Publications by authors named "Frank Westermann"

95Publications

Identification of VRK1 as a New Neuroblastoma Tumor Progression Marker Regulating Cell Proliferation.

Cancers (Basel) 2020 Nov 20;12(11). Epub 2020 Nov 20.

Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, 41013 Seville, Spain.

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November 2020

Therapeutic vulnerabilities in the DNA damage response for the treatment of ATRX mutant neuroblastoma.

EBioMedicine 2020 Sep 23;59:102971. Epub 2020 Aug 23.

Paediatric Tumour Biology, Division of Clinical Studies, The Institute of Cancer Research, Sutton, Surrey SM2 5NG, United Kingdom; Children and Young People's Unit, Royal Marsden NHS Foundation Trust, Sutton, Surrey SM2 5PT United Kingdom.

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September 2020

Functional high-throughput screening reveals miR-323a-5p and miR-342-5p as new tumor-suppressive microRNA for neuroblastoma.

Cell Mol Life Sci 2019 Jun 15;76(11):2231-2243. Epub 2019 Feb 15.

Group of Translational Research in Child and Adolescent Cancer, Vall d'Hebron Research Institute (VHIR)-Universitat Autònoma de Barcelona (UAB), Passeig Vall d'Hebron 119-129, Collserola Building. Lab 207, 08035, Barcelona, Spain.

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June 2019

Comparative Analysis of Dry and Wet Porometry Methods for Characterization of Regular and Cross-Linked Virus Removal Filter Papers.

Membranes (Basel) 2018 Dec 20;9(1). Epub 2018 Dec 20.

Division for Nanotechnology and Functional Materials, Department for Engineering Sciences, Uppsala University, Box 534, SE-751 21 Uppsala, Sweden.

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December 2018

Author Correction: The landscape of genomic alterations across childhood cancers.

Nature 2018 07;559(7714):E10

Hopp-Children's Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany.

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July 2018

The landscape of genomic alterations across childhood cancers.

Nature 2018 03 28;555(7696):321-327. Epub 2018 Feb 28.

Hopp-Children's Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany.

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March 2018

Cell-Cycle Position of Single MYC-Driven Cancer Cells Dictates Their Susceptibility to a Chemotherapeutic Drug.

Cell Syst 2017 09 23;5(3):237-250.e8. Epub 2017 Aug 23.

Division of Theoretical Systems Biology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany; Bioquant Center, University of Heidelberg, 69120 Heidelberg, Germany. Electronic address:

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September 2017

SwitchFinder - a novel method and query facility for discovering dynamic gene expression patterns.

BMC Bioinformatics 2016 Dec 15;17(1):532. Epub 2016 Dec 15.

B-IT Bonn-Aachen International Center for Information Technology, University of Bonn, Dahlmannstr. 2, Bonn, 53113, Germany.

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December 2016

Establishment of an Immortalized Skin Keratinocyte Cell Line Derived from the Animal Model Mastomys coucha.

PLoS One 2016 17;11(8):e0161283. Epub 2016 Aug 17.

Division of Viral Transformation Mechanisms (F030), German Cancer Research Center, Heidelberg, Germany.

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August 2017

Next-generation personalised medicine for high-risk paediatric cancer patients - The INFORM pilot study.

Eur J Cancer 2016 09 29;65:91-101. Epub 2016 Jul 29.

Department of Pediatric Oncology, Hematology & Immunology, Heidelberg University Hospital, Im Neuenheimer Feld 430, Heidelberg, 69120, Germany; German Cancer Consortium (DKTK), Im Neuenheimer Feld 280, Heidelberg, 69120, Germany; Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg, 69120, Germany. Electronic address:

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September 2016

Signaling pathway models as biomarkers: Patient-specific simulations of JNK activity predict the survival of neuroblastoma patients.

Sci Signal 2015 Dec 22;8(408):ra130. Epub 2015 Dec 22.

Systems Biology Ireland, University College Dublin, Belfield, Dublin 4, Ireland. The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Sydney, New South Wales 2010, Australia. St Vincent's Clinical School, University of New South Wales, Sydney, New South Wales 2052, Australia.

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December 2015

Targeting MYCN-Driven Transcription By BET-Bromodomain Inhibition.

Clin Cancer Res 2016 05 2;22(10):2470-81. Epub 2015 Dec 2.

Department of Pediatric Oncology and Hematology, University Children's Hospital Essen, Essen, Germany. German Consortium for Translational Cancer Research (DKTK), Partner Site Essen/Duesseldorf, Essen, Germany. Neuroblastoma Genomics, B087, German Cancer Research Center (DKFZ), Heidelberg, Germany. Translational Neuro-Oncology, West German Cancer Center (WTZ), University Hospital Essen, University Duisburg-Essen, Essen, Germany. Centre for Medical Biotechnology, University Duisburg-Essen, Essen, Germany.

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May 2016

Transcription factor activating protein 2 beta (TFAP2B) mediates noradrenergic neuronal differentiation in neuroblastoma.

Mol Oncol 2016 Feb 7;10(2):344-59. Epub 2015 Nov 7.

Department of Pediatric Oncology and Hematology, University Children's Hospital of Cologne, Germany; Center for Molecular Medicine Cologne (CMMC), University of Cologne, Germany; Max Planck Institute for Metabolism Research, Cologne, Germany. Electronic address:

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February 2016

Large-scale tracking and classification for automatic analysis of cell migration and proliferation, and experimental optimization of high-throughput screens of neuroblastoma cells.

Cytometry A 2015 Jun 28;87(6):524-40. Epub 2015 Jan 28.

Department of Bioinformatics and Functional Genomics, Biomedical Computer Vision Group, BioQuant and Institute of Pharmacy and Molecular Biotechnology (IPMB), Heidelberg University, 69120, Heidelberg, Germany.

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June 2015

NOTCH ligands JAG1 and JAG2 as critical pro-survival factors in childhood medulloblastoma.

Acta Neuropathol Commun 2014 Apr 7;2:39. Epub 2014 Apr 7.

Department of Oncology, University Children's Hospital of Zurich, Zurich, Switzerland.

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April 2014

GRHL1 acts as tumor suppressor in neuroblastoma and is negatively regulated by MYCN and HDAC3.

Cancer Res 2014 May 13;74(9):2604-16. Epub 2014 Jan 13.

Authors' Affiliations: Clinical Cooperation Unit Pediatric Oncology; Departments of Biostatistics and Tumor Genetics; Clinical Cooperation Unit Neuropathology; Division of Epigenomics and Cancer Risk Factors, German Cancer Research Center (DKFZ); Departments of Neuropathology and Pediatric Hematology and Oncology, University of Heidelberg, Heidelberg; Transcriptome Analysis Laboratory, University of Goettingen, Goettingen; St. Lukas Klinik Solingen, Solingen; Department of Pediatric Hematology and Oncology; and Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany.

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May 2014

Cell survival signalling through PPARδ and arachidonic acid metabolites in neuroblastoma.

PLoS One 2013 9;8(7):e68859. Epub 2013 Jul 9.

Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, United Kingdom.

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February 2014

Stronger prognostic power of the CpG island methylator phenotype than methylation of individual genes in neuroblastomas.

Jpn J Clin Oncol 2013 Jun 25;43(6):641-5. Epub 2013 Apr 25.

Division of Epigenomics, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan.

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June 2013

Time-lapse imaging of neuroblastoma cells to determine cell fate upon gene knockdown.

PLoS One 2012 12;7(12):e50988. Epub 2012 Dec 12.

Department of Bioinformatics and Functional Genomics, Institute of Pharmacy and Molecular Biotechnology, Bioquant, University of Heidelberg, Heidelberg, Germany.

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June 2013

1p36 tumor suppression--a matter of dosage?

Cancer Res 2012 Dec 20;72(23):6079-88. Epub 2012 Nov 20.

Division of Tumor Genetics B030, German Cancer Research Center, Heidelberg, Germany.

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December 2012

Cep63 recruits Cdk1 to the centrosome: implications for regulation of mitotic entry, centrosome amplification, and genome maintenance.

Cancer Res 2011 Mar;71(6):2129-39

Clinical Cooperation Unit Molecular Hematology/Oncology, German Cancer Research Center and Department of Medicine V, University of Heidelberg, Germany.

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March 2011

CAMTA1, a 1p36 tumor suppressor candidate, inhibits growth and activates differentiation programs in neuroblastoma cells.

Cancer Res 2011 Apr 8;71(8):3142-51. Epub 2011 Mar 8.

Division of Tumor Genetics B030, Clinical Cooperation Unit Pediatric Oncology G340, German Cancer Research Center, Bioquant, Heidelberg, Germany.

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April 2011

The MicroArray Quality Control (MAQC)-II study of common practices for the development and validation of microarray-based predictive models.

Authors:
Leming Shi Gregory Campbell Wendell D Jones Fabien Campagne Zhining Wen Stephen J Walker Zhenqiang Su Tzu-Ming Chu Federico M Goodsaid Lajos Pusztai John D Shaughnessy André Oberthuer Russell S Thomas Richard S Paules Mark Fielden Bart Barlogie Weijie Chen Pan Du Matthias Fischer Cesare Furlanello Brandon D Gallas Xijin Ge Dalila B Megherbi W Fraser Symmans May D Wang John Zhang Hans Bitter Benedikt Brors Pierre R Bushel Max Bylesjo Minjun Chen Jie Cheng Jing Cheng Jeff Chou Timothy S Davison Mauro Delorenzi Youping Deng Viswanath Devanarayan David J Dix Joaquin Dopazo Kevin C Dorff Fathi Elloumi Jianqing Fan Shicai Fan Xiaohui Fan Hong Fang Nina Gonzaludo Kenneth R Hess Huixiao Hong Jun Huan Rafael A Irizarry Richard Judson Dilafruz Juraeva Samir Lababidi Christophe G Lambert Li Li Yanen Li Zhen Li Simon M Lin Guozhen Liu Edward K Lobenhofer Jun Luo Wen Luo Matthew N McCall Yuri Nikolsky Gene A Pennello Roger G Perkins Reena Philip Vlad Popovici Nathan D Price Feng Qian Andreas Scherer Tieliu Shi Weiwei Shi Jaeyun Sung Danielle Thierry-Mieg Jean Thierry-Mieg Venkata Thodima Johan Trygg Lakshmi Vishnuvajjala Sue Jane Wang Jianping Wu Yichao Wu Qian Xie Waleed A Yousef Liang Zhang Xuegong Zhang Sheng Zhong Yiming Zhou Sheng Zhu Dhivya Arasappan Wenjun Bao Anne Bergstrom Lucas Frank Berthold Richard J Brennan Andreas Buness Jennifer G Catalano Chang Chang Rong Chen Yiyu Cheng Jian Cui Wendy Czika Francesca Demichelis Xutao Deng Damir Dosymbekov Roland Eils Yang Feng Jennifer Fostel Stephanie Fulmer-Smentek James C Fuscoe Laurent Gatto Weigong Ge Darlene R Goldstein Li Guo Donald N Halbert Jing Han Stephen C Harris Christos Hatzis Damir Herman Jianping Huang Roderick V Jensen Rui Jiang Charles D Johnson Giuseppe Jurman Yvonne Kahlert Sadik A Khuder Matthias Kohl Jianying Li Li Li Menglong Li Quan-Zhen Li Shao Li Zhiguang Li Jie Liu Ying Liu Zhichao Liu Lu Meng Manuel Madera Francisco Martinez-Murillo Ignacio Medina Joseph Meehan Kelci Miclaus Richard A Moffitt David Montaner Piali Mukherjee George J Mulligan Padraic Neville Tatiana Nikolskaya Baitang Ning Grier P Page Joel Parker R Mitchell Parry Xuejun Peng Ron L Peterson John H Phan Brian Quanz Yi Ren Samantha Riccadonna Alan H Roter Frank W Samuelson Martin M Schumacher Joseph D Shambaugh Qiang Shi Richard Shippy Shengzhu Si Aaron Smalter Christos Sotiriou Mat Soukup Frank Staedtler Guido Steiner Todd H Stokes Qinglan Sun Pei-Yi Tan Rong Tang Zivana Tezak Brett Thorn Marina Tsyganova Yaron Turpaz Silvia C Vega Roberto Visintainer Juergen von Frese Charles Wang Eric Wang Junwei Wang Wei Wang Frank Westermann James C Willey Matthew Woods Shujian Wu Nianqing Xiao Joshua Xu Lei Xu Lun Yang Xiao Zeng Jialu Zhang Li Zhang Min Zhang Chen Zhao Raj K Puri Uwe Scherf Weida Tong Russell D Wolfinger

Nat Biotechnol 2010 Aug 30;28(8):827-38. Epub 2010 Jul 30.

National Center for Toxicological Research, US Food and Drug Administration, Jefferson, Arkansas, USA.

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August 2010

PathWave: discovering patterns of differentially regulated enzymes in metabolic pathways.

Bioinformatics 2010 May 24;26(9):1225-31. Epub 2010 Mar 24.

Department of Bioinformatics and Functional Genomics, University of Heidelberg, Heidelberg, Germany.

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May 2010

miR-9, a MYC/MYCN-activated microRNA, regulates E-cadherin and cancer metastasis.

Nat Cell Biol 2010 Mar 21;12(3):247-56. Epub 2010 Feb 21.

Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA.

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March 2010

A novel and universal method for microRNA RT-qPCR data normalization.

Genome Biol 2009 16;10(6):R64. Epub 2009 Jun 16.

Center for Medical Genetics, Ghent University Hospital, De Pintelaan 185, Ghent, Belgium.

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September 2009

Molecular characterization and classification of neuroblastoma.

Future Oncol 2009 Jun;5(5):625-39

University Children's Hospital, Department of Pediatric Oncology, Cologne, Germany.

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June 2009

Regulation of BIRC5 and its isoform BIRC5-2B in neuroblastoma.

Cancer Lett 2009 Nov 3;285(1):99-107. Epub 2009 Jun 3.

Department of Tumor Genetics, German Cancer Research Center, Heidelberg, Germany.

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November 2009

Heterogeneity of the MYCN oncogene in neuroblastoma.

Clin Cancer Res 2009 Mar 10;15(6):2085-90. Epub 2009 Mar 10.

Department of Pediatric Oncology and Hematology, Children's Hospital, University of Cologne, Cologne, Germany.

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March 2009

Cathepsin D protects human neuroblastoma cells from doxorubicin-induced cell death.

Carcinogenesis 2008 Oct 19;29(10):1869-77. Epub 2008 Jun 19.

Department of Tumor Genetics B030, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.

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October 2008

New miRNAs cloned from neuroblastoma.

BMC Genomics 2008 Jan 29;9:52. Epub 2008 Jan 29.

Department of Tumour Genetics, B030, German Cancer Research Center, Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany.

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January 2008

Novel aphidicolin-inducible common fragile site FRA9G maps to 9p22.2, within the C9orf39 gene.

Genes Chromosomes Cancer 2007 Nov;46(11):991-9

Division of Tumor Genetics, German Cancer Research Center, Im Neuenheimer Feld, Heidelberg, Germany.

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November 2007

Cross-study analysis of gene expression data for intermediate neuroblastoma identifies two biological subtypes.

BMC Cancer 2007 May 25;7:89. Epub 2007 May 25.

Department of Theoretical Bioinformatics (B080), German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg, Germany.

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May 2007

Allelic variants of CAMTA1 and FLJ10737 within a commonly deleted region at 1p36 in neuroblastoma.

Eur J Cancer 2007 Feb 11;43(3):607-16. Epub 2007 Jan 11.

Division of Tumour Genetics B030, German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.

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February 2007

Targeted MYCN expression affects cytotoxic potential of chemotherapeutic drugs in neuroblastoma cells.

Cancer Lett 2007 May 4;250(1):17-24. Epub 2006 Dec 4.

Division of Tumour Genetics, German Cancer Research Center, DKFZ, Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany.

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May 2007

Classification of neuroblastoma patients by published gene-expression markers reveals a low sensitivity for unfavorable courses of MYCN non-amplified disease.

Cancer Lett 2007 Jun 28;250(2):250-67. Epub 2006 Nov 28.

Children's Hospital, Department of Pediatric Oncology and Hematology and Center for Molecular Medicine Cologne (CMMC), University of Cologne, Kerpener Strasse 62, D-50924 Cologne, Germany.

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June 2007

Increased WSB1 copy number correlates with its over-expression which associates with increased survival in neuroblastoma.

Genes Chromosomes Cancer 2006 Sep;45(9):856-62

Oncogenomics Section, Pediatric Oncology Branch, Advanced Technology Center, National Cancer Institute, 8717 Grovemont Circle, Gaithersburg, MD 20877, USA.

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September 2006

Marked and independent prognostic significance of the CpG island methylator phenotype in neuroblastomas.

Cancer Lett 2007 Mar 6;247(2):253-8. Epub 2006 Jun 6.

Carcinogenesis Division, National Cancer Center Research Institute, University of Tokyo Graduate School of Medicine, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan.

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March 2007

Characterization of a complex genomic alteration on chromosome 2p that leads to four alternatively spliced fusion transcripts in the neuroblastoma cell lines IMR-5, IMR-5/75 and IMR-32.

Gene 2005 Dec 10;363:41-50. Epub 2005 Oct 10.

Children's Hospital, Department of Pediatric Oncology and Hematology and Center for Molecular Medicine Cologne, University of Cologne, Kerpener Strasse 62, D-50924 Köln, Cologne, Germany.

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December 2005

Altered expression of cell cycle genes distinguishes aggressive neuroblastoma.

Oncogene 2005 Feb;24(9):1533-41

Oncogenomics Section, Pediatric Oncology Branch, Advanced Technology Center, National Cancer Institute, 8717 Grovemont Circle, Gaithersburg, MD 20877, USA.

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February 2005

cDNA array-CGH profiling identifies genomic alterations specific to stage and MYCN-amplification in neuroblastoma.

BMC Genomics 2004 Sep 20;5:70. Epub 2004 Sep 20.

Oncogenomics Section, Pediatric Oncology Branch, Advanced Technology Center, National Cancer Institute, 8717 Grovemont Circle, Gaithersburg, MD 20877, USA.

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September 2004

Increased rates of spontaneous sister chromatid exchange in lymphocytes of BRCA2+/- carriers of familial breast cancer clusters.

Cancer Lett 2004 Jul;210(1):85-94

Deutsches Krebsforschungszentrum, Abteilung Tumorgenetik B030, Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany.

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July 2004

Neuroblastoma: biology and molecular and chromosomal pathology.

Lancet Oncol 2003 Aug;4(8):472-80

Division of Tumour Genetics, German Cancer Research Centre, Heidelberg, Germany.

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August 2003

Ataxin-2 promotes apoptosis of human neuroblastoma cells.

Oncogene 2003 Jan;22(3):401-11

Department of Cytogenetics (H0400), German Cancer Research Center, Heidelberg, Germany.

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January 2003

Genetic parameters of neuroblastomas.

Cancer Lett 2002 Oct;184(2):127-47

Department of Cytogenetics (H0400), German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.

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October 2002