Frauke Zipp

Frauke Zipp

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Frauke Zipp

Frauke Zipp

Publications by authors named "Frauke Zipp"

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100Publications

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GFAPα IgG-associated encephalitis upon daclizumab treatment of MS.

Neurol Neuroimmunol Neuroinflamm 2018 Sep 13;5(5):e481. Epub 2018 Jul 13.

Department of Neurology and Focus Program Translational Neuroscience (FTN), Rhine Main Neuroscience Network (rmn2), University Medical Center of the Johannes Gutenberg University Mainz, Germany.

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September 2018

Discriminative power of intra-retinal layers in early multiple sclerosis using 3D OCT imaging.

J Neurol 2018 Aug 2. Epub 2018 Aug 2.

Department of Neurology, Focus Program Translational Neuroscience (FTN), Rhine Main Neuroscience Network (rmn2), University Medical Center of the Johannes Gutenberg University Mainz, Langenbeckstr. 1, 55131, Mainz, Germany.

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August 2018

Studying the blood-brain barrier will provide new insights into neurodegeneration - Commentary.

Mult Scler 2018 Jul 5;24(8):1026-1028. Epub 2018 Mar 5.

Department of Neurology, Focus Program Translational Neuroscience (FTN), Research Centre for Immunotherapy (FZI), Rhine-Main Neuroscience Network (rmn2), University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.

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July 2018

Monitoring B-cell repopulation after depletion therapy in neurologic patients.

Neurol Neuroimmunol Neuroinflamm 2018 Jul 25;5(4):e463. Epub 2018 Apr 25.

Focus Program Translational Neurosciences (FTN) and Immunology (FZI) (E.E., S.B., F.Z.), Rhine Main Neuroscience Network (rmn), Department of Neurology, University Medical Center of the Johannes Gutenberg University Mainz; and Institute of Sociology and Social Psychology (L.E.), University of Cologne, Germany.

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July 2018

Targeting prohibitins at the cell surface prevents Th17-mediated autoimmunity.

EMBO J 2018 Jul 26. Epub 2018 Jul 26.

Cell Biology Unit, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany

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July 2018

AAN unveils new guidelines for MS disease-modifying therapy.

Nat Rev Neurol 2018 Jun 12. Epub 2018 Jun 12.

Department of Neurology, Focus Program Translational Neurosciences and Immunotherapy, Rhine-Main Neuroscience Network, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.

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June 2018

Treatment choices and neuropsychological symptoms of a large cohort of early MS.

Neurol Neuroimmunol Neuroinflamm 2018 May 1;5(3):e446. Epub 2018 Mar 1.

Department of Neurology (O.v.B., B.A., R.G., A.S.), St. Josef-Hospital, Ruhr-University Bochum; Institute of Medical Biometry and Statistics (T.D., N.H., A.Z.), University of Lübeck, University Hospital Schleswig-Holstein, Campus Lübeck; Central Information Office (CIO) (G.A.), Philipps-University Marburg, Germany; School of Mathematics (A.Z.), Statistics and Computer Science, University of KwaZulu-Natal, Pietermaritzburg, South Africa; Department of Neurology (M.-M.H., L.A., B.H.), Klinikum rechts der Isar, Technical University of Munich; Munich Cluster for Systems Neurology (SyNergy) (L.A., B.H.); Department of Neurology (F.L., S.G., F.Z.), University Medicine Mainz, Johannes Gutenberg University Mainz; Department of Neurology (L.K., S.G.M., H.W.), University Hospital Münster; Department of Neurology (B.T.), Philipps-University Marburg; Department of Neurology (M.Stoppe, F.T.B.), University of Leipzig; Department of Neurology (H.T.), University of Ulm; Clinic of Neurology Dietenbronn (H.T.), Schwendi; Institute of Clinical Neuroimmunology (T.K.), Ludwig Maximilian University of Munich; Department of Neurology (M.Stangel), Hannover Medical School; Institut für Neuroimmunologie und Multiple Sklerose (C.H.), Universitätsklinikum Hamburg-Eppendorf; Department of Neurology (B.W.), University of Heidelberg; NeuroCure Clinical Research Center and Experimental and Clinical Research Center (F.P.), Charité-University Medicine Berlin and Max Delbrueck Center for Molecular Medicine; Department of Neurology (A.B.), Klinikum Augsburg; Department of Neurology (C.W.), Heinrich-Heine-University, Düsseldorf; Department of Neurology (C.W.), University Hospital Köln; Neurology (F.W.), Max-Planck-Institute of Psychiatry, Munich; Neurological Clinic (F.W.), MATERNUS Kliniken AG, Bad Oeynhausen; Department of Neurology (R.A.L.), University Hospital Erlangen; Department of Neurology & Stroke (U.Z.), Hertie Institute for Clinical Brain Research, Eberhard-Karls-University Tübingen; Department of Neurology (U.K.Z.), University of Rostock, Germany; and Department of Neurology (A.S.), Inselspital Bern, University Hospital and University of Bern, Switzerland.

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May 2018

Treatment response to dimethyl fumarate is characterized by disproportionate CD8+ T cell reduction in MS.

Mult Scler 2018 Apr 24;24(5):632-641. Epub 2017 Apr 24.

Department of Neurology, Focus Program Translational Neuroscience (FTN), and Immunology (FZI), Rhine-Main Neuroscience Network (rmn2), University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.

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April 2018

CCR7 on CD4 T Cells Plays a Crucial Role in the Induction of Experimental Autoimmune Encephalomyelitis.

J Immunol 2018 Apr 16;200(8):2554-2562. Epub 2018 Mar 16.

Department of Neurology, Focus Program Translational Neuroscience and Immunotherapy, Rhine Main Neuroscience Network, University Medical Center of the Johannes Gutenberg University Mainz, 55131 Mainz, Germany.

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April 2018

Characterizing Microstructural Tissue Properties in Multiple Sclerosis with Diffusion MRI at 7 T and 3 T: The Impact of the Experimental Design.

Neuroscience 2018 Apr 7. Epub 2018 Apr 7.

Dept. of Cognitive Neuroscience, Faculty of Psychology & Neuroscience, Maastricht University, Maastricht, Netherlands.

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April 2018

Diagnosis of multiple sclerosis: a multicentre study to compare revised McDonald-2010 and Filippi-2010 criteria.

J Neurol Neurosurg Psychiatry 2018 Mar 19;89(3):316-318. Epub 2017 Jul 19.

Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy.

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March 2018

Preservation of neuronal function as measured by clinical and MRI endpoints in relapsing-remitting multiple sclerosis: how effective are current treatment strategies?

Expert Rev Neurother 2018 Mar 15;18(3):203-219. Epub 2018 Feb 15.

a Department of Neurology, Focus Program Translational Neuroscience (FTN), Rhine Main Neuroscience Network (rmn2) , University Medical Center of the Johannes Gutenberg University Mainz , Mainz , Germany.

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March 2018

Serum neurofilament light chain is a biomarker of acute and chronic neuronal damage in early multiple sclerosis.

Mult Scler 2018 Mar 1:1352458518765666. Epub 2018 Mar 1.

Department of Neurology and Focus Program Translational Neuroscience (FTN), Research Center for Immunotherapy (FZI), Rhine-Main Neuroscience Network (rmn2), University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.

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March 2018

ECTRIMS/EAN Guideline on the pharmacological treatment of people with multiple sclerosis.

Mult Scler 2018 Feb 20;24(2):96-120. Epub 2018 Jan 20.

Department of Neurology, Focus Program Translational Neuroscience (FTN) and Immunology (FZI), Rhine-Main Neuroscience Network (rmn2), University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.

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February 2018

EGFL7 reduces CNS inflammation in mouse.

Nat Commun 2018 Feb 26;9(1):819. Epub 2018 Feb 26.

Department of Neurology, Focus Program Translational Neuroscience (FTN), Research Center Immunotherapy (FZI), Rhine Main Neuroscience Network (rmn2), University Medical Center of the Johannes Gutenberg University Mainz, Langenbeckstr. 1, 55131, Mainz, Germany.

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February 2018

Fast direct neuronal signaling via the IL-4 receptor as therapeutic target in neuroinflammation.

Sci Transl Med 2018 Feb;10(430)

Department of Neurology, Focus Program Translational Neuroscience (FTN) and Research Center for Immunotherapy (FZI), Rhine-Main Neuroscience Network (rmn), University Medical Center of the Johannes Gutenberg University Mainz, 55131 Mainz, Germany.

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February 2018

Disease reactivation after switching from natalizumab to daclizumab.

J Neurol 2017 Dec 3;264(12):2491-2494. Epub 2017 Oct 3.

Department of Neurology, Focus Program Translational Neuroscience (FTN) and Immunotherapy (FZI), Rhine-Main Neuroscience Network (rmn2), University Medical Center of the Johannes Gutenberg University Mainz, Langenbeckstr. 1, Mainz, 55131, Germany.

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December 2017

Increased cerebrospinal fluid albumin and immunoglobulin A fractions forecast cortical atrophy and longitudinal functional deterioration in relapsing-remitting multiple sclerosis.

Mult Scler 2017 Dec 1:1352458517748474. Epub 2017 Dec 1.

Department of Neurology, Focus Program Translational Neuroscience (FTN), Research Center for Immunology (FZI), Rhine-Main Neuroscience Network (rmn2), University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.

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December 2017

Graph Theoretical Framework of Brain Networks in Multiple Sclerosis: A Review of Concepts.

Neuroscience 2017 Nov 1. Epub 2017 Nov 1.

Department of Neurology and Neuroimaging Center (NIC) of the Focus Program Translational Neuroscience (FTN), University Medical Center of the Johannes Gutenberg University Mainz, Germany. Electronic address:

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November 2017

The Role of ERK Signaling in Experimental Autoimmune Encephalomyelitis.

Int J Mol Sci 2017 Sep 15;18(9). Epub 2017 Sep 15.

Department of Neurology, Focus Program Translational Neuroscience (FTN) and Immunotherapy (FZI), Rhine Main Neuroscience Network (rmn2), University Medical Center of the Johannes Gutenberg University Mainz, Langenbeckstr. 1, 55131 Mainz, Germany.

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September 2017

A "kissing lesion": In-vivo 7T evidence of meningeal inflammation in early multiple sclerosis.

Mult Scler 2017 Jul 18;23(8):1167-1169. Epub 2017 Apr 18.

Focus Program Translational Neurosciences (FTN), Rhine Main Neuroscience Network (rmn2), Department of Neurology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.

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July 2017

Phenotype of Antigen Unexperienced T Cells in the Inflamed Central Nervous System in Experimental Autoimmune Encephalomyelitis.

J Neuroimmune Pharmacol 2017 Jun 10;12(2):305-313. Epub 2016 Nov 10.

Department of Neurology, Focus Program Translational Neuroscience (FTN) and Immunotherapy (FZI), Rhine-Main Neuroscience Network (rmn2), University Medical Center of the Johannes Gutenberg University, Langenbeckstrasse 1, Building 708, 55131, Mainz, Germany.

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June 2017

Dimethyl fumarate-induced lymphopenia in MS due to differential T-cell subset apoptosis.

Neurol Neuroimmunol Neuroinflamm 2017 May 23;4(3):e340. Epub 2017 Mar 23.

Montreal Neurological Institute (M.G., A.R., R.L., P.S.G., J.A., A.B.-O.), McGill University, Montreal, QC, Canada; Brain and Mind Centre (M.G.), University of Sydney, NSW, Australia; Institute of Actuaries of Australia (A.E.); Department of Neurology (F.L., F.Z.), University Medical Center Mainz, Germany; and Department of Neurology (A.R., R.L., A.B.-O.), Perelman School of Medicine, University of Pennsylvania, Philadelphia.

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May 2017

Role of IL-17-producing lymphocytes in severity of multiple sclerosis upon natalizumab treatment.

Mult Scler 2017 Apr 21;23(4):567-576. Epub 2016 Jul 21.

Focus Program Translational Neurosciences (FTN), Rhine-Main Neuroscience Network (rmn2), Department of Neurology, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.

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April 2017

Increased structural white and grey matter network connectivity compensates for functional decline in early multiple sclerosis.

Mult Scler 2017 Mar 11;23(3):432-441. Epub 2016 Jul 11.

Department of Neurology and Neuroimaging Center (NIC), Focus Program Translational Neuroscience (FTN), Rhine-Main Neuroscience Network (rmn2), University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.

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March 2017

Dendritic cells tip the balance towards induction of regulatory T cells upon priming in experimental autoimmune encephalomyelitis.

J Autoimmun 2017 Jan 2;76:108-114. Epub 2016 Oct 2.

Department of Neurology, Focus Program Translational Neuroscience (FTN) and Immunotherapy (FZI), Rhine-Main Neuroscience Network (rmn(2)), University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany. Electronic address:

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January 2017

Dimethyl Fumarate Treatment Mediates an Anti-Inflammatory Shift in B Cell Subsets of Patients with Multiple Sclerosis.

J Immunol 2017 01 14;198(2):691-698. Epub 2016 Dec 14.

Neuroimmunology Unit, Montreal Neurological Institute, McGill University, Montreal, Quebec H3A 2B4, Canada;

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January 2017

Increase of Alternatively Activated Antigen Presenting Cells in Active Experimental Autoimmune Encephalomyelitis.

J Neuroimmune Pharmacol 2016 12 16;11(4):721-732. Epub 2016 Jul 16.

Department of Neurology, Focus Program Translational Neuroscience (FTN), Research Center for Immunotherapy (FZI), Rhine Main Neuroscience Network (rmn2), University Medical Center of the Johannes Gutenberg-University of Mainz, Langenbeckstrasse 1, Building 708, 55131, Mainz, Germany.

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December 2016

No role of IFITM3 in brain tumor formation in vivo.

Oncotarget 2016 12;7(52):86388-86405

Molecular Signal Transduction Laboratories, Institute for Microscopic Anatomy and Neurobiology, Focus Program Translational Neuroscience (FTN), Rhine Main Neuroscience Network (rmn2), Johannes Gutenberg University, School of Medicine, Mainz, Germany.

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December 2016

Metabolic Patterns in Chronic Multiple Sclerosis Lesions and Normal-appearing White Matter: Intraindividual Comparison by Using 2D MR Spectroscopic Imaging.

Radiology 2016 Nov 30;281(2):536-543. Epub 2016 May 30.

From the Department of Neurology and Neuroimaging Center of Focus Program Translational Neuroscience, University Medical Center of the Johannes Gutenberg-University Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany (V.F., S.G., F.Z., A.G.); and Department of Diagnostic and Interventional Neuroradiology, Magnetic Resonance Research Group, University Hospital Tübingen, Tübingen, Germany (R.K., U.K.).

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November 2016

Down-regulation of neuronal L1 cell adhesion molecule expression alleviates inflammatory neuronal injury.

Acta Neuropathol 2016 Nov 20;132(5):703-720. Epub 2016 Aug 20.

Department of Anesthesiology, University Medical Center of the Johannes-Gutenberg-University Mainz, Mainz, Germany.

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November 2016

Past, present and future of immunology in Mainz.

Cell Immunol 2016 10;308:1-6

Research Center for Immunotherapy (FZI), University Medical Center of the Johannes Gutenberg University, Mainz, Germany; Institute for Immunology, University Medical Center of the Johannes Gutenberg University, Mainz, Germany.

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October 2016

Dendritic cells as therapeutic targets in neuroinflammation.

Cell Mol Life Sci 2016 07 12;73(13):2425-50. Epub 2016 Mar 12.

Department of Neurology, Focus Program Translational Neuroscience (FTN), University Medical Center of the Johannes Gutenberg-University of Mainz,Rhine Main Neuroscience Network (rmn2), Langenbeckstrasse 1, 55131, Mainz, Germany.

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July 2016

Erratum to: Dendritic cells as therapeutic targets in neuroinflammation.

Cell Mol Life Sci 2016 07;73(13):2451

Department of Neurology, Focus Program Translational Neuroscience (FTN), University Medical Center of the Johannes Gutenberg-University of Mainz, Rhine Main Neuroscience Network (rmn2), Langenbeckstrasse 1, 55131, Mainz, Germany.

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July 2016

Novel multiple sclerosis susceptibility loci implicated in epigenetic regulation.

Sci Adv 2016 06 17;2(6):e1501678. Epub 2016 Jun 17.

Max Planck Institute of Psychiatry, 80804 Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), 81377 Munich, Germany.; Institute of Translational Medicine, University of Liverpool, Liverpool L69 3BX, UK.

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June 2016

Secondary Progression in Multiple Sclerosis: Neuronal Exhaustion or Distinct Pathology?

Trends Neurosci 2016 05 15;39(5):325-339. Epub 2016 Mar 15.

Department of Neurology, Focus Program Translational Neuroscience (FTN) and Immunotherapy (FZI), Rhine-Main Neuroscience Network (rmn(2)), University Medical Centre of the Johannes Gutenberg University Mainz, Germany. Electronic address:

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May 2016

Flow cytometric analysis of T cell/monocyte ratio in clinically isolated syndrome identifies patients at risk of rapid disease progression.

Mult Scler 2016 Apr 10;22(4):483-93. Epub 2015 Jul 10.

Neurology Department, Johannes Gutenberg University Mainz, Germany/Charité - Universitätsmedizin Berlin, Germany

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April 2016

A novel automated segmentation method for retinal layers in OCT images proves retinal degeneration after optic neuritis.

Br J Ophthalmol 2016 Apr 25;100(4):484-90. Epub 2015 Aug 25.

Department of Neurology, University Medical Center of the Johannes Gutenberg University, Mainz, Germany.

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April 2016

The impact of isolated lesions on white-matter fiber tracts in multiple sclerosis patients.

Neuroimage Clin 2015 10;8:110-6. Epub 2015 Apr 10.

Department of Neurology, University Medical Center of the Johannes Gutenberg University, Mainz, Germany ; Neuroimage Center (NIC) of the Focus Program Translational Neuroscience (FTN), Johannes Gutenberg University, Mainz, Germany.

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March 2016

In vivo and in vitro effects of multiple sclerosis immunomodulatory therapeutics on glutamatergic excitotoxicity.

J Neurochem 2016 Mar 11;136(5):971-80. Epub 2016 Jan 11.

Department of Neurology, Focus Program Translational Neuroscience (FTN), Rhine Main Neuroscience Network (rmn²), University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.

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March 2016

Microglia-blood vessel interactions: a double-edged sword in brain pathologies.

Acta Neuropathol 2016 03 28;131(3):347-63. Epub 2015 Dec 28.

Molecular Signal Transduction Laboratories, Institute for Microscopic Anatomy and Neurobiology, Focus Program Translational Neuroscience (FTN), Rhine Main Neuroscience Network (rmn²), University Medical Center of the Johannes Gutenberg University, Langenbeckstr. 1, 55131, Mainz, Germany.

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March 2016

Structural correlates for fatigue in early relapsing remitting multiple sclerosis.

Eur Radiol 2016 Feb 31;26(2):515-23. Epub 2015 May 31.

Department of Neurology and Neuroimaging Center (NIC) of Focus Program Translational Neuroscience (FTN), University Medical Center of the Johannes Gutenberg-University Mainz, Langenbeckstraße 1, 55131, Mainz, Germany.

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February 2016

Understanding the Role of T Cells in CNS Homeostasis.

Trends Immunol 2016 Feb 14;37(2):154-165. Epub 2016 Jan 14.

Department of Neurology, Focus Program Translational Neuroscience (FTN) and Immunotherapy (FZI), Rhine-Main Neuroscience Network (rmn(2)), University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.

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February 2016

Structural Brain Network Characteristics Can Differentiate CIS from Early RRMS.

Front Neurosci 2016 2;10:14. Epub 2016 Feb 2.

Department of Neurology and Neuroimaging Center of the Focus Program Translational Neuroscience, University Medical Center of the Johannes Gutenberg-University Mainz Mainz, Germany.

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February 2016

Evidence for early, non-lesional cerebellar damage in patients with multiple sclerosis: DTI measures correlate with disability, atrophy, and disease duration.

Mult Scler 2016 Jan 28;22(1):73-84. Epub 2015 Apr 28.

Department of Neurology, Westfälische Wilhelms University, Albert-Schweitzer-Campus 1, Gebäude A1, Münster, 48149, Germany.

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January 2016

Gatekeeper role of brain antigen-presenting CD11c+ cells in neuroinflammation.

EMBO J 2016 Jan 26;35(1):89-101. Epub 2015 Nov 26.

Department of Neurology, Focus Program Translational Neurosciences (FTN), Research Center for Immunotherapy (FZI), Rhine-Main Neuroscience Network (rmn²) University Medical Center of the Johannes Gutenberg University, Mainz, Germany

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January 2016

Genome-wide significant association with seven novel multiple sclerosis risk loci.

J Med Genet 2015 Dec 16;52(12):848-55. Epub 2015 Oct 16.

Platform for Genome Analytics, Institutes of Neurogenetics & Integrative and Experimental Genomics, University of Lübeck, Lübeck, Germany Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin, Germany Department of Medicine, School of Public Health, Imperial College London, London, UK.

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December 2015

Role of Sortilin in Models of Autoimmune Neuroinflammation.

J Immunol 2015 Dec 13;195(12):5762-9. Epub 2015 Nov 13.

Department of Neurology, University Medical Center of the Johannes Gutenberg University Mainz, 55131 Mainz, Germany;

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December 2015

Putaminal alteration in multiple sclerosis patients with spinal cord lesions.

J Neural Transm (Vienna) 2015 Oct 14;122(10):1465-73. Epub 2015 May 14.

Department of Neurology and Neuroimaging Center (NIC) of the Focus Program Translational Neuroscience (FTN), University Medical Center of the Johannes Gutenberg-University Mainz, Langenbeckstraße 1, 55131, Mainz, Germany.

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October 2015

Increased cortical curvature reflects white matter atrophy in individual patients with early multiple sclerosis.

Neuroimage Clin 2014 3;6:475-87. Epub 2014 Mar 3.

Department of Neurology, Westfälische Wilhelms University, Münster, Germany.

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August 2015

FRET based ratiometric Ca(2+) imaging to investigate immune-mediated neuronal and axonal damage processes in experimental autoimmune encephalomyelitis.

J Neurosci Methods 2015 Jul 10;249:8-15. Epub 2015 Apr 10.

Neurology Department, University Medical Center of the Johannes Gutenberg University Mainz, 55131 Mainz, Germany.

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July 2015

Genetic Cell Ablation Reveals Clusters of Local Self-Renewing Microglia in the Mammalian Central Nervous System.

Immunity 2015 Jul 7;43(1):92-106. Epub 2015 Jul 7.

Institute for Molecular Medicine, University Medical Center of the Johannes Gutenberg-University Mainz, Obere Zahlbacher Str. 67, 55131 Mainz, Germany. Electronic address:

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July 2015

Identification of cortical lesions using DIR and FLAIR in early stages of multiple sclerosis.

J Neurol 2015 Jun 11;262(6):1473-82. Epub 2015 Apr 11.

Department of Neurology, Neuroimaging Center (NIC) of the Focus Program Translational Neuroscience (FTN), University Medical Center of the Johannes Gutenberg-University Mainz, Langenbeckstraße 1, 55131, Mainz, Germany.

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June 2015

New candidates for CD4 T cell pathogenicity in experimental neuroinflammation and multiple sclerosis.

Brain 2015 Apr 9;138(Pt 4):902-17. Epub 2015 Feb 9.

1 Department of Neurology, Focus Program Translational Neuroscience (FTN) and Immunotherapy (FZI), Rhine-Main Neuroscience Network (rmn), University Medical Centre of the Johannes Gutenberg University Mainz, Langenbeckstr. 1, 55131 Mainz, Germany

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April 2015

Long-term performance of the bovine pericardium patch in conventional carotid endarterectomy.

Thorac Cardiovasc Surg 2015 Mar 25;63(2):168-74. Epub 2014 Jun 25.

Department of Cardiothoracic and Vascular Surgery, University Medical Center, Mainz, Germany.

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March 2015

Cross-recognition of a myelin peptide by CD8+ T cells in the CNS is not sufficient to promote neuronal damage.

J Neurosci 2015 Mar;35(12):4837-50

Department of Neurology, Research Center Translational Neurosciences, Rhine Main Neuroscience Network (rmn), and Molecular Neurology Group, Max Delbrueck Center for Molecular Medicine Berlin-Buch, 13125 Berlin, Germany, Charité University Medicine Berlin, ECRC, 13125 Berlin, Germany, and

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March 2015

Perivascular microglia promote blood vessel disintegration in the ischemic penumbra.

Acta Neuropathol 2015 02 13;129(2):279-95. Epub 2014 Dec 13.

Department of Neurology, Focus Program Translational Neuroscience (FTN), Rhine Main Neuroscience Network (rmn2), Johannes Gutenberg University, University Medical Center, Mainz, Germany.

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February 2015

Molecular mechanisms linking neuroinflammation and neurodegeneration in MS.

Exp Neurol 2014 Dec 14;262 Pt A:8-17. Epub 2014 Feb 14.

Focus Program Translational Neurosciences (FTN), Rhine Main Neuroscience Network (rmn2), Department of Neurology, University Medical Center of the Johannes-Gutenberg University Mainz, Langenbeckstr. 1, 55131 Mainz, Germany. Electronic address:

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December 2014

Experimental applications of TNF-reporter mice with far-red fluorescent label.

Methods Mol Biol 2014 ;1155:151-62

German Rheumatism Research Center, a Leibniz Institute, Berlin, Germany.

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December 2014

Remyelinating strategies in multiple sclerosis.

Expert Rev Neurother 2014 Nov;14(11):1315-34

Department of Neurology, Focus Program Translational Neuroscience (FTN), Rhine Main Neuroscience Network (rmn²), University Medical Center of the Johannes Gutenberg-University of Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany.

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November 2014

Cardiotoxicity of mitoxantrone treatment in a german cohort of 639 multiple sclerosis patients.

J Clin Neurol 2014 Oct 6;10(4):289-95. Epub 2014 Oct 6.

Department of Neurology, Focus Program Translational Neuroscience, Rhine Main Neuroscience Network, University Medical Center, Johannes Gutenberg University of Mainz, Mainz, Germany.

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October 2014

IL-17 and related cytokines involved in the pathology and immunotherapy of multiple sclerosis: Current and future developments.

Cytokine Growth Factor Rev 2014 Aug 29;25(4):403-13. Epub 2014 Jul 29.

Department of Neurology, Focus Program Translational Neuroscience (FTN), Rhine Main Neuroscience Network (rmn(2)), University Medical Center of the Johannes Gutenberg University, Mainz, Germany.

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August 2014

Kinetics of IL-6 production defines T effector cell responsiveness to regulatory T cells in multiple sclerosis.

PLoS One 2013 14;8(10):e77634. Epub 2013 Oct 14.

Department of Dermatology, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany.

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June 2014

How to treat tumefactive demyelinating disease?

Mult Scler 2014 Apr 17;20(5):631-3. Epub 2013 Dec 17.

Department of Neurology, Johannes Gutenberg University Mainz, Germany.

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April 2014

Cladribine exerts an immunomodulatory effect on human and murine dendritic cells.

Int Immunopharmacol 2014 Feb 5;18(2):347-57. Epub 2013 Dec 5.

Department of Neurology, Focus Program Translational Neuroscience (FTN), Rhine Main Neuroscience Network (rmn(2)), University Medical Center of the Johannes Gutenberg-University of Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany.

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February 2014

Identification of inflammatory neuronal injury and prevention of neuronal damage in multiple sclerosis: hope for novel therapies?

JAMA Neurol 2013 Dec;70(12):1569-74

Department of Neurology, University of Münster, Münster, Germany.

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December 2013

Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis.

Authors:
Ashley H Beecham Nikolaos A Patsopoulos Dionysia K Xifara Mary F Davis Anu Kemppinen Chris Cotsapas Tejas S Shah Chris Spencer David Booth An Goris Annette Oturai Janna Saarela Bertrand Fontaine Bernhard Hemmer Claes Martin Frauke Zipp Sandra D'Alfonso Filippo Martinelli-Boneschi Bruce Taylor Hanne F Harbo Ingrid Kockum Jan Hillert Tomas Olsson Maria Ban Jorge R Oksenberg Rogier Hintzen Lisa F Barcellos Cristina Agliardi Lars Alfredsson Mehdi Alizadeh Carl Anderson Robert Andrews Helle Bach Søndergaard Amie Baker Gavin Band Sergio E Baranzini Nadia Barizzone Jeffrey Barrett Céline Bellenguez Laura Bergamaschi Luisa Bernardinelli Achim Berthele Viola Biberacher Thomas M C Binder Hannah Blackburn Izaura L Bomfim Paola Brambilla Simon Broadley Bruno Brochet Lou Brundin Dorothea Buck Helmut Butzkueven Stacy J Caillier William Camu Wassila Carpentier Paola Cavalla Elisabeth G Celius Irène Coman Giancarlo Comi Lucia Corrado Leentje Cosemans Isabelle Cournu-Rebeix Bruce A C Cree Daniele Cusi Vincent Damotte Gilles Defer Silvia R Delgado Panos Deloukas Alessia di Sapio Alexander T Dilthey Peter Donnelly Bénédicte Dubois Martin Duddy Sarah Edkins Irina Elovaara Federica Esposito Nikos Evangelou Barnaby Fiddes Judith Field Andre Franke Colin Freeman Irene Y Frohlich Daniela Galimberti Christian Gieger Pierre-Antoine Gourraud Christiane Graetz Andrew Graham Verena Grummel Clara Guaschino Athena Hadjixenofontos Hakon Hakonarson Christopher Halfpenny Gillian Hall Per Hall Anders Hamsten James Harley Timothy Harrower Clive Hawkins Garrett Hellenthal Charles Hillier Jeremy Hobart Muni Hoshi Sarah E Hunt Maja Jagodic Ilijas Jelčić Angela Jochim Brian Kendall Allan Kermode Trevor Kilpatrick Keijo Koivisto Ioanna Konidari Thomas Korn Helena Kronsbein Cordelia Langford Malin Larsson Mark Lathrop Christine Lebrun-Frenay Jeannette Lechner-Scott Michelle H Lee Maurizio A Leone Virpi Leppä Giuseppe Liberatore Benedicte A Lie Christina M Lill Magdalena Lindén Jenny Link Felix Luessi Jan Lycke Fabio Macciardi Satu Männistö Clara P Manrique Roland Martin Vittorio Martinelli Deborah Mason Gordon Mazibrada Cristin McCabe Inger-Lise Mero Julia Mescheriakova Loukas Moutsianas Kjell-Morten Myhr Guy Nagels Richard Nicholas Petra Nilsson Fredrik Piehl Matti Pirinen Siân E Price Hong Quach Mauri Reunanen Wim Robberecht Neil P Robertson Mariaemma Rodegher David Rog Marco Salvetti Nathalie C Schnetz-Boutaud Finn Sellebjerg Rebecca C Selter Catherine Schaefer Sandip Shaunak Ling Shen Simon Shields Volker Siffrin Mark Slee Per Soelberg Sorensen Melissa Sorosina Mireia Sospedra Anne Spurkland Amy Strange Emilie Sundqvist Vincent Thijs John Thorpe Anna Ticca Pentti Tienari Cornelia van Duijn Elizabeth M Visser Steve Vucic Helga Westerlind James S Wiley Alastair Wilkins James F Wilson Juliane Winkelmann John Zajicek Eva Zindler Jonathan L Haines Margaret A Pericak-Vance Adrian J Ivinson Graeme Stewart David Hafler Stephen L Hauser Alastair Compston Gil McVean Philip De Jager Stephen J Sawcer Jacob L McCauley

Nat Genet 2013 Nov 29;45(11):1353-60. Epub 2013 Sep 29.

1] John P. Hussman Institute for Human Genomics, University of Miami, Miller School of Medicine, Miami, Florida, USA. [2].

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J Immunol 2013 Nov 11;191(10):4960-8. Epub 2013 Oct 11.

Department of Neurology, Focus Program Translational Neurosciences, Rhine Main Neuroscience Network, Johannes Gutenberg University Mainz, 55131 Mainz, Germany;

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Bilateral vertebral artery dissection, agenesis of both ICAs, and connective tissue aberrations.

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Two-photon imaging of immune cells in neural tissue.

Cold Spring Harb Protoc 2013 Mar 1;2013(3). Epub 2013 Mar 1.

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Multiple sclerosis in 2012: Novel therapeutic options and drug targets in MS.

Nat Rev Neurol 2013 Feb 22;9(2):72-3. Epub 2013 Jan 22.

Focus Program Translational Neuroscience, Rhine Main Neuroscience Network, Johannes Gutenberg University Medical Centre Mainz, Department of Neurology, Langenbeckstrasse 1, D-55131 Mainz, Germany.

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