Frank Speleman

Frank Speleman

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SMARTer single cell total RNA sequencing.

Nucleic Acids Res 2019 09;47(16):e93

Center for Medical Genetics, Ghent University, Ghent, Belgium.

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http://dx.doi.org/10.1093/nar/gkz535DOI Listing
September 2019

Long noncoding RNA expression profiling in cancer: Challenges and opportunities.

Genes Chromosomes Cancer 2019 04 20;58(4):191-199. Epub 2019 Jan 20.

Center for Medical Genetics Ghent (CMGG), Ghent University, Ghent, Belgium.

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http://dx.doi.org/10.1002/gcc.22709DOI Listing
April 2019

Pinpointing a potential role for CLEC12B in cancer predisposition through familial exome sequencing.

Pediatr Blood Cancer 2019 02 23;66(2):e27513. Epub 2018 Oct 23.

Department of Pediatric Hematology-Oncology and Stem Cell Transplantation, Ghent University Hospital, Ghent, Belgium.

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http://doi.wiley.com/10.1002/pbc.27513
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http://dx.doi.org/10.1002/pbc.27513DOI Listing
February 2019

DREAM target reactivation by core transcriptional regulators supports neuroblastoma growth.

Mol Cell Oncol 2019 3;6(2):1565470. Epub 2019 Feb 3.

Center for Medical Genetics, Ghent University, Ghent, Belgium.

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http://dx.doi.org/10.1080/23723556.2019.1565470DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6512935PMC
February 2019

Integrated proximal proteomics reveals IRS2 as a determinant of cell survival in ALK-driven neuroblastoma.

Sci Signal 2018 11 20;11(557). Epub 2018 Nov 20.

Proteomics Program, Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, DK-2200 Copenhagen, Denmark.

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http://dx.doi.org/10.1126/scisignal.aap9752DOI Listing
November 2018

Meta-mining of copy number profiles of high-risk neuroblastoma tumors.

Sci Data 2018 10 30;5:180240. Epub 2018 Oct 30.

Center for Medical Genetics, Ghent University, Ghent, Belgium.

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http://dx.doi.org/10.1038/sdata.2018.240DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6207068PMC
October 2018

Cell of origin dictates aggression and stem cell number in acute lymphoblastic leukemia.

Leukemia 2018 08 18;32(8):1860-1865. Epub 2018 Apr 18.

Department of Pathology, Massachusetts General Hospital Research Institute, Boston, MA, 02114, USA.

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http://dx.doi.org/10.1038/s41375-018-0130-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6620784PMC
August 2018

Epigenetic regulation of neuroblastoma development.

Cell Tissue Res 2018 May 19;372(2):309-324. Epub 2018 Jan 19.

Center for Medical Genetics, Ghent University, Ghent, Belgium.

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http://dx.doi.org/10.1007/s00441-017-2773-yDOI Listing
May 2018

Correction to: Epigenetic regulation of neuroblastoma development.

Cell Tissue Res 2018 05;372(2):443

Center for Medical Genetics, Ghent University, Ghent, Belgium.

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http://dx.doi.org/10.1007/s00441-018-2811-4DOI Listing
May 2018

Promoter-associated proteins of EPAS1 identified by enChIP-MS - A putative role of HDX as a negative regulator.

Biochem Biophys Res Commun 2018 05 26;499(2):291-298. Epub 2018 Mar 26.

Department of Pediatrics, Clinical Sciences, Lund University, Lund, Sweden. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2018.03.150DOI Listing
May 2018

Early and late effects of pharmacological ALK inhibition on the neuroblastoma transcriptome.

Oncotarget 2017 Dec 6;8(63):106820-106832. Epub 2017 Nov 6.

Center for Medical Genetics, Ghent University, Ghent, Belgium.

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http://dx.doi.org/10.18632/oncotarget.22423DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5739776PMC
December 2017

Dynamic Activity of miR-125b and miR-93 during Murine Neural Stem Cell Differentiation In Vitro and in the Subventricular Zone Neurogenic Niche.

PLoS One 2013 27;8(6):e67411. Epub 2013 Jun 27.

San Raffaele Scientific Institute, Telethon Institute for Gene Therapy (TIGET), Milano, Italy ; Department of Experimental Medicine and Biochemical Sciences, Section of Biochemistry and Molecular Biology, University of Perugia, Perugia, Italy.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0067411PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3694868PMC
October 2017

Long non-coding RNAs in leukemia: biology and clinical impact.

Curr Opin Hematol 2017 Jul;24(4):353-358

aDepartment of Pediatric Hematology-Oncology and Stem Cell Transplantation, Ghent University Hospital bCancer Research Institute Ghent (CRIG) cCenter for Medical Genetics Ghent, Ghent University, Ghent, Belgium.

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http://Insights.ovid.com/crossref?an=00062752-201707000-0001
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http://dx.doi.org/10.1097/MOH.0000000000000354DOI Listing
July 2017

T-ALL and thymocytes: a message of noncoding RNAs.

J Hematol Oncol 2017 03 7;10(1):66. Epub 2017 Mar 7.

Center for Medical Genetics, Ghent University, Ghent, Belgium.

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http://dx.doi.org/10.1186/s13045-017-0432-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5341419PMC
March 2017

Neuroblastoma: A Tough Nut to Crack.

Am Soc Clin Oncol Educ Book 2016 ;35:e548-57

From the Center for Medical Genetics Ghent, Cancer Research Institute Ghent, Ghent, Belgium; Seattle Children's Hospital, Seattle, WA; Department of Pediatrics, University of Washington School of Medicine, Seattle, WA; University of Chicago Comer Children's Hospital, Chicago, IL.

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http://dx.doi.org/10.1200/EDBK_159169DOI Listing
January 2017

Glutathione biosynthesis is upregulated at the initiation of MYCN-driven neuroblastoma tumorigenesis.

Mol Oncol 2016 06 2;10(6):866-78. Epub 2016 Mar 2.

Children's Cancer Institute, Lowy Cancer Research Centre, University of New South Wales, Randwick 2031, Australia; Kids Cancer Centre, Sydney Children's Hospital, Randwick 2031, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.molonc.2016.02.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5423163PMC
June 2016

Targeting MYCN-Driven Transcription By BET-Bromodomain Inhibition.

Clin Cancer Res 2016 05 2;22(10):2470-81. Epub 2015 Dec 2.

Department of Pediatric Oncology and Hematology, University Children's Hospital Essen, Essen, Germany. German Consortium for Translational Cancer Research (DKTK), Partner Site Essen/Duesseldorf, Essen, Germany. Neuroblastoma Genomics, B087, German Cancer Research Center (DKFZ), Heidelberg, Germany. Translational Neuro-Oncology, West German Cancer Center (WTZ), University Hospital Essen, University Duisburg-Essen, Essen, Germany. Centre for Medical Biotechnology, University Duisburg-Essen, Essen, Germany.

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http://dx.doi.org/10.1158/1078-0432.CCR-15-1449DOI Listing
May 2016

GATA3 induces human T-cell commitment by restraining Notch activity and repressing NK-cell fate.

Nat Commun 2016 Apr 6;7:11171. Epub 2016 Apr 6.

Faculty of Medicine and Health Sciences, Department of Clinical Chemistry, Microbiology and Immunology, Ghent University, University Hospital Ghent, 4BlokA, De Pintelaan 185, B-9000 Ghent, Belgium.

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http://dx.doi.org/10.1038/ncomms11171DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4823830PMC
April 2016

DNA methylation profiling of primary neuroblastoma tumors using methyl-CpG-binding domain sequencing.

Sci Data 2016 Feb 2;3:160004. Epub 2016 Feb 2.

Center for Medical Genetics, Ghent University Hospital, De Pintelaan 185, Ghent 9000, Belgium.

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http://dx.doi.org/10.1038/sdata.2016.4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4736656PMC
February 2016

Molecular basis and clinical significance of genetic aberrations in B-cell precursor acute lymphoblastic leukemia.

Exp Hematol 2015 Aug 20;43(8):640-53. Epub 2015 Jun 20.

Department of Pediatric Hematology-Oncology and Stem Cell Transplantation, Ghent University Hospital, Ghent, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.exphem.2015.05.015DOI Listing
August 2015

Mutational dynamics between primary and relapse neuroblastomas.

Nat Genet 2015 Aug 29;47(8):872-7. Epub 2015 Jun 29.

1] Pediatric Oncology and Hematology, University Children's Hospital Essen, University of Duisburg-Essen, Essen, Germany. [2] Pediatric Oncology and Hematology, Charité University Medicine, Berlin, Germany. [3] German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), Heidelberg, Germany.

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http://search.proquest.com/openview/bef3fe020af3cd6708016aba
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http://dx.doi.org/10.1038/ng.3349DOI Listing
August 2015

Inhibition of CDK4/6 as a novel therapeutic option for neuroblastoma.

Cancer Cell Int 2015 30;15:76. Epub 2015 Jul 30.

Center for Medical Genetics, Ghent University, De Pintelaan 185, 9000 Ghent, Belgium.

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http://dx.doi.org/10.1186/s12935-015-0224-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4518532PMC
July 2015

miR-135a Inhibits Cancer Stem Cell-Driven Medulloblastoma Development by Directly Repressing Arhgef6 Expression.

Stem Cells 2015 May;33(5):1377-89

Neural Stem Cell Biology Unit, Division of Regenerative Medicine, Stem Cells and Gene Therapy, Telethon Institute for Gene Therapy, San Raffaele Scientific Institute, Milan, Italy; Vita-Salute San Raffaele University, Milan, Italy.

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http://dx.doi.org/10.1002/stem.1958DOI Listing
May 2015

miR-542-3p exerts tumor suppressive functions in neuroblastoma by downregulating Survivin.

Int J Cancer 2015 Mar 5;136(6):1308-20. Epub 2014 Aug 5.

Department of Pediatric Oncology and Hematology, University Children's Hospital Essen, Essen, Germany; German Cancer Consortium (DKTK), Germany.

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http://dx.doi.org/10.1002/ijc.29091DOI Listing
March 2015

Epigenetics in T-cell acute lymphoblastic leukemia.

Immunol Rev 2015 Jan;263(1):50-67

Center for Medical Genetics, Ghent University, Ghent, Belgium.

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http://doi.wiley.com/10.1111/imr.12237
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http://dx.doi.org/10.1111/imr.12237DOI Listing
January 2015

ZEB2 drives immature T-cell lymphoblastic leukaemia development via enhanced tumour-initiating potential and IL-7 receptor signalling.

Nat Commun 2015 Jan 7;6:5794. Epub 2015 Jan 7.

1] Vascular Cell Biology Unit, VIB Inflammation Research Center, Ghent University, Ghent B-9052, Belgium [2] Department for Biomedical Molecular Biology, Ghent University, Ghent B-9052, Belgium [3] Mammalian Functional Genetics Laboratory, Division of Blood Cancers, Australian Centre for Blood Diseases, Department of Clinical Haematology, Monash University and Alfred Health Alfred Centre, 99 Commercial Road, Melbourne, Victoria 3004, Australia.

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http://dx.doi.org/10.1038/ncomms6794DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4354161PMC
January 2015

A nanobody modulates the p53 transcriptional program without perturbing its functional architecture.

Nucleic Acids Res 2014 Nov 16;42(20):12928-38. Epub 2014 Oct 16.

Nanobody Lab, Department of Biochemistry, Ghent University, Albert Baertsoenkaai 3, B-9000 Ghent, Belgium

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http://dx.doi.org/10.1093/nar/gku962DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4227789PMC
November 2014

Emergence of new ALK mutations at relapse of neuroblastoma.

J Clin Oncol 2014 Sep 28;32(25):2727-34. Epub 2014 Jul 28.

Gudrun Schleiermacher, Julie Cappo, Isabelle Janoueix-Lerosey, and Olivier Delattre, L'Institut National de la Santé et de la Recherche Médicale U830, Laboratoire de Génétique et Biologie des Cancers; Gudrun Schleiermacher, Virginie Bernard, Quentin Leroy, Thomas Rio Frio, Gaelle Pierron, Eve Lapouble, and Jean Michon, Institut Curie; Michel Peuchmaur, Assistance Publique-Hôpitaux de Paris, Hôpital Universitaire Robert Debré, Service de Pathologie; Michel Peuchmaur, Université Diderot Paris 7, Sorbonne Paris-Cité, Paris; Valérie Combaret, Centre Léon-Bérard, Laboratoire de Recherche Translationnelle, Lyon, France; Niloufar Javanmardi, Anna Djos, Jonas Abrahamsson, and Tommy Martinsson, The Sahlgrenska Academy, University of Gothenburg, Sahlgrenska University Hospital, Gothenburg; Ingrid Øra, Lund University, Lund; Fredrik Hedborg, Uppsala University, and Centre for Research and Development, Uppsala University/County Council of Gävleborg, Gävle; Catarina Träger and Per Kogner, Karolinska Institute, Astrid Lindgren Children's Hospital, Stockholm; Britt-Marie Holmqvist, Linköping University Hospital, Linköping, Sweden; Frank Speleman and Bram de Wilde, Center for Medical Genetics, Ghent University Hospital, Ghent, Belgium.

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http://dx.doi.org/10.1200/JCO.2013.54.0674DOI Listing
September 2014

Genome dynamics of the human embryonic kidney 293 lineage in response to cell biology manipulations.

Nat Commun 2014 Sep 3;5:4767. Epub 2014 Sep 3.

1] Unit for Medical Biotechnology, Inflammation Research Center, VIB, Technologiepark 927, Ghent B-9052, Belgium [2] Laboratory for Protein Biochemistry and Biomolecular Engineering, Department of Biochemistry and Microbiology, Ghent University, Ledeganckstraat 35, Ghent B-9052, Belgium.

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http://dx.doi.org/10.1038/ncomms5767DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4166678PMC
September 2014

The epigenetic landscape of T-cell acute lymphoblastic leukemia.

Int J Biochem Cell Biol 2014 Aug 28;53:547-57. Epub 2014 Apr 28.

Center for Medical Genetics, Ghent University, Ghent, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.biocel.2014.04.015DOI Listing
August 2014

A p53 drug response signature identifies prognostic genes in high-risk neuroblastoma.

PLoS One 2013 19;8(11):e79843. Epub 2013 Nov 19.

Texas Children's Cancer Center and Center for Cell and Gene Therapy, Department of Pediatrics, Baylor College of Medicine, Houston, Texas, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0079843PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3865347PMC
July 2014

The H3K27me3 demethylase UTX in normal development and disease.

Epigenetics 2014 May 21;9(5):658-68. Epub 2014 Feb 21.

Center for Medical Genetics; Ghent University; Ghent, Belgium.

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http://dx.doi.org/10.4161/epi.28298DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4063824PMC
May 2014

Pharmacologic activation of wild-type p53 by nutlin therapy in childhood cancer.

Cancer Lett 2014 Mar 18;344(2):157-65. Epub 2013 Nov 18.

Center for Medical Genetics, Ghent University Hospital, Ghent, Belgium.

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http://dx.doi.org/10.1016/j.canlet.2013.11.002DOI Listing
March 2014

Histone chaperone CHAF1A inhibits differentiation and promotes aggressive neuroblastoma.

Cancer Res 2014 Feb 12;74(3):765-74. Epub 2013 Dec 12.

Authors' Affiliations: Texas Children's Cancer Center and Center for Cell and Gene Therapy; Department of Surgery, Baylor College of Medicine, Houston, Texas; Center for Medical Genetics, Ghent University, Ghent, Belgium; CEINGE Biotecnologie Avanzate, Department of Biochemistry and Medical Biotechnology, University of Naples Federico II, Naples; Pediatric Research Institute, University of Padua, Padua; Paediatric Oncology and Haematology Unit "Lalla Seràgnoli," Sant'Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy; and Department of Oncogenomics, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.

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http://cancerres.aacrjournals.org/content/74/3/765.full.pdf
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http://cancerres.aacrjournals.org/content/early/2013/12/12/0
Web Search
http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
Publisher Site
http://dx.doi.org/10.1158/0008-5472.CAN-13-1315DOI Listing
February 2014

MiR-137 functions as a tumor suppressor in neuroblastoma by downregulating KDM1A.

Int J Cancer 2013 Sep 7;133(5):1064-73. Epub 2013 Mar 7.

Department of Pediatric Oncology and Hematology, University Children's Hospital Essen, Essen, Germany.

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http://dx.doi.org/10.1002/ijc.28091DOI Listing
September 2013

Identification of BIRC6 as a novel intervention target for neuroblastoma therapy.

BMC Cancer 2012 Jul 12;12:285. Epub 2012 Jul 12.

Department of Oncogenomics, Academic Medical Center, University of Amsterdam, Meibergdreef 15, PO box 22700, Amsterdam, AZ 1105, The Netherlands.

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http://dx.doi.org/10.1186/1471-2407-12-285DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3495678PMC
July 2012