Publications by authors named "Frederic Bornancin"

51Publications

Discovery of Potent, Highly Selective, and Efficacious, Allosteric MALT1 Inhibitors by Iterative Scaffold Morphing.

Authors:
Carole Pissot Soldermann Oliver Simic Martin Renatus Paulus Erbel Samu Melkko Markus Wartmann Marc Bigaud Andreas Weiss Paul McSheehy Ralf Endres Paulo Santos Jutta Blank Ansgar Schuffenhauer Guido Bold Nicole Buschmann Thomas Zoller Eva Altmann Paul W Manley Ina Dix Elisabeth Buchdunger Julien Scesa Jean Quancard Achim Schlapbach Frédéric Bornancin Thomas Radimerski Catherine H Régnier

J Med Chem 2020 12 30;63(23):14576-14593. Epub 2020 Nov 30.

Novartis Institutes for BioMedical Research, Novartis Campus, CH-4002 Basel, Switzerland.

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December 2020

Optimization of the Potency of Pyrazolopyrimidine MALT1 Protease Inhibitors by Reducing Metabolism and Increasing Potency in Whole Blood.

Authors:
Jean Quancard Oliver Simic Carole Pissot Soldermann Reiner Aichholz Markus Blatter Martin Renatus Paulus Erbel Samu Melkko Ralf Endres Mickael Sorge Laurence Kieffer Trixie Wagner Karen Beltz Paul Mcsheehy Markus Wartmann Catherine H Régnier Thomas Calzascia Thomas Radimerski Marc Bigaud Andreas Weiss Frédéric Bornancin Achim Schlapbach

J Med Chem 2020 12 20;63(23):14594-14608. Epub 2020 Nov 20.

Novartis Pharma AG, Novartis Institutes for BioMedical Research, Novartis Campus, CH-4056 Basel, Switzerland.

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December 2020

Pharmacological Inhibition of MALT1 Protease Leads to a Progressive IPEX-Like Pathology.

Authors:
Kea Martin Ursula Junker Elaine Tritto Esther Sutter Tina Rubic-Schneider Hannah Morgan Satoru Niwa Jianping Li Achim Schlapbach Dana Walker Marc Bigaud Christian Beerli Amanda Littlewood-Evans Bettina Rudolph Marc Laisney David Ledieu Karen Beltz Jean Quancard Frédéric Bornancin Natasa Zamurovic Ribrioux Thomas Calzascia

Front Immunol 2020 30;11:745. Epub 2020 Apr 30.

Autoimmunity, Transplantation and Inflammation, Novartis Institutes for Biomedical Research, Basel, Switzerland.

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April 2020

Classification and Nomenclature of Metacaspases and Paracaspases: No More Confusion with Caspases.

Authors:
Elena A Minina Jens Staal Vanina E Alvarez John A Berges Ilana Berman-Frank Rudi Beyaert Kay D Bidle Frédéric Bornancin Magali Casanova Juan J Cazzulo Chang Jae Choi Nuria S Coll Vishva M Dixit Marko Dolinar Nicolas Fasel Christiane Funk Patrick Gallois Kris Gevaert Emilio Gutierrez-Beltran Stephan Hailfinger Marina Klemenčič Eugene V Koonin Daniel Krappmann Anna Linusson Maurício F M Machado Frank Madeo Lynn A Megeney Panagiotis N Moschou Jeremy C Mottram Thomas Nyström Heinz D Osiewacz Christopher M Overall Kailash C Pandey Jürgen Ruland Guy S Salvesen Yigong Shi Andrei Smertenko Simon Stael Jerry Ståhlberg María Fernanda Suárez Margot Thome Hannele Tuominen Frank Van Breusegem Renier A L van der Hoorn Assaf Vardi Boris Zhivotovsky Eric Lam Peter V Bozhkov

Mol Cell 2020 03;77(5):927-929

Department of Molecular Sciences, Uppsala BioCenter, Swedish University of Agricultural Sciences and Linnean Center for Plant Biology, Uppsala, Sweden. Electronic address:

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March 2020

Requirement of Mucosa-Associated Lymphoid Tissue Lymphoma Translocation Protein 1 Protease Activity for Fcγ Receptor-Induced Arthritis, but Not Fcγ Receptor-Mediated Platelet Elimination, in Mice.

Authors:
Kea Martin Ratiba Touil Grozdan Cvijetic Laura Israel Yeter Kolb Sophie Sarret Stéphanie Valeaux Elena Degl'Innocenti Thomas Le Meur Nadja Caesar Maureen Bardet Christian Beerli Hans-Guenter Zerwes Jiri Kovarik Karen Beltz Achim Schlapbach Jean Quancard Catherine H Régnier Marc Bigaud Tobias Junt Grazyna Wieczorek Isabelle Isnardi Amanda Littlewood-Evans Frédéric Bornancin Thomas Calzascia

Arthritis Rheumatol 2020 06 26;72(6):919-930. Epub 2020 Apr 26.

Novartis Institutes for BioMedical Research, Basel, Switzerland.

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June 2020

Malt1 Protease Deficiency in Mice Disrupts Immune Homeostasis at Environmental Barriers and Drives Systemic T Cell-Mediated Autoimmunity.

Authors:
Kea Martin Ratiba Touil Yeter Kolb Grozdan Cvijetic Kiichi Murakami Laura Israel Fernanda Duraes David Buffet Anton Glück Satoru Niwa Marc Bigaud Tobias Junt Natasa Zamurovic Philip Smith Kathy D McCoy Pamela S Ohashi Frédéric Bornancin Thomas Calzascia

J Immunol 2019 12 28;203(11):2791-2806. Epub 2019 Oct 28.

Novartis Institutes for BioMedical Research, Novartis Pharma AG, 4002 Basel, Switzerland;

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December 2019

Editorial: CARMA Proteins: Playing a Hand of Four CARDs.

Authors:
Frédéric Bornancin Andrew L Snow

Front Immunol 2019 29;10:1217. Epub 2019 May 29.

Department of Pharmacology and Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, United States.

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June 2020

An allosteric MALT1 inhibitor is a molecular corrector rescuing function in an immunodeficient patient.

Authors:
Jean Quancard Theo Klein Shan-Yu Fung Martin Renatus Nicola Hughes Laura Israël John J Priatel Sohyeong Kang Michael A Blank Rosa I Viner Jutta Blank Achim Schlapbach Paul Erbel Jayachandran Kizhakkedathu Frédéric Villard René Hersperger Stuart E Turvey Joerg Eder Frédéric Bornancin Christopher M Overall

Nat Chem Biol 2019 03 28;15(3):304-313. Epub 2019 Jan 28.

Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia, Canada.

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March 2019

Myeloid Innate Signaling Pathway Regulation by MALT1 Paracaspase Activity.

Authors:
Adeline Unterreiner Ratiba Touil Daniele Anastasi Nicolas Dubois Satoru Niwa Thomas Calzascia Frederic Bornancin

J Vis Exp 2019 01 7(143). Epub 2019 Jan 7.

Autoimmunity, Transplantation and Inflammation, Novartis Institutes for BioMedical Research;

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January 2019

MALT1 activation by TRAF6 needs neither BCL10 nor CARD11.

Authors:
Maureen Bardet Thomas Seeholzer Adeline Unterreiner Simone Woods Daniel Krappmann Frédéric Bornancin

Biochem Biophys Res Commun 2018 11 15;506(1):48-52. Epub 2018 Oct 15.

Novartis Institutes for BioMedical Research, Novartis Campus, Basel, Switzerland. Electronic address:

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November 2018

Pharmacological inhibition of MALT1 protease activity suppresses endothelial activation via enhancing MCPIP1 expression.

Authors:
Yong Li Shengping Huang Xuan Huang Xiuzhen Li Adrian Falcon Adele Soutar Frederic Bornancin Zhisheng Jiang Hong-Bo Xin Mingui Fu

Cell Signal 2018 Oct 18;50:1-8. Epub 2018 Jun 18.

Department of Biomedical Science and Shock/Trauma Research Center, School of Medicine, University of Missouri-Kansas City, 2411 Holmes Street, Kansas City, MO 64108, USA. Electronic address:

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October 2018

N-aryl-piperidine-4-carboxamides as a novel class of potent inhibitors of MALT1 proteolytic activity.

Authors:
Achim Schlapbach Laszlo Revesz Carole Pissot Soldermann Thomas Zoller Catherine H Régnier Frédéric Bornancin Thomas Radimerski Jutta Blank Ansgar Schuffenhauer Martin Renatus Paulus Erbel Samu Melkko Richard Heng Oliver Simic Ralf Endres Markus Wartmann Jean Quancard

Bioorg Med Chem Lett 2018 07 9;28(12):2153-2158. Epub 2018 May 9.

Novartis Institutes for BioMedical Research, CH-4002 Basel, Switzerland.

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July 2018

A CARD10-Dependent Tonic Signalosome Activates MALT1 Paracaspase and Regulates IL-17/TNF-α-Driven Keratinocyte Inflammation.

Authors:
Laura Israël Maureen Bardet Antje Huppertz Nicolas Mercado Stefanie Ginster Adeline Unterreiner Anita Schlierf Jean François Goetschy Hans-Günter Zerwes Lukas Roth Frank Kolbinger Frédéric Bornancin

J Invest Dermatol 2018 09 20;138(9):2075-2079. Epub 2018 Mar 20.

Novartis Institutes for BioMedical Research, Novartis Campus, Basel, Switzerland. Electronic address:

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September 2018

The T-cell fingerprint of MALT1 paracaspase revealed by selective inhibition.

Authors:
Maureen Bardet Adeline Unterreiner Claire Malinverni Frédérique Lafossas Corinne Vedrine Danielle Boesch Yeter Kolb Daniel Kaiser Anton Glück Martin A Schneider Andreas Katopodis Martin Renatus Oliver Simic Achim Schlapbach Jean Quancard Catherine H Régnier Guido Bold Carole Pissot-Soldermann José M Carballido Jiri Kovarik Thomas Calzascia Frédéric Bornancin

Immunol Cell Biol 2018 01 21;96(1):81-99. Epub 2017 Dec 21.

Novartis Institutes for BioMedical Research, Novartis Campus, Basel, Switzerland.

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January 2018

Selective MALT1 paracaspase inhibition does not block TNF-α production downstream of TLR4 in myeloid cells.

Authors:
Adeline Unterreiner Natacha Stoehr Christine Huppertz Thomas Calzascia Christopher J Farady Frédéric Bornancin

Immunol Lett 2017 12 24;192:48-51. Epub 2017 Oct 24.

Novartis Institutes for BioMedical Research, Basel, Switzerland. Electronic address:

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December 2017

Ways and waves of MALT1 paracaspase activation.

Authors:
Laura Israël Frédéric Bornancin

Cell Mol Immunol 2018 01 7;15(1):8-11. Epub 2017 Aug 7.

Novartis Institutes for BioMedical Research, Novartis Campus, Basel CH-4002, Switzerland.

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January 2018

Two Antagonistic MALT1 Auto-Cleavage Mechanisms Reveal a Role for TRAF6 to Unleash MALT1 Activation.

Authors:
Stefanie Ginster Maureen Bardet Adeline Unterreiner Claire Malinverni Florian Renner Stephen Lam Felix Freuler Bertran Gerrits Johannes Voshol Thomas Calzascia Catherine H Régnier Martin Renatus Rainer Nikolay Laura Israël Frédéric Bornancin

PLoS One 2017 4;12(1):e0169026. Epub 2017 Jan 4.

Novartis Institutes for BioMedical Research, Novartis Campus, Basel, Switzerland.

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August 2017

Deficiency of MALT1 paracaspase activity results in unbalanced regulatory and effector T and B cell responses leading to multiorgan inflammation.

Authors:
Frédéric Bornancin Florian Renner Ratiba Touil Heiko Sic Yeter Kolb Ismahane Touil-Allaoui James S Rush Paul A Smith Marc Bigaud Ursula Junker-Walker Christoph Burkhart Janet Dawson Satoru Niwa Andreas Katopodis Barbara Nuesslein-Hildesheim Gisbert Weckbecker Gerhard Zenke Bernd Kinzel Elisabetta Traggiai Dirk Brenner Anne Brüstle Michael St Paul Natasa Zamurovic Kathy D McCoy Antonius Rolink Catherine H Régnier Tak W Mak Pamela S Ohashi Dhavalkumar D Patel Thomas Calzascia

J Immunol 2015 Apr 11;194(8):3723-34. Epub 2015 Mar 11.

Novartis Institutes for BioMedical Research, Novartis Pharma AG, 4056 Basel, Switzerland;

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April 2015

The ceramide kinase inhibitor NVP-231 inhibits breast and lung cancer cell proliferation by inducing M phase arrest and subsequent cell death.

Authors:
Oleksandr Pastukhov Stephanie Schwalm Uwe Zangemeister-Wittke Doriano Fabbro Frederic Bornancin Lukasz Japtok Burkhard Kleuser Josef Pfeilschifter Andrea Huwiler

Br J Pharmacol 2014 Dec;171(24):5829-44

Institute of Pharmacology, University of Bern, Bern, Switzerland.

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December 2014

Structural determinants of MALT1 protease activity.

Authors:
Christian Wiesmann Lukas Leder Jutta Blank Anna Bernardi Samu Melkko Arnaud Decock Allan D'Arcy Frederic Villard Paulus Erbel Nicola Hughes Felix Freuler Rainer Nikolay Juliano Alves Frederic Bornancin Martin Renatus

J Mol Biol 2012 May 23;419(1-2):4-21. Epub 2012 Feb 23.

Novartis Institutes for BioMedical Research, Forum 1, Novartis Campus, CH-4002 Basel, Switzerland.

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May 2012

Ceramide kinase: the first decade.

Authors:
Frédéric Bornancin

Cell Signal 2011 Jun 25;23(6):999-1008. Epub 2010 Nov 25.

Novartis Institutes for BioMedical Research, CH-4056 Basle, Switzerland.

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June 2011

Transcriptional repression of ceramide kinase in LPS-challenged macrophages.

Authors:
Philipp Rovina Markus Jaritz Frédéric Bornancin

Biochem Biophys Res Commun 2010 Oct 16;401(1):164-7. Epub 2010 Sep 16.

Novartis Institutes for BioMedical Research, Brunnerstrasse 59, A-1235 Vienna, Austria.

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October 2010

Cleavage by MALT1 induces cytosolic release of A20.

Authors:
Claire Malinverni Adeline Unterreiner Jens Staal Annelies Demeyer Marion Galaup Marcel Luyten Rudi Beyaert Frédéric Bornancin

Biochem Biophys Res Commun 2010 Oct 20;400(4):543-7. Epub 2010 Sep 20.

Novartis Institutes for BioMedical Research, Forum 1, Novartis Campus, CH-4056 Basle, Switzerland.

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October 2010

Modulation of ceramide metabolism in mouse primary macrophages.

Authors:
Philipp Rovina Christine Graf Frédéric Bornancin

Biochem Biophys Res Commun 2010 Aug 15;399(2):150-4. Epub 2010 Jul 15.

Novartis Institutes for BioMedical Research, Brunnerstrasse 59, A-1235 Vienna, Austria.

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August 2010

Ovalbumin-induced plasma interleukin-4 levels are reduced in ceramide kinase-deficient DO11.10 RAG1-/- mice.

Authors:
Satoru Niwa Nicole Urtz Thomas Baumruker Andreas Billich Frédéric Bornancin

Lipids Health Dis 2010 Jan 6;9. Epub 2010 Jan 6.

Novartis Institutes for BioMedical Research, Brunnerstrasse 59, A-1235 Vienna, Austria.

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January 2010

Ceramide kinase profiling by mass spectrometry reveals a conserved phosphorylation pattern downstream of the catalytic site.

Authors:
Wei-Qiang Chen Christine Graf David Zimmel Philipp Rovina Kurt Krapfenbauer Markus Jaritz Peter J Parker Gert Lubec Frédéric Bornancin

J Proteome Res 2010 Jan;9(1):420-9

Department of Pediatrics, Medical University of Vienna, Waehringer Guertel 18, A-1090 Vienna, Austria.

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January 2010

4,5,6-Trisubstituted piperidinones as conformationally restricted ceramide analogues: synthesis and evaluation as inhibitors of sphingosine and ceramide kinases and as NKT cell-stimulatory antigens.

Authors:
Thresen Mathew Marco Cavallari Andreas Billich Frederic Bornancin Peter Nussbaumer Gennaro De Libero Andrea Vasella

Chem Biodivers 2009 Oct;6(10):1688-715

Laboratorium für Organische Chemie, Departement Chemie und Angewandte Biowissenschaften, ETH Zürich, Wolfgang-Pauli-Strasse 10, CH-8093 Zürich.

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October 2009

Subcellular localization of ceramide kinase and ceramide kinase-like protein requires interplay of their Pleckstrin Homology domain-containing N-terminal regions together with C-terminal domains.

Authors:
Philipp Rovina Andrea Schanzer Christine Graf Diana Mechtcheriakova Markus Jaritz Frédéric Bornancin

Biochim Biophys Acta 2009 Oct 6;1791(10):1023-30. Epub 2009 Jun 6.

Novartis Institutes for BioMedical Research, Brunnerstrasse 59, A-1235 Vienna, Austria.

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October 2009

Synthesis and evaluation of sphingolipid analogues: modification of the hydroxy group at C(1) of 7-oxasphingosine, and of the hydroxy group at C(1) and the amide group of 7-oxaceramides.

Authors:
Thresen Mathew Andreas Billich Marco Cavallari Frederic Bornancin Peter Nussbaumer Gennaro De Libero Andrea Vasella

Chem Biodivers 2009 May;6(5):705-24

Laboratorium für Organische Chemie, Departement Chemie und Angewandte Biowissenschaften, ETH-Zürich, Wolfgang-Pauli-Strasse 10, Zürich.

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May 2009

Ceramide kinase deficiency impairs microendothelial cell angiogenesis in vitro.

Authors:
Satoru Niwa Christine Graf Frédéric Bornancin

Microvasc Res 2009 May 6;77(3):389-93. Epub 2009 Feb 6.

Novartis Institutes for BioMedical Research, Brunnerstrasse 59, A-1235 Vienna, Austria.

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May 2009

A secondary assay for ceramide kinase inhibitors based on cell growth inhibition by short-chain ceramides.

Authors:
Christine Graf Philipp Rovina Frédéric Bornancin

Anal Biochem 2009 Jan 14;384(1):166-9. Epub 2008 Sep 14.

Novartis Institutes for BioMedical Research, A-1235 Vienna, Austria.

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January 2009

A conserved cysteine motif essential for ceramide kinase function.

Authors:
Emilie Lidome Christine Graf Markus Jaritz Andrea Schanzer Philipp Rovina Rainer Nikolay Frédéric Bornancin

Biochimie 2008 Oct 10;90(10):1560-5. Epub 2008 Jul 10.

Novartis Institutes for BioMedical Research, Vienna, Vienna, Austria.

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October 2008

Targeting ceramide metabolism with a potent and specific ceramide kinase inhibitor.

Authors:
Christine Graf Martin Klumpp Michael Habig Philipp Rovina Andreas Billich Thomas Baumruker Berndt Oberhauser Frédéric Bornancin

Mol Pharmacol 2008 Oct 8;74(4):925-32. Epub 2008 Jul 8.

Novartis Institutes for BioMedical Research, Vienna, Austria.

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October 2008

Wild-type levels of ceramide and ceramide-1-phosphate in the retina of ceramide kinase-like-deficient mice.

Authors:
Christine Graf Satoru Niwa Matthias Müller Bernd Kinzel Frédéric Bornancin

Biochem Biophys Res Commun 2008 Aug 12;373(1):159-63. Epub 2008 Jun 12.

Novartis Institutes for BioMedical Research, Brunnerstrasse 59, A-1235 Vienna, Austria.

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August 2008

FTY720 rescue therapy in the dark agouti rat model of experimental autoimmune encephalomyelitis: expression of central nervous system genes and reversal of blood-brain-barrier damage.

Authors:
Carolyn A Foster Diana Mechtcheriakova Maria K Storch Balázs Balatoni Laurence M Howard Frédéric Bornancin Alexander Wlachos Jury Sobanov Anu Kinnunen Thomas Baumruker

Brain Pathol 2009 Apr 4;19(2):254-66. Epub 2008 Jun 4.

Novartis Institutes for BioMedical Research, Brunner Strasse 59, Vienna, Austria.

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April 2009

Neutropenia with impaired immune response to Streptococcus pneumoniae in ceramide kinase-deficient mice.

Authors:
Christine Graf Barbara Zemann Philipp Rovina Nicole Urtz Andrea Schanzer Roland Reuschel Diana Mechtcheriakova Matthias Müller Evelin Fischer Claudia Reichel Susanna Huber Janet Dawson Josef G Meingassner Andreas Billich Satoru Niwa Rudolf Badegruber Paul P Van Veldhoven Bernd Kinzel Thomas Baumruker Frédéric Bornancin

J Immunol 2008 Mar;180(5):3457-66

Novartis Institutes for BioMedical Research, Vienna, Austria.

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March 2008

Regulation and traffic of ceramide 1-phosphate produced by ceramide kinase: comparative analysis to glucosylceramide and sphingomyelin.

Authors:
Alistair Boath Christine Graf Emilie Lidome Thomas Ullrich Peter Nussbaumer Frédéric Bornancin

J Biol Chem 2008 Mar 16;283(13):8517-26. Epub 2007 Dec 16.

Novartis Institutes for BioMedical Research, Vienna, Brunnerstrasse 59, Wien, Austria.

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March 2008

FTY720-phosphate is dephosphorylated by lipid phosphate phosphatase 3.

Authors:
Diana Mechtcheriakova Alexander Wlachos Jury Sobanov Frederic Bornancin Gerhard Zlabinger Thomas Baumruker Andreas Billich

FEBS Lett 2007 Jun 4;581(16):3063-8. Epub 2007 Jun 4.

Novartis Institutes for BioMedical Research, Vienna, Austria.

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June 2007

Normal neutrophil functions in sphingosine kinase type 1 and 2 knockout mice.

Authors:
Barbara Zemann Nicole Urtz Roland Reuschel Diana Mechtcheriakova Frédéric Bornancin Rudolf Badegruber Thomas Baumruker Andreas Billich

Immunol Lett 2007 Mar 30;109(1):56-63. Epub 2007 Jan 30.

Novartis Institutes for BioMedical Research, Vienna, Brunnerstrasse 59, A-1235 Wien, Austria.

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March 2007

Enhanced ceramide-induced apoptosis in ceramide kinase overexpressing cells.

Authors:
Christine Graf Philipp Rovina Loïc Tauzin Andrea Schanzer Frédéric Bornancin

Biochem Biophys Res Commun 2007 Mar 8;354(1):309-14. Epub 2007 Jan 8.

Novartis Institutes for BioMedical Research, Brunnerstrasse 59, A-1235 Vienna, Austria.

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March 2007

Sphingosine 1-phosphate phosphatase 2 is induced during inflammatory responses.

Authors:
Diana Mechtcheriakova Alexander Wlachos Jury Sobanov Tamara Kopp Roland Reuschel Frederic Bornancin Richard Cai Barbara Zemann Nicole Urtz Georg Stingl Gerhard Zlabinger Maximilian Woisetschläger Thomas Baumruker Andreas Billich

Cell Signal 2007 Apr 30;19(4):748-60. Epub 2006 Sep 30.

Novartis Institutes for BioMedical Research, Vienna, Brunnerstrasse 59, A-1235 Vienna, Austria.

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April 2007

Effects of ceramide-1-phosphate on cultured cells: dependence on dodecane in the vehicle.

Authors:
Loïc Tauzin Christine Graf Mei Sun Philipp Rovina Nicolas Bouveyron Markus Jaritz Anthony Winiski Nicole Hartmann Frank Staedtler Andreas Billich Thomas Baumruker Mei Zhang Frédéric Bornancin

J Lipid Res 2007 Jan 3;48(1):66-76. Epub 2006 Oct 3.

Novartis Institutes for BioMedical Research, A-1235 Vienna, Austria.

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January 2007

A critical beta6-beta7 loop in the pleckstrin homology domain of ceramide kinase.

Authors:
Philipp Rovina Markus Jaritz Siegfried Höfinger Christine Graf Piroska Dévay Andreas Billich Thomas Baumruker Frédéric Bornancin

Biochem J 2006 Dec;400(2):255-65

Novartis Institutes for BioMedical Research, Brunnerstrasse 59, A-1235 Vienna, Austria.

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December 2006

Sphingosine kinase type 2 is essential for lymphopenia induced by the immunomodulatory drug FTY720.

Authors:
Barbara Zemann Bernd Kinzel Matthias Müller Roland Reuschel Diana Mechtcheriakova Nicole Urtz Frédéric Bornancin Thomas Baumruker Andreas Billich

Blood 2006 Feb 13;107(4):1454-8. Epub 2005 Oct 13.

Novartis Institutes for BioMedical Research, Brunnerstrasse 59, A-1235 Vienna, Austria.

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February 2006

Basal and induced sphingosine kinase 1 activity in A549 carcinoma cells: function in cell survival and IL-1beta and TNF-alpha induced production of inflammatory mediators.

Authors:
Andreas Billich Frédéric Bornancin Diana Mechtcheriakova François Natt Dieter Huesken Thomas Baumruker

Cell Signal 2005 Oct 18;17(10):1203-17. Epub 2005 Jan 18.

Novartis Institutes for BioMedical Research, Brunnerstrasse 59, Vienna A-1235, Austria.

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October 2005

Characterization of a ceramide kinase-like protein.

Authors:
Frédéric Bornancin Diana Mechtcheriakova Samantha Stora Christine Graf Alexander Wlachos Piroska Dévay Nicole Urtz Thomas Baumruker Andreas Billich

Biochim Biophys Acta 2005 Feb;1687(1-3):31-43

Novartis Institutes for BioMedical Research, Brunnerstrasse 59, A-1235 Vienna, Austria.

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February 2005

The role of sphingosine and ceramide kinases in inflammatory responses.

Authors:
Thomas Baumruker Frédéric Bornancin Andreas Billich

Immunol Lett 2005 Jan;96(2):175-85

Novartis Institute for BioMedical Research Vienna, Brunner Strasse 59, A-1235 Vienna, Austria.

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January 2005

Ceramide kinase targeting and activity determined by its N-terminal pleckstrin homology domain.

Authors:
Adeline Carré Christine Graf Samantha Stora Diana Mechtcheriakova Robert Csonga Nicole Urtz Andreas Billich Thomas Baumruker Frédéric Bornancin

Biochem Biophys Res Commun 2004 Nov;324(4):1215-9

Novartis Institute for BioMedical Research Vienna, Brunnerstrasse 59, A-1235 Vienna, Austria.

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November 2004

Early activation of sphingosine kinase in mast cells and recruitment to FcepsilonRI are mediated by its interaction with Lyn kinase.

Authors:
Nicole Urtz Ana Olivera Elisa Bofill-Cardona Robert Csonga Andreas Billich Diana Mechtcheriakova Frederic Bornancin Max Woisetschläger Juan Rivera Thomas Baumruker

Mol Cell Biol 2004 Oct;24(19):8765-77

Novartis Institute for Biomedical Research, Brunner Strasse 59, A-1235 Vienna, Austria.

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October 2004

Phosphorylation of the immunomodulatory drug FTY720 by sphingosine kinases.

Authors:
Andreas Billich Frederic Bornancin Piroska Dévay Diana Mechtcheriakova Nicole Urtz Thomas Baumruker

J Biol Chem 2003 Nov 16;278(48):47408-15. Epub 2003 Sep 16.

Novartis Research Institute, Brunnerstrasse 59, A-1235 Vienna, Austria.

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November 2003

Ligand modulation of [35S]GTPgammaS binding at human alpha(2A), alpha(2B) and alpha(2C) adrenoceptors.

Authors:
Valérie Audinot Nelly Fabry Jean-Paul Nicolas Philippe Beauverger Adrian Newman-Tancredi Mark J Millan Anne Try Frédéric Bornancin Emmanuel Canet Jean A Boutin

Cell Signal 2002 Oct;14(10):829-37

Département de Pharmacologie Moléculaire et Cellulaire, Institut de Recherches Servier, 125, Chemin de Ronde, 78290 Croissy-sur-Seine, France.

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October 2002