Publications by authors named "Frauke Zipp"

100Publications

High anti-JCPyV serum titers coincide with high CSF cell counts in RRMS patients.

Mult Scler 2020 Nov 5:1352458520970103. Epub 2020 Nov 5.

Department of Neurology with Institute of Translational Neurology, University of Münster, Münster, Germany.

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http://dx.doi.org/10.1177/1352458520970103DOI Listing
November 2020

Supplementary medication in multiple sclerosis: Real-world experience and potential interference with neurofilament light chain measurement.

Mult Scler J Exp Transl Clin 2020 Jul-Sep;6(3):2055217320936318. Epub 2020 Aug 27.

Department of Neurology, Focus Program Translational Neuroscience (FTN), and Immunotherapy (FZI), University Medical Center of the Johannes Gutenberg University, Germany.

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http://dx.doi.org/10.1177/2055217320936318DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7457677PMC
August 2020

Genetic determinants of the humoral immune response in MS.

Neurol Neuroimmunol Neuroinflamm 2020 09 16;7(5). Epub 2020 Jul 16.

From the Department of Neurology (C.G., T.F.M.A., A. Keating, B.K., A. Klein, V.P., A. Berthele, B.H.), Klinikum rechts der Isar, School of Medicine, Technical University of Munich; Institute of Human Genetics (P.L.), Helmholtz Zentrum München, Neuherberg; Department of Neurology (R.G.), St. Josef Hospital, Ruhr-University Bochum; Department of Neurology, Focus Program Translational Neurosciences (FTN) and Research Center for Immunotherapy (FZI), Rhine-Main Neuroscience Network (rmn2) (F.Z.), University Medical Center of the Johannes Gutenberg University Mainz; Department of Neurology and Translational Center for Regenerative Medicine (F.T.B.), University of Leipzig; Clinical Neuroimmunology and Neurochemistry (M.S.), Department of Neurology, Hannover Medical School, Hannover; Department of Neurology (H.T.), University of Ulm; Clinic of Neurology Dietenbronn (H.T.), Schwendi; Department of Neurology (B.W.), University Hospital Heidelberg; Department of Neurology (H.W.), University of Münster; Department of Neurology (A. Bayas), University Hospital Augsburg; Institute of Clinical Neuroimmunology (T.K.), University Hospital and Biomedical Center, Ludwig-Maximilians University Munich; Department of Neurology (U.K.Z.), Neuroimmunological Section, University of Rostock; Department of Neurology (R.A.L.), University Hospital Erlangen; Department of Neurology (R.A.L.), University of Regensburg; Department of Neurology & Stroke and Hertie-Institute for Clinical Brain Research (U.Z.), Eberhard-Karls-Universität Tübingen; Max Planck Institute of Psychiatry (M.K.), Munich; Department of Neurology (C.W.), Medical Faculty, Heinrich Heine University, Düsseldorf; Department of Neurology (C.W.), University Hospital Cologne; Institute of Neuroimmunology and Multiple Sclerosis (M.A.F), University Medical Centre Hamburg-Eppendorf, Hamburg; NeuroCure Clinical Research Center (F.P.), Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin; Berlin Institute of Health and Experimental and Clinical Research Center (F.P.), Max Delbrück Center for Molecular Medicine and Charité-Universitätsmedizin Berlin; and Center of Neuroimmunology (B.T.), Philipps-University Marburg; and Munich Cluster for Systems Neurology (SyNergy) (B.H.), Germany.

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http://dx.doi.org/10.1212/NXI.0000000000000827DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7371373PMC
September 2020

Neuropsychological Symptoms After Anterior Cerebral Artery Ischemic Stroke.

Can J Neurol Sci 2020 Jul 10:1-3. Epub 2020 Jul 10.

Department of Neurology and Neuroimaging Center (NIC) of the Focus Program Translational Neuroscience (FTN), University Medical Center of the Johannes Gutenberg University Mainz,Mainz, Germany.

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http://dx.doi.org/10.1017/cjn.2020.142DOI Listing
July 2020

Is ε4 associated with cognitive performance in early MS?

Neurol Neuroimmunol Neuroinflamm 2020 07 1;7(4). Epub 2020 May 1.

From the Department of Neurology and Focus Program Translational Neuroscience (FTN) (S.E., C.G., M.M., S.B., S.G., F.Z., C.M.L., F.L.), Rhine Main Neuroscience Network (rmn2), University Medical Center of the Johannes Gutenberg University Mainz, Germany; Department of Neurology (A.S.), Inselspital, Bern University Hospital, University of Bern, Switzerland; Department of Neurology (A.S., B.A., R.G.), St. Josef-Hospital, Ruhr-University Bochum; Institute of Medical Biostatistics (G.T.), Epidemiology and Informatics (IMBEI), University Medical Center of the Johannes Gutenberg University Mainz; Department of Neurology (A. Bayas), Klinikum Augsburg; Department of Neurology (A. Berthele, B.H.), Klinikum rechts der Isar, Technical University of Munich; Institut für Neuroimmunologie und Multiple Sklerose (C.H.), Universitätsklinikum Hamburg-Eppendorf; Clinic of Neurology (L.K., S.G.M., H.W.), University Hospital Münster, Westphalian-Wilhelms-University Münster; Institute of Clinical Neuroimmunology (T.K.), Ludwig Maximilian University of Munich; Department of Neurology (R.A.L.), University Hospital Erlangen; NeuroCure Clinical Research Center and Experimental and Clinical Research Center (F.P.), Charité - Universitätsmedizin Berlin and Max Delbrueck Center for Molecular Medicine; Department of Neurology (M.S.), Hannover Medical School; Department of Neurology (B.T.), Philipps-University Marburg; Department of Neurology (F.T.B.), University of Leipzig; Department of Neurology (H.T.), University of Ulm; Clinic of Neurology Dietenbronn (H.T.), Schwendi; Neurology (F.W.), Max-Planck-Institute of Psychiatry, Munich; Neurological Clinic (F.W.), Sana Kliniken des Landkreises Cham; Department of Neurology (B.W.), University of Heidelberg; Department. of Neurology (U.K.Z.), University of Rostock; Central Information Office (CIO) (G.A.), Philipps-University Marburg; and Genetic and Molecular Epidemiology Group (C.M.L.), Lübeck Interdisciplinary Platform for Genome Analytics, Institutes of Neurogenetics and Cardiogenetics, University of Lübeck, Germany.

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http://dx.doi.org/10.1212/NXI.0000000000000728DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7217661PMC
July 2020

Ocrelizumab initiation in patients with MS: A multicenter observational study.

Neurol Neuroimmunol Neuroinflamm 2020 07 9;7(4). Epub 2020 Apr 9.

From the Focus Program Translational Neurosciences (FTN) and Immunology (FZI) (E.E., K.P., F.Z., S.B.), Rhine Main Neuroscience Network (rmn), Department of Neurology, University Medical Center of the Johannes Gutenberg University Mainz; Department of Neurology (L.R., T.R., H.W.), University of Muenster; Department of Neurology (J.K., M.S., C.W.), Faculty of Medicine and University Hospital Cologne, University of Cologne; and Department of Neurology (S.G.M.), Institute of Translational Neurology, University of Muenster, Germany.

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http://dx.doi.org/10.1212/NXI.0000000000000719DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7176249PMC
July 2020

CNS-localized myeloid cells capture living invading T cells during neuroinflammation.

J Exp Med 2020 Jun;217(6)

Department of Neurology, Focus Program Translational Neuroscience and Immunotherapy, Rhine Main Neuroscience Network, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.

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http://dx.doi.org/10.1084/jem.20190812DOI Listing
June 2020

Growth-Promoting Treatment Screening for Corticospinal Neurons in Mouse and Man.

Cell Mol Neurobiol 2020 Nov 14;40(8):1327-1338. Epub 2020 Mar 14.

Department of Neurology, Focus Program Translational Neuroscience (FTN) and Immunotherapy (FZI), Rhine Main Neuroscience Network (rmn2), University Medical Center of the Johannes Gutenberg University Mainz, 55131, Mainz, Germany.

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http://dx.doi.org/10.1007/s10571-020-00820-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7497511PMC
November 2020

MOG encephalomyelitis: distinct clinical, MRI and CSF features in patients with longitudinal extensive transverse myelitis as first clinical presentation.

J Neurol 2020 Jun 13;267(6):1632-1642. Epub 2020 Feb 13.

Department of Neurology, Focus Program Translational Neuroscience (FTN), Rhine Main Neuroscience Network (rmn2), University Medical Center of the Johannes Gutenberg-University of Mainz, Mainz, Germany.

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http://dx.doi.org/10.1007/s00415-020-09755-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7293681PMC
June 2020

Covarying patterns of white matter lesions and cortical atrophy predict progression in early MS.

Neurol Neuroimmunol Neuroinflamm 2020 05 5;7(3). Epub 2020 Feb 5.

From the Department of Neurology (M.M., V.F., J.K., D.C., A.R., N.K., G.G.-E., F.Z., S.G.), Focus Program Translational Neuroscience (FTN), Research Center for Immunotherapy (FZI), Rhine-Main Neuroscience Network (rmn), University Medical Center of the Johannes Gutenberg University Mainz; and Department of Neurology with Institute of Translational Neurology (H.W., S.G.M.), University of Munster, Germany.

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http://dx.doi.org/10.1212/NXI.0000000000000681DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7051213PMC
May 2020

Association of intrathecal pleocytosis and IgG synthesis with axonal damage in early MS.

Neurol Neuroimmunol Neuroinflamm 2020 05 4;7(3). Epub 2020 Feb 4.

From the Department of Neurology (S.E., F.S., T.U., F.Z., S.B., F.L.), Focus Program Translational Neuroscience (FTN), and Immunotherapy (FZI), Rhine-Main Neuroscience Network (rmn), University Medical Center of the Johannes Gutenberg University; and Institute of Medical Biostatistics (P.S.-K.), Epidemiology and Informatics, University Medical Center of the Johannes Gutenberg University, Mainz, Germany.

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http://dx.doi.org/10.1212/NXI.0000000000000679DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7051198PMC
May 2020

Continuous reorganization of cortical information flow in multiple sclerosis: A longitudinal fMRI effective connectivity study.

Sci Rep 2020 01 21;10(1):806. Epub 2020 Jan 21.

Department of Neurology, Focus Program Translational Neuroscience (FTN), University Medical Center of the Johannes Gutenberg University, Mainz, Germany.

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http://dx.doi.org/10.1038/s41598-020-57895-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6972853PMC
January 2020

PPMS onset upon adalimumab treatment extends the spectrum of anti-TNF-α therapy-associated demyelinating disorders.

Ther Adv Neurol Disord 2020 2;13:1756286419895155. Epub 2020 Jan 2.

Department of Neurology, Focus Program Translational Neuroscience (FTN), Rhine Main Neuroscience Network (rmn²), University Medical Center of the Johannes Gutenberg University Mainz, Langenbeckstrasse 1, Mainz 55131, Germany.

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http://dx.doi.org/10.1177/1756286419895155DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6940603PMC
January 2020

β1-Integrin- and KV1.3 channel-dependent signaling stimulates glutamate release from Th17 cells.

J Clin Invest 2020 02;130(2):715-732

Department of Neurology, Focus Program Translational Neuroscience (FTN) and Immunotherapy (FZI), Rhine Main Neuroscience Network (rmn2, ), University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.

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http://dx.doi.org/10.1172/JCI126381DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6994160PMC
February 2020

NfL (Neurofilament Light Chain) Levels as a Predictive Marker for Long-Term Outcome After Ischemic Stroke.

Stroke 2019 11 20;50(11):3077-3084. Epub 2019 Sep 20.

From the Department of Neurology, University Medical Center of the Johannes Gutenberg University Mainz, Germany (T.U., S.B., S.G., F.S., M.M., F.Z., K.G.).

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http://dx.doi.org/10.1161/STROKEAHA.119.026410DOI Listing
November 2019

Intrathecal B-cell accumulation and axonal damage distinguish MRI-based benign from aggressive onset in MS.

Neurol Neuroimmunol Neuroinflamm 2019 09 19;6(5). Epub 2019 Jul 19.

From the Department of Neurology (S.E., M.F., M.M., F.S., S.G., S.B., F.Z., F.L.), Focus Program Translational Neuroscience (FTN), and Immunotherapy (FZI), Rhine-Main Neuroscience Network (rmn), University Medical Center of the Johannes Gutenberg University, Mainz; and Institute of Medical Biostatistics (A.P.), Epidemiology and Informatics, University Medical Center of the Johannes Gutenberg University, Mainz, Germany.

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http://dx.doi.org/10.1212/NXI.0000000000000595DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6705631PMC
September 2019

Imaging in mice and men: Pathophysiological insights into multiple sclerosis from conventional and advanced MRI techniques.

Prog Neurobiol 2019 11 30;182:101663. Epub 2019 Jul 30.

Department of Neurology with Institute of Translational Neurology, University Hospital Münster, Albert-Schweitzer-Campus 1, Building A1, 48149, Münster, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.pneurobio.2019.101663DOI Listing
November 2019

[Diagnostics and treatment of tuberculosis under immunotherapy for multiple sclerosis : Current status and recommendations in Germany].

Nervenarzt 2019 Dec;90(12):1245-1253

Klinik für Neurologie, Forschungszentrum Translationale Neurowissenschaften (FTN), Forschungszentrum für Immuntherapie (FZI), Rhine Main Neuroscience Network (rmn2), Universitätsmedizin der Johannes Gutenberg-Universität Mainz, Langenbeckstr. 1, 55131, Mainz, Deutschland.

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http://link.springer.com/10.1007/s00115-019-0760-0
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http://dx.doi.org/10.1007/s00115-019-0760-0DOI Listing
December 2019

Implementing the 2017 McDonald criteria for the diagnosis of multiple sclerosis.

Nat Rev Neurol 2019 08;15(8):441-445

Department of Neurology, University of California-San Francisco, San Francisco, CA, USA.

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http://www.nature.com/articles/s41582-019-0194-0
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http://dx.doi.org/10.1038/s41582-019-0194-0DOI Listing
August 2019

Automated segmentation of changes in FLAIR-hyperintense white matter lesions in multiple sclerosis on serial magnetic resonance imaging.

Neuroimage Clin 2019 2;23:101849. Epub 2019 May 2.

Neurology, Technische Universität München, Ismaninger Str. 22, 81541 Munich, Germany; TUM-Neuroimaging Center, Technische Universität München, Ismaninger Str. 22, 81541 Munich, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.nicl.2019.101849DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6517532PMC
March 2020

Longitudinal cortical network reorganization in early relapsing-remitting multiple sclerosis.

Ther Adv Neurol Disord 2019 24;12:1756286419838673. Epub 2019 Apr 24.

Neuroimaging and Neurostimulation, Department of Neurology, Focus Program Translational Neuroscience (FTN), Rhine-Main-Neuroscience Network (rmn), University Medical Center of the Johannes Gutenberg University Mainz, Langenbeckstr.1, 55131 Mainz, Germany.

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http://dx.doi.org/10.1177/1756286419838673DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6482642PMC
April 2019

Immunoneuropsychiatry - novel perspectives on brain disorders.

Nat Rev Neurol 2019 06;15(6):317-328

Department of Neurology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.

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http://www.nature.com/articles/s41582-019-0174-4
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http://dx.doi.org/10.1038/s41582-019-0174-4DOI Listing
June 2019

Neuronal ICAM-5 Plays a Neuroprotective Role in Progressive Neurodegeneration.

Front Neurol 2019 12;10:205. Epub 2019 Mar 12.

Department of Neurology, Focus Program Translational Neuroscience (FTN) and Immunotherapy (FZI), Rhine Main Neuroscience Network (rmn2), University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.

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http://dx.doi.org/10.3389/fneur.2019.00205DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422935PMC
March 2019

[Milestone or missed opportunity? : Commentary on the revision of the McDonald criteria 2017].

Nervenarzt 2019 Feb;90(2):183-184

Klinik und Poliklinik für Neurologie, Universitätsmedizin Mainz, Langenbeckstr. 1, 55131, Mainz, Deutschland.

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http://dx.doi.org/10.1007/s00115-019-0682-xDOI Listing
February 2019

EGFL7 - a potential therapeutic target for multiple sclerosis?

Expert Opin Ther Targets 2018 11 17;22(11):899-902. Epub 2018 Oct 17.

b Department of Neurosciences , Centre de recherche du centre hospitalier de l'Université de Montréal (CRCHUM) , Montréal (Québec) , Canada.

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https://www.tandfonline.com/doi/full/10.1080/14728222.2018.1
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http://dx.doi.org/10.1080/14728222.2018.1535595DOI Listing
November 2018

Maladaptive cortical hyperactivity upon recovery from experimental autoimmune encephalomyelitis.

Nat Neurosci 2018 10 26;21(10):1392-1403. Epub 2018 Sep 26.

Focus Program Translational Neurosciences & Institute of Pathophysiology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.

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http://www.nature.com/articles/s41593-018-0193-2
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http://dx.doi.org/10.1038/s41593-018-0193-2DOI Listing
October 2018

Discriminative power of intra-retinal layers in early multiple sclerosis using 3D OCT imaging.

J Neurol 2018 Oct 2;265(10):2284-2294. Epub 2018 Aug 2.

Department of Neurology, Focus Program Translational Neuroscience (FTN), Rhine Main Neuroscience Network (rmn2), University Medical Center of the Johannes Gutenberg University Mainz, Langenbeckstr. 1, 55131, Mainz, Germany.

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http://dx.doi.org/10.1007/s00415-018-8988-3DOI Listing
October 2018

Targeting prohibitins at the cell surface prevents Th17-mediated autoimmunity.

EMBO J 2018 08 26;37(16). Epub 2018 Jul 26.

Cell Biology Unit, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany

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http://dx.doi.org/10.15252/embj.201899429DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6092617PMC
August 2018

GFAPα IgG-associated encephalitis upon daclizumab treatment of MS.

Neurol Neuroimmunol Neuroinflamm 2018 Sep 13;5(5):e481. Epub 2018 Jul 13.

Department of Neurology and Focus Program Translational Neuroscience (FTN), Rhine Main Neuroscience Network (rmn2), University Medical Center of the Johannes Gutenberg University Mainz, Germany.

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http://dx.doi.org/10.1212/NXI.0000000000000481DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6047833PMC
September 2018

AAN unveils new guidelines for MS disease-modifying therapy.

Nat Rev Neurol 2018 Jul;14(7):384-386

Department of Neurology, Focus Program Translational Neurosciences and Immunotherapy, Rhine-Main Neuroscience Network, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.

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http://dx.doi.org/10.1038/s41582-018-0026-7DOI Listing
July 2018

Monitoring B-cell repopulation after depletion therapy in neurologic patients.

Neurol Neuroimmunol Neuroinflamm 2018 Jul 25;5(4):e463. Epub 2018 Apr 25.

Focus Program Translational Neurosciences (FTN) and Immunology (FZI) (E.E., S.B., F.Z.), Rhine Main Neuroscience Network (rmn), Department of Neurology, University Medical Center of the Johannes Gutenberg University Mainz; and Institute of Sociology and Social Psychology (L.E.), University of Cologne, Germany.

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http://dx.doi.org/10.1212/NXI.0000000000000463DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5919296PMC
July 2018

Characterizing Microstructural Tissue Properties in Multiple Sclerosis with Diffusion MRI at 7 T and 3 T: The Impact of the Experimental Design.

Neuroscience 2019 04 7;403:17-26. Epub 2018 Apr 7.

Dept. of Cognitive Neuroscience, Faculty of Psychology & Neuroscience, Maastricht University, Maastricht, Netherlands.

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http://dx.doi.org/10.1016/j.neuroscience.2018.03.048DOI Listing
April 2019

CCR7 on CD4 T Cells Plays a Crucial Role in the Induction of Experimental Autoimmune Encephalomyelitis.

J Immunol 2018 04 16;200(8):2554-2562. Epub 2018 Mar 16.

Department of Neurology, Focus Program Translational Neuroscience and Immunotherapy, Rhine Main Neuroscience Network, University Medical Center of the Johannes Gutenberg University Mainz, 55131 Mainz, Germany.

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http://dx.doi.org/10.4049/jimmunol.1701419DOI Listing
April 2018

Serum neurofilament light chain is a biomarker of acute and chronic neuronal damage in early multiple sclerosis.

Mult Scler 2019 04 15;25(5):678-686. Epub 2018 Mar 15.

Department of Neurology and Focus Program Translational Neuroscience (FTN), Research Center for Immunotherapy (FZI), Rhine-Main Neuroscience Network (rmn2), University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.

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http://dx.doi.org/10.1177/1352458518765666DOI Listing
April 2019

Treatment choices and neuropsychological symptoms of a large cohort of early MS.

Neurol Neuroimmunol Neuroinflamm 2018 May 1;5(3):e446. Epub 2018 Mar 1.

Department of Neurology (O.v.B., B.A., R.G., A.S.), St. Josef-Hospital, Ruhr-University Bochum; Institute of Medical Biometry and Statistics (T.D., N.H., A.Z.), University of Lübeck, University Hospital Schleswig-Holstein, Campus Lübeck; Central Information Office (CIO) (G.A.), Philipps-University Marburg, Germany; School of Mathematics (A.Z.), Statistics and Computer Science, University of KwaZulu-Natal, Pietermaritzburg, South Africa; Department of Neurology (M.-M.H., L.A., B.H.), Klinikum rechts der Isar, Technical University of Munich; Munich Cluster for Systems Neurology (SyNergy) (L.A., B.H.); Department of Neurology (F.L., S.G., F.Z.), University Medicine Mainz, Johannes Gutenberg University Mainz; Department of Neurology (L.K., S.G.M., H.W.), University Hospital Münster; Department of Neurology (B.T.), Philipps-University Marburg; Department of Neurology (M.Stoppe, F.T.B.), University of Leipzig; Department of Neurology (H.T.), University of Ulm; Clinic of Neurology Dietenbronn (H.T.), Schwendi; Institute of Clinical Neuroimmunology (T.K.), Ludwig Maximilian University of Munich; Department of Neurology (M.Stangel), Hannover Medical School; Institut für Neuroimmunologie und Multiple Sklerose (C.H.), Universitätsklinikum Hamburg-Eppendorf; Department of Neurology (B.W.), University of Heidelberg; NeuroCure Clinical Research Center and Experimental and Clinical Research Center (F.P.), Charité-University Medicine Berlin and Max Delbrueck Center for Molecular Medicine; Department of Neurology (A.B.), Klinikum Augsburg; Department of Neurology (C.W.), Heinrich-Heine-University, Düsseldorf; Department of Neurology (C.W.), University Hospital Köln; Neurology (F.W.), Max-Planck-Institute of Psychiatry, Munich; Neurological Clinic (F.W.), MATERNUS Kliniken AG, Bad Oeynhausen; Department of Neurology (R.A.L.), University Hospital Erlangen; Department of Neurology & Stroke (U.Z.), Hertie Institute for Clinical Brain Research, Eberhard-Karls-University Tübingen; Department of Neurology (U.K.Z.), University of Rostock, Germany; and Department of Neurology (A.S.), Inselspital Bern, University Hospital and University of Bern, Switzerland.

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http://dx.doi.org/10.1212/NXI.0000000000000446DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833336PMC
May 2018

Studying the blood-brain barrier will provide new insights into neurodegeneration - Commentary.

Mult Scler 2018 07 5;24(8):1026-1028. Epub 2018 Mar 5.

Department of Neurology, Focus Program Translational Neuroscience (FTN), Research Centre for Immunotherapy (FZI), Rhine-Main Neuroscience Network (rmn2), University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.

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http://dx.doi.org/10.1177/1352458518759430DOI Listing
July 2018

Fast direct neuronal signaling via the IL-4 receptor as therapeutic target in neuroinflammation.

Sci Transl Med 2018 02;10(430)

Department of Neurology, Focus Program Translational Neuroscience (FTN) and Research Center for Immunotherapy (FZI), Rhine-Main Neuroscience Network (rmn), University Medical Center of the Johannes Gutenberg University Mainz, 55131 Mainz, Germany.

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http://dx.doi.org/10.1126/scitranslmed.aao2304DOI Listing
February 2018

EGFL7 reduces CNS inflammation in mouse.

Nat Commun 2018 02 26;9(1):819. Epub 2018 Feb 26.

Department of Neurology, Focus Program Translational Neuroscience (FTN), Research Center Immunotherapy (FZI), Rhine Main Neuroscience Network (rmn2), University Medical Center of the Johannes Gutenberg University Mainz, Langenbeckstr. 1, 55131, Mainz, Germany.

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http://www.nature.com/articles/s41467-018-03186-z
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http://dx.doi.org/10.1038/s41467-018-03186-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5827652PMC
February 2018

Preservation of neuronal function as measured by clinical and MRI endpoints in relapsing-remitting multiple sclerosis: how effective are current treatment strategies?

Expert Rev Neurother 2018 03 15;18(3):203-219. Epub 2018 Feb 15.

a Department of Neurology, Focus Program Translational Neuroscience (FTN), Rhine Main Neuroscience Network (rmn2) , University Medical Center of the Johannes Gutenberg University Mainz , Mainz , Germany.

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http://dx.doi.org/10.1080/14737175.2018.1438190DOI Listing
March 2018

ECTRIMS/EAN Guideline on the pharmacological treatment of people with multiple sclerosis.

Mult Scler 2018 02 20;24(2):96-120. Epub 2018 Jan 20.

Department of Neurology, Focus Program Translational Neuroscience (FTN) and Immunology (FZI), Rhine-Main Neuroscience Network (rmn2), University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.

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http://dx.doi.org/10.1177/1352458517751049DOI Listing
February 2018

Increased cerebrospinal fluid albumin and immunoglobulin A fractions forecast cortical atrophy and longitudinal functional deterioration in relapsing-remitting multiple sclerosis.

Mult Scler 2019 03 11;25(3):338-343. Epub 2017 Dec 11.

Department of Neurology, Focus Program Translational Neuroscience (FTN), Research Center for Immunology (FZI), Rhine-Main Neuroscience Network (rmn2), University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.

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http://dx.doi.org/10.1177/1352458517748474DOI Listing
March 2019

Graph Theoretical Framework of Brain Networks in Multiple Sclerosis: A Review of Concepts.

Neuroscience 2019 04 1;403:35-53. Epub 2017 Nov 1.

Department of Neurology and Neuroimaging Center (NIC) of the Focus Program Translational Neuroscience (FTN), University Medical Center of the Johannes Gutenberg University Mainz, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.neuroscience.2017.10.033DOI Listing
April 2019

Disease reactivation after switching from natalizumab to daclizumab.

J Neurol 2017 Dec 3;264(12):2491-2494. Epub 2017 Oct 3.

Department of Neurology, Focus Program Translational Neuroscience (FTN) and Immunotherapy (FZI), Rhine-Main Neuroscience Network (rmn2), University Medical Center of the Johannes Gutenberg University Mainz, Langenbeckstr. 1, Mainz, 55131, Germany.

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http://dx.doi.org/10.1007/s00415-017-8622-9DOI Listing
December 2017

The Role of ERK Signaling in Experimental Autoimmune Encephalomyelitis.

Int J Mol Sci 2017 Sep 15;18(9). Epub 2017 Sep 15.

Department of Neurology, Focus Program Translational Neuroscience (FTN) and Immunotherapy (FZI), Rhine Main Neuroscience Network (rmn2), University Medical Center of the Johannes Gutenberg University Mainz, Langenbeckstr. 1, 55131 Mainz, Germany.

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http://dx.doi.org/10.3390/ijms18091990DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5618639PMC
September 2017

Diagnosis of multiple sclerosis: a multicentre study to compare revised McDonald-2010 and Filippi-2010 criteria.

J Neurol Neurosurg Psychiatry 2018 03 19;89(3):316-318. Epub 2017 Jul 19.

Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy.

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http://dx.doi.org/10.1136/jnnp-2017-315863DOI Listing
March 2018

Treatment response to dimethyl fumarate is characterized by disproportionate CD8+ T cell reduction in MS.

Mult Scler 2018 04 24;24(5):632-641. Epub 2017 Apr 24.

Department of Neurology, Focus Program Translational Neuroscience (FTN), and Immunology (FZI), Rhine-Main Neuroscience Network (rmn2), University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.

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http://dx.doi.org/10.1177/1352458517703799DOI Listing
April 2018

A "kissing lesion": In-vivo 7T evidence of meningeal inflammation in early multiple sclerosis.

Mult Scler 2017 Jul 18;23(8):1167-1169. Epub 2017 Apr 18.

Focus Program Translational Neurosciences (FTN), Rhine Main Neuroscience Network (rmn2), Department of Neurology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.

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http://dx.doi.org/10.1177/1352458516683267DOI Listing
July 2017

Dimethyl fumarate-induced lymphopenia in MS due to differential T-cell subset apoptosis.

Neurol Neuroimmunol Neuroinflamm 2017 May 23;4(3):e340. Epub 2017 Mar 23.

Montreal Neurological Institute (M.G., A.R., R.L., P.S.G., J.A., A.B.-O.), McGill University, Montreal, QC, Canada; Brain and Mind Centre (M.G.), University of Sydney, NSW, Australia; Institute of Actuaries of Australia (A.E.); Department of Neurology (F.L., F.Z.), University Medical Center Mainz, Germany; and Department of Neurology (A.R., R.L., A.B.-O.), Perelman School of Medicine, University of Pennsylvania, Philadelphia.

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http://dx.doi.org/10.1212/NXI.0000000000000340DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5365096PMC
May 2017

Dimethyl Fumarate Treatment Mediates an Anti-Inflammatory Shift in B Cell Subsets of Patients with Multiple Sclerosis.

J Immunol 2017 01 14;198(2):691-698. Epub 2016 Dec 14.

Neuroimmunology Unit, Montreal Neurological Institute, McGill University, Montreal, Quebec H3A 2B4, Canada;

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http://dx.doi.org/10.4049/jimmunol.1601649DOI Listing
January 2017

No role of IFITM3 in brain tumor formation in vivo.

Oncotarget 2016 12;7(52):86388-86405

Molecular Signal Transduction Laboratories, Institute for Microscopic Anatomy and Neurobiology, Focus Program Translational Neuroscience (FTN), Rhine Main Neuroscience Network (rmn2), Johannes Gutenberg University, School of Medicine, Mainz, Germany.

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http://dx.doi.org/10.18632/oncotarget.13199DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5349921PMC
December 2016

Phenotype of Antigen Unexperienced T Cells in the Inflamed Central Nervous System in Experimental Autoimmune Encephalomyelitis.

J Neuroimmune Pharmacol 2017 06 10;12(2):305-313. Epub 2016 Nov 10.

Department of Neurology, Focus Program Translational Neuroscience (FTN) and Immunotherapy (FZI), Rhine-Main Neuroscience Network (rmn2), University Medical Center of the Johannes Gutenberg University, Langenbeckstrasse 1, Building 708, 55131, Mainz, Germany.

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http://dx.doi.org/10.1007/s11481-016-9718-1DOI Listing
June 2017

Down-regulation of neuronal L1 cell adhesion molecule expression alleviates inflammatory neuronal injury.

Acta Neuropathol 2016 11 20;132(5):703-720. Epub 2016 Aug 20.

Department of Anesthesiology, University Medical Center of the Johannes-Gutenberg-University Mainz, Mainz, Germany.

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http://dx.doi.org/10.1007/s00401-016-1607-4DOI Listing
November 2016

Metabolic Patterns in Chronic Multiple Sclerosis Lesions and Normal-appearing White Matter: Intraindividual Comparison by Using 2D MR Spectroscopic Imaging.

Radiology 2016 Nov 30;281(2):536-543. Epub 2016 May 30.

From the Department of Neurology and Neuroimaging Center of Focus Program Translational Neuroscience, University Medical Center of the Johannes Gutenberg-University Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany (V.F., S.G., F.Z., A.G.); and Department of Diagnostic and Interventional Neuroradiology, Magnetic Resonance Research Group, University Hospital Tübingen, Tübingen, Germany (R.K., U.K.).

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http://dx.doi.org/10.1148/radiol.2016151654DOI Listing
November 2016

Past, present and future of immunology in Mainz.

Cell Immunol 2016 10;308:1-6

Research Center for Immunotherapy (FZI), University Medical Center of the Johannes Gutenberg University, Mainz, Germany; Institute for Immunology, University Medical Center of the Johannes Gutenberg University, Mainz, Germany.

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http://dx.doi.org/10.1016/j.cellimm.2016.09.001DOI Listing
October 2016

Dendritic cells tip the balance towards induction of regulatory T cells upon priming in experimental autoimmune encephalomyelitis.

J Autoimmun 2017 01 2;76:108-114. Epub 2016 Oct 2.

Department of Neurology, Focus Program Translational Neuroscience (FTN) and Immunotherapy (FZI), Rhine-Main Neuroscience Network (rmn(2)), University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jaut.2016.09.008DOI Listing
January 2017

Role of IL-17-producing lymphocytes in severity of multiple sclerosis upon natalizumab treatment.

Mult Scler 2017 Apr 21;23(4):567-576. Epub 2016 Jul 21.

Focus Program Translational Neurosciences (FTN), Rhine-Main Neuroscience Network (rmn2), Department of Neurology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.

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http://dx.doi.org/10.1177/1352458516658559DOI Listing
April 2017

Increase of Alternatively Activated Antigen Presenting Cells in Active Experimental Autoimmune Encephalomyelitis.

J Neuroimmune Pharmacol 2016 12 16;11(4):721-732. Epub 2016 Jul 16.

Department of Neurology, Focus Program Translational Neuroscience (FTN), Research Center for Immunotherapy (FZI), Rhine Main Neuroscience Network (rmn2), University Medical Center of the Johannes Gutenberg-University of Mainz, Langenbeckstrasse 1, Building 708, 55131, Mainz, Germany.

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http://dx.doi.org/10.1007/s11481-016-9696-3DOI Listing
December 2016

Novel multiple sclerosis susceptibility loci implicated in epigenetic regulation.

Sci Adv 2016 06 17;2(6):e1501678. Epub 2016 Jun 17.

Max Planck Institute of Psychiatry, 80804 Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), 81377 Munich, Germany.; Institute of Translational Medicine, University of Liverpool, Liverpool L69 3BX, UK.

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http://dx.doi.org/10.1126/sciadv.1501678DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4928990PMC
June 2016

Increased structural white and grey matter network connectivity compensates for functional decline in early multiple sclerosis.

Mult Scler 2017 Mar 11;23(3):432-441. Epub 2016 Jul 11.

Department of Neurology and Neuroimaging Center (NIC), Focus Program Translational Neuroscience (FTN), Rhine-Main Neuroscience Network (rmn2), University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.

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http://dx.doi.org/10.1177/1352458516651503DOI Listing
March 2017

Erratum to: Dendritic cells as therapeutic targets in neuroinflammation.

Cell Mol Life Sci 2016 07;73(13):2451

Department of Neurology, Focus Program Translational Neuroscience (FTN), University Medical Center of the Johannes Gutenberg-University of Mainz, Rhine Main Neuroscience Network (rmn2), Langenbeckstrasse 1, 55131, Mainz, Germany.

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http://dx.doi.org/10.1007/s00018-016-2227-9DOI Listing
July 2016

Secondary Progression in Multiple Sclerosis: Neuronal Exhaustion or Distinct Pathology?

Trends Neurosci 2016 05 15;39(5):325-339. Epub 2016 Mar 15.

Department of Neurology, Focus Program Translational Neuroscience (FTN) and Immunotherapy (FZI), Rhine-Main Neuroscience Network (rmn(2)), University Medical Centre of the Johannes Gutenberg University Mainz, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.tins.2016.02.001DOI Listing
May 2016

Dendritic cells as therapeutic targets in neuroinflammation.

Cell Mol Life Sci 2016 07 12;73(13):2425-50. Epub 2016 Mar 12.

Department of Neurology, Focus Program Translational Neuroscience (FTN), University Medical Center of the Johannes Gutenberg-University of Mainz,Rhine Main Neuroscience Network (rmn2), Langenbeckstrasse 1, 55131, Mainz, Germany.

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http://dx.doi.org/10.1007/s00018-016-2170-9DOI Listing
July 2016

An improved anatomical MRI technique with suppression of fixative fluid artifacts for the investigation of human postmortem brain phantoms.

Magn Reson Med 2017 03 7;77(3):1115-1123. Epub 2016 Mar 7.

Brain Imaging Center (BIC), Goethe University, Frankfurt am Main, Germany.

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http://dx.doi.org/10.1002/mrm.26196DOI Listing
March 2017

Structural Brain Network Characteristics Can Differentiate CIS from Early RRMS.

Front Neurosci 2016 2;10:14. Epub 2016 Feb 2.

Department of Neurology and Neuroimaging Center of the Focus Program Translational Neuroscience, University Medical Center of the Johannes Gutenberg-University Mainz Mainz, Germany.

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http://dx.doi.org/10.3389/fnins.2016.00014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4735423PMC
February 2016

Assessment of cortical damage in early multiple sclerosis with quantitative T2 relaxometry.

NMR Biomed 2016 Apr 28;29(4):444-50. Epub 2016 Jan 28.

Department of Neurology, Goethe University, Frankfurt/Main, Germany.

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http://dx.doi.org/10.1002/nbm.3486DOI Listing
April 2016

Understanding the Role of T Cells in CNS Homeostasis.

Trends Immunol 2016 Feb 14;37(2):154-165. Epub 2016 Jan 14.

Department of Neurology, Focus Program Translational Neuroscience (FTN) and Immunotherapy (FZI), Rhine-Main Neuroscience Network (rmn(2)), University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.

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http://dx.doi.org/10.1016/j.it.2015.12.008DOI Listing
February 2016

Microglia-blood vessel interactions: a double-edged sword in brain pathologies.

Acta Neuropathol 2016 03 28;131(3):347-63. Epub 2015 Dec 28.

Molecular Signal Transduction Laboratories, Institute for Microscopic Anatomy and Neurobiology, Focus Program Translational Neuroscience (FTN), Rhine Main Neuroscience Network (rmn²), University Medical Center of the Johannes Gutenberg University, Langenbeckstr. 1, 55131, Mainz, Germany.

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http://dx.doi.org/10.1007/s00401-015-1524-yDOI Listing
March 2016

In vivo and in vitro effects of multiple sclerosis immunomodulatory therapeutics on glutamatergic excitotoxicity.

J Neurochem 2016 Mar 11;136(5):971-80. Epub 2016 Jan 11.

Department of Neurology, Focus Program Translational Neuroscience (FTN), Rhine Main Neuroscience Network (rmn²), University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.

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http://dx.doi.org/10.1111/jnc.13456DOI Listing
March 2016

Gatekeeper role of brain antigen-presenting CD11c+ cells in neuroinflammation.

EMBO J 2016 Jan 26;35(1):89-101. Epub 2015 Nov 26.

Department of Neurology, Focus Program Translational Neurosciences (FTN), Research Center for Immunotherapy (FZI), Rhine-Main Neuroscience Network (rmn²) University Medical Center of the Johannes Gutenberg University, Mainz, Germany

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http://dx.doi.org/10.15252/embj.201591488DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4718005PMC
January 2016

Role of Sortilin in Models of Autoimmune Neuroinflammation.

J Immunol 2015 Dec 13;195(12):5762-9. Epub 2015 Nov 13.

Department of Neurology, University Medical Center of the Johannes Gutenberg University Mainz, 55131 Mainz, Germany;

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http://dx.doi.org/10.4049/jimmunol.1403156DOI Listing
December 2015

Changes in brain functional connectivity patterns are driven by an individual lesion in MS: a resting-state fMRI study.

Brain Imaging Behav 2016 12;10(4):1117-1126

Department of Neurology, University Medical Centre of the Johannes Gutenberg University Mainz, Mainz, Germany.

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http://dx.doi.org/10.1007/s11682-015-9476-3DOI Listing
December 2016

Genome-wide significant association with seven novel multiple sclerosis risk loci.

J Med Genet 2015 Dec 16;52(12):848-55. Epub 2015 Oct 16.

Platform for Genome Analytics, Institutes of Neurogenetics & Integrative and Experimental Genomics, University of Lübeck, Lübeck, Germany Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin, Germany Department of Medicine, School of Public Health, Imperial College London, London, UK.

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http://dx.doi.org/10.1136/jmedgenet-2015-103442DOI Listing
December 2015

A novel automated segmentation method for retinal layers in OCT images proves retinal degeneration after optic neuritis.

Br J Ophthalmol 2016 Apr 25;100(4):484-90. Epub 2015 Aug 25.

Department of Neurology, University Medical Center of the Johannes Gutenberg University, Mainz, Germany.

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http://dx.doi.org/10.1136/bjophthalmol-2014-306015DOI Listing
April 2016

Genetic Cell Ablation Reveals Clusters of Local Self-Renewing Microglia in the Mammalian Central Nervous System.

Immunity 2015 Jul 7;43(1):92-106. Epub 2015 Jul 7.

Institute for Molecular Medicine, University Medical Center of the Johannes Gutenberg-University Mainz, Obere Zahlbacher Str. 67, 55131 Mainz, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.immuni.2015.06.012DOI Listing
July 2015

Flow cytometric analysis of T cell/monocyte ratio in clinically isolated syndrome identifies patients at risk of rapid disease progression.

Mult Scler 2016 Apr 10;22(4):483-93. Epub 2015 Jul 10.

Neurology Department, Johannes Gutenberg University Mainz, Germany/Charité - Universitätsmedizin Berlin, Germany

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http://dx.doi.org/10.1177/1352458515593821DOI Listing
April 2016