Frank Stegmeier

Frank Stegmeier

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Frank Stegmeier

Frank Stegmeier

Publications by authors named "Frank Stegmeier"

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34Publications

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Project DRIVE: A Compendium of Cancer Dependencies and Synthetic Lethal Relationships Uncovered by Large-Scale, Deep RNAi Screening.

Cell 2017 Jul;170(3):577-592.e10

Novartis Institutes for Biomedical Research, Oncology Disease Area, Basel 4002, Switzerland; Cambridge, MA 02139, USA; and Emeryville, CA 94608, USA.

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http://dx.doi.org/10.1016/j.cell.2017.07.005DOI Listing
July 2017

A chemical genetics approach for the functional assessment of novel cancer genes.

Cancer Res 2015 May 18;75(10):1949-58. Epub 2015 Mar 18.

Oncology Disease Area, Novartis Institutes for BioMedical Research, Cambridge, Massachusetts.

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http://dx.doi.org/10.1158/0008-5472.CAN-14-2930DOI Listing
May 2015

MELK is an oncogenic kinase essential for mitotic progression in basal-like breast cancer cells.

Elife 2014 May 20;3:e01763. Epub 2014 May 20.

Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, United States Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, United States

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https://elifesciences.org/articles/01763
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http://dx.doi.org/10.7554/eLife.01763DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4059381PMC
May 2014

An F876L mutation in androgen receptor confers genetic and phenotypic resistance to MDV3100 (enzalutamide).

Cancer Discov 2013 Sep 10;3(9):1030-43. Epub 2013 Jul 10.

1Oncology Disease Area, 2Department of Oncology Translational Medicine, Novartis Institutes for BioMedical Research, Cambridge; and 3Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts.

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http://cancerdiscovery.aacrjournals.org/cgi/doi/10.1158/2159
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http://dx.doi.org/10.1158/2159-8290.CD-13-0142DOI Listing
September 2013

PI3K pathway activation mediates resistance to MEK inhibitors in KRAS mutant cancers.

Cancer Res 2009 May 28;69(10):4286-93. Epub 2009 Apr 28.

Novartis Institutes for BioMedical Research, Cambridge, MA, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-08-4765DOI Listing
May 2009

PTEN-deficient cancers depend on PIK3CB.

Proc Natl Acad Sci U S A 2008 Sep 28;105(35):13057-62. Epub 2008 Aug 28.

Novartis Institutes for BioMedical Research, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1073/pnas.0802655105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2529105PMC
September 2008

A functional genomic screen identifies a role for TAO1 kinase in spindle-checkpoint signalling.

Nat Cell Biol 2007 May 8;9(5):556-64. Epub 2007 Apr 8.

Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1038/ncb1569DOI Listing
May 2007

The tumor suppressor CYLD regulates entry into mitosis.

Proc Natl Acad Sci U S A 2007 May 10;104(21):8869-74. Epub 2007 May 10.

Department of Genetics, Harvard Medical School, Center for Genetics and Genomics, Howard Hughes Medical Institute, Brigham and Women's Hospital, Boston, MA 02115, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0703268104
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http://dx.doi.org/10.1073/pnas.0703268104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1867381PMC
May 2007

Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities.

Nature 2007 Apr;446(7138):876-81

Howard Hughes Medical Institute, Department of Genetics, Harvard Partners Center for Genetics and Genomics,Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/nature05694DOI Listing
April 2007

Identification and classification of genes that act antagonistically to let-60 Ras signaling in Caenorhabditis elegans vulval development.

Genetics 2006 Jun 19;173(2):709-26. Epub 2006 Apr 19.

Department of Biology, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

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http://dx.doi.org/10.1534/genetics.106.056465DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1526536PMC
June 2006

A lentiviral microRNA-based system for single-copy polymerase II-regulated RNA interference in mammalian cells.

Proc Natl Acad Sci U S A 2005 Sep 1;102(37):13212-7. Epub 2005 Sep 1.

Harvard University Medical School, Department of Genetics, Center for Genetics and Genomics, Howard Hughes Medical Institute, and Brigham and Women's Hospital, Boston, MA 02115, USA.

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http://dx.doi.org/10.1073/pnas.0506306102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1196357PMC
September 2005

Closing mitosis: the functions of the Cdc14 phosphatase and its regulation.

Annu Rev Genet 2004 ;38:203-32

Center for Cancer Research, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

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http://dx.doi.org/10.1146/annurev.genet.38.072902.093051DOI Listing
March 2005

Cdc14 and condensin control the dissolution of cohesin-independent chromosome linkages at repeated DNA.

Cell 2004 May;117(4):455-69

Center for Cancer Research, Howard Hughes Medical Institute, Massachusetts Institute of Technology, E17-233, 40 Ames Street, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1016/s0092-8674(04)00413-1DOI Listing
May 2004

The replication fork block protein Fob1 functions as a negative regulator of the FEAR network.

Curr Biol 2004 Mar;14(6):467-80

Center for Cancer Research, Howard Hughes Medical Institute, Massachusetts Institute of Technology, E17-233, 40 Ames St., Cambridge, MA 02139, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S096098220400174
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http://dx.doi.org/10.1016/j.cub.2004.03.009DOI Listing
March 2004

The role of the polo kinase Cdc5 in controlling Cdc14 localization.

Mol Biol Cell 2003 Nov 7;14(11):4486-98. Epub 2003 Aug 7.

Center for Cancer Research, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

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http://dx.doi.org/10.1091/mbc.e03-02-0095DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC266767PMC
November 2003

Separase, polo kinase, the kinetochore protein Slk19, and Spo12 function in a network that controls Cdc14 localization during early anaphase.

Cell 2002 Jan;108(2):207-20

Center for Cancer Research, Howard Hughes Medical Institute, Massachusetts Institute of Technology, E17-233, 40 Ames Street, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1016/s0092-8674(02)00618-9DOI Listing
January 2002