April 2014

Alzheimer's and prion diseases: PDK1 at the crossroads.

Nat Med 2013 Sep;19(9):1088-90

Institut de Pharmacologie Moléculaire et Cellulaire, UMR7275 CNRS/Université Nice Sophia-Antipolis, Laboratory of Excellence "DISTALZ," Valbonne, France.

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http://dx.doi.org/10.1038/nm.3332DOI Listing
September 2013

ER-stress-associated functional link between Parkin and DJ-1 via a transcriptional cascade involving the tumor suppressor p53 and the spliced X-box binding protein XBP-1.

J Cell Sci 2013 May 27;126(Pt 9):2124-33. Epub 2013 Feb 27.

Institut de Pharmacologie Moléculaire et Cellulaire, UMR7275 CNRS/UNSA, Team Fondation pour la Recherche Médicale and Labex Distalz, 660 route des Lucioles, 06560, Sophia-Antipolis, Valbonne, France.

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http://dx.doi.org/10.1242/jcs.127340DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6518232PMC
May 2013

Parkin differently regulates presenilin-1 and presenilin-2 functions by direct control of their promoter transcription.

J Mol Cell Biol 2013 Apr 28;5(2):132-42. Epub 2013 Jan 28.

Institut de Pharmacologie Moléculaire et Cellulaire, UMR7275 CNRS/UNSA, Sophia-Antipolis, Valbonne 06560, France.

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http://dx.doi.org/10.1093/jmcb/mjt003DOI Listing
April 2013

Further characterization of a putative serine protease contributing to the γ-secretase cleavage of β-amyloid precursor protein.

Bioorg Med Chem 2013 Feb 5;21(4):1018-29. Epub 2012 Dec 5.

Institut des Biomolécules Max Mousseron, UMR5247 CNRS, Universités Montpellier 1 and 2, Faculté de Pharmacie, 15 avenue Charles Flahault, 34093 Montpellier Cedex 5, France.

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http://dx.doi.org/10.1016/j.bmc.2012.11.045DOI Listing
February 2013

The β-secretase-derived C-terminal fragment of βAPP, C99, but not Aβ, is a key contributor to early intraneuronal lesions in triple-transgenic mouse hippocampus.

J Neurosci 2012 Nov;32(46):16243-1655a

Université de Nice-Sophia-Antipolis, Institut de Pharmacologie Moléculaire et Cellulaire, CNRS-UMR7275, team labelised «Fondation pour la Recherche Médicale» et "Laboratoire d'excellence Distalz", Sophia-Antipolis, France.

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http://dx.doi.org/10.1523/JNEUROSCI.2775-12.2012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5019353PMC
November 2012

BACE1 is at the crossroad of a toxic vicious cycle involving cellular stress and β-amyloid production in Alzheimer's disease.

Mol Neurodegener 2012 Oct 5;7:52. Epub 2012 Oct 5.

Institut de Pharmacologie Moléculaire et Cellulaire, UMR7275 CNRS/UNSA, 06560 Valbonne, France.

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http://dx.doi.org/10.1186/1750-1326-7-52DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3507664PMC
October 2012

Evidence that the amyloid-β protein precursor intracellular domain, AICD, derives from β-secretase-generated C-terminal fragment.

J Alzheimers Dis 2012 ;30(1):145-53

Université de Nice-Sophia-Antipolis, Institut de Pharmacologie Moléculaire et Cellulaire, UMR 6097 CNRS, Fondation pour la Recherche Médicale/Excellence Laboratory DISTALZ, Sophia-Antipolis, Valbonne, France.

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http://www.medra.org/servlet/aliasResolver?alias=iospress&am
Publisher Site
http://dx.doi.org/10.3233/JAD-2012-112186DOI Listing
September 2012

γ-Secretase-mediated regulation of neprilysin: influence of cell density and aging and modulation by imatinib.

J Alzheimers Dis 2011 ;27(3):511-20

Institut de Pharmacologie Moléculaire et Cellulaire and Institut de NeuroMédecine Moléculaire, team labeled Fondation pour la Recherche Médicale, Valbonne, France.

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http://dx.doi.org/10.3233/JAD-2011-110746DOI Listing
August 2012

Two-steps control of cellular prion physiology by the extracellular regulated kinase-1 (ERK1).

Prion 2012 Jan-Mar;6(1):23-5

Institut de Pharmacologie Moléculaire et Cellulaire and Institut de NeuroMédecine Moléculaire, Equipe labellisée Fondation pour la Recherche Médicale, Valbonne, France.

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http://dx.doi.org/10.4161/pri.6.1.18004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3338960PMC
August 2012

Nuclear factor-κB regulates βAPP and β- and γ-secretases differently at physiological and supraphysiological Aβ concentrations.

J Biol Chem 2012 Jul 31;287(29):24573-84. Epub 2012 May 31.

Équipe Labellisée "Fondation pour la Recherche Médicale" and "Excellence Laboratory Distalz", Institut de Pharmacologie Moléculaire et Cellulaire, UMR7275 CNRS/UNSA, 660 Route des Lucioles, 06560, Valbonne, France.

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http://dx.doi.org/10.1074/jbc.M111.333054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3397882PMC
July 2012

α-Secretase in Alzheimer's disease and beyond: mechanistic, regulation and function in the shedding of membrane proteins.

Curr Alzheimer Res 2012 Feb;9(2):140-56

Institute of Molecular Biosciences, Center for Neuroscience, Mahidol University, Salaya campus, 999 Phuttamonthon 4 Road, Nakhon Pathom 73170, Thailand.

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http://dx.doi.org/10.2174/156720512799361646DOI Listing
February 2012

α-Secretase-derived fragment of cellular prion, N1, protects against monomeric and oligomeric amyloid β (Aβ)-associated cell death.

J Biol Chem 2012 Feb 19;287(7):5021-32. Epub 2011 Dec 19.

Institut de Pharmacologie Moléculaire et Cellulaire, UMR6097 CNRS/Université de Nice-Sophia-Antipolis (UNSA), 660 route des Lucioles, Sophia-Antipolis, 06560 Valbonne, France.

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http://dx.doi.org/10.1074/jbc.M111.323626DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3281657PMC
February 2012

The physiology of the β-amyloid precursor protein intracellular domain AICD.

J Neurochem 2012 Jan 28;120 Suppl 1:109-24. Epub 2011 Nov 28.

Université de Nice Sophia-Antipolis, Institut de Pharmacologie Moléculaire et Cellulaire UMR6097 CNRS, Equipe labellisée Fondation pour la Recherche Médicale, Sophia-Antipolis, Valbonne, France.

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http://dx.doi.org/10.1111/j.1471-4159.2011.07475.xDOI Listing
January 2012

Journal of Neurochemistry special issue on Alzheimer's disease: 'amyloid cascade hypothesis--20 years on'.

J Neurochem 2012 Jan 19;120 Suppl 1:iii-iv. Epub 2011 Dec 19.

Institut de Pharmacologie Moléculaire et Cellulaire, UMR6097 CNRS/UNSA, Valbonne, France.

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http://dx.doi.org/10.1111/j.1471-4159.2011.07603.xDOI Listing
January 2012

The extracellular regulated kinase-1 (ERK1) controls regulated alpha-secretase-mediated processing, promoter transactivation, and mRNA levels of the cellular prion protein.

J Biol Chem 2011 Aug 17;286(33):29192-206. Epub 2011 May 17.

Institut de Pharmacologie Moléculaire et Cellulaire, Unité Mixte de Recherche, 6097 Centre National de la Recherche Scientifique/Université de Nice-Sophia-Antipolis, Equipe labellisée Fondation pour la Recherche Médicale, 660 route des lucioles, Sophia-Antipolis, 06560 Valbonne, France.

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http://dx.doi.org/10.1074/jbc.M110.208249DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3190726PMC
August 2011

ERK1-independent α-secretase cut of β-amyloid precursor protein via M1 muscarinic receptors and PKCα/ε.

Mol Cell Neurosci 2011 Jul 4;47(3):223-32. Epub 2011 May 4.

Université de Nice-Sophia-Antipolis, Institut de Neuro-Médecine Moléculaire, Unité Mixte de Recherche, 6097 Centre National de la Recherche Scientifique, Equipe labellisée Fondation pour la Recherche Médicale, 660 route des lucioles, Sophia-Antipolis, 06560 Valbonne, France.

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http://linkinghub.elsevier.com/retrieve/pii/S104474311100093
Publisher Site
http://dx.doi.org/10.1016/j.mcn.2011.04.008DOI Listing
July 2011

Apoptosis in Parkinson's disease: is p53 the missing link between genetic and sporadic Parkinsonism?

Cell Signal 2011 Jun 20;23(6):963-8. Epub 2010 Oct 20.

Institut de Pharmacologie Moléculaire et Cellulaire (IPMC) and Institut de NeuroMédecine Moléculaire (IN2M), UMR6097 CNRS/UNSA, team “Fondation pour la Recherche Médicale”,660 Route des Lucioles, 06560, Valbonne, France.

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http://dx.doi.org/10.1016/j.cellsig.2010.10.020DOI Listing
June 2011

[Production and catabolism of amyloid peptides in Alzheimer's disease].

Therapie 2010 Sep-Oct;65(5):409-14. Epub 2010 Dec 13.

Institute de Pharmacologie Molécualire, UMR 6097 CNRS/UNSA, VAlbonne, France.

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http://dx.doi.org/10.2515/therapie/2010053DOI Listing
April 2011

p53 is regulated by and regulates members of the gamma-secretase complex.

Neurodegener Dis 2010 13;7(1-3):50-5. Epub 2010 Feb 13.

Institut de Pharmacologie Moléculaire et Cellulaire et Institut de NeuroMédecine Moléculaire, UMR6097 CNRS/UNSA, Valbonne, France.

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http://dx.doi.org/10.1159/000283483DOI Listing
July 2010

A novel parkin-mediated transcriptional function links p53 to familial Parkinson's disease.

Cell Cycle 2010 Jan 23;9(1):16-7. Epub 2010 Jan 23.

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http://dx.doi.org/10.4161/cc.9.1.10420DOI Listing
January 2010

The alpha-secretase-derived N-terminal product of cellular prion, N1, displays neuroprotective function in vitro and in vivo.

J Biol Chem 2009 Dec;284(51):35973-86

Institut de Pharmacologie Moléculaire et Cellulaire and Institut de Neuromédecine Moléculaire, UMR6097 CNRS/UNSA, Equipe Labellisée Fondation pour la Recherche Médicale, 660 Route des Lucioles, Sophia-Antipolis, 06560 Valbonne, France.

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http://dx.doi.org/10.1074/jbc.M109.051086DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2791025PMC
December 2009

Transcriptional repression of p53 by parkin and impairment by mutations associated with autosomal recessive juvenile Parkinson's disease.

Nat Cell Biol 2009 Nov 4;11(11):1370-5. Epub 2009 Oct 4.

Institut de Pharmacologie Moléculaire et Cellulaire, UMR6097 CNRS/UNSA, Equipe labellisée Fondation pour la Recherche Médicale, 660 Route des Lucioles, 06560, Valbonne, France.

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http://dx.doi.org/10.1038/ncb1981DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2952934PMC
November 2009

p53-dependent control of transactivation of the Pen2 promoter by presenilins.

J Cell Sci 2009 Nov;122(Pt 21):4003-8

Institut de Pharmacologie Moléculaire et Cellulaire of Centre National de la Recherche Scientifique and Institut de NeuroMédecine Moléculaire, Equipe labellisée Fondation pour la Recherche Médicale, Valbonne, France.

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http://dx.doi.org/10.1242/jcs.051169DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3188804PMC
November 2009

TMP21 transmembrane domain regulates gamma-secretase cleavage.

J Biol Chem 2009 Oct 25;284(42):28634-41. Epub 2009 Aug 25.

Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario M5S 3H2, Canada.

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http://dx.doi.org/10.1074/jbc.M109.059345DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2781407PMC
October 2009

Pharmacological evidences for DFK167-sensitive presenilin-independent gamma-secretase-like activity.

J Neurochem 2009 Jul 29;110(1):275-83. Epub 2009 Apr 29.

Institut de Pharmacologie Moléculaire et Cellulaire and Institut de NeuroMédecine Moléculaire, UMR6097 CNRS/UNSA, Equipe labellisée Fondation pour la Recherche Médicale, Sophia-Antipolis, Valbonne, France.

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http://dx.doi.org/10.1111/j.1471-4159.2009.06131.xDOI Listing
July 2009

Amyloid-beta42 is preferentially accumulated in muscle fibers of patients with sporadic inclusion-body myositis.

Acta Neuropathol 2009 May 12;117(5):569-74. Epub 2009 Mar 12.

USC Neuromuscular Center, Department of Neurology, University of Southern California Keck School of Medicine, Good Samaritan Hospital, Los Angeles, CA, 90017, USA.

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http://dx.doi.org/10.1007/s00401-009-0511-6DOI Listing
May 2009

p53-Dependent transcriptional control of cellular prion by presenilins.

J Neurosci 2009 May;29(20):6752-60

Institut de Pharmacologie Moléculaire et Cellulaire, Unité Mixte de Recherche 6097 Centre National de la Recherche Scientifique/Université de Nice-Sophia-Antipolis, 06560 Valbonne, France.

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http://dx.doi.org/10.1523/JNEUROSCI.0789-09.2009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6665908PMC
May 2009

p53-dependent control of cell death by nicastrin: lack of requirement for presenilin-dependent gamma-secretase complex.

J Neurochem 2009 Apr 23;109(1):225-37. Epub 2009 Feb 23.

Institut de Pharmacologie Moléculaire et Cellulaire and Institut de NeuroMédecine Moléculaire of Centre National de la Recherche Scientifique, Equipe labellisée Fondation pour la Recherche Médicale, Valbonne, France.

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http://dx.doi.org/10.1111/j.1471-4159.2009.05952.xDOI Listing
April 2009

Aminopeptidase A contributes to the N-terminal truncation of amyloid beta-peptide.

J Neurochem 2009 Apr 23;109(1):248-56. Epub 2009 Feb 23.

Institut de Pharmacologie Moléculaire et Cellulaire and Institut de NeuroMédecine Moléculaire, UMR6097 CNRS/UNSA, Equipe labellisée Fondation pour la Recherche Médicale, Sophia-Antipolis, Valbonne, France.

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http://dx.doi.org/10.1111/j.1471-4159.2009.05950.xDOI Listing
April 2009

Isoform-specific contribution of protein kinase C to prion processing.

Mol Cell Neurosci 2008 Nov 29;39(3):400-10. Epub 2008 Jul 29.

Institut de Pharmacologie Moléculaire et Cellulaire du CNRS, UMR6097, UNSA, Equipe labellisée Fondation pour la Recherche Médicale, Sophia-Antipolis, Valbonne, France.

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http://dx.doi.org/10.1016/j.mcn.2008.07.013DOI Listing
November 2008

TMP21 regulates Abeta production but does not affect caspase-3, p53, and neprilysin.

Biochem Biophys Res Commun 2008 Jun 9;371(1):69-74. Epub 2008 Apr 9.

Institut de Pharmacologie Moléculaire et Cellulaire, UMR 6097, Centre National de la Recherche Scientifique-Université Nice-Sophia-Antipolis, Equipe labellisée Fondation pour la Recherche Médicale, 660 Route des Lucioles, 06560 Valbonne, France.

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http://dx.doi.org/10.1016/j.bbrc.2008.03.151DOI Listing
June 2008

NFkappaB-dependent control of BACE1 promoter transactivation by Abeta42.

J Biol Chem 2008 Apr 8;283(15):10037-47. Epub 2008 Feb 8.

Institut de Pharmacologie Moléculaire et Cellulaire, UMR 6097 CNRS/UNSA, Equipe Labellisée Fondation pour la Recherche Médicale, 06560 Valbonne, France.

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http://dx.doi.org/10.1074/jbc.M706579200DOI Listing
April 2008

Production and fate of amyloid peptides: recent advances and perspectives.

Authors:
Frederic Checler

Curr Alzheimer Res 2008 Apr;5(2):90-1

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http://dx.doi.org/10.2174/156720508783954794DOI Listing
April 2008

Regulation of betaAPP and PrPc cleavage by alpha-secretase: mechanistic and therapeutic perspectives.

Curr Alzheimer Res 2008 Apr;5(2):202-11

Institut de Pharmacologie Moléculaire et Cellulaire, UMR 6097 CNRS/Université de Nice-Sophia-Antipolis, Equipe labellisée Fondation pour la Recherche Médicale, 660 route des Lucioles, 06560 Valbonne, France.

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http://dx.doi.org/10.2174/156720508783954749DOI Listing
April 2008

Study on the putative contribution of caspases and the proteasome to the degradation of Aph-1a and Pen-2.

Neurodegener Dis 2007 ;4(2-3):156-63

Institut de Pharmacologie Moléculaire et Cellulaire, UMR6097 CNRS/UNSA, Equipe labellisée Fondation pour la Recherche Médicale, Valbonne, France.

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https://www.karger.com/Article/FullText/101840
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http://dx.doi.org/10.1159/000101840DOI Listing
October 2007

The gamma/epsilon-secretase-derived APP intracellular domain fragments regulate p53.

Curr Alzheimer Res 2007 Sep;4(4):423-6

Institut de Pharmacologie Moléculaire et Cellulaire, UMR6097CNRS/UNSA, Valbonne 06560, France.

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http://dx.doi.org/10.2174/156720507781788945DOI Listing
September 2007

p53-Dependent Aph-1 and Pen-2 anti-apoptotic phenotype requires the integrity of the gamma-secretase complex but is independent of its activity.

J Biol Chem 2007 Apr 2;282(14):10516-25. Epub 2007 Feb 2.

Institut de Pharmacologie Moléculaire et Cellulaire, UMR 6097 CNRS/UNSA, Equipe labellisée, Fondation pour la Recherche Médicale, 660 Route des Lucioles, 06560 Valbonne, France.

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http://dx.doi.org/10.1074/jbc.M611572200DOI Listing
April 2007

The C-terminal products of cellular prion protein processing, C1 and C2, exert distinct influence on p53-dependent staurosporine-induced caspase-3 activation.

J Biol Chem 2007 Jan 22;282(3):1956-63. Epub 2006 Nov 22.

Institut de Pharmacologie Moleculaire et cellulaire du CNRS, UMR6097, Université Nice-Sophia-Antipolis, Equipe labellisée Fondation pour la Recherche Médicale, 660 route des Lucioles, Sophia-Antipolis, 06560 Valbonne, France.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M609663200
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http://dx.doi.org/10.1074/jbc.M609663200DOI Listing
January 2007

Design and characterization of a novel cellular prion-derived quenched fluorimetric substrate of alpha-secretase.

Biochem Biophys Res Commun 2006 Aug 21;347(1):254-60. Epub 2006 Jun 21.

Institut de Pharmacologie Moléculaire et Cellulaire, UMR6097 CNRS/UNSA, Equipe labélisée Fondation pour la Recherche Médicale, Valbonne, France.

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http://dx.doi.org/10.1016/j.bbrc.2006.06.065DOI Listing
August 2006

Presenilin-dependent gamma-secretase-mediated control of p53-associated cell death in Alzheimer's disease.

J Neurosci 2006 Jun;26(23):6377-85

Institute of Molecular and Cellular Pharmacology, Coeducational Unit of Research 6097, National Center of Scientific Research/Nice-Sophia-Antipolis University, 06560 Valbonne, France.

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http://dx.doi.org/10.1523/JNEUROSCI.0651-06.2006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6675197PMC
June 2006

APPepsilon, the epsilon-secretase-derived N-terminal product of the beta-amyloid precursor protein, behaves as a type I protein and undergoes alpha-, beta-, and gamma-secretase cleavages.

J Neurochem 2006 May 8;97(3):807-17. Epub 2006 Mar 8.

Institut de Pharmacologie Moléculaire et Cellulaire, UMR6097 CNRS/UNSA, Equipe labellisée Fondation pour la Recherche Médicale, Valbonne, France.

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http://dx.doi.org/10.1111/j.1471-4159.2006.03748.xDOI Listing
May 2006

6-Hydroxydopamine but not 1-methyl-4-phenylpyridinium abolishes alpha-synuclein anti-apoptotic phenotype by inhibiting its proteasomal degradation and by promoting its aggregation.

J Biol Chem 2006 Apr 7;281(14):9824-31. Epub 2006 Feb 7.

IPMC du CNRS, UMR6097, Equipe Labellisée FRM, 660 Route des Lucioles, 06560 Valbonne, France.

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http://dx.doi.org/10.1074/jbc.M513903200DOI Listing
April 2006

Caspase-3-derived C-terminal product of synphilin-1 displays antiapoptotic function via modulation of the p53-dependent cell death pathway.

J Biol Chem 2006 Apr 22;281(17):11515-22. Epub 2006 Feb 22.

Institut de Pharmacologie Moléculaire et Cellulaire, CNRS, UMR6097/Université de Nice Sophia Antipolis, Equipe Labellisée Fondation pour la Recherche Médicale, 660 Route des Lucioles, 06560, Valbonne, France.

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http://dx.doi.org/10.1074/jbc.M508619200DOI Listing
April 2006

The disintegrin ADAM9 indirectly contributes to the physiological processing of cellular prion by modulating ADAM10 activity.

J Biol Chem 2005 Dec 18;280(49):40624-31. Epub 2005 Oct 18.

Institut de Pharmacologie Moléculaire et Cellulaire, du CNRS, UMR6097, Sophia-Antipolis, 06560 Valbonne, France.

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http://dx.doi.org/10.1074/jbc.M506069200DOI Listing
December 2005

Intracellular Abeta42 activates p53 promoter: a pathway to neurodegeneration in Alzheimer's disease.

FASEB J 2005 Feb 17;19(2):255-7. Epub 2004 Nov 17.

Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.

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http://dx.doi.org/10.1096/fj.04-2637fjeDOI Listing
February 2005

Presenilin-directed inhibitors of gamma-secretase trigger caspase 3 activation in presenilin-expressing and presenilin-deficient cells.

J Neurochem 2004 Aug;90(4):800-6

Institut de Pharmacologie Moléculaire et Cellulaire of Centre National de la Recherche Scientifique, Valbonne, France.

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http://dx.doi.org/10.1111/j.1471-4159.2004.02512.xDOI Listing
August 2004

Increased expression of neuronal cyclooxygenase-2 in the hippocampus in amyotrophic lateral sclerosis both with and without dementia.

Acta Neuropathol 2004 May 25;107(5):399-405. Epub 2004 Feb 25.

Department of Neuropsychiatry, Okayama University Graduate School of Medicine and Dentistry, 2-5-1 Shikata-cho, Okayama 700-8558, Japan.

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http://dx.doi.org/10.1007/s00401-004-0826-2DOI Listing
May 2004