Fred Van Leuven

Fred Van Leuven

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Fred Van Leuven

Publications by authors named "Fred Van Leuven"

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Regional vulnerability and spreading of hyperphosphorylated tau in seeded mouse brain.

Neurobiol Dis 2019 07 14;127:398-409. Epub 2019 Mar 14.

Laboratory of Cell Biology and Histology, Department of Veterinary Sciences, University of Antwerp, Universiteitsplein 1, 2610 Wilrijk, Belgium; Department of Molecular Biotechnology, Ghent University, Coupure Links 653, 9000 Ghent, Belgium.

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https://linkinghub.elsevier.com/retrieve/pii/S09699961193006
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http://dx.doi.org/10.1016/j.nbd.2019.03.010DOI Listing
July 2019

Quantitative Assessment of Age-Associated Alterations in Brain Vasculature in Wild-Type Mice and in Bigenic Mice that Model Alzheimer's Disease.

Mol Imaging Biol 2019 Jul 11. Epub 2019 Jul 11.

Biomedical MRI/ MoSAIC, Department of Imaging & Pathology, KU Leuven, Herestraat 49, Bus 505, 3000, Leuven, Belgium.

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http://dx.doi.org/10.1007/s11307-019-01402-wDOI Listing
July 2019

Identification of GSK-3 as a Potential Therapeutic Entry Point for Epilepsy.

ACS Chem Neurosci 2019 Apr 6;10(4):1992-2003. Epub 2018 Nov 6.

Laboratory for Molecular Biodiscovery, Department of Pharmaceutical and Pharmacological Sciences , University of Leuven , Leuven 3000 , Belgium.

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http://pubs.acs.org/doi/10.1021/acschemneuro.8b00281
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http://dx.doi.org/10.1021/acschemneuro.8b00281DOI Listing
April 2019

Deficiency in the transcription factor NRF2 worsens inflammatory parameters in a mouse model with combined tauopathy and amyloidopathy.

Redox Biol 2018 09 11;18:173-180. Epub 2018 Jul 11.

Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), ISCIII. Instituto de Investigaciones Biomédicas "Alberto Sols", UAM-CSIC. Instituto de Investigación Sanitaria La Paz (IdiPaz) and Department of Biochemistry, Faculty of Medicine, Autonomous University of MadridMadrid, Spain; Cellular and Molecular Medicine Department, Radiobiology Laboratory, "Victor Babes" National Institute of Pathology, Bucharest, Romania. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22132317183041
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http://dx.doi.org/10.1016/j.redox.2018.07.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6052199PMC
September 2018

TauBI or not TauBI: what was the question?

Brain 2018 09;141(9):2536-2539

Division of Brain Sciences, Imperial College London, London, UK.

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http://fdslive.oup.com/www.oup.com/pdf/production_in_progres
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http://dx.doi.org/10.1093/brain/awy225DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6113641PMC
September 2018

GSK3β Controls mTOR and Prosurvival Signaling in Neurons.

Mol Neurobiol 2018 Jul 15;55(7):6050-6062. Epub 2017 Nov 15.

Laboratory of Molecular and Cellular Neurobiology, International Institute of Molecular and Cell Biology, Ks. Trojdena St. 4, 02-109, Warsaw, Poland.

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http://dx.doi.org/10.1007/s12035-017-0823-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5994211PMC
July 2018

The age-related slow increase in amyloid pathology in APP.V717I mice activates microglia, but does not alter hippocampal neurogenesis.

Neurobiol Aging 2018 01 22;61:112-123. Epub 2017 Sep 22.

Brain Plasticity Group, Center for Neuroscience, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, the Netherlands.

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http://dx.doi.org/10.1016/j.neurobiolaging.2017.09.013DOI Listing
January 2018

NRF2 deficiency replicates transcriptomic changes in Alzheimer's patients and worsens APP and TAU pathology.

Redox Biol 2017 10 5;13:444-451. Epub 2017 Jul 5.

Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), ISCIII. Instituto de Investigaciones Biomédicas "Alberto Sols" UAM-CSIC. Instituto de Investigación Sanitaria La Paz (IdiPaz), and Department of Biochemistry, Faculty of Medicine, Autonomous University of Madrid, Madrid, Spain; Cellular and Molecular Medicine Department, Radiobiology Laboratory, "Victor Babes" National Institute of Pathology, Bucharest, Romania. Electronic address:

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http://dx.doi.org/10.1016/j.redox.2017.07.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5508523PMC
October 2017

GSK-3β and MMP-9 Cooperate in the Control of Dendritic Spine Morphology.

Mol Neurobiol 2017 01 6;54(1):200-211. Epub 2016 Jan 6.

Laboratory of Neurobiology, The Nencki Institute of Experimental Biology, 3 Pasteur, 02-093, Warsaw, Poland.

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http://dx.doi.org/10.1007/s12035-015-9625-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5219889PMC
January 2017

Transcription factor NFE2L2/NRF2 is a regulator of macroautophagy genes.

Autophagy 2016 10 18;12(10):1902-1916. Epub 2016 Jul 18.

a Instituto de Investigaciones Biomédicas "Alberto Sols" UAM-CSIC, Instituto de Investigación Sanitaria La Paz (IdiPaz) and Department of Biochemistry, Faculty of Medicine, Autonomous University of Madrid , Madrid , Spain.

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http://dx.doi.org/10.1080/15548627.2016.1208889DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5079676PMC
October 2016

Small-Animal PET Imaging of Tau Pathology with 18F-THK5117 in 2 Transgenic Mouse Models.

J Nucl Med 2016 05 11;57(5):792-8. Epub 2016 Feb 11.

Department of Nuclear Medicine, Ludwig-Maximilians-University of Munich, Munich, Germany Munich Cluster for Systems Neurology (SyNergy), Munich, Germany

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http://dx.doi.org/10.2967/jnumed.115.163493DOI Listing
May 2016

Transcriptional upregulation of myelin components in spontaneous myelin basic protein-deficient mice.

Brain Res 2015 May 20;1606:125-32. Epub 2015 Feb 20.

Autoimmune Genetics Laboratory, VIB, Leuven, Belgium; Department of Microbiology and Immunology, University of Leuven, Leuven, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.brainres.2015.02.021DOI Listing
May 2015

Phosphorylation of protein Tau by GSK3β prolongs survival of bigenic Tau.P301L×GSK3β mice by delaying brainstem tauopathy.

Neurobiol Dis 2014 Jul 2;67:119-32. Epub 2014 Apr 2.

Experimental Genetics Group - LEGTEGG, Dept. Human Genetics, KU Leuven, B-3000 Leuven, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2014.03.016DOI Listing
July 2014

Terminal hypothermic Tau.P301L mice have increased Tau phosphorylation independently of glycogen synthase kinase 3α/β.

Eur J Neurosci 2014 Jul 23;40(2):2442-53. Epub 2014 Apr 23.

Experimental Genetics Group LEGTEGG, Department of Human Genetics, KU Leuven, Campus Gasthuisberg ON1 06.602, Herestraat 49, B-3000, Leuven, Belgium.

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http://dx.doi.org/10.1111/ejn.12595DOI Listing
July 2014

Increased mtDNA mutations with aging promotes amyloid accumulation and brain atrophy in the APP/Ld transgenic mouse model of Alzheimer's disease.

Mol Neurodegener 2014 May 2;9:16. Epub 2014 May 2.

Department of Cell and Molecular Biology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.

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http://dx.doi.org/10.1186/1750-1326-9-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4028006PMC
May 2014

Fractalkine activates NRF2/NFE2L2 and heme oxygenase 1 to restrain tauopathy-induced microgliosis.

Brain 2014 Jan 25;137(Pt 1):78-91. Epub 2013 Nov 25.

1 Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Instituto de Investigación Sanitaria La Paz (IdiPaz), Instituto de Investigaciones Biomédicas Alberto Sols UAM-CSIC, and Department of Biochemistry, Faculty of Medicine, Autonomous University of Madrid, Madrid, Spain.

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http://dx.doi.org/10.1093/brain/awt323DOI Listing
January 2014

BACE1 levels correlate with phospho-tau levels in human cerebrospinal fluid.

Curr Alzheimer Res 2013 Sep;10(7):671-8

VIB Center for the Biology of Disease and Center for Human Genetics, KULeuven, Herestraat 49, 3000 Leuven, Belgium.

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September 2013

Glycogen synthase kinase-3beta affects size of dentate gyrus and species-typical behavioral tasks in transgenic and knockout mice.

Behav Brain Res 2013 Jul 6;248:46-50. Epub 2013 Apr 6.

Laboratory of Neurobiology, Nencki Institute, Polish Academy of Sciences, 3 Pasteur St., 02-093 Warsaw, Poland.

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http://dx.doi.org/10.1016/j.bbr.2013.03.045DOI Listing
July 2013

Glycogen synthase kinase-3β (GSK3β) expression in a mouse model of Alzheimer's disease: a light and electron microscopy study.

Synapse 2013 Jun 5;67(6):313-27. Epub 2013 Mar 5.

Department of Neurobiology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA.

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http://dx.doi.org/10.1002/syn.21642DOI Listing
June 2013

Structural and functional characterization of Nrf2 degradation by the glycogen synthase kinase 3/β-TrCP axis.

Mol Cell Biol 2012 Sep 2;32(17):3486-99. Epub 2012 Jul 2.

Departamento de Bioquímica e Instituto de Investigaciones Biomédicas Alberto Sols UAM-CSIC, Centro de Investigación en Red Sobre Enfermedades Neurodegenerativas, Madrid, Spain.

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http://dx.doi.org/10.1128/MCB.00180-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3422007PMC
September 2012

Protein tau: prime cause of synaptic and neuronal degeneration in Alzheimer's disease.

Int J Alzheimers Dis 2012 8;2012:251426. Epub 2012 Jun 8.

Experimental Genetics Group (LEGTEGG), Department of Human Genetics, KU Leuven, Campus Gasthuisberg ON1-06.602, Herestraat 49, 3000 Leuven, Belgium.

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http://dx.doi.org/10.1155/2012/251426DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3376502PMC
August 2012

Isoflurane anesthesia precipitates tauopathy and upper airways dysfunction in pre-symptomatic Tau.P301L mice: possible implication for neurodegenerative diseases.

Neurobiol Dis 2012 Apr 31;46(1):234-43. Epub 2012 Jan 31.

MP3-respiration team, Unité Mixte de Recherche 6231, Centre de Recherche en Neurobiologie et Neurophysiologie de Marseille, Faculté Saint Jérôme, service 362, 13397 Marseille, cedex 20, France.

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http://dx.doi.org/10.1016/j.nbd.2012.01.012DOI Listing
April 2012

Age-related impairment of ultrasonic vocalization in Tau.P301L mice: possible implication for progressive language disorders.

PLoS One 2011 12;6(10):e25770. Epub 2011 Oct 12.

Maturation, Plasticity, Physiology and Pathology of Respiration, Unité Mixte de Recherche 6231, Centre National de la Recherche Scientifique, Université de la Méditerranée, Université Paul Cézanne, Marseille, France.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0025770PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3192129PMC
February 2012

Role of presenilin 1 in structural plasticity of cortical dendritic spines in vivo.

J Neurochem 2011 Dec 24;119(5):1064-73. Epub 2011 Oct 24.

Center for Neuropathology and Prion Research, Laboratory of Experimental Neuropathology, Ludwig-Maximilian-University, Munich, Germany.

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http://dx.doi.org/10.1111/j.1471-4159.2011.07503.xDOI Listing
December 2011

GSK-3α/β kinases and amyloid production in vivo.

Nature 2011 Dec 7;480(7376):E4-5; discussion E6. Epub 2011 Dec 7.

Experimental Genetics Group, KU Leuven, Leuven, Belgium.

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http://www.nature.com/articles/nature10615
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http://dx.doi.org/10.1038/nature10615DOI Listing
December 2011

Early improved and late defective cognition is reflected by dendritic spines in Tau.P301L mice.

J Neurosci 2011 Dec;31(49):18036-47

Laboratory of Experimental Genetics and Transgenesis/Experimental Genetics Group, Department of Human Genetics, Katholieke Universiteit Leuven, Campus Gasthuisberg, B-3000 Leuven, Belgium.

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http://dx.doi.org/10.1523/JNEUROSCI.4859-11.2011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6634152PMC
December 2011

GSK3 and Alzheimer's Disease: Facts and Fiction….

Front Mol Neurosci 2011 26;4:17. Epub 2011 Aug 26.

Experimental Genetics Group - LEGTEGG, Department Human Genetics KULeuven, Leuven, Belgium.

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http://dx.doi.org/10.3389/fnmol.2011.00017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3162188PMC
November 2011

Dendritic degeneration, neurovascular defects, and inflammation precede neuronal loss in a mouse model for tau-mediated neurodegeneration.

Am J Pathol 2011 Oct 10;179(4):2001-15. Epub 2011 Aug 10.

Laboratory of Experimental Genetics and Transgenesis/Experimental Genetics Group (LEGTEGG), Department of Human Genetics, Katholieke Universiteit Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1016/j.ajpath.2011.06.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3181369PMC
October 2011

Raphé tauopathy alters serotonin metabolism and breathing activity in terminal Tau.P301L mice: possible implications for tauopathies and Alzheimer's disease.

Respir Physiol Neurobiol 2011 Sep 6;178(2):290-303. Epub 2011 Jul 6.

Maturation, Plasticity, Physiology and Pathology of Respiration (MP3-Respiration), Unité Mixte de Recherche 6231, Centre National de la Recherche Scientifique, Université de la Méditerranée, Université Paul Cézanne, Faculté Saint Jérôme (Service 362), 13397 Marseille Cedex 20, France.

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http://dx.doi.org/10.1016/j.resp.2011.06.030DOI Listing
September 2011

The capsaicin receptor TRPV1 is a crucial mediator of the noxious effects of mustard oil.

Curr Biol 2011 Feb;21(4):316-21

Laboratory for Ion Channel Research, Department of Molecular Cell Biology, KU Leuven, 3000 Leuven, Belgium.

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http://dx.doi.org/10.1016/j.cub.2011.01.031DOI Listing
February 2011

Potential amyloid plaque-specific peptides for the diagnosis of Alzheimer's disease.

Neurobiol Aging 2010 Oct 22;31(10):1679-89. Epub 2008 Nov 22.

Department of General, Organic and Biomedical Chemistry, NMR and Molecular Imaging Laboratory, University of Mons-Hainaut, 24 Avenue du Champ de Mars, B-7000 Mons, Belgium.

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http://dx.doi.org/10.1016/j.neurobiolaging.2008.09.021DOI Listing
October 2010

Alzheimer's disease: old problem, new views from transgenic and viral models.

Biochim Biophys Acta 2010 Oct 21;1802(10):808-18. Epub 2010 Mar 21.

Experimental Genetics Group, LEGTEGG, Dept. Human Genetics, KULeuven-Campus Gasthuisberg ON1-06.602, Herestraat 49, B-3000 Leuven, Belgium.

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http://dx.doi.org/10.1016/j.bbadis.2010.03.005DOI Listing
October 2010

Modeling of tau-mediated synaptic and neuronal degeneration in Alzheimer's disease.

Int J Alzheimers Dis 2010 Aug 24;2010. Epub 2010 Aug 24.

Experimental Genetics Group, Department of Human Genetics, KULeuven-Campus Gasthuisberg ON1-06.602, Herestraat 49, 3000 Leuven, Belgium.

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http://dx.doi.org/10.4061/2010/573138DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2938448PMC
August 2010

Absence of ApoE upregulates murine brain ApoD and ABCA1 levels, but does not affect brain sterol levels, while human ApoE3 and human ApoE4 upregulate brain cholesterol precursor levels.

J Alzheimers Dis 2009 ;18(2):319-29

Department of Molecular Cell Biology, Research Institute Brain and Behaviour (EURON), University of Maastricht, Maastricht, The Netherlands.

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http://dx.doi.org/10.3233/JAD-2009-1150DOI Listing
December 2009

Decreased expression of multidrug efflux transporters in the brains of GSK-3beta transgenic mice.

Brain Res 2009 Jun 22;1276:1-10. Epub 2009 Apr 22.

Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1PD, UK.

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http://dx.doi.org/10.1016/j.brainres.2009.04.031DOI Listing
June 2009

Phosphorylation, lipid raft interaction and traffic of alpha-synuclein in a yeast model for Parkinson.

Biochim Biophys Acta 2008 Oct 19;1783(10):1767-80. Epub 2008 Jun 19.

Laboratory of Functional Biology, Kasteelpark Arenberg 31, 3001 Heverlee, Belgium.

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http://dx.doi.org/10.1016/j.bbamcr.2008.06.010DOI Listing
October 2008

Protein folding diseases and neurodegeneration: lessons learned from yeast.

Biochim Biophys Acta 2008 Jul 11;1783(7):1381-95. Epub 2008 Feb 11.

Functional Biology, Katholieke Universiteit Leuven, Kasteelpark Arenberg 31, Leuven-Heverlee, Belgium.

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http://dx.doi.org/10.1016/j.bbamcr.2008.01.020DOI Listing
July 2008

Amyloid activates GSK-3beta to aggravate neuronal tauopathy in bigenic mice.

Am J Pathol 2008 Mar 7;172(3):786-98. Epub 2008 Feb 7.

Experimental Genetics Group, Department Human Genetics, Katholieke Universiteit Leuven-Campus Gasthuisberg ON1-06.602, B-3000 Leuven, Belgium.

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http://dx.doi.org/10.2353/ajpath.2008.070904DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2258274PMC
March 2008

Tau-4R suppresses proliferation and promotes neuronal differentiation in the hippocampus of tau knockin/knockout mice.

FASEB J 2007 Jul 6;21(9):2149-61. Epub 2007 Mar 6.

Experimental Genetics Group, Department Human Genetics, KULeuven-Campus Gasthuisberg ON1-06.602, B-3000 Leuven, Belgium.

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http://dx.doi.org/10.1096/fj.06-7735comDOI Listing
July 2007

Mutant presenilin 1 alters synaptic transmission in cultured hippocampal neurons.

J Biol Chem 2007 Jan 6;282(2):1119-27. Epub 2006 Nov 6.

Department of Neuropathology, Ludwig-Maximilians-Universität Munich, Feodor-Lynen-Strasse 23, 81377 München, Germany.

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http://dx.doi.org/10.1074/jbc.M605066200DOI Listing
January 2007

A yeast-based model of alpha-synucleinopathy identifies compounds with therapeutic potential.

Biochim Biophys Acta 2006 Mar 27;1762(3):312-8. Epub 2005 Dec 27.

N.V. reMYND, Minderbroedersstraat 12, B-3000 Leuven, Belgium.

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http://dx.doi.org/10.1016/j.bbadis.2005.11.009DOI Listing
March 2006

A ketogenic diet reduces amyloid beta 40 and 42 in a mouse model of Alzheimer's disease.

Nutr Metab (Lond) 2005 Oct 17;2:28. Epub 2005 Oct 17.

NV reMYND, Minderbroederstraat 12, 3000 Leuven, Belgium.

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http://dx.doi.org/10.1186/1743-7075-2-28DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1282589PMC
October 2005

Mice lacking Dfna5 show a diverging number of cochlear fourth row outer hair cells.

Neurobiol Dis 2005 Aug;19(3):386-99

Department of Medical Genetics, University of Antwerp, Campus Drie Eiken, Universiteitsplein 1, B-2610 Antwerp, Belgium.

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http://dx.doi.org/10.1016/j.nbd.2005.01.019DOI Listing
August 2005

Transgenic mouse models for APP processing and Alzheimer's disease: early and late defects.

Subcell Biochem 2005 ;38:45-63

Experimental Genetics Group, Department of Human Genetics, K U Leuven, B-3000 Leuven, Belgium.

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April 2005

Characterization of a murine alpha 2 macroglobulin gene expressed in reproductive and cardiovascular tissue.

Biol Reprod 2005 Feb 8;72(2):266-75. Epub 2004 Sep 8.

Department of Biomedical Sciences, University of Guelph, Guelph, Ontario, Canada.

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http://dx.doi.org/10.1095/biolreprod.104.029835DOI Listing
February 2005

Changed conformation of mutant Tau-P301L underlies the moribund tauopathy, absent in progressive, nonlethal axonopathy of Tau-4R/2N transgenic mice.

J Biol Chem 2005 Feb 27;280(5):3963-73. Epub 2004 Oct 27.

Experimental Genetics Group, Department of Human Genetics, KU Leuven, B-3000 Leuven, Belgium.

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http://dx.doi.org/10.1074/jbc.M409876200DOI Listing
February 2005

Astrocytic calcium/zinc binding protein S100A6 over expression in Alzheimer's disease and in PS1/APP transgenic mice models.

Biochim Biophys Acta 2004 Dec;1742(1-3):161-8

Laboratory of Histology, Neuroanatomy and Neuropathology, School of Medicine, Université Libre de Bruxelles, 808, route de Lennik, Bldg GE, 1070 Brussels, Belgium.

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http://dx.doi.org/10.1016/j.bbamcr.2004.09.011DOI Listing
December 2004

Capacitative calcium entry induces hippocampal long term potentiation in the absence of presenilin-1.

J Biol Chem 2003 Nov 5;278(45):44393-9. Epub 2003 Aug 5.

Laboratory of Neuroscience, University of Mons-Hainaut, B-7000 Mons, Belgium.

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http://dx.doi.org/10.1074/jbc.M300971200DOI Listing
November 2003

Neuropathobiology in transgenic mice. The case of Alzheimer's disease.

Methods Mol Biol 2003 ;209:333-61

Experimental Genetics Group, Center for Human Genetics, Flemish Institute for Biotechnology, Katholieke Universiteit Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1385/1-59259-340-2:333DOI Listing
June 2003

Influence of exonic polymorphisms in the gene for LDL receptor-related protein (LRP) on risk of coronary artery disease.

Atherosclerosis 2003 May;168(1):115-21

Department of Clinical Immunology and Biochemical Genetics, Royal Perth Hospital, GPO Box X2213, WA, Australia.

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http://dx.doi.org/10.1016/s0021-9150(03)00087-xDOI Listing
May 2003

Reduction of beta-amyloid plaques in brain of transgenic mouse model of Alzheimer's disease by EFRH-phage immunization.

Vaccine 2003 Mar;21(11-12):1060-5

Department of Molecular Microbiology & Biotechnology, The George S Wise Faculty of Life Sciences, Tel-Aviv University, Ramat Aviv, Tel-Aviv 69978, Israel.

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http://dx.doi.org/10.1016/s0264-410x(02)00609-6DOI Listing
March 2003

Evaluation of 18F-FA-4 and 11C-pipzA-4 as radioligands for the in vivo evaluation of the high-affinity choline uptake system.

J Nucl Med 2003 Feb;44(2):269-75

Laboratory of Radiopharmaceutical Chemistry, Faculteit Farmaceutische Wetenschappen, Katholieke Universiteit Leuven, Leuven, Belgium.

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February 2003

Axonal transport, tau protein, and neurodegeneration in Alzheimer's disease.

Neuromolecular Med 2002 ;2(2):151-65

Experimental Genetics Group, K.U.Leuven, Belgium.

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http://dx.doi.org/10.1385/NMM:2:2:151DOI Listing
January 2003

Capacitive calcium entry is directly attenuated by mutant presenilin-1, independent of the expression of the amyloid precursor protein.

J Biol Chem 2003 Jan 12;278(4):2484-9. Epub 2002 Nov 12.

Department of Neuropathology, Ludwig-Maximilians-Universität, 81377 Munich, Germany.

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http://dx.doi.org/10.1074/jbc.M206769200DOI Listing
January 2003

Secretases as targets for the treatment of Alzheimer's disease: the prospects.

Lancet Neurol 2002 Nov;1(7):409-16

Experimental Genetics Group, Department of Human Genetics, KU Leuven, B-3000 Leuven, Belgium.

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November 2002