Publications by authors named "Frauke Zipp"

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Monitoring B-cell repopulation after depletion therapy in neurologic patients.
Neurol Neuroimmunol Neuroinflamm 2018 Jul 25;5(4):e463. Epub 2018 Apr 25.
Focus Program Translational Neurosciences (FTN) and Immunology (FZI) (E.E., S.B., F.Z.), Rhine Main Neuroscience Network (rmn), Department of Neurology, University Medical Center of the Johannes Gutenberg University Mainz; and Institute of Sociology and Social Psychology (L.E.), University of Cologne, Germany.

Treatment choices and neuropsychological symptoms of a large cohort of early MS.
Neurol Neuroimmunol Neuroinflamm 2018 May 1;5(3):e446. Epub 2018 Mar 1.
Department of Neurology (O.v.B., B.A., R.G., A.S.), St. Josef-Hospital, Ruhr-University Bochum; Institute of Medical Biometry and Statistics (T.D., N.H., A.Z.), University of Lübeck, University Hospital Schleswig-Holstein, Campus Lübeck; Central Information Office (CIO) (G.A.), Philipps-University Marburg, Germany; School of Mathematics (A.Z.), Statistics and Computer Science, University of KwaZulu-Natal, Pietermaritzburg, South Africa; Department of Neurology (M.-M.H., L.A., B.H.), Klinikum rechts der Isar, Technical University of Munich; Munich Cluster for Systems Neurology (SyNergy) (L.A., B.H.); Department of Neurology (F.L., S.G., F.Z.), University Medicine Mainz, Johannes Gutenberg University Mainz; Department of Neurology (L.K., S.G.M., H.W.), University Hospital Münster; Department of Neurology (B.T.), Philipps-University Marburg; Department of Neurology (M.Stoppe, F.T.B.), University of Leipzig; Department of Neurology (H.T.), University of Ulm; Clinic of Neurology Dietenbronn (H.T.), Schwendi; Institute of Clinical Neuroimmunology (T.K.), Ludwig Maximilian University of Munich; Department of Neurology (M.Stangel), Hannover Medical School; Institut für Neuroimmunologie und Multiple Sklerose (C.H.), Universitätsklinikum Hamburg-Eppendorf; Department of Neurology (B.W.), University of Heidelberg; NeuroCure Clinical Research Center and Experimental and Clinical Research Center (F.P.), Charité-University Medicine Berlin and Max Delbrueck Center for Molecular Medicine; Department of Neurology (A.B.), Klinikum Augsburg; Department of Neurology (C.W.), Heinrich-Heine-University, Düsseldorf; Department of Neurology (C.W.), University Hospital Köln; Neurology (F.W.), Max-Planck-Institute of Psychiatry, Munich; Neurological Clinic (F.W.), MATERNUS Kliniken AG, Bad Oeynhausen; Department of Neurology (R.A.L.), University Hospital Erlangen; Department of Neurology & Stroke (U.Z.), Hertie Institute for Clinical Brain Research, Eberhard-Karls-University Tübingen; Department of Neurology (U.K.Z.), University of Rostock, Germany; and Department of Neurology (A.S.), Inselspital Bern, University Hospital and University of Bern, Switzerland.

Treatment response to dimethyl fumarate is characterized by disproportionate CD8+ T cell reduction in MS.
Mult Scler 2018 Apr 24;24(5):632-641. Epub 2017 Apr 24.
Department of Neurology, Focus Program Translational Neuroscience (FTN), and Immunology (FZI), Rhine-Main Neuroscience Network (rmn2), University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.

CCR7 on CD4 T Cells Plays a Crucial Role in the Induction of Experimental Autoimmune Encephalomyelitis.
J Immunol 2018 Apr 16;200(8):2554-2562. Epub 2018 Mar 16.
Department of Neurology, Focus Program Translational Neuroscience and Immunotherapy, Rhine Main Neuroscience Network, University Medical Center of the Johannes Gutenberg University Mainz, 55131 Mainz, Germany.

Diagnosis of multiple sclerosis: a multicentre study to compare revised McDonald-2010 and Filippi-2010 criteria.
J Neurol Neurosurg Psychiatry 2018 Mar 19;89(3):316-318. Epub 2017 Jul 19.
Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy.

Preservation of neuronal function as measured by clinical and MRI endpoints in relapsing-remitting multiple sclerosis: how effective are current treatment strategies?
Expert Rev Neurother 2018 Mar 15;18(3):203-219. Epub 2018 Feb 15.
a Department of Neurology, Focus Program Translational Neuroscience (FTN), Rhine Main Neuroscience Network (rmn2) , University Medical Center of the Johannes Gutenberg University Mainz , Mainz , Germany.


Serum neurofilament light chain is a biomarker of acute and chronic neuronal damage in early multiple sclerosis.
Mult Scler 2018 Mar 1:1352458518765666. Epub 2018 Mar 1.
Department of Neurology and Focus Program Translational Neuroscience (FTN), Research Center for Immunotherapy (FZI), Rhine-Main Neuroscience Network (rmn2), University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.

ECTRIMS/EAN Guideline on the pharmacological treatment of people with multiple sclerosis.
Mult Scler 2018 Feb 20;24(2):96-120. Epub 2018 Jan 20.
Department of Neurology, Focus Program Translational Neuroscience (FTN) and Immunology (FZI), Rhine-Main Neuroscience Network (rmn2), University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.

EGFL7 reduces CNS inflammation in mouse.
Nat Commun 2018 Feb 26;9(1):819. Epub 2018 Feb 26.
Department of Neurology, Focus Program Translational Neuroscience (FTN), Research Center Immunotherapy (FZI), Rhine Main Neuroscience Network (rmn2), University Medical Center of the Johannes Gutenberg University Mainz, Langenbeckstr. 1, 55131, Mainz, Germany.

Fast direct neuronal signaling via the IL-4 receptor as therapeutic target in neuroinflammation.
Sci Transl Med 2018 Feb;10(430)
Department of Neurology, Focus Program Translational Neuroscience (FTN) and Research Center for Immunotherapy (FZI), Rhine-Main Neuroscience Network (rmn), University Medical Center of the Johannes Gutenberg University Mainz, 55131 Mainz, Germany.

Increased cerebrospinal fluid albumin and immunoglobulin A fractions forecast cortical atrophy and longitudinal functional deterioration in relapsing-remitting multiple sclerosis.
Mult Scler 2017 Dec 1:1352458517748474. Epub 2017 Dec 1.
Department of Neurology, Focus Program Translational Neuroscience (FTN), Research Center for Immunology (FZI), Rhine-Main Neuroscience Network (rmn2), University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.

Graph Theoretical Framework of Brain Networks in Multiple Sclerosis: A Review of Concepts.
Neuroscience 2017 Nov 1. Epub 2017 Nov 1.
Department of Neurology and Neuroimaging Center (NIC) of the Focus Program Translational Neuroscience (FTN), University Medical Center of the Johannes Gutenberg University Mainz, Germany. Electronic address:

The Role of ERK Signaling in Experimental Autoimmune Encephalomyelitis.
Int J Mol Sci 2017 Sep 15;18(9). Epub 2017 Sep 15.
Department of Neurology, Focus Program Translational Neuroscience (FTN) and Immunotherapy (FZI), Rhine Main Neuroscience Network (rmn2), University Medical Center of the Johannes Gutenberg University Mainz, Langenbeckstr. 1, 55131 Mainz, Germany.

Phenotype of Antigen Unexperienced T Cells in the Inflamed Central Nervous System in Experimental Autoimmune Encephalomyelitis.
J Neuroimmune Pharmacol 2017 Jun 10;12(2):305-313. Epub 2016 Nov 10.
Department of Neurology, Focus Program Translational Neuroscience (FTN) and Immunotherapy (FZI), Rhine-Main Neuroscience Network (rmn2), University Medical Center of the Johannes Gutenberg University, Langenbeckstrasse 1, Building 708, 55131, Mainz, Germany.

Dimethyl fumarate-induced lymphopenia in MS due to differential T-cell subset apoptosis.
Neurol Neuroimmunol Neuroinflamm 2017 May 23;4(3):e340. Epub 2017 Mar 23.
Montreal Neurological Institute (M.G., A.R., R.L., P.S.G., J.A., A.B.-O.), McGill University, Montreal, QC, Canada; Brain and Mind Centre (M.G.), University of Sydney, NSW, Australia; Institute of Actuaries of Australia (A.E.); Department of Neurology (F.L., F.Z.), University Medical Center Mainz, Germany; and Department of Neurology (A.R., R.L., A.B.-O.), Perelman School of Medicine, University of Pennsylvania, Philadelphia.

Role of IL-17-producing lymphocytes in severity of multiple sclerosis upon natalizumab treatment.
Mult Scler 2017 Apr 21;23(4):567-576. Epub 2016 Jul 21.
Focus Program Translational Neurosciences (FTN), Rhine-Main Neuroscience Network (rmn2), Department of Neurology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.

Increased structural white and grey matter network connectivity compensates for functional decline in early multiple sclerosis.
Mult Scler 2017 Mar 11;23(3):432-441. Epub 2016 Jul 11.
Department of Neurology and Neuroimaging Center (NIC), Focus Program Translational Neuroscience (FTN), Rhine-Main Neuroscience Network (rmn2), University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.

Dendritic cells tip the balance towards induction of regulatory T cells upon priming in experimental autoimmune encephalomyelitis.
J Autoimmun 2017 Jan 2;76:108-114. Epub 2016 Oct 2.
Department of Neurology, Focus Program Translational Neuroscience (FTN) and Immunotherapy (FZI), Rhine-Main Neuroscience Network (rmn(2)), University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany. Electronic address:

No role of IFITM3 in brain tumor formation in vivo.
Oncotarget 2016 Dec;7(52):86388-86405
Molecular Signal Transduction Laboratories, Institute for Microscopic Anatomy and Neurobiology, Focus Program Translational Neuroscience (FTN), Rhine Main Neuroscience Network (rmn2), Johannes Gutenberg University, School of Medicine, Mainz, Germany.

Metabolic Patterns in Chronic Multiple Sclerosis Lesions and Normal-appearing White Matter: Intraindividual Comparison by Using 2D MR Spectroscopic Imaging.
Radiology 2016 Nov 30;281(2):536-543. Epub 2016 May 30.
From the Department of Neurology and Neuroimaging Center of Focus Program Translational Neuroscience, University Medical Center of the Johannes Gutenberg-University Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany (V.F., S.G., F.Z., A.G.); and Department of Diagnostic and Interventional Neuroradiology, Magnetic Resonance Research Group, University Hospital Tübingen, Tübingen, Germany (R.K., U.K.).

Down-regulation of neuronal L1 cell adhesion molecule expression alleviates inflammatory neuronal injury.
Acta Neuropathol 2016 Nov 20;132(5):703-720. Epub 2016 Aug 20.
Department of Anesthesiology, University Medical Center of the Johannes-Gutenberg-University Mainz, Mainz, Germany.

Past, present and future of immunology in Mainz.
Cell Immunol 2016 Oct;308:1-6
Research Center for Immunotherapy (FZI), University Medical Center of the Johannes Gutenberg University, Mainz, Germany; Institute for Immunology, University Medical Center of the Johannes Gutenberg University, Mainz, Germany.



Flow cytometric analysis of T cell/monocyte ratio in clinically isolated syndrome identifies patients at risk of rapid disease progression.
Mult Scler 2016 Apr 10;22(4):483-93. Epub 2015 Jul 10.
Neurology Department, Johannes Gutenberg University Mainz, Germany/Charité - Universitätsmedizin Berlin, Germany

In vivo and in vitro effects of multiple sclerosis immunomodulatory therapeutics on glutamatergic excitotoxicity.
J Neurochem 2016 Mar 11;136(5):971-80. Epub 2016 Jan 11.
Department of Neurology, Focus Program Translational Neuroscience (FTN), Rhine Main Neuroscience Network (rmn²), University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.

Microglia-blood vessel interactions: a double-edged sword in brain pathologies.
Acta Neuropathol 2016 Mar 28;131(3):347-63. Epub 2015 Dec 28.
Molecular Signal Transduction Laboratories, Institute for Microscopic Anatomy and Neurobiology, Focus Program Translational Neuroscience (FTN), Rhine Main Neuroscience Network (rmn²), University Medical Center of the Johannes Gutenberg University, Langenbeckstr. 1, 55131, Mainz, Germany.

Structural correlates for fatigue in early relapsing remitting multiple sclerosis.
Eur Radiol 2016 Feb 31;26(2):515-23. Epub 2015 May 31.
Department of Neurology and Neuroimaging Center (NIC) of Focus Program Translational Neuroscience (FTN), University Medical Center of the Johannes Gutenberg-University Mainz, Langenbeckstraße 1, 55131, Mainz, Germany.

Evidence for early, non-lesional cerebellar damage in patients with multiple sclerosis: DTI measures correlate with disability, atrophy, and disease duration.
Mult Scler 2016 Jan 28;22(1):73-84. Epub 2015 Apr 28.
Department of Neurology, Westfälische Wilhelms University, Albert-Schweitzer-Campus 1, Gebäude A1, Münster, 48149, Germany.

Gatekeeper role of brain antigen-presenting CD11c+ cells in neuroinflammation.
EMBO J 2016 Jan 26;35(1):89-101. Epub 2015 Nov 26.
Department of Neurology, Focus Program Translational Neurosciences (FTN), Research Center for Immunotherapy (FZI), Rhine-Main Neuroscience Network (rmn²) University Medical Center of the Johannes Gutenberg University, Mainz, Germany


Genome-wide significant association with seven novel multiple sclerosis risk loci.
J Med Genet 2015 Dec 16;52(12):848-55. Epub 2015 Oct 16.
Platform for Genome Analytics, Institutes of Neurogenetics & Integrative and Experimental Genomics, University of Lübeck, Lübeck, Germany Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin, Germany Department of Medicine, School of Public Health, Imperial College London, London, UK.


Putaminal alteration in multiple sclerosis patients with spinal cord lesions.
J Neural Transm (Vienna) 2015 Oct 14;122(10):1465-73. Epub 2015 May 14.
Department of Neurology and Neuroimaging Center (NIC) of the Focus Program Translational Neuroscience (FTN), University Medical Center of the Johannes Gutenberg-University Mainz, Langenbeckstraße 1, 55131, Mainz, Germany.


Genetic Cell Ablation Reveals Clusters of Local Self-Renewing Microglia in the Mammalian Central Nervous System.
Immunity 2015 Jul 7;43(1):92-106. Epub 2015 Jul 7.
Institute for Molecular Medicine, University Medical Center of the Johannes Gutenberg-University Mainz, Obere Zahlbacher Str. 67, 55131 Mainz, Germany. Electronic address:

Identification of cortical lesions using DIR and FLAIR in early stages of multiple sclerosis.
J Neurol 2015 Jun 11;262(6):1473-82. Epub 2015 Apr 11.
Department of Neurology, Neuroimaging Center (NIC) of the Focus Program Translational Neuroscience (FTN), University Medical Center of the Johannes Gutenberg-University Mainz, Langenbeckstraße 1, 55131, Mainz, Germany.


New candidates for CD4 T cell pathogenicity in experimental neuroinflammation and multiple sclerosis.
Brain 2015 Apr 9;138(Pt 4):902-17. Epub 2015 Feb 9.
1 Department of Neurology, Focus Program Translational Neuroscience (FTN) and Immunotherapy (FZI), Rhine-Main Neuroscience Network (rmn), University Medical Centre of the Johannes Gutenberg University Mainz, Langenbeckstr. 1, 55131 Mainz, Germany


Cross-recognition of a myelin peptide by CD8+ T cells in the CNS is not sufficient to promote neuronal damage.
J Neurosci 2015 Mar;35(12):4837-50
Department of Neurology, Research Center Translational Neurosciences, Rhine Main Neuroscience Network (rmn), and Molecular Neurology Group, Max Delbrueck Center for Molecular Medicine Berlin-Buch, 13125 Berlin, Germany, Charité University Medicine Berlin, ECRC, 13125 Berlin, Germany, and

Perivascular microglia promote blood vessel disintegration in the ischemic penumbra.
Acta Neuropathol 2015 Feb 13;129(2):279-95. Epub 2014 Dec 13.
Department of Neurology, Focus Program Translational Neuroscience (FTN), Rhine Main Neuroscience Network (rmn2), Johannes Gutenberg University, University Medical Center, Mainz, Germany.



IL-17 and related cytokines involved in the pathology and immunotherapy of multiple sclerosis: Current and future developments.
Cytokine Growth Factor Rev 2014 Aug 29;25(4):403-13. Epub 2014 Jul 29.
Department of Neurology, Focus Program Translational Neuroscience (FTN), Rhine Main Neuroscience Network (rmn(2)), University Medical Center of the Johannes Gutenberg University, Mainz, Germany.


Cladribine exerts an immunomodulatory effect on human and murine dendritic cells.
Int Immunopharmacol 2014 Feb 5;18(2):347-57. Epub 2013 Dec 5.
Department of Neurology, Focus Program Translational Neuroscience (FTN), Rhine Main Neuroscience Network (rmn(2)), University Medical Center of the Johannes Gutenberg-University of Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany.

Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis.
Nat Genet 2013 Nov 29;45(11):1353-60. Epub 2013 Sep 29.
1] John P. Hussman Institute for Human Genomics, University of Miami, Miller School of Medicine, Miami, Florida, USA. [2].

The role of CD8+ T cells and their local interaction with CD4+ T cells in myelin oligodendrocyte glycoprotein35-55-induced experimental autoimmune encephalomyelitis.
J Immunol 2013 Nov 11;191(10):4960-8. Epub 2013 Oct 11.
Department of Neurology, Focus Program Translational Neurosciences, Rhine Main Neuroscience Network, Johannes Gutenberg University Mainz, 55131 Mainz, Germany;


Modulation of dendritic cell properties by laquinimod as a mechanism for modulating multiple sclerosis.
Brain 2013 Apr 20;136(Pt 4):1048-66. Epub 2013 Mar 20.
Focus Program Translational Neuroscience, Rhine Main Neuroscience Network, University Medical Centre of the Johannes Gutenberg-University of Mainz, 55131 Mainz, Germany.




The impact of isolated lesions on white-matter fiber tracts in multiple sclerosis patients.
Neuroimage Clin 2015 10;8:110-6. Epub 2015 Apr 10.
Department of Neurology, University Medical Center of the Johannes Gutenberg University, Mainz, Germany ; Neuroimage Center (NIC) of the Focus Program Translational Neuroscience (FTN), Johannes Gutenberg University, Mainz, Germany.




Novel multiple sclerosis susceptibility loci implicated in epigenetic regulation.
Sci Adv 2016 06 17;2(6):e1501678. Epub 2016 Jun 17.
Max Planck Institute of Psychiatry, 80804 Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), 81377 Munich, Germany.; Institute of Translational Medicine, University of Liverpool, Liverpool L69 3BX, UK.

Increase of Alternatively Activated Antigen Presenting Cells in Active Experimental Autoimmune Encephalomyelitis.
J Neuroimmune Pharmacol 2016 12 16;11(4):721-732. Epub 2016 Jul 16.
Department of Neurology, Focus Program Translational Neuroscience (FTN), Research Center for Immunotherapy (FZI), Rhine Main Neuroscience Network (rmn2), University Medical Center of the Johannes Gutenberg-University of Mainz, Langenbeckstrasse 1, Building 708, 55131, Mainz, Germany.




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