Fraydoon Rastinejad

Fraydoon Rastinejad

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Fraydoon Rastinejad

Fraydoon Rastinejad

Publications by authors named "Fraydoon Rastinejad"

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Bidirectional modulation of HIF-2 activity through chemical ligands.

Nat Chem Biol 2019 04 25;15(4):367-376. Epub 2019 Feb 25.

Integrative Metabolism Program, Sanford Burnham Prebys Medical Discovery Institute, Orlando, FL, USA.

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http://dx.doi.org/10.1038/s41589-019-0234-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447045PMC
April 2019

The Nuclear Receptor PPARγ Controls Progressive Macrophage Polarization as a Ligand-Insensitive Epigenomic Ratchet of Transcriptional Memory.

Immunity 2018 10;49(4):615-626.e6

Sanford-Burnham-Prebys Medical Discovery Institute, Orlando, Florida, USA; Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary; MTA-DE "Lendulet" Immunogenomics Research Group, University of Debrecen, Debrecen, Hungary. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2018.09.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197058PMC
October 2018

The quaternary architecture of RARβ-RXRα heterodimer facilitates domain-domain signal transmission.

Nat Commun 2017 10 11;8(1):868. Epub 2017 Oct 11.

Integrative Metabolism Program, Sanford Burnham Prebys Medical Discovery Institute, Orlando, FL, 32827, USA.

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http://dx.doi.org/10.1038/s41467-017-00981-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5636793PMC
October 2017

Structural characterization of mammalian bHLH-PAS transcription factors.

Curr Opin Struct Biol 2017 04 6;43:1-9. Epub 2016 Oct 6.

Integrative Metabolism Program, Sanford Burnham Prebys Medical Discovery Institute, Orlando, FL 32827, USA. Electronic address:

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http://dx.doi.org/10.1016/j.sbi.2016.09.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5382129PMC
April 2017

Visualizing the Architectures and Interactions of Nuclear Receptors.

Endocrinology 2016 Nov 5;157(11):4212-4221. Epub 2016 Oct 5.

Integrative Metabolism Program, SBP Medical Discovery Institute, Orlando, Florida 32827.

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http://dx.doi.org/10.1210/en.2016-1559DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6285253PMC
November 2016

NPAS1-ARNT and NPAS3-ARNT crystal structures implicate the bHLH-PAS family as multi-ligand binding transcription factors.

Elife 2016 10 26;5. Epub 2016 Oct 26.

Integrative Metabolism Program, Sanford Burnham Prebys Medical Discovery Institute, Orlando, United States.

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http://dx.doi.org/10.7554/eLife.18790DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5111884PMC
October 2016

Structural integration in hypoxia-inducible factors.

Nature 2015 Aug 5;524(7565):303-8. Epub 2015 Aug 5.

Metabolic Disease Program, Sanford Burnham Prebys Medical Discovery Institute, Orlando, Florida 32827, USA.

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http://www.nature.com/articles/nature14883
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http://dx.doi.org/10.1038/nature14883DOI Listing
August 2015

Response to Moras et al.

Trends Biochem Sci 2015 Jun 15;40(6):290-2. Epub 2015 Apr 15.

Instituto de Física de São Carlos (IFSC), Universidade de São Paulo (USP), Avenida Trabalhador São-Carlense 400, São Carlos, SP, 13560-970 Brazil.

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http://dx.doi.org/10.1016/j.tibs.2015.03.008DOI Listing
June 2015

Identification of natural RORγ ligands that regulate the development of lymphoid cells.

Cell Metab 2015 Feb;21(2):286-298

The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, NY 10016, USA; Howard Hughes Medical Institute, New York University School of Medicine, New York, NY 10016, USA.

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http://dx.doi.org/10.1016/j.cmet.2015.01.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4317570PMC
February 2015

Nuclear receptor full-length architectures: confronting myth and illusion with high resolution.

Trends Biochem Sci 2015 Jan 28;40(1):16-24. Epub 2014 Nov 28.

Instituto de Física de São Carlos, Universidade de São Paulo, Av. Trabalhador São-Carlense, 400, São Carlos, SP, 13560-970, Brazil.

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http://dx.doi.org/10.1016/j.tibs.2014.10.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4274238PMC
January 2015

Retinoic acid actions through mammalian nuclear receptors.

Chem Rev 2014 Jan 5;114(1):233-54. Epub 2013 Dec 5.

Metabolic Signaling and Disease Program, Sanford-Burnham Medical Research Institute , Orlando, Florida 32827, United States.

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http://dx.doi.org/10.1021/cr400161bDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3931982PMC
January 2014

Understanding nuclear receptor form and function using structural biology.

J Mol Endocrinol 2013 Dec 7;51(3):T1-T21. Epub 2013 Nov 7.

Metabolic Signaling and Disease Program, Sanford-Burnham Medical Research Institute, Orlando, Florida 32827, USA.

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http://dx.doi.org/10.1530/JME-13-0173DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3871882PMC
December 2013

Structure and dimerization properties of the aryl hydrocarbon receptor PAS-A domain.

Mol Cell Biol 2013 Nov 3;33(21):4346-56. Epub 2013 Sep 3.

Metabolic Signaling and Disease Program, Sanford-Burnham Medical Research Institute, Orlando, Florida, USA.

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http://dx.doi.org/10.1128/MCB.00698-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3811902PMC
November 2013

Multidomain integration in the structure of the HNF-4α nuclear receptor complex.

Nature 2013 Mar 13;495(7441):394-8. Epub 2013 Mar 13.

Metabolic Signaling and Disease Program, Sanford-Burnham Medical Research Institute, Orlando, Florida 32827, USA.

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http://dx.doi.org/10.1038/nature11966DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3606643PMC
March 2013

Identification of Potent and Selective Diphenylpropanamide RORγ Inhibitors.

ACS Med Chem Lett 2013 Jan;4(1):79-84

Molecular Pathogenesis Program, The Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, NY 10016, USA.

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http://dx.doi.org/10.1021/ml300286hDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3770298PMC
January 2013

Corecognition of DNA and a methylated histone tail by the MSL3 chromodomain.

Nat Struct Mol Biol 2010 Aug 25;17(8):1027-9. Epub 2010 Jul 25.

Department of Biochemistry and Molecular Genetics, University of Virginia Health System, Charlottesville, Virginia, USA.

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http://dx.doi.org/10.1038/nsmb.1856DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2924628PMC
August 2010

Structural overview of the nuclear receptor superfamily: insights into physiology and therapeutics.

Annu Rev Physiol 2010 ;72:247-72

Department of Pharmacology, and Center for Molecular Design, University of Virginia Health System, Charlottesville, VA 22908, USA.

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http://dx.doi.org/10.1146/annurev-physiol-021909-135917DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3677810PMC
May 2010

Structure of the intact PPAR-gamma-RXR- nuclear receptor complex on DNA.

Nature 2008 Nov;456(7220):350-6

Department of Pharmacology, and Center for Molecular Design, University of Virginia Health System, 1300 Jefferson Park Avenue, Charlottesville, Virginia 22908-0735, USA.

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http://www.nature.com/articles/nature07413
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http://dx.doi.org/10.1038/nature07413DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2743566PMC
November 2008

Identification of heme as the ligand for the orphan nuclear receptors REV-ERBalpha and REV-ERBbeta.

Nat Struct Mol Biol 2007 Dec 25;14(12):1207-13. Epub 2007 Nov 25.

Department of Pharmacology and Center for Molecular Design, University of Virginia Health System, 1300 Jefferson Park Avenue, Charlottesville, Virginia 22908-0733, USA.

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http://dx.doi.org/10.1038/nsmb1344DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2743565PMC
December 2007

Molecular implications of evolutionary differences in CHD double chromodomains.

J Mol Biol 2007 Jun 19;369(2):334-42. Epub 2007 Mar 19.

Department of Biochemistry and Molecular Genetics, University of Virginia Health System, Charlottesville, VA 22908, USA.

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http://dx.doi.org/10.1016/j.jmb.2007.03.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1948097PMC
June 2007

The molecular basis for T-type Ca2+ channel inhibition by G protein beta2gamma2 subunits.

Proc Natl Acad Sci U S A 2006 Sep 14;103(39):14590-5. Epub 2006 Sep 14.

Department of Pharmacology, University of Virginia, 1300 Jefferson Park Avenue, Charlottesville, VA 22908, USA.

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http://dx.doi.org/10.1073/pnas.0603945103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1600004PMC
September 2006

Double chromodomains cooperate to recognize the methylated histone H3 tail.

Nature 2005 Dec;438(7071):1181-5

Department of Biochemistry and Molecular Genetics, University of Virginia Health System, Charlottesville, Virginia 22908, USA.

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http://dx.doi.org/10.1038/nature04290DOI Listing
December 2005

Crystal structure analysis of phosphatidylcholine-GM2-activator product complexes: evidence for hydrolase activity.

Biochemistry 2005 Oct;44(41):13510-21

Department of Pharmacology, X-ray Crystallography Laboratory, University of Virginia, Charlottesville, Virginia 22908-0735, USA.

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http://dx.doi.org/10.1021/bi050668wDOI Listing
October 2005

Plasticity of the ecdysone receptor DNA binding domain.

Mol Endocrinol 2004 Sep 10;18(9):2166-84. Epub 2004 Jun 10.

Institute of Organic Chemistry, Biochemistry and Biotechnology, Division of Biochemistry, Wrocław University of Technology, 50-370 Wrocław, Poland.

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http://dx.doi.org/10.1210/me.2004-0154DOI Listing
September 2004

Evidence for lipid packaging in the crystal structure of the GM2-activator complex with platelet activating factor.

J Mol Biol 2004 Sep;342(2):585-92

Department of Pharmacology, X-ray Crystallography Laboratory, University of Virginia, Charlottesville, VA 22908-0735, USA.

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http://dx.doi.org/10.1016/j.jmb.2004.07.063DOI Listing
September 2004

The emerging structural understanding of transglutaminase 3.

J Struct Biol 2004 Aug;147(2):200-7

X-ray Crystallography Facility, Office of Science and Technology, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892-8023, USA.

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http://dx.doi.org/10.1016/j.jsb.2004.03.009DOI Listing
August 2004

Structural basis for the coordinated regulation of transglutaminase 3 by guanine nucleotides and calcium/magnesium.

J Biol Chem 2004 Feb 28;279(8):7180-92. Epub 2003 Nov 28.

X-ray Crystallography Facility/Office of Science and Technology, NIAMS, National Institutes of Health, Bethesda, Maryland 20892-8023, USA.

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http://dx.doi.org/10.1074/jbc.M312310200DOI Listing
February 2004

Insights into catalysis by a knotted TrmD tRNA methyltransferase.

J Mol Biol 2003 Nov;333(5):931-49

GlaxoSmithKline, 709 Swedeland Road, UE0447, King of Prussia, PA 19406, USA.

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http://dx.doi.org/10.1016/j.jmb.2003.09.011DOI Listing
November 2003

Structure of the heterodimeric ecdysone receptor DNA-binding complex.

EMBO J 2003 Nov;22(21):5827-40

Department of Pharmacology, University of Virginia Health System, Charlottesville, VA 22908, USA.

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http://dx.doi.org/10.1093/emboj/cdg569DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC275426PMC
November 2003

Structural analysis of lipid complexes of GM2-activator protein.

J Mol Biol 2003 Aug;331(4):951-64

Department of Pharmacology, X-ray Laboratory and University of Virginia Health System, PO Box 800735, Charlottesville, VA 22908-0735, USA.

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http://dx.doi.org/10.1016/s0022-2836(03)00794-0DOI Listing
August 2003

Structural basis for bile acid binding and activation of the nuclear receptor FXR.

Mol Cell 2003 Apr;11(4):1093-100

Department of Pharmacology, University of Virginia Health System, Charlottesville 22908, USA.

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April 2003

The active site of the SET domain is constructed on a knot.

Nat Struct Biol 2002 Nov;9(11):833-8

Department of Biochemistry and Molecular Genetics, University of Virginia Health System, Charlottesville, Virginia 22908, USA.

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http://dx.doi.org/10.1038/nsb861DOI Listing
November 2002

Ca2+-dependent nuclear export mediated by calreticulin.

Mol Cell Biol 2002 Sep;22(17):6286-97

Center for Cell Signaling. Departments of Microbiology. Biochemistry and Molecular Genetics. Pharmacology, University of Virginia, Charlottesville, Virginia 22908, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC133999PMC
http://dx.doi.org/10.1128/mcb.22.17.6286-6297.2002DOI Listing
September 2002