Frederic Brocard

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Frederic Brocard

Publications by authors named "Frederic Brocard"

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26Publications

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[Calpain as a new therapeutic target for treating spasticity after a spinal cord injury].

Med Sci (Paris) 2017 Jun-Jul;33(6-7):629-636. Epub 2017 Jul 19.

Équipe P3M, Institut de Neurosciences de la Timone, UMR7289, Aix Marseille Université et Centre National de la Recherche Scientifique (CNRS), Marseille, France.

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June 2018

Kv1.2 Channels Promote Nonlinear Spiking Motoneurons for Powering Up Locomotion.

Cell Rep 2018 Mar;22(12):3315-3327

Institut de Neurosciences de la Timone (UMR7289), Aix-Marseille Université and Centre National de la Recherche Scientifique (CNRS), Marseille, France. Electronic address:

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March 2018

Prochlorperazine Increases KCC2 Function and Reduces Spasticity after Spinal Cord Injury.

J Neurotrauma 2017 Dec 19;34(24):3397-3406. Epub 2017 Sep 19.

Team P3M, Institut de Neurosciences de la Timone, UMR7289, Aix Marseille Université and Centre National de la Recherche Scientifique (CNRS) , Marseille, France .

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December 2017

Activation of 5-HT receptors restores KCC2 function and reduces neuropathic pain after spinal cord injury.

Neuroscience 2017 Aug 30. Epub 2017 Aug 30.

Team P3M, Institut de Neurosciences de la Timone, UMR7289, Aix Marseille Université and Centre National de la Recherche Scientifique (CNRS), Marseille, France. Electronic address:

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August 2017

Cleavage of Na(+) channels by calpain increases persistent Na(+) current and promotes spasticity after spinal cord injury.

Nat Med 2016 Apr 14;22(4):404-11. Epub 2016 Mar 14.

Team P3M, Institut de Neurosciences de la Timone, UMR7289, Aix-Marseille Université and Centre National de la Recherche Scientifique (CNRS), Marseille, France.

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April 2016

KCNK5 channels mostly expressed in cochlear outer sulcus cells are indispensable for hearing.

Nat Commun 2015 Nov 9;6:8780. Epub 2015 Nov 9.

Centre de Recherche en Neurobiologie et Neurophysiologie de Marseille (UMR7286), Aix-Marseille-Université and CNRS, Marseille 13344, France.

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November 2015

Sensitization of neonatal rat lumbar motoneuron by the inflammatory pain mediator bradykinin.

Elife 2015 Mar 17;4:e06195. Epub 2015 Mar 17.

Institut de Neurosciences de la Timone (UMR7289), Aix-Marseille Université and CNRS, Marseille, France.

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March 2015

Sodium-mediated plateau potentials in lumbar motoneurons of neonatal rats.

J Neurosci 2013 Sep;33(39):15626-41

Institut de Neurosciences de la Timone (UMR7289), Aix-Marseille Université and CNRS, Marseille, France, and Institut de Biologie du Développement de Marseille Luminy (UMR6216), Aix-Marseille Université and CNRS, Marseille, France.

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September 2013

Activity-dependent changes in extracellular Ca2+ and K+ reveal pacemakers in the spinal locomotor-related network.

Neuron 2013 Mar;77(6):1047-54

Team P3M, Institut de Neurosciences de la Timone, UMR 7289, CNRS and Aix-Marseille Université, F-13385 Marseille, France.

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March 2013

Primary afferent terminals acting as excitatory interneurons contribute to spontaneous motor activities in the immature spinal cord.

J Neurosci 2011 Jul;31(28):10184-8

Laboratoire Plasticité et Physio-Pathologie de la Motricité, UMR 6196, Centre National de la Recherche Scientifique, and Aix-Marseille Université, F-13402 Marseille cedex 20, France.

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July 2011

Chapter 1--importance of chloride homeostasis in the operation of rhythmic motor networks.

Prog Brain Res 2011 ;188:3-14

Laboratoire Plasticité et Physio-Pathologie de la Motricité (UMR6196), Centre National de la Recherche Scientifique CNRS) & Aix-Marseille Université, 31 Chemin Joseph Aiguier, Marseille Cedex 20, France.

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June 2011

Do pacemakers drive the central pattern generator for locomotion in mammals?

Neuroscientist 2010 Apr;16(2):139-55

Lab Plasticité et Physio-Pathologie de la Motricité, Centre National De La Recherche Scientifique, Université Aix-Marseille, Marseille, France.

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April 2010

Differential plasticity of the GABAergic and glycinergic synaptic transmission to rat lumbar motoneurons after spinal cord injury.

J Neurosci 2010 Mar;30(9):3358-69

Laboratoire Plasticité et Physio-Pathologie de la Motricité (Unité Mixte de Recherche 6196), Centre National de la Recherche Scientifique and Aix-Marseille Université, Marseille, France.

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March 2010

The transformation of a unilateral locomotor command into a symmetrical bilateral activation in the brainstem.

J Neurosci 2010 Jan;30(2):523-33

Département de Kinanthropologie Université du Québec à Montréal, Montréal, Québec H3C 3P8, Canada.

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January 2010

The persistent sodium current generates pacemaker activities in the central pattern generator for locomotion and regulates the locomotor rhythm.

J Neurosci 2008 Aug;28(34):8577-89

Laboratoire Plasticité et Physio-Pathologie de la Motricité, Unité Mixte de Recherche 6196, Centre National de la Recherche Scientifique, Université Aix-Marseille, F-13402 Marseille Cedex 20, France.

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August 2008

Initiation of locomotion in lampreys.

Brain Res Rev 2008 Jan 22;57(1):172-82. Epub 2007 Aug 22.

Département de kinanthropologie, Université du Québec à Montréal, Case postale 8888, succursale Centre-ville, Montréal, (Québec), Canada H3C 3P8.

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January 2008

Contribution of persistent sodium current to locomotor pattern generation in neonatal rats.

J Neurophysiol 2007 Aug 13;98(2):613-28. Epub 2007 Jun 13.

Laboratoire de Plasticité et Physio-Pathologie de la Motricité, Unité Mixte de Recherche 6196, Centre National de la Recherche Scientifique, Aix-Marseille Université, Marseille, France.

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August 2007

A review of burst generation by trigeminal main sensory neurons.

Arch Oral Biol 2007 Apr 18;52(4):325-8. Epub 2006 Dec 18.

Faculté de médecine dentaire, Université de Montréal, Canada.

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April 2007

Emergence of intrinsic bursting in trigeminal sensory neurons parallels the acquisition of mastication in weanling rats.

J Neurophysiol 2006 Nov 16;96(5):2410-24. Epub 2006 Aug 16.

Université de Montréal, Pavillon Paul Desmarais, C.P. 6128, Succursale Centre Ville, Montreal, Quebec H3C 3J7, Canada.

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November 2006

Perinatal development of the motor systems involved in postural control.

Neural Plast 2005 ;12(2-3):131-9; discussion 263-72

Centre National de la Recherche Scientifiqu and Universite de la Méditerranée, Laboratoire Plasticité et Physio-Pathologie de la Motricité (UMR6196), CNRS, F-13402 Marseille, France.

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September 2005

Modulatory effect of substance P to the brain stem locomotor command in lampreys.

J Neurophysiol 2005 Apr 17;93(4):2127-41. Epub 2004 Nov 17.

Département de Kinanthropologie, Université du Québec à Montréal, C.P. 8888, Succ. Centre-Ville, Montréal, Québec H3C 3P8, Canada.

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April 2005

Muscarinic modulation of the trigemino-reticular pathway in lampreys.

J Neurophysiol 2004 Aug 24;92(2):926-38. Epub 2004 Mar 24.

Dépt. de Kinanthropologie, C.P. 8888, Université du Québec à Montréal, Succ. Centre-Ville, Montréal, Québec H3C 3P8, Canada.

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August 2004

The maturation of locomotor networks.

Prog Brain Res 2004 ;143:57-66

Institut de Neurosciences Physiologiques et Cognitives-INPC, CNRS, Aix-Marseille II, 13402 Marseille, France.

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December 2003

Differential contribution of reticulospinal cells to the control of locomotion induced by the mesencephalic locomotor region.

J Neurophysiol 2003 Sep 7;90(3):1714-27. Epub 2003 May 7.

Département de Kinanthropologie, Université du Québec, Montreal H3C 3P8, Canada.

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September 2003

Nicotinic activation of reticulospinal cells involved in the control of swimming in lampreys.

Eur J Neurosci 2003 Jan;17(1):137-48

Département de kinanthropologie, Université du Québec à Montréal, Montréal Québec, Canada, H3C 3P8.

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January 2003