Frank Sinner

Frank Sinner

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Insulin Distribution in Human Adipose Tissue via a Novel Insulin Infusion Catheter.

Diabetes Technol Ther 2019 Dec 3;21(12):740-744. Epub 2019 Oct 3.

Joanneum Research Forschungsgesellschaft mbH, HEALTH-Institute for Biomedicine and Health Sciences, Graz, Austria.

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http://dx.doi.org/10.1089/dia.2019.0195DOI Listing
December 2019

Comparison of cerebral Open Flow Microperfusion and Microdialysis when sampling small lipophilic and small hydrophilic substances.

J Neurosci Methods 2019 01 25;311:394-401. Epub 2018 Sep 25.

JOANNEUM RESEARCH Forschungsgesellschaft mbH, HEALTH - Institute for Biomedicine and Health Sciences, Neue Stiftingtalstraße 2, 8010 Graz, Austria. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01650270183029
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http://dx.doi.org/10.1016/j.jneumeth.2018.09.024DOI Listing
January 2019

Quantification of acyclovir in dermal interstitial fluid and human serum by ultra-high-performance liquid-high-resolution tandem mass spectrometry for topical bioequivalence evaluation.

Biomed Chromatogr 2018 Jun 27;32(6):e4194. Epub 2018 Feb 27.

Joanneum Research Forschungsgesellschaft mbH, HEALTH Institute for Biomedicine and Health Sciences, Graz, Austria.

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http://dx.doi.org/10.1002/bmc.4194DOI Listing
June 2018

A comprehensive approach to qualify and validate the essential parameters of an in vitro release test (IVRT) method for acyclovir cream, 5.

Int J Pharm 2018 Jan 19;535(1-2):217-227. Epub 2017 Sep 19.

Joanneum Research Forschungsgesellschaft mbH, Health - Institute for Biomedicine and Health Sciences, Neue Stiftingtalstr. 2, 8010 Graz, Austria.

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http://dx.doi.org/10.1016/j.ijpharm.2017.09.049DOI Listing
January 2018

Quantification of Basal Insulin Peglispro and Human Insulin in Adipose Tissue Interstitial Fluid by Open-Flow Microperfusion.

Diabetes Technol Ther 2017 05 22;19(5):305-314. Epub 2017 Mar 22.

1 HEALTH-Institute for Biomedicine and Health Sciences , Joanneum Research Forschungsgesellschaft mbH, Graz, Austria .

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http://dx.doi.org/10.1089/dia.2016.0384DOI Listing
May 2017

Open Flow Microperfusion as a Dermal Pharmacokinetic Approach to Evaluate Topical Bioequivalence.

Clin Pharmacokinet 2017 01;56(1):91-98

HEALTH-Institute for Biomedicine and Health Sciences, Joanneum Research Forschungsgesellschaft mbH, Neue Stiftingtalstrasse 2, 8010, Graz, Austria.

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http://dx.doi.org/10.1007/s40262-016-0442-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5222896PMC
January 2017

Erratum to: Open Flow Microperfusion as a Dermal Pharmacokinetic Approach to Evaluate Topical Bioequivalence.

Clin Pharmacokinet 2017 01;56(1):99

HEALTH-Institute for Biomedicine and Health Sciences, Joanneum Research Forschungsgesellschaft mbH, Neue Stiftingtalstrasse 2, 8010, Graz, Austria.

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http://dx.doi.org/10.1007/s40262-016-0487-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6828129PMC
January 2017

Determination of (2)H-enrichment of rat brain interstitial fluid and rat plasma by headspace-gas-chromatography - quadrupole-mass-spectrometry.

Anal Biochem 2016 09 9;509:130-134. Epub 2016 Jul 9.

Health - Institute for Biomedicine and Health Sciences, Joanneum Research Forschungsgesellschaft m.b.H, Neue Stiftingtalstrasse 2, 8010, Graz, Austria.

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http://dx.doi.org/10.1016/j.ab.2016.07.010DOI Listing
September 2016

Cerebral open flow microperfusion (cOFM) an innovative interface to brain tissue.

Drug Discov Today Technol 2016 Jun 2;20:19-25. Epub 2016 Dec 2.

Joanneum Research GmbH, HEALTH - Institute for Biomedicine and Health Sciences, Neue Stiftingtalstrasse 2, 8010 Graz, Austria; Medical University of Graz, Department of Internal Medicine, Division of Endocrinology and Diabetology, Auenbruggerplatz 15, 8036 Graz, Austria.

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https://linkinghub.elsevier.com/retrieve/pii/S17406749163001
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http://dx.doi.org/10.1016/j.ddtec.2016.07.003DOI Listing
June 2016

Detection of Peptide-based nanoparticles in blood plasma by ELISA.

PLoS One 2015 21;10(5):e0126136. Epub 2015 May 21.

Department of Neuroscience, School for Mental Health and Neuroscience, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, the Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0126136PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4440766PMC
February 2016

Long-term implanted cOFM probe causes minimal tissue reaction in the brain.

PLoS One 2014 12;9(3):e90221. Epub 2014 Mar 12.

HEALTH - Institute of Biomedicine and Health Sciences, JOANNEUM RESEARCH, Graz, Austria; Division of Endocrinology and Metabolism, Medical University of Graz, Graz, Austria.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0090221PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3951198PMC
May 2015

IPO: a tool for automated optimization of XCMS parameters.

BMC Bioinformatics 2015 Apr 16;16:118. Epub 2015 Apr 16.

Joanneum Research Forschungsgesellschaft m.b.H., HEALTH, Institute for Biomedicine and Health Sciences, Graz, Austria.

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http://dx.doi.org/10.1186/s12859-015-0562-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4404568PMC
April 2015

Integrated catheter system for continuous glucose measurement and simultaneous insulin infusion.

Biosens Bioelectron 2015 Feb 15;64:102-10. Epub 2014 Aug 15.

Institute of Analytical Chemistry and Food Chemistry, Graz University of Technology, Stremayrgasse 9/II, Graz 8010, Austria. Electronic address:

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http://dx.doi.org/10.1016/j.bios.2014.08.012DOI Listing
February 2015

Assessment of blood-brain barrier function and the neuroinflammatory response in the rat brain by using cerebral open flow microperfusion (cOFM).

PLoS One 2014 22;9(5):e98143. Epub 2014 May 22.

Division of Endocrinology and Metabolism, Medical University of Graz, Graz, Austria; HEALTH - Institute of Biomedicine and Health Sciences, Joanneum Research, Graz, Austria.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0098143PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4031165PMC
January 2015

The single-port concept: combining optical glucose measurement with insulin infusion.

Acta Diabetol 2014 Oct 1;51(5):883-6. Epub 2014 Apr 1.

HEALTH - Institute for Biomedicine and Health Sciences, Joanneum Research, Graz, Austria.

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http://dx.doi.org/10.1007/s00592-014-0578-yDOI Listing
October 2014

In vivo evaluation of thiolated chitosan tablets for oral insulin delivery.

J Pharm Sci 2014 Oct 19;103(10):3165-70. Epub 2014 Aug 19.

Department of Pharmaceutical Technology, Institute of Pharmacy, Center for Molecular Biosciences Innsbruck, University of Innsbruck, Innsbruck, Austria.

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http://dx.doi.org/10.1002/jps.24102DOI Listing
October 2014

Enhanced doxorubicin delivery to the brain administered through glutathione PEGylated liposomal doxorubicin (2B3-101) as compared with generic Caelyx,(®)/Doxil(®)--a cerebral open flow microperfusion pilot study.

J Pharm Sci 2014 Jul 6;103(7):1945-1948. Epub 2014 May 6.

HEALTH - Institute for Biomedicine and Health Sciences, Joanneum Research, Graz, Austria; Division of Endocrinology and Metabolism, Department of Internal Medicine, Medical University of Graz, Graz, Austria.

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https://linkinghub.elsevier.com/retrieve/pii/S00223549153050
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http://dx.doi.org/10.1002/jps.23994DOI Listing
July 2014

Design and physicochemical characterization of poly(amidoamine) nanoparticles and the toxicological evaluation in human endothelial cells: applications to peptide delivery to the brain.

J Biomater Sci Polym Ed 2013 2;24(8):957-71. Epub 2012 Oct 2.

Department of Biomedical Chemistry, Faculty of Science and Technology, MIRA Institute for Biomedical Technology & Technical Medicine, University of Twente, 217, 7500, AE Enschede, the Netherlands.

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http://dx.doi.org/10.1080/09205063.2012.727378DOI Listing
April 2014

Regulation of autophagy by cytosolic acetyl-coenzyme A.

Mol Cell 2014 Mar 20;53(5):710-25. Epub 2014 Feb 20.

Equipe 11 Labelisée par la Ligue Nationale Contre le Cancer, INSERM U1138, Centre de Recherche des Cordeliers, 75006 Paris, France; Metabolomics and Molecular Cell Biology Platforms, Gustave Roussy, 94805 Villejuif, France; Université Paris Descartes/Paris 5, Sorbonne Paris Cité, 75006 Paris, France; Pôle de Biologie, Hôpital Européen Georges Pompidou, AP-HP, 75015 Paris, France. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2014.01.016DOI Listing
March 2014

Polyamines in biological samples: rapid and robust quantification by solid-phase extraction online-coupled to liquid chromatography-tandem mass spectrometry.

J Chromatogr A 2014 Feb 14;1331:44-51. Epub 2014 Jan 14.

HEALTH-Institute for Biomedicine and Health Sciences, Joanneum Research, Forschungsgesellschaft m.b.H., Graz, Austria; Division of Endocrinology and Metabolism, Department of Internal Medicine, Medical University of Graz, Graz, Austria.

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https://linkinghub.elsevier.com/retrieve/pii/S00219673130194
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http://dx.doi.org/10.1016/j.chroma.2013.12.061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3991419PMC
February 2014

Cerebral open flow microperfusion: a new in vivo technique for continuous measurement of substance transport across the intact blood-brain barrier.

Clin Exp Pharmacol Physiol 2013 Dec;40(12):864-71

Joanneum Research GmbH, HEALTH-Institute for Biomedicine and Health Sciences, Graz, Austria.

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http://dx.doi.org/10.1111/1440-1681.12174DOI Listing
December 2013

Neuropeptide Y and peptide YY protect from weight loss caused by Bacille Calmette-Guérin in mice.

Br J Pharmacol 2013 Nov;170(5):1014-26

Research Unit of Translational Neurogastroenterology, Institute of Experimental and Clinical Pharmacology, Medical University of Graz, Graz, Austria.

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http://dx.doi.org/10.1111/bph.12354DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3949650PMC
November 2013

Monolithic precolumns as efficient tools for guiding the design of nanoparticulate drug-delivery formulations.

Anal Chem 2012 Sep 22;84(17):7415-21. Epub 2012 Aug 22.

Joanneum Research, HEALTH, Elisabethstrasse 5, 8010 Graz, Austria.

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http://dx.doi.org/10.1021/ac3012208DOI Listing
September 2012

Remodeling of lipid droplets during lipolysis and growth in adipocytes.

J Biol Chem 2012 Mar 6;287(14):11164-73. Epub 2012 Feb 6.

Institute of Molecular Biosciences, Lipidomics Research Center LRC Graz, University of Graz, 8010 Graz, Austria.

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http://dx.doi.org/10.1074/jbc.M111.316794DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3322829PMC
March 2012

Alterations in lipid metabolism mediate inflammation, fibrosis, and proliferation in a mouse model of chronic cholestatic liver injury.

Gastroenterology 2012 Jan 14;142(1):140-151.e12. Epub 2011 Oct 14.

Laboratory of Experimental and Molecular Hepatology, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.

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http://dx.doi.org/10.1053/j.gastro.2011.09.051DOI Listing
January 2012

Prolonged depression-like behavior caused by immune challenge: influence of mouse strain and social environment.

PLoS One 2011 6;6(6):e20719. Epub 2011 Jun 6.

Research Unit of Translational Neurogastroenterology, Institute of Experimental and Clinical Pharmacology, Medical University of Graz, Graz, Austria.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0020719PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3108969PMC
September 2011

Headspace-SPME-GC/MS as a simple cleanup tool for sensitive 2,6-diisopropylphenol analysis from lipid emulsions and adaptable to other matrices.

J Pharm Biomed Anal 2011 Jul 17;55(5):1231-6. Epub 2011 Mar 17.

Health - Institute for Biomedicine and Health Sciences, Joanneum Research, Graz, Austria.

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http://dx.doi.org/10.1016/j.jpba.2011.03.019DOI Listing
July 2011

The use of chitosan-6-mercaptonicotinic acid nanoparticles for oral peptide drug delivery.

Drug Deliv 2011 Apr 2;18(3):190-7. Epub 2010 Nov 2.

University of Innsbruck, Pharmaceutical Technology, Innrain 52c, Innsbruck, 6020 Austria.

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http://dx.doi.org/10.3109/10717544.2010.522611DOI Listing
April 2011

Ring-opening metathesis polymerization for the preparation of norbornene-based weak cation-exchange monolithic capillary columns.

J Chromatogr A 2009 Mar 7;1216(13):2651-7. Epub 2008 Nov 7.

Institute of Medical Technologies and Health Management, Joanneum Research, Auenbruggerplatz 20/3, A-8036 Graz, Austria.

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http://dx.doi.org/10.1016/j.chroma.2008.11.006DOI Listing
March 2009

Validated comprehensive analytical method for quantification of coenzyme A activated compounds in biological tissues by online solid-phase extraction LC/MS/MS.

Anal Chem 2008 Aug 9;80(15):5736-42. Epub 2008 Jul 9.

Institute of Medical Technologies and Health Management, Joanneum Research, Auenbruggerplatz 20,8036 Graz, Austria.

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http://pubs.acs.org/doi/abs/10.1021/ac800031u
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http://dx.doi.org/10.1021/ac800031uDOI Listing
August 2008

Ring-opening metathesis polymerization-derived monolithic capillary columns for high-performance liquid chromatography. Downscaling and application in medical research.

J Chromatogr A 2008 May 8;1191(1-2):274-81. Epub 2008 Jan 8.

Institute of Medical Technologies and Health Management, Joanneum Research, Auenbruggerplatz 20/3, A-8036 Graz, Austria.

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http://dx.doi.org/10.1016/j.chroma.2008.01.005DOI Listing
May 2008

Voltage-assisted capillary LC of peptides using monolithic capillary columns prepared by ring-opening metathesis polymerization.

Electrophoresis 2007 Jul;28(13):2219-22

Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic.

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http://dx.doi.org/10.1002/elps.200700125DOI Listing
July 2007

Rapid online-SPE-MS/MS method for ketoprofen determination in dermal interstitial fluid samples from rats obtained by microdialysis or open-flow microperfusion.

J Chromatogr B Analyt Technol Biomed Life Sci 2007 May 30;850(1-2):432-9. Epub 2006 Dec 30.

Institute of Medical Technologies and Health Management, Joanneum Research, Auenbruggerplatz 20/3, 8036 Graz, Austria.

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http://dx.doi.org/10.1016/j.jchromb.2006.12.026DOI Listing
May 2007

Enantioseparation of glycyl-dipeptides by CEC using particle-loaded monoliths prepared by ring-opening metathesis polymerization (ROMP).

J Biochem Biophys Methods 2006 Nov 17;69(1-2):67-77. Epub 2006 Feb 17.

Institute of Medical Technologies and Health Management, JOANNEUM RESEARCH, Auenbruggerplatz 20/3, A-8036 Graz, Austria.

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http://dx.doi.org/10.1016/j.jbbm.2006.01.010DOI Listing
November 2006

Poly(cyclooctene)-based monolithic columns for capillary high performance liquid chromatography prepared via ring-opening metathesis polymerization.

J Chromatogr A 2006 Nov 24;1132(1-2):124-31. Epub 2006 Aug 24.

Leibniz Institut für Oberflächenmodifizierung e.V. (IOM), Permoserstrasse 15, D-04318 Leipzig, Germany.

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http://dx.doi.org/10.1016/j.chroma.2006.07.058DOI Listing
November 2006

Evaluation of ring-opening metathesis polymerization (ROMP)-derived monolithic capillary high performance liquid chromatography columns.

J Chromatogr A 2005 Oct;1090(1-2):81-9

Institute of Medical Technologies and Health Management, Joanneum Research, Auenbruggerplatz 20/3, A-8036 Graz, Austria.

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http://dx.doi.org/10.1016/j.chroma.2005.06.098DOI Listing
October 2005

Measurement of interstitial insulin in human adipose and muscle tissue under moderate hyperinsulinemia by means of direct interstitial access.

Am J Physiol Endocrinol Metab 2005 Aug 15;289(2):E296-300. Epub 2005 Mar 15.

Dept. of Internal Medicine, Medical Univ. Graz, Auenbruggerplatz 15, A-8036 Graz, Austria.

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http://dx.doi.org/10.1152/ajpendo.00431.2004DOI Listing
August 2005

LC/MS/MS method for quantitative determination of long-chain fatty acyl-CoAs.

Anal Chem 2005 May;77(9):2889-94

Institute of Medical Technologies and Health Management, Joanneum Research, Auenbruggerplatz 20, 8036 Graz, Austria.

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http://pubs.acs.org/doi/abs/10.1021/ac048314i
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http://dx.doi.org/10.1021/ac048314iDOI Listing
May 2005