Frank Rutsch

Frank Rutsch

UNVERIFIED PROFILE

Are you Frank Rutsch?   Register this Author

Register author
Frank Rutsch

Frank Rutsch

Publications by authors named "Frank Rutsch"

Are you Frank Rutsch?   Register this Author

76Publications

1898Reads

43Profile Views

Generation of three induced pluripotent cell lines (iPSCs) from an Aicardi-Goutières syndrome (AGS) patient harboring a deletion in the genomic locus of the sterile alpha motif and HD domain containing protein 1 (SAMHD1).

Stem Cell Res 2020 Mar 9;43:101697. Epub 2020 Jan 9.

Host-Pathogen Interactions, Paul-Ehrlich-Institut, 63225 Langen, Germany; Immunity and Pathogenesis Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, United States. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.scr.2019.101697DOI Listing
March 2020

Reversion of arterial calcification by elastin-targeted DTPA-HSA nanoparticles.

Eur J Pharm Biopharm 2020 Mar 6. Epub 2020 Mar 6.

Institute of Pharmaceutical Technology and Biopharmacy, University of Muenster, Corrensstraße 48, 48149 Muenster, Germany. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ejpb.2020.03.007DOI Listing
March 2020

Long-term comparative effectiveness of pegvaliase versus standard of care comparators in adults with phenylketonuria.

Mol Genet Metab 2019 Sep - Oct;128(1-2):92-101. Epub 2019 Aug 7.

Oregon Health & Science University, Portland, OR, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ymgme.2019.07.018DOI Listing
August 2019

Prevalence of shoulder calcification in pseudoxanthoma elasticum patients.

Joint Bone Spine 2018 12 6;85(6):777-778. Epub 2018 Apr 6.

Reference Centre for PXE, Angers University Hospital, 49933 Angers, France; Department of Dermatology, Angers University Hospital, 49933 Angers, France. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jbspin.2018.03.008DOI Listing
December 2018

Antibodies against PEGylated enzymes: Treat them with respect!

Authors:
Frank Rutsch

EBioMedicine 2018 12 16;38:15-16. Epub 2018 Nov 16.

Department of General Pediatrics, Muenster University Children's Hospital, Albert-Schweitzer Campus 1, D-48149 Münster, Germany. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ebiom.2018.11.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306382PMC
December 2018

ENPP1-Fc prevents neointima formation in generalized arterial calcification of infancy through the generation of AMP.

Exp Mol Med 2018 10 29;50(10):1-12. Epub 2018 Oct 29.

Department of General Pediatrics, Münster University Children's Hospital, Albert-Schweitzer-Campus 1, D-48149, Münster, Germany.

View Article

Download full-text PDF

Source
http://www.nature.com/articles/s12276-018-0163-5
Publisher Site
http://dx.doi.org/10.1038/s12276-018-0163-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6204430PMC
October 2018

Inherited Arterial Calcification Syndromes: Etiologies and Treatment Concepts.

Curr Osteoporos Rep 2017 08;15(4):255-270

Department of General Pediatrics, Münster University Children's Hospital, Albert-Schweitzer-Campus 1, D-48149, Münster, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11914-017-0370-3DOI Listing
August 2017

3-Hydroxy-3-methylglutaryl-coenzyme A lyase deficiency: Clinical presentation and outcome in a series of 37 patients.

Mol Genet Metab 2017 07 22;121(3):206-215. Epub 2017 May 22.

Department of General Pediatrics, Adolescent Medicine and Neonatology, Medical Center - University of Freiburg, Faculty of Medicine, Freiburg, Germany; Division of Clinical Chemistry & Biochemistry and Children's Research Center, University Children's Hospital, Zürich, Switzerland; Bioanalytics & Biochemistry, Department of Natural Sciences, University of Applied Sciences, Rheinbach, Germany. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ymgme.2017.05.014DOI Listing
July 2017

Sapropterin treatment does not enhance the health-related quality of life of patients with phenylketonuria and their parents.

Acta Paediatr 2017 Jun 19;106(6):953-959. Epub 2017 Mar 19.

Department of General Pediatrics, Münster University Children's Hospital, Münster, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/apa.13799DOI Listing
June 2017

MDA5-Associated Neuroinflammation and the Singleton-Merten Syndrome: Two Faces of the Same Type I Interferonopathy Spectrum.

J Interferon Cytokine Res 2017 05;37(5):214-219

1 Department of General Pediatrics, Muenster University Children's Hospital , Muenster, Germany .

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/jir.2017.0004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5439407PMC
May 2017

Effects of Different Variants in the ENPP1 Gene on the Functional Properties of Ectonucleotide Pyrophosphatase/Phosphodiesterase Family Member 1.

Hum Mutat 2016 11 23;37(11):1190-1201. Epub 2016 Aug 23.

Department of General Pediatrics, Muenster University Children's Hospital, Albert-Schweitzer-Campus 1, Muenster, 48149, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/humu.23057DOI Listing
November 2016

Lmbrd1 expression is essential for the initiation of gastrulation.

J Cell Mol Med 2016 08 8;20(8):1523-33. Epub 2016 Apr 8.

Department of General Pediatrics, Müenster University Children's Hospital, Müenster, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jcmm.12844DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4956942PMC
August 2016

New perspectives on rare connective tissue calcifying diseases.

Curr Opin Pharmacol 2016 06 27;28:14-23. Epub 2016 Feb 27.

The Roslin Institute, Royal (Dick) School of Veterinary Studies, The University of Edinburgh, Easter Bush, Midlothian, EH25 9RG Scotland, United Kingdom. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.coph.2016.02.002DOI Listing
June 2016

Novel interferonopathies associated with mutations in RIG-I like receptors.

Cytokine Growth Factor Rev 2016 06 11;29:101-7. Epub 2016 Mar 11.

Department of General Pediatrics, Muenster University Children's Hospital, Albert-Schweitzer-Campus 1, Building A1, 48149 Muenster, Germany. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cytogfr.2016.03.005DOI Listing
June 2016

Nephrotic syndrome and thrombotic microangiopathy caused by cobalamin C deficiency.

Pediatr Nephrol 2015 Jul 18;30(7):1203-6. Epub 2015 Apr 18.

University Children's Hospital Muenster, Muenster, NRW, Germany,

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00467-015-3110-xDOI Listing
July 2015

Modulators of networks: molecular targets of arterial calcification identified in man and mice.

Curr Pharm Des 2014 ;20(37):5839-52

Department of General Pediatrics, Munster University Children's Hospital, Albert-Schweitzer-Campus 1, D-48149 Munster, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1381612820666140212193330DOI Listing
June 2015

Establishment of Singleton-Merten syndrome pulp cells: evidence of mineralization dysregulation.

Connect Tissue Res 2014 Aug;55 Suppl 1:57-61

Institute of Oral Health Research, School of Dentistry University of Alabama , Birmingham, AL , USA and.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3109/03008207.2014.923880DOI Listing
August 2014

Influence of PAH Genotype on Sapropterin Response in PKU: Results of a Single-Center Cohort Study.

JIMD Rep 2014 5;13:101-9. Epub 2013 Nov 5.

Department of General Pediatrics, Münster University Children's Hospital, Albert-Schweitzer Campus 1, Gbd. A1, D-48149, Münster, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/8904_2013_263DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4110336PMC
July 2014

Generalized Arterial Calcification of Infancy: Fatal Clinical Course Associated with a Novel Mutation in ENPP1.

JIMD Rep 2011 25;1:23-7. Epub 2011 Jun 25.

Department of Gynecological, Obstetric and Pediatric Sciences, University Hospital of Bologna, Bologna, Italy.

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/8904_2011_11
Publisher Site
http://dx.doi.org/10.1007/8904_2011_11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3509810PMC
February 2013

Singleton-Merten syndrome: an autosomal dominant disorder with variable expression.

Am J Med Genet A 2013 Feb 15;161A(2):360-70. Epub 2013 Jan 15.

Department of Clinical and Metabolic Genetics, The Hospital for Sick Children and University of Toronto, Toronto, Ontario, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ajmg.a.35732DOI Listing
February 2013

Genetics in arterial calcification: lessons learned from rare diseases.

Trends Cardiovasc Med 2012 Aug;22(6):145-9

Department of General Pediatrics, Münster University Children's Hospital, D-48149 Münster, Germany.

View Article

Download full-text PDF

Source
http://linkinghub.elsevier.com/retrieve/pii/S105017381200224
Publisher Site
http://dx.doi.org/10.1016/j.tcm.2012.07.011DOI Listing
August 2012

Molecular diagnosis of generalized arterial calcification of infancy (GACI).

J Cardiovasc Dis Res 2012 Apr;3(2):150-4

Department of Molecular Biology and Cytogenetics, Apollo Health city, Jubilee Hills, Hyderabad, India.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/0975-3583.95373DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3354462PMC
April 2012

Efficacy and safety of 2-year etidronate treatment in a child with generalized arterial calcification of infancy.

Eur J Pediatr 2011 Dec 20;170(12):1585-90. Epub 2011 Sep 20.

Bone Metabolism Clinic, Department of Pediatrics, Sainte-Justine University Hospital, 3175 Chemin de la Côte Sainte-Catherine, Montreal, QC, H3T1C5, Canada.

View Article

Download full-text PDF

Source
http://link.springer.com/content/pdf/10.1007/s00431-011-1572
Web Search
http://link.springer.com/10.1007/s00431-011-1572-9
Publisher Site
http://dx.doi.org/10.1007/s00431-011-1572-9DOI Listing
December 2011

Npp1 promotes atherosclerosis in ApoE knockout mice.

J Cell Mol Med 2011 Nov;15(11):2273-83

Department of General Pediatrics, Muenster University Children's Hospital, Muenster, Germany.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/j.1582-4934.2011.01327.x
Publisher Site
http://dx.doi.org/10.1111/j.1582-4934.2011.01327.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3154990PMC
November 2011

Genetics in arterial calcification: pieces of a puzzle and cogs in a wheel.

Circ Res 2011 Aug;109(5):578-92

Department of General Pediatrics, Münster University Children's Hospital, Albert-Schweitzer-Campus 1, D-48149 Münster, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1161/CIRCRESAHA.111.247965DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3248761PMC
August 2011

Expression of NPP1 is regulated during atheromatous plaque calcification.

J Cell Mol Med 2011 Feb;15(2):220-31

Department of General Pediatrics, Münster University Children's Hospital, Münster, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1582-4934.2009.00988.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3822790PMC
February 2011

LMBRD1: the gene for the cblF defect of vitamin B₁₂ metabolism.

J Inherit Metab Dis 2011 Feb 6;34(1):121-6. Epub 2010 May 6.

Department of General Pediatrics, Münster University Children's Hospital, Münster, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10545-010-9083-9DOI Listing
February 2011

Insights into lysosomal cobalamin trafficking: lessons learned from cblF disease.

J Mol Med (Berl) 2010 May 20;88(5):459-66. Epub 2010 Feb 20.

Department of General Pediatrics, Münster University Children's Hospital, Münster, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00109-010-0601-xDOI Listing
May 2010

Successful treatment of cold-induced sweating in Crisponi syndrome and its possible mechanism of action.

Dev Med Child Neurol 2010 May 24;52(5):494-7. Epub 2010 Feb 24.

Department of General Pediatics, Münster University Children's Hospital, Münster, Germany.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/j.1469-8749.2010.03630.x
Publisher Site
http://dx.doi.org/10.1111/j.1469-8749.2010.03630.xDOI Listing
May 2010

A novel mutation in LMBRD1 causes the cblF defect of vitamin B(12) metabolism in a Turkish patient.

J Inherit Metab Dis 2010 Feb 3;33(1):17-24. Epub 2010 Feb 3.

Department of General Pediatrics, Münster University Children's Hospital, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10545-009-9032-7DOI Listing
February 2010

Generalized arterial calcification of infancy: phenotypic spectrum among three siblings including one case without obvious arterial calcifications.

Am J Med Genet A 2009 Mar;149A(3):456-60

Department of Paediatric Neurology, Evelina Children's Hospital, St Thomas' Hospital, London, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ajmg.a.32646DOI Listing
March 2009

Generalized arterial calcification of infancy: treatment with bisphosphonates.

Nat Clin Pract Endocrinol Metab 2009 Mar;5(3):167-72

Institute of Endocrinology and Diabetes, The Children's Hospital at Westmead, Westmead, Australia.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ncpendmet1067DOI Listing
March 2009

Case 1: An infant with heart failure (case presentation).

Acta Paediatr 2009 Jan;98(1):5-6, 199-201

Department of Pediatrics, University of Torino, Turin, Italy.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/j.1651-2227.2008.01012.x
Publisher Site
http://dx.doi.org/10.1111/j.1651-2227.2008.01012.xDOI Listing
January 2009

Mechanisms of arterial calcification: spotlight on the inhibitors.

Adv Clin Chem 2008 ;46:263-93

Department of Cardiothoracic Surgery, Münster University Hospital, Münster, Germany.

View Article

Download full-text PDF

Source
November 2008

Kocuria rhizophila adds to the emerging spectrum of micrococcal species involved in human infections.

J Clin Microbiol 2008 Oct 9;46(10):3537-9. Epub 2008 Jul 9.

University Hospital of Münster, Institute of Medical Microbiology, Domagkstr. 10, 48149 Münster, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1128/JCM.00823-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2566074PMC
October 2008

Inborn error of amino acid synthesis: human glutamine synthetase deficiency.

J Inherit Metab Dis 2006 Apr-Jun;29(2-3):352-8

Klinik und Poliklinik für Kinder- und Jugendmedizin, Universitätsklinikum Münster, Albert-Schweitzer-Str. 33, 48129, Münster, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10545-006-0256-5DOI Listing
January 2007

Association of ENPP1 gene polymorphisms with hand osteoarthritis in a Chuvasha population.

Arthritis Res Ther 2005 13;7(5):R1082-90. Epub 2005 Jul 13.

Gene Mapping Center, Max Delbrück Center for Molecular Medicine, Berlin, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/ar1786DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1257435PMC
April 2006

Generalized arterial calcification of infancy: two siblings with prolonged survival.

Eur J Pediatr 2006 Apr 29;165(4):258-63. Epub 2005 Nov 29.

S.C. di Neonatologia e Terapia Intensiva Neonatale, Istituto per l'Infanzia Burlo Garofolo, Via dell'Istria 65/1-34100, Trieste, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00431-005-0035-6DOI Listing
April 2006

Congenital glutamine deficiency with glutamine synthetase mutations.

N Engl J Med 2005 Nov;353(18):1926-33

Universitätsklinikum Münster, Klinik und Poliklinik für Kinderheilkunde und Jugendmedizin, Münster, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1056/NEJMoa050456DOI Listing
November 2005

Generalized arterial calcification of infancy: different clinical courses in two affected siblings.

Am J Med Genet A 2005 Jul;136(2):210-3

Department of Pediatrics, Mackay Memorial Hospital, Taipei, Taiwan.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/ajmg.a.30800
Publisher Site
http://dx.doi.org/10.1002/ajmg.a.30800DOI Listing
July 2005

Deficiencies of physiologic calcification inhibitors and low-grade inflammation in arterial calcification: lessons for cartilage calcification.

Joint Bone Spine 2005 Mar;72(2):110-8

Klinik und Poliklinik für Kinder- und Jugendmedizin, Universitätsklinikum Münster, Albert-Schweitzer-Strasse 33, D-48149 Münster, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jbspin.2004.05.014DOI Listing
March 2005

The mutational spectrum of ENPP1 as arising after the analysis of 23 unrelated patients with generalized arterial calcification of infancy (GACI).

Hum Mutat 2005 Jan;25(1):98

Gene Mapping Center, Max-Delbrück-Center for Molecular Medicine, Berlin-Buch, Germany.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/humu.9297DOI Listing
January 2005

Parallels between arterial and cartilage calcification: what understanding artery calcification can teach us about chondrocalcinosis.

Curr Opin Rheumatol 2003 May;15(3):302-10

Veterans Affairs Medical Center, University of California, San Diego School of Medicine, San Diego, California 92161, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/00002281-200305000-00019DOI Listing
May 2003